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Apocrine sweat gland neoplasm

MedGen UID:: 272320
•Concept ID:: C1332318
•: Neoplastic Process

Synonyms:	Apocrine Neoplasm; apocrine neoplasm; Apocrine Neoplasm of Skin; apocrine neoplasm of skin; Apocrine Neoplasm of the Skin; apocrine neoplasm of the skin; Apocrine Skin Neoplasm; apocrine skin neoplasm; Apocrine Skin Tumor; apocrine skin tumor; apocrine skin tumour; apocrine sweat gland neoplasm; apocrine sweat gland neoplasm (disease); apocrine sweat gland tumor; apocrine sweat gland tumour; Apocrine Tumor; apocrine tumor; Apocrine Tumor of Skin; apocrine tumor of skin; Apocrine Tumor of the Skin; apocrine tumor of the skin; apocrine tumour; apocrine tumour of skin; apocrine tumour of the skin; neoplasm of apocrine sweat gland; tumor of apocrine sweat gland; tumour of apocrine sweat gland

Monarch Initiative:	MONDO:0003686

Definition

A benign or malignant sweat gland neoplasm with apocrine differentiation. Representative examples include apocrine adenoma, ceruminous adenocarcinoma, and apocrine breast carcinoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVApocrine sweat gland neoplasm

Pathological process
- Disease
  - Disorder by Site
    - Skin disorder
      - Disorder of sweat gland
        Sweat gland neoplasm
        Apocrine sweat gland neoplasm
        Apocrine sweat gland cancer
        Apocrine adenocarcinoma
        Breast apocrine carcinoma
        Ceruminous carcinoma
        Vulvar apocrine adenocarcinoma
        Benign Apocrine Neoplasm
        Apocrine adenoma
        Apocrine hidrocystoma
        Neoplasm of the ceruminal gland
        Ceruminous Neoplasm

Professional guidelines

PubMed

Aggressive Digital Papillary Adenocarcinoma: Population-Based Analysis of Incidence, Demographics, Treatment, and Outcomes.

Rismiller K, Knackstedt TJ
Dermatol Surg 2018 Jul;44(7):911-917. doi: 10.1097/DSS.0000000000001483. PMID: 29578881

Cutaneous Sweat Gland Carcinomas with Basaloid Differentiation: An Update with Emphasis on Differential Diagnoses.

Flux K, Brenn T
Clin Lab Med 2017 Sep;37(3):587-601. Epub 2017 Jun 9 doi: 10.1016/j.cll.2017.05.006. PMID: 28802502

Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars.

Ogawa R, Akaishi S, Hyakusoku H
Ann Plast Surg 2009 Jun;62(6):660-4. doi: 10.1097/SAP.0b013e31817e9d67. PMID: 19461281

See all (13)

Recent clinical studies

Etiology

Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.

Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546 Free PMC Article

Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.

Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875

Squamoid Eccrine Ductal Carcinoma.

Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321

Alternative Clinical Indications of Botulinum Toxin.

Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806

Poroma: a review of eccrine, apocrine, and malignant forms.

Sawaya JL, Khachemoune A
Int J Dermatol 2014 Sep;53(9):1053-61. Epub 2014 Apr 2 doi: 10.1111/ijd.12448. PMID: 24697501

See all (153)

Diagnosis

Adnexal and Sebaceous Carcinomas.

Seger EW, Neill BC, Tolkachjov SN
Dermatol Clin 2023 Jan;41(1):117-132. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.010. PMID: 36410972

Apocrine lesions of the breast.

Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861 Free PMC Article

Malignant Sweat Gland Tumors.

Ahn CS, Sangüeza OP
Hematol Oncol Clin North Am 2019 Feb;33(1):53-71. doi: 10.1016/j.hoc.2018.09.002. PMID: 30497677

Dermoscopy of Adnexal Tumors.

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Topics in histopathology of sweat gland and sebaceous neoplasms.

Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768

See all (558)

Therapy

Alternative Clinical Indications of Botulinum Toxin.

Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806

Central Nervous System-Invading Eccrine Gland Carcinoma: A Clinicopathologic Case Series and Literature Review.

Gupta S, Hulsbergen AFC, Segar DJ, Hauser BM, Bernstock JD, Nazarian RM, Lawrence DP, Nahed BV, Broekman MLD, Smith TR
World Neurosurg 2020 Jun;138:e17-e25. Epub 2020 Mar 3 doi: 10.1016/j.wneu.2020.01.111. PMID: 32142948

SOX10 immunohistochemistry in sweat ductal/glandular neoplasms.

Cassarino DS, Su A, Robbins BA, Altree-Tacha D, Ra S
J Cutan Pathol 2017 Jun;44(6):544-547. Epub 2017 Apr 20 doi: 10.1111/cup.12939. PMID: 28343365

Apocrine carcinoma of the breast: A brief update on the molecular features and targetable biomarkers.

Vranic S, Feldman R, Gatalica Z
Bosn J Basic Med Sci 2017 Feb 21;17(1):9-11. doi: 10.17305/bjbms.2016.1811. PMID: 28027454 Free PMC Article

Apocrine sweat gland obstruction by antiperspirants allowing transdermal absorption of cutaneous generated hormones and pheromones as a link to the observed incidence rates of breast and prostate cancer in the 20th century.

McGrath KG
Med Hypotheses 2009 Jun;72(6):665-74. doi: 10.1016/j.mehy.2009.01.025. PMID: 19307063

See all (51)

Prognosis

Adnexal and Sebaceous Carcinomas.

Seger EW, Neill BC, Tolkachjov SN
Dermatol Clin 2023 Jan;41(1):117-132. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.010. PMID: 36410972

Sweat Gland Tumor Microenvironment.

Yuda Handaya A, Anwar SL, Fauzi AR, Werdana VAP
Adv Exp Med Biol 2020;1296:259-274. doi: 10.1007/978-3-030-59038-3_16. PMID: 34185298

Topics in histopathology of sweat gland and sebaceous neoplasms.

Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768

Epidemiology and Prognosis of Primary Periocular Sweat Gland Carcinomas.

Baker MS, Yin VT, Ivan D, Allen RC, Carter KD, Esmaeli B, Shriver EM
Ophthalmic Plast Reconstr Surg 2017 Mar/Apr;33(2):101-105. doi: 10.1097/IOP.0000000000000658. PMID: 26974419

Malignant adnexal neoplasms.

Crowson AN, Magro CM, Mihm MC
Mod Pathol 2006 Feb;19 Suppl 2:S93-S126. doi: 10.1038/modpathol.3800511. PMID: 16446719

See all (135)

Clinical prediction guides

NECTIN4 expression in sebaceous and sweat gland carcinoma.

Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Oda Y, Kaku-Ito Y
Eur J Dermatol 2022 Apr 1;32(2):181-186. doi: 10.1684/ejd.2022.4241. PMID: 35866909

An Update on the Molecular and Clinical Characteristics of Apocrine Carcinoma of the Breast.

Vranic S, Gatalica Z
Clin Breast Cancer 2022 Jun;22(4):e576-e585. Epub 2021 Dec 27 doi: 10.1016/j.clbc.2021.12.009. PMID: 35027319

Molecular pathology of skin adnexal tumours.

Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659

Apocrine and eccrine hidrocystomas: a clinicopathological study.

Koumaki D, Papadakis M, Lagoudaki E, Manios GA, Kassotakis D, Doxastaki A, Krasagakis K, Manios A
Acta Dermatovenerol Alp Pannonica Adriat 2021 Jun;30(2):53-56. PMID: 34169699

Dermoscopy of Adnexal Tumors.

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

See all (172)