U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Immunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder

MedGen UID:
232639
•Concept ID:
C1334157
•
Neoplastic Process
Synonyms: Immunoblastic Diffuse Large B-Cell Lymphoma PTLD; Immunoblastic Lymphoma PTLD

Definition

An immunoblastic lymphoma that arises in a patient with a history of organ transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder

Recent clinical studies

Etiology

Post-transplant lymphoproliferative disorders: molecular basis of disease histogenesis and pathogenesis.
Capello D, Rossi D, Gaidano G
Hematol Oncol 2005 Jun;23(2):61-7. doi: 10.1002/hon.751. PMID: 16216037
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups.
Prince HM, Imrie K, Crump M, Stewart AK, Girouard C, Colwill R, Brandwein J, Tsang RW, Scott JG, Sutton DM, Pantalony D, Carstairs K, Sutcliffe SB, Keating A
Br J Haematol 1996 Mar;92(4):880-9. doi: 10.1046/j.1365-2141.1996.437976.x. PMID: 8616081
Epstein-Barr virus latent and replicative gene expression in post-transplant lymphoproliferative disorders and AIDS-related non-Hodgkin's lymphomas. French Study Group of Pathology for HIV-associated Tumors.
Rea D, Delecluse HJ, Hamilton-Dutoit SJ, Marelle L, Joab I, Edelman L, Finet JF, Raphael M
Ann Oncol 1994;5 Suppl 1:113-6. doi: 10.1093/annonc/5.suppl_1.s113. PMID: 8172807
EBV-induced human B cell lymphomas in hu-PBL-SCID mice.
Mosier DE, Picchio GR, Kirven MB, Garnier JL, Torbett BE, Baird SM, Kobayashi R, Kipps TJ
AIDS Res Hum Retroviruses 1992 May;8(5):735-40. PMID: 1325170
Occurrence of lymphoproliferative disorders in heart transplant recipients.
Selleslag DL, Boogaerts MA, Daenen W, De Wolf-Peeters C, Janssens L, Vanhaecke J
Acta Clin Belg 1991;46(2):68-74. doi: 10.1080/17843286.1991.11718145. PMID: 1649531

Diagnosis

Methotrexate-associated lymphoproliferative disorders mimicking angioimmunoblastic T-cell lymphoma.
Hatanaka K, Nakamura N, Kojima M, Ando K, Irie S, Bunno M, Nakamine H, Uekusa T
Pathol Res Pract 2010 Jan 15;206(1):9-13. Epub 2009 Jul 23 doi: 10.1016/j.prp.2009.03.005. PMID: 19628340
Cytotoxic drug sensitivity of Epstein-Barr virus transformed lymphoblastoid B-cells.
Markasz L, Stuber G, Flaberg E, Jernberg AG, Eksborg S, Olah E, Skribek H, Szekely L
BMC Cancer 2006 Nov 13;6:265. doi: 10.1186/1471-2407-6-265. PMID: 17101045Free PMC Article
Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients.
Jenkins D, DiFrancesco L, Chaudhry A, Morris D, Glück S, Jones A, Woodman R, Brown CB, Russell J, Stewart DA
Bone Marrow Transplant 2002 Sep;30(5):321-6. doi: 10.1038/sj.bmt.1703603. PMID: 12209355
Epstein-Barr virus (EBV)-associated smooth-muscle tumor arising in a post-transplant patient treated successfully for two PT-EBV-associated large-cell lymphomas. Case report.
Kingma DW, Shad A, Tsokos M, Fest T, Otsuki T, Frekko K, Werner E, Werner A, Magrath I, Raffeld M, Jaffe ES
Am J Surg Pathol 1996 Dec;20(12):1511-9. doi: 10.1097/00000478-199612000-00011. PMID: 8944045
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups.
Prince HM, Imrie K, Crump M, Stewart AK, Girouard C, Colwill R, Brandwein J, Tsang RW, Scott JG, Sutton DM, Pantalony D, Carstairs K, Sutcliffe SB, Keating A
Br J Haematol 1996 Mar;92(4):880-9. doi: 10.1046/j.1365-2141.1996.437976.x. PMID: 8616081

Therapy

Plasmablastic lymphomas may occur as post-transplant lymphoproliferative disorders.
Borenstein J, Pezzella F, Gatter KC
Histopathology 2007 Dec;51(6):774-7. Epub 2007 Oct 17 doi: 10.1111/j.1365-2559.2007.02870.x. PMID: 17944927
Post-transplant lymphoproliferative disorders: molecular basis of disease histogenesis and pathogenesis.
Capello D, Rossi D, Gaidano G
Hematol Oncol 2005 Jun;23(2):61-7. doi: 10.1002/hon.751. PMID: 16216037
Fatal EBV-related post-transplant lymphoproliferative disorder (LPD) after matched related donor nonmyeloablative peripheral blood progenitor cell transplant.
Zamkoff KW, Bergman S, Beaty MW, Buss DH, Pettenati MJ, Hurd DD
Bone Marrow Transplant 2003 Feb;31(3):219-22. doi: 10.1038/sj.bmt.1703838. PMID: 12621485
Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients.
Jenkins D, DiFrancesco L, Chaudhry A, Morris D, Glück S, Jones A, Woodman R, Brown CB, Russell J, Stewart DA
Bone Marrow Transplant 2002 Sep;30(5):321-6. doi: 10.1038/sj.bmt.1703603. PMID: 12209355
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups.
Prince HM, Imrie K, Crump M, Stewart AK, Girouard C, Colwill R, Brandwein J, Tsang RW, Scott JG, Sutton DM, Pantalony D, Carstairs K, Sutcliffe SB, Keating A
Br J Haematol 1996 Mar;92(4):880-9. doi: 10.1046/j.1365-2141.1996.437976.x. PMID: 8616081

Prognosis

Fulminant Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder with hemophagocytosis following autologous peripheral blood stem cell transplantation for relapsed angioimmunoblastic T-cell lymphoma.
Awaya N, Adachi A, Mori T, Kamata H, Nakahara J, Yokoyama K, Yamada T, Kizaki M, Sakamoto M, Ikeda Y, Okamoto S
Leuk Res 2006 Aug;30(8):1059-62. Epub 2005 Dec 2 doi: 10.1016/j.leukres.2005.10.022. PMID: 16330097
T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation.
Narumi H, Kojima K, Matsuo Y, Shikata H, Sekiya K, Niiya T, Bando S, Niiya H, Azuma T, Yakushijin Y, Sakai I, Yasukawa M, Fujita S
Bone Marrow Transplant 2004 Jan;33(1):99-101. doi: 10.1038/sj.bmt.1704298. PMID: 14704662
Fatal EBV-related post-transplant lymphoproliferative disorder (LPD) after matched related donor nonmyeloablative peripheral blood progenitor cell transplant.
Zamkoff KW, Bergman S, Beaty MW, Buss DH, Pettenati MJ, Hurd DD
Bone Marrow Transplant 2003 Feb;31(3):219-22. doi: 10.1038/sj.bmt.1703838. PMID: 12621485
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups.
Prince HM, Imrie K, Crump M, Stewart AK, Girouard C, Colwill R, Brandwein J, Tsang RW, Scott JG, Sutton DM, Pantalony D, Carstairs K, Sutcliffe SB, Keating A
Br J Haematol 1996 Mar;92(4):880-9. doi: 10.1046/j.1365-2141.1996.437976.x. PMID: 8616081
EBV-induced human B cell lymphomas in hu-PBL-SCID mice.
Mosier DE, Picchio GR, Kirven MB, Garnier JL, Torbett BE, Baird SM, Kobayashi R, Kipps TJ
AIDS Res Hum Retroviruses 1992 May;8(5):735-40. PMID: 1325170

Clinical prediction guides

Fulminant Epstein-Barr virus (EBV)-associated T-cell lymphoproliferative disorder with hemophagocytosis following autologous peripheral blood stem cell transplantation for relapsed angioimmunoblastic T-cell lymphoma.
Awaya N, Adachi A, Mori T, Kamata H, Nakahara J, Yokoyama K, Yamada T, Kizaki M, Sakamoto M, Ikeda Y, Okamoto S
Leuk Res 2006 Aug;30(8):1059-62. Epub 2005 Dec 2 doi: 10.1016/j.leukres.2005.10.022. PMID: 16330097
The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups.
Prince HM, Imrie K, Crump M, Stewart AK, Girouard C, Colwill R, Brandwein J, Tsang RW, Scott JG, Sutton DM, Pantalony D, Carstairs K, Sutcliffe SB, Keating A
Br J Haematol 1996 Mar;92(4):880-9. doi: 10.1046/j.1365-2141.1996.437976.x. PMID: 8616081
EBV-induced human B cell lymphomas in hu-PBL-SCID mice.
Mosier DE, Picchio GR, Kirven MB, Garnier JL, Torbett BE, Baird SM, Kobayashi R, Kipps TJ
AIDS Res Hum Retroviruses 1992 May;8(5):735-40. PMID: 1325170
Primary gastrointestinal malignant lymphomas associated with Epstein-Barr virus after heart transplantation.
Guettier C, Hamilton-Dutoit S, Guillemain R, Farge D, Amrein C, Vulser C, Hofman P, Carpentier A, Diebold J
Histopathology 1992 Jan;20(1):21-8. doi: 10.1111/j.1365-2559.1992.tb00911.x. PMID: 1310668
Post-transplant malignant lymphoma. Distinctive morphologic features related to its pathogenesis.
Matas AJ, Hertel BF, Rosai J, Simmoms RL, Najarian JS
Am J Med 1976 Nov;61(5):716-20. doi: 10.1016/0002-9343(76)90151-0. PMID: 790955

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...