U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gastric cardia adenocarcinoma

MedGen UID:
232543
•Concept ID:
C1333762
•
Neoplastic Process
Synonyms: Adenocarcinoma of Cardia of Stomach; adenocarcinoma of cardia of stomach; Adenocarcinoma of Gastric Cardia; adenocarcinoma of gastric cardia; Adenocarcinoma of the Cardia of the Stomach; adenocarcinoma of the cardia of the stomach; Adenocarcinoma of the Gastric Cardia; adenocarcinoma of the gastric cardia; cardia of stomach adenocarcinoma; Gastric Cardia Adenocarcinoma; gastric cardia adenocarcinoma
 
Monarch Initiative: MONDO:0003835

Definition

An adenocarcinoma that arises from the gastric cardia. The majority of cases have been reclassified as gastroesophageal junction adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric cardia adenocarcinoma

Professional guidelines

PubMed

Missed Opportunities for Screening or Surveillance Among Patients with Newly Diagnosed Non-cardia Gastric Adenocarcinoma.
Tan MC, Mallepally N, Nguyen TH, Hammad T, Kim DK, Othman MO, El-Serag HB, Thrift AP
Dig Dis Sci 2023 Mar;68(3):761-769. Epub 2022 Jun 11 doi: 10.1007/s10620-022-07587-5. PMID: 35689702
Helicobacter pylori eradication treatment and the risk of gastric adenocarcinoma in a Western population.
Doorakkers E, Lagergren J, Engstrand L, Brusselaers N
Gut 2018 Dec;67(12):2092-2096. Epub 2018 Jan 30 doi: 10.1136/gutjnl-2017-315363. PMID: 29382776
Asia-Pacific consensus guidelines on gastric cancer prevention.
Fock KM, Talley N, Moayyedi P, Hunt R, Azuma T, Sugano K, Xiao SD, Lam SK, Goh KL, Chiba T, Uemura N, Kim JG, Kim N, Ang TL, Mahachai V, Mitchell H, Rani AA, Liou JM, Vilaichone RK, Sollano J; Asia-Pacific Gastric Cancer Consensus Conference
J Gastroenterol Hepatol 2008 Mar;23(3):351-65. doi: 10.1111/j.1440-1746.2008.05314.x. PMID: 18318820

Recent clinical studies

Etiology

Adherence to the Mediterranean Diet and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis.
Bai X, Li X, Ding S, Dai D
Nutrients 2023 Sep 1;15(17) doi: 10.3390/nu15173826. PMID: 37686858Free PMC Article
Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort.
Wang L, Ge J, Feng L, Wang Z, Wang W, Han H, Qin Y
Cancer Med 2023 Jun;12(12):13111-13122. Epub 2023 May 3 doi: 10.1002/cam4.5994. PMID: 37132269Free PMC Article
Diet quality and risk of gastric adenocarcinoma: The Multiethnic Cohort.
Acuna N, Park SY, Le Marchand L, Hébert JR, Boushey C, Wilkens LR, Wu AH, Setiawan VW
Am J Clin Nutr 2023 Jan;117(1):46-54. Epub 2022 Dec 20 doi: 10.1016/j.ajcnut.2022.11.009. PMID: 36789943Free PMC Article
Obesity and related risk factors in gastric cardia adenocarcinoma.
Olefson S, Moss SF
Gastric Cancer 2015 Jan;18(1):23-32. Epub 2014 Sep 11 doi: 10.1007/s10120-014-0425-4. PMID: 25209115
Tobacco smoking and esophageal and gastric cardia adenocarcinoma: a meta-analysis.
Tramacere I, La Vecchia C, Negri E
Epidemiology 2011 May;22(3):344-9. doi: 10.1097/EDE.0b013e31821092cd. PMID: 21330928

Diagnosis

Predicting Incident Adenocarcinoma of the Esophagus or Gastric Cardia Using Machine Learning of Electronic Health Records.
Rubenstein JH, Fontaine S, MacDonald PW, Burns JA, Evans RR, Arasim ME, Chang JW, Firsht EM, Hawley ST, Saini SD, Wallner LP, Zhu J, Waljee AK
Gastroenterology 2023 Dec;165(6):1420-1429.e10. Epub 2023 Aug 18 doi: 10.1053/j.gastro.2023.08.011. PMID: 37597631Free PMC Article
Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort.
Wang L, Ge J, Feng L, Wang Z, Wang W, Han H, Qin Y
Cancer Med 2023 Jun;12(12):13111-13122. Epub 2023 May 3 doi: 10.1002/cam4.5994. PMID: 37132269Free PMC Article
NNMT enriches for AQP5(+) cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.
Wang Z, Wang Q, Chen C, Zhao X, Wang H, Xu L, Fu Y, Huang G, Li M, Xu J, Zhang Q, Wang B, Xu G, Wang L, Zou X, Wang S
Gut 2023 Dec 7;73(1):63-77. doi: 10.1136/gutjnl-2022-328408. PMID: 36977555
Expression of MiR-129 in Patients with Gastric Cardia Adenocarcinoma and Prognostic Analysis.
Yang J
Clin Lab 2022 Jan 1;68(1) doi: 10.7754/Clin.Lab.2021.210338. PMID: 35023689
Clinicopathological features and prognosis of gastric cardia adenocarcinoma: a multi-institutional US study.
Amini N, Spolverato G, Kim Y, Squires MH, Poultsides GA, Fields R, Schmidt C, Weber SM, Votanopoulos K, Maithel SK, Pawlik TM
J Surg Oncol 2015 Mar;111(3):285-92. Epub 2014 Oct 10 doi: 10.1002/jso.23799. PMID: 25308915

Therapy

Adherence to the Mediterranean Diet and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis.
Bai X, Li X, Ding S, Dai D
Nutrients 2023 Sep 1;15(17) doi: 10.3390/nu15173826. PMID: 37686858Free PMC Article
Predicting Incident Adenocarcinoma of the Esophagus or Gastric Cardia Using Machine Learning of Electronic Health Records.
Rubenstein JH, Fontaine S, MacDonald PW, Burns JA, Evans RR, Arasim ME, Chang JW, Firsht EM, Hawley ST, Saini SD, Wallner LP, Zhu J, Waljee AK
Gastroenterology 2023 Dec;165(6):1420-1429.e10. Epub 2023 Aug 18 doi: 10.1053/j.gastro.2023.08.011. PMID: 37597631Free PMC Article
Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort.
Wang L, Ge J, Feng L, Wang Z, Wang W, Han H, Qin Y
Cancer Med 2023 Jun;12(12):13111-13122. Epub 2023 May 3 doi: 10.1002/cam4.5994. PMID: 37132269Free PMC Article
Diet quality and risk of gastric adenocarcinoma: The Multiethnic Cohort.
Acuna N, Park SY, Le Marchand L, Hébert JR, Boushey C, Wilkens LR, Wu AH, Setiawan VW
Am J Clin Nutr 2023 Jan;117(1):46-54. Epub 2022 Dec 20 doi: 10.1016/j.ajcnut.2022.11.009. PMID: 36789943Free PMC Article
Tobacco smoking and esophageal and gastric cardia adenocarcinoma: a meta-analysis.
Tramacere I, La Vecchia C, Negri E
Epidemiology 2011 May;22(3):344-9. doi: 10.1097/EDE.0b013e31821092cd. PMID: 21330928

Prognosis

Predicting Incident Adenocarcinoma of the Esophagus or Gastric Cardia Using Machine Learning of Electronic Health Records.
Rubenstein JH, Fontaine S, MacDonald PW, Burns JA, Evans RR, Arasim ME, Chang JW, Firsht EM, Hawley ST, Saini SD, Wallner LP, Zhu J, Waljee AK
Gastroenterology 2023 Dec;165(6):1420-1429.e10. Epub 2023 Aug 18 doi: 10.1053/j.gastro.2023.08.011. PMID: 37597631Free PMC Article
Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort.
Wang L, Ge J, Feng L, Wang Z, Wang W, Han H, Qin Y
Cancer Med 2023 Jun;12(12):13111-13122. Epub 2023 May 3 doi: 10.1002/cam4.5994. PMID: 37132269Free PMC Article
NNMT enriches for AQP5(+) cancer stem cells to drive malignant progression in early gastric cardia adenocarcinoma.
Wang Z, Wang Q, Chen C, Zhao X, Wang H, Xu L, Fu Y, Huang G, Li M, Xu J, Zhang Q, Wang B, Xu G, Wang L, Zou X, Wang S
Gut 2023 Dec 7;73(1):63-77. doi: 10.1136/gutjnl-2022-328408. PMID: 36977555
Expression of MiR-129 in Patients with Gastric Cardia Adenocarcinoma and Prognostic Analysis.
Yang J
Clin Lab 2022 Jan 1;68(1) doi: 10.7754/Clin.Lab.2021.210338. PMID: 35023689
Tobacco smoking and esophageal and gastric cardia adenocarcinoma: a meta-analysis.
Tramacere I, La Vecchia C, Negri E
Epidemiology 2011 May;22(3):344-9. doi: 10.1097/EDE.0b013e31821092cd. PMID: 21330928

Clinical prediction guides

Predicting Incident Adenocarcinoma of the Esophagus or Gastric Cardia Using Machine Learning of Electronic Health Records.
Rubenstein JH, Fontaine S, MacDonald PW, Burns JA, Evans RR, Arasim ME, Chang JW, Firsht EM, Hawley ST, Saini SD, Wallner LP, Zhu J, Waljee AK
Gastroenterology 2023 Dec;165(6):1420-1429.e10. Epub 2023 Aug 18 doi: 10.1053/j.gastro.2023.08.011. PMID: 37597631Free PMC Article
Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort.
Wang L, Ge J, Feng L, Wang Z, Wang W, Han H, Qin Y
Cancer Med 2023 Jun;12(12):13111-13122. Epub 2023 May 3 doi: 10.1002/cam4.5994. PMID: 37132269Free PMC Article
Diet quality and risk of gastric adenocarcinoma: The Multiethnic Cohort.
Acuna N, Park SY, Le Marchand L, Hébert JR, Boushey C, Wilkens LR, Wu AH, Setiawan VW
Am J Clin Nutr 2023 Jan;117(1):46-54. Epub 2022 Dec 20 doi: 10.1016/j.ajcnut.2022.11.009. PMID: 36789943Free PMC Article
Expression of MiR-129 in Patients with Gastric Cardia Adenocarcinoma and Prognostic Analysis.
Yang J
Clin Lab 2022 Jan 1;68(1) doi: 10.7754/Clin.Lab.2021.210338. PMID: 35023689
ABO genotypes and the risk of esophageal and gastric cancers.
Chen Y, Hu N, Liao L, Yu K, Shu XO, Zheng W, Yuan JM, Koh WP, Qiao YL, Fan JH, Dawsey SM, Freedman ND, Taylor PR, Goldstein AM, Abnet CC
BMC Cancer 2021 May 22;21(1):589. doi: 10.1186/s12885-021-08334-1. PMID: 34022824Free PMC Article

Recent systematic reviews

Adherence to the Mediterranean Diet and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis.
Bai X, Li X, Ding S, Dai D
Nutrients 2023 Sep 1;15(17) doi: 10.3390/nu15173826. PMID: 37686858Free PMC Article
Red and processed meat consumption and gastric cancer risk: a systematic review and meta-analysis.
Zhao Z, Yin Z, Zhao Q
Oncotarget 2017 May 2;8(18):30563-30575. doi: 10.18632/oncotarget.15699. PMID: 28430644Free PMC Article
Abdominal obesity and gastroesophageal cancer risk: systematic review and meta-analysis of prospective studies.
Du X, Hidayat K, Shi BM
Biosci Rep 2017 Jun 30;37(3) Epub 2017 May 11 doi: 10.1042/BSR20160474. PMID: 28336766Free PMC Article
The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis.
Behrens G, Jochem C, Keimling M, Ricci C, Schmid D, Leitzmann MF
Eur J Epidemiol 2014 Mar;29(3):151-70. Epub 2014 Apr 6 doi: 10.1007/s10654-014-9895-2. PMID: 24705782
Gastric atrophy and risk of oesophageal cancer and gastric cardia adenocarcinoma--a systematic review and meta-analysis.
Islami F, Sheikhattari P, Ren JS, Kamangar F
Ann Oncol 2011 Apr;22(4):754-760. Epub 2010 Sep 22 doi: 10.1093/annonc/mdq411. PMID: 20860989

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...