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Mediastinum synovial sarcoma

MedGen UID:
233174
•Concept ID:
C1334681
•
Neoplastic Process
Synonyms: Mediastinal Synovial Sarcoma; mediastinal synovial sarcoma; mediastinum synovial sarcoma; mediastinum synovial sarcoma (disease); Synovial Sarcoma of Mediastinum; synovial sarcoma of mediastinum; Synovial Sarcoma of the Mediastinum; synovial sarcoma of the mediastinum
 
Monarch Initiative: MONDO:0003467

Definition

A synovial sarcoma arising from the mediastinum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinum synovial sarcoma

Professional guidelines

PubMed

Primary synovial sarcoma of the mediastinum: a rare tumor diagnosed by endoscopic ultrasound-fine needle biopsy (EUS-FNB)-Cytomorphologic, immunohistochemical, and molecular analysis.
Khamaysi I, Naroditsky I, Malkin L
Clin J Gastroenterol 2021 Aug;14(4):961-964. Epub 2021 Apr 1 doi: 10.1007/s12328-021-01393-8. PMID: 33792887
Primary Pulmonary Synovial Sarcoma in a Tertiary Referral Center: Clinical Characteristics, CT, and 18F-FDG PET Findings, With Pathologic Correlations.
Kim GH, Kim MY, Koo HJ, Song JS, Choi CM
Medicine (Baltimore) 2015 Aug;94(34):e1392. doi: 10.1097/MD.0000000000001392. PMID: 26313782Free PMC Article

Recent clinical studies

Etiology

Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach.
Choi JH, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):351-381. doi: 10.1097/PAP.0000000000000306. PMID: 34050062
Primary Synovial Sarcoma of the Mediastinum with Long-term Follow-up.
Kanemura H, Nishimura N, Bando T, Ishikawa Y, Kojima F, Mori T, Suzuki K, Tamura T
Intern Med 2019 May 15;58(10):1463-1465. Epub 2019 Jan 10 doi: 10.2169/internalmedicine.2199-18. PMID: 30626843Free PMC Article
Primary Pulmonary Synovial Sarcoma in a Tertiary Referral Center: Clinical Characteristics, CT, and 18F-FDG PET Findings, With Pathologic Correlations.
Kim GH, Kim MY, Koo HJ, Song JS, Choi CM
Medicine (Baltimore) 2015 Aug;94(34):e1392. doi: 10.1097/MD.0000000000001392. PMID: 26313782Free PMC Article
Fine needle aspiration of primary mediastinal synovial sarcoma: cytomorphologic, immunohistochemical, and molecular study.
Huang CC, Michael CW, Pang JC
Diagn Cytopathol 2014 Feb;42(2):170-6. Epub 2012 Aug 31 doi: 10.1002/dc.22912. PMID: 24436244
Primary thoracic sarcomas.
Gladish GW, Sabloff BM, Munden RF, Truong MT, Erasmus JJ, Chasen MH
Radiographics 2002 May-Jun;22(3):621-37. doi: 10.1148/radiographics.22.3.g02ma17621. PMID: 12006691

Diagnosis

Sarcoma of the Lung and Mediastinum.
Yoshida KI, Yoshida A
Surg Pathol Clin 2024 Jun;17(2):243-255. Epub 2023 Dec 15 doi: 10.1016/j.path.2023.11.008. PMID: 38692808
A review on pulmonary and mediastinal synovial sarcoma.
Dewi KP, Dewi IP, Iswanto I, Wulandari L
J Basic Clin Physiol Pharmacol 2023 Mar 1;34(2):169-175. Epub 2023 Feb 20 doi: 10.1515/jbcpp-2022-0286. PMID: 36800987
Rare mediastinal masses - imaging review.
Patnaik S, Malempati AR, Uppin M, Susarla R
J Cancer Res Ther 2021 Jan-Mar;17(1):13-21. doi: 10.4103/jcrt.JCRT_587_19. PMID: 33723126
Primary cardiac synovial sarcoma.
Varma T, Adegboyega P
Arch Pathol Lab Med 2012 Apr;136(4):454-8. doi: 10.5858/arpa.2011-0008-RS. PMID: 22458908
Primary thoracic sarcomas.
Gladish GW, Sabloff BM, Munden RF, Truong MT, Erasmus JJ, Chasen MH
Radiographics 2002 May-Jun;22(3):621-37. doi: 10.1148/radiographics.22.3.g02ma17621. PMID: 12006691

Therapy

A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients.
Giraudet AL, Cassier PA, Iwao-Fukukawa C, Garin G, Badel JN, Kryza D, Chabaud S, Gilles-Afchain L, Clapisson G, Desuzinges C, Sarrut D, Halty A, Italiano A, Mori M, Tsunoda T, Katagiri T, Nakamura Y, Alberti L, Cropet C, Baconnier S, Berge-Montamat S, Pérol D, Blay JY
BMC Cancer 2018 Jun 8;18(1):646. doi: 10.1186/s12885-018-4544-x. PMID: 29884132Free PMC Article
Fine needle aspiration of primary mediastinal synovial sarcoma: cytomorphologic, immunohistochemical, and molecular study.
Huang CC, Michael CW, Pang JC
Diagn Cytopathol 2014 Feb;42(2):170-6. Epub 2012 Aug 31 doi: 10.1002/dc.22912. PMID: 24436244
Vascularized fibular graft for bone reconstruction of the extremities after tumor resection in limb-saving procedures.
Minami A, Kutsumi K, Takeda N, Kaneda K
Microsurgery 1995;16(2):56-64. doi: 10.1002/micr.1920160204. PMID: 7783606

Prognosis

Aortic transection for resection of middle mediastinal tumor.
Bierler J, Poncelet A, Lacroix V
Acta Chir Belg 2023 Feb;123(1):68-71. Epub 2021 Mar 24 doi: 10.1080/00015458.2021.1900522. PMID: 33715597
Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach.
Choi JH, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):351-381. doi: 10.1097/PAP.0000000000000306. PMID: 34050062
Primary pulmonary synovial sarcoma: A reappraisal.
Panigrahi MK, Pradhan G, Sahoo N, Mishra P, Patra S, Mohapatra PR
J Cancer Res Ther 2018 Apr-Jun;14(3):481-489. doi: 10.4103/0973-1482.204883. PMID: 29893303
Synovial sarcoma presenting with huge mediastinal mass: a case report and review of literature.
Salah S, Al-Ibraheem A, Daboor A, Al-Hussaini M
BMC Res Notes 2013 Jun 25;6:240. doi: 10.1186/1756-0500-6-240. PMID: 23800262Free PMC Article
Primary cardiac synovial sarcoma.
Varma T, Adegboyega P
Arch Pathol Lab Med 2012 Apr;136(4):454-8. doi: 10.5858/arpa.2011-0008-RS. PMID: 22458908

Clinical prediction guides

Usefulness of SS18-SSX antibody as a diagnostic marker for pulmonary metastatic synovial sarcoma.
Miura K, Shimizu K, Eguchi T, Koike S, Matsuoka S, Takeda T, Hamanaka K, Uehara T
Diagn Pathol 2021 Jun 14;16(1):54. doi: 10.1186/s13000-021-01110-6. PMID: 34127031Free PMC Article
A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients.
Giraudet AL, Cassier PA, Iwao-Fukukawa C, Garin G, Badel JN, Kryza D, Chabaud S, Gilles-Afchain L, Clapisson G, Desuzinges C, Sarrut D, Halty A, Italiano A, Mori M, Tsunoda T, Katagiri T, Nakamura Y, Alberti L, Cropet C, Baconnier S, Berge-Montamat S, Pérol D, Blay JY
BMC Cancer 2018 Jun 8;18(1):646. doi: 10.1186/s12885-018-4544-x. PMID: 29884132Free PMC Article
Synovial sarcoma showing loss of a green signal in SS18 fluorescence in situ hybridization: a clinicopathological and molecular study of 12 cases.
Jiang D, Peng R, Yan X, Chen M, Lan T, Chen H, Zhang Z, Jing W, Jiang L, Ma L, Zhang H
Virchows Arch 2017 Dec;471(6):799-807. Epub 2017 Jul 31 doi: 10.1007/s00428-017-2211-2. PMID: 28761985
Primary pleuropulmonary and mediastinal synovial sarcoma: a clinicopathologic and molecular study of 26 genetically confirmed cases in the largest institution of southwest China.
Lan T, Chen H, Xiong B, Zhou T, Peng R, Chen M, Ye F, Yao J, He X, Wang Y, Zhang H
Diagn Pathol 2016 Jul 11;11(1):62. doi: 10.1186/s13000-016-0513-3. PMID: 27401493Free PMC Article
A biphasic tumor of the mediastinum with features of synovial sarcoma. A report of four cases.
Witkin GB, Miettinen M, Rosai J
Am J Surg Pathol 1989 Jun;13(6):490-9. doi: 10.1097/00000478-198906000-00005. PMID: 2471414

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