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Choroid mixed cell melanoma

MedGen UID:
232361
•Concept ID:
C1333025
•
Neoplastic Process
Synonyms: Choroid Mixed Cell Melanoma; choroid mixed cell melanoma; mixed cell uveal melanoma of optic choroid; optic choroid mixed cell uveal melanoma
 
Monarch Initiative: MONDO:0003913

Definition

A melanoma arising from the choroid. It is characterized by the presence of a mixture of spindle A melanoma cells, spindle B melanoma cells, and epithelioid melanoma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChoroid mixed cell melanoma

Professional guidelines

PubMed

Management of small elevated pigmented choroidal lesions.
Char DH, Hogan MJ
Br J Ophthalmol 1977 Jan;61(1):54-8. doi: 10.1136/bjo.61.1.54. PMID: 836778Free PMC Article

Recent clinical studies

Etiology

Autophagy and vesicular trafficking in human uveal melanoma: A histopathological study.
Taskaeva I, Shatruk A, Bgatova N, Yeremina A, Trunov A, Kononova N, Chernykh V
Microsc Res Tech 2024 Jan;87(1):122-132. Epub 2023 Sep 12 doi: 10.1002/jemt.24417. PMID: 37698482
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article
Eye-wall resection.
Char DH, Miller T, Crawford JB
Trans Am Ophthalmol Soc 2000;98:153-9; discussion 159-61. PMID: 11190019Free PMC Article

Diagnosis

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
PEMBROLIZUMAB ADMINISTRATION ASSOCIATED WITH POSTERIOR UVEITIS.
Aaberg MT, Aaberg TM Jr
Retin Cases Brief Rep 2017 Fall;11(4):348-351. doi: 10.1097/ICB.0000000000000368. PMID: 27490976
Uveal melanoma: An analysis of cellular features and comparison to monosomy 3 status.
Hamadeh F, Medina CA, Singh AD, Reynolds JP, Biscotti CV
Diagn Cytopathol 2016 May;44(5):377-83. Epub 2016 Feb 15 doi: 10.1002/dc.23450. PMID: 26876235
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122

Therapy

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
PEMBROLIZUMAB ADMINISTRATION ASSOCIATED WITH POSTERIOR UVEITIS.
Aaberg MT, Aaberg TM Jr
Retin Cases Brief Rep 2017 Fall;11(4):348-351. doi: 10.1097/ICB.0000000000000368. PMID: 27490976
Autologous cell vaccine as a post operative adjuvant treatment for high-risk melanoma patients (AJCC stages III and IV). The new American Joint Committee on Cancer.
Lotem M, Peretz T, Drize O, Gimmon Z, Ad El D, Weitzen R, Goldberg H, Ben David I, Prus D, Hamburger T, Shiloni E
Br J Cancer 2002 May 20;86(10):1534-9. doi: 10.1038/sj.bjc.6600251. PMID: 12085200Free PMC Article
Two discrete choroidal melanomas in an eye with ocular melanocytosis.
Honavar SG, Shields CL, Singh AD, Demirci H, Rutledge BK, Shields JA, Eagle RC Jr
Surv Ophthalmol 2002 Jan-Feb;47(1):36-41. doi: 10.1016/s0039-6257(01)00281-8. PMID: 11801268
Trends in incidence of ocular malignant melanoma in Denmark 1943-1982.
Osterlind A
Int J Cancer 1987 Aug 15;40(2):161-4. doi: 10.1002/ijc.2910400206. PMID: 3610385

Prognosis

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.
Sabazade S, Herrspiegel C, Gill V, Stålhammar G
BMC Cancer 2021 Nov 24;21(1):1270. doi: 10.1186/s12885-021-09002-0. PMID: 34819035Free PMC Article
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098
Uveal tumour resection.
Char DH, Miller T, Crawford JB
Br J Ophthalmol 2001 Oct;85(10):1213-9. doi: 10.1136/bjo.85.10.1213. PMID: 11567967Free PMC Article

Clinical prediction guides

Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Diagnostic Cytologic Features of Uveal Melanoma.
Medina CA, Biscotti CV, Singh N, Singh AD
Ophthalmology 2015 Aug;122(8):1580-4. Epub 2015 May 23 doi: 10.1016/j.ophtha.2015.04.013. PMID: 26012864
Epidemiological trends in uveal melanoma.
Andreoli MT, Mieler WF, Leiderman YI
Br J Ophthalmol 2015 Nov;99(11):1550-3. Epub 2015 Apr 22 doi: 10.1136/bjophthalmol-2015-306810. PMID: 25904122
Expression and distribution of MMPs and TIMPs in human uveal melanoma.
Lai K, Conway RM, Crouch R, Jager MJ, Madigan MC
Exp Eye Res 2008 Jun;86(6):936-41. Epub 2008 Mar 16 doi: 10.1016/j.exer.2008.03.010. PMID: 18423620
Pathological and prognostic features of uveal melanomas.
McLean IW, Saraiva VS, Burnier MN Jr
Can J Ophthalmol 2004 Jun;39(4):343-50. doi: 10.1016/s0008-4182(04)80004-8. PMID: 15327098

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