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Invasive Breast Apocrine Carcinoma

MedGen UID:
232670
•Concept ID:
C1334272
•
Neoplastic Process
Synonyms: Infiltrating Apocrine Breast Carcinoma; Infiltrating Apocrine Carcinoma of Breast; Infiltrating Apocrine Carcinoma of the Breast; Invasive Apocrine Breast Carcinoma; Invasive Apocrine Carcinoma of Breast; Invasive Apocrine Carcinoma of the Breast; Invasive Breast Carcinoma with Apocrine Differentiation

Definition

An invasive breast adenocarcinoma with cytological and immunophenotypic characteristics of apocrine differentiation in more than 90 percent of the malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Breast Apocrine Carcinoma

Professional guidelines

PubMed

Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Significance of rat mammary tumors for human risk assessment.
Russo J
Toxicol Pathol 2015 Feb;43(2):145-70. Epub 2014 May 28 doi: 10.1177/0192623314532036. PMID: 25714400Free PMC Article

Recent clinical studies

Etiology

Defining triple-negative breast cancer with neuroendocrine differentiation (TNBC-NED).
Hacking SM, Yakirevich E, Wang Y
J Pathol Clin Res 2023 Jul;9(4):313-321. Epub 2023 Apr 20 doi: 10.1002/cjp2.318. PMID: 37082801Free PMC Article
Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Apocrine Breast Cancer: Unique Features of a Predominantly Triple-Negative Breast Cancer.
Saridakis A, Berger ER, Harigopal M, Park T, Horowitz N, Le Blanc J, Zanieski G, Chagpar A, Greenup R, Golshan M, Lannin DR
Ann Surg Oncol 2021 Oct;28(10):5610-5616. Epub 2021 Aug 23 doi: 10.1245/s10434-021-10518-9. PMID: 34426884
Lobular carcinoma in situ: diagnostic criteria and molecular correlates.
Sokolova A, Lakhani SR
Mod Pathol 2021 Jan;34(Suppl 1):8-14. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00689-3. PMID: 33024303

Diagnosis

TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma.
Yoon EC, Wang G, Parkinson B, Huo L, Peng Y, Wang J, Salisbury T, Wu Y, Chen H, Albarracin CT, Resetkova E, Middleton LP, Krishnamurthy S, Gan Q, Sun H, Huang X, Shen T, Chen W, Parwani AV, Sahin AA, Li Z, Ding Q
Hum Pathol 2022 Jul;125:97-107. Epub 2022 Apr 9 doi: 10.1016/j.humpath.2022.04.006. PMID: 35413381
FOXC1.
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Molecular and diagnostic features of apocrine breast lesions.
Gromov P, Espinoza JA, Gromova I
Expert Rev Mol Diagn 2015;15(8):1011-22. Epub 2015 Jun 25 doi: 10.1586/14737159.2015.1057125. PMID: 26111757

Therapy

mTOR inhibition abrogates human mammary stem cells and early breast cancer progression markers.
Bouamar H, Broome LE, Lathrop KI, Jatoi I, Brenner AJ, Nazarullah A, Gorena KM, Garcia M, Chen Y, Kaklamani V, Sun LZ
Breast Cancer Res 2023 Oct 30;25(1):131. doi: 10.1186/s13058-023-01727-z. PMID: 37904250Free PMC Article
Prognostic relevance of mixed histological subtypes in invasive breast carcinoma: a retrospective analysis.
Rechsteiner A, Dietrich D, Varga Z
J Cancer Res Clin Oncol 2023 Jul;149(8):4967-4978. Epub 2022 Oct 31 doi: 10.1007/s00432-022-04443-x. PMID: 36310301Free PMC Article
Poor histologic tumor response after adjuvant therapy in basal-like HER2-positive breast carcinoma.
Zhao D, Fu X, Rohr J, Wang Y, Li M, Zhang X, Qin J, Xu M, Li C, Sun G, Wang Z, Guo S
Pathol Res Pract 2021 Dec;228:153677. Epub 2021 Oct 30 doi: 10.1016/j.prp.2021.153677. PMID: 34775151
Triple-Positive Breast Carcinoma: Histopathologic Features and Response to Neoadjuvant Chemotherapy.
Zeng J, Edelweiss M, Ross DS, Xu B, Moo TA, Brogi E, D'Alfonso TM
Arch Pathol Lab Med 2021 Jun 1;145(6):728-735. doi: 10.5858/arpa.2020-0293-OA. PMID: 33112958Free PMC Article
Apocrine carcinoma of the breast: A brief update on the molecular features and targetable biomarkers.
Vranic S, Feldman R, Gatalica Z
Bosn J Basic Med Sci 2017 Feb 21;17(1):9-11. doi: 10.17305/bjbms.2016.1811. PMID: 28027454Free PMC Article

Prognosis

Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor.
Emerick C, Mariano FV, Vargas PA, Nör JE, Squarize CH, Castilho RM
Crit Rev Oncol Hematol 2022 Nov;179:103792. Epub 2022 Aug 13 doi: 10.1016/j.critrevonc.2022.103792. PMID: 35973662
FOXC1.
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Intraductal Carcinomas of the Salivary Gland.
Todorovic E, Weinreb I
Surg Pathol Clin 2021 Mar;14(1):1-15. Epub 2021 Jan 6 doi: 10.1016/j.path.2020.09.003. PMID: 33526215
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742

Clinical prediction guides

Salivary Gland Secretory Carcinoma: Clinicopathologic and Genetic Characteristics of 215 Cases and Proposal for a Grading System.
Baněčková M, Thompson LDR, Hyrcza MD, Vaněček T, Agaimy A, Laco J, Simpson RHW, Di Palma S, Stevens TM, Brcic L, Etebarian A, Dimnik K, Majewska H, Stárek I, O'Regan E, Salviato T, Helliwell T, Horáková M, Biernat W, Onyuma T, Michal M, Leivo I, Skalova A
Am J Surg Pathol 2023 Jun 1;47(6):661-677. Epub 2023 Apr 18 doi: 10.1097/PAS.0000000000002043. PMID: 37070739
FOXC1.
Li M, Lv H, Zhong S, Zhou S, Lu H, Yang W
Arch Pathol Lab Med 2022 Aug 1;146(8):994-1003. doi: 10.5858/arpa.2021-0039-OA. PMID: 34784418
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Molecular and diagnostic features of apocrine breast lesions.
Gromov P, Espinoza JA, Gromova I
Expert Rev Mol Diagn 2015;15(8):1011-22. Epub 2015 Jun 25 doi: 10.1586/14737159.2015.1057125. PMID: 26111757

Recent systematic reviews

Non-mass-like lesions on breast ultrasonography: a systematic review.
Uematsu T
Breast Cancer 2012 Oct;19(4):295-301. Epub 2012 Mar 29 doi: 10.1007/s12282-012-0364-z. PMID: 22456924

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