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Skull base chordoma

MedGen UID:
233448
•Concept ID:
C1335975
•
Neoplastic Process
Synonyms: Chordoma of Skull Base; chordoma of skull base; Chordoma of the Skull Base; chordoma of the skull base; Skull Base Chordoma; skull base chordoma
 
Monarch Initiative: MONDO:0002892

Definition

A chordoma that arises from the base of the skull. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkull base chordoma

Professional guidelines

PubMed

Treatment outcomes of proton or carbon ion therapy for skull base chordoma: a retrospective study.
Takagi M, Demizu Y, Nagano F, Terashima K, Fujii O, Jin D, Mima M, Niwa Y, Katsui K, Suga M, Yamashita T, Akagi T, Sakata KI, Fuwa N, Okimoto T
Radiat Oncol 2018 Nov 26;13(1):232. doi: 10.1186/s13014-018-1173-0. PMID: 30477528Free PMC Article
Endoscopic Endonasal Management of Skull Base Chordomas: Surgical Technique, Nuances, and Pitfalls.
Mangussi-Gomes J, Beer-Furlan A, Balsalobre L, Vellutini EA, Stamm AC
Otolaryngol Clin North Am 2016 Feb;49(1):167-82. doi: 10.1016/j.otc.2015.09.011. PMID: 26614836
Photon-based fractionated stereotactic radiotherapy for postoperative treatment of skull base chordomas.
Bugoci DM, Girvigian MR, Chen JC, Miller MM, Rahimian J
Am J Clin Oncol 2013 Aug;36(4):404-10. doi: 10.1097/COC.0b013e318248dc6f. PMID: 22772429

Recent clinical studies

Etiology

Revisitation of imaging features of skull base chondrosarcoma in comparison to chordoma.
Hasegawa H, Shin M, Niwa R, Koizumi S, Yoshimoto S, Shono N, Shinya Y, Takami H, Tanaka S, Umekawa M, Amemiya S, Kin T, Saito N
J Neurooncol 2022 Sep;159(3):581-590. Epub 2022 Jul 26 doi: 10.1007/s11060-022-04097-2. PMID: 35882753
The Influence of Facility Volume and Type on Skull Base Chordoma Treatment and Outcomes.
Du AT, Pang JC, Victor R, Tang Meller LL, Torabi SJ, Goshtasbi K, Kim MG, Hsu FPK, Kuan EC
World Neurosurg 2022 Oct;166:e561-e567. Epub 2022 Jul 19 doi: 10.1016/j.wneu.2022.07.064. PMID: 35868508
Skull Base Chordoma: Long-Term Observation and Evaluation of Prognostic Factors after Surgical Resection.
Roy A, Warade A, Jha AK, Misra BK
Neurol India 2021 Nov-Dec;69(6):1608-1612. doi: 10.4103/0028-3886.333474. PMID: 34979650
Characteristics and overall survival in pediatric versus adult skull base chordoma: a population-based study.
Xu JC, Lehrich BM, Yasaka TM, Fong BM, Hsu FPK, Kuan EC
Childs Nerv Syst 2021 Jun;37(6):1901-1908. Epub 2021 Jan 18 doi: 10.1007/s00381-021-05046-6. PMID: 33459820
Skull base chordoma.
Mendenhall WM, Mendenhall CM, Lewis SB, Villaret DB, Mendenhall NP
Head Neck 2005 Feb;27(2):159-65. doi: 10.1002/hed.20144. PMID: 15641104

Diagnosis

Chordoma of the Skull Base: A National Cancer Database Analysis of Current Practice Patterns and Outcomes.
Nunna R, Patel S, Karuparti S, Ortiz-Torres M, Ryoo J, Ansari D, Carr S, Mehta AI
World Neurosurg 2022 Dec;168:e260-e268. Epub 2022 Sep 30 doi: 10.1016/j.wneu.2022.09.102. PMID: 36184046
Revisitation of imaging features of skull base chondrosarcoma in comparison to chordoma.
Hasegawa H, Shin M, Niwa R, Koizumi S, Yoshimoto S, Shono N, Shinya Y, Takami H, Tanaka S, Umekawa M, Amemiya S, Kin T, Saito N
J Neurooncol 2022 Sep;159(3):581-590. Epub 2022 Jul 26 doi: 10.1007/s11060-022-04097-2. PMID: 35882753
Differentiating skull base chordomas and invasive pituitary adenomas with conventional MRI.
Gao A, Bai J, Cheng J, Cheng X, Li S, Zhang Z, Zhang Y
Acta Radiol 2018 Nov;59(11):1358-1364. Epub 2018 Feb 15 doi: 10.1177/0284185118757576. PMID: 29448805
Genetic aberrations and molecular biology of skull base chordoma and chondrosarcoma.
Kitamura Y, Sasaki H, Yoshida K
Brain Tumor Pathol 2017 Apr;34(2):78-90. Epub 2017 Apr 21 doi: 10.1007/s10014-017-0283-y. PMID: 28432450
Skull base chordoma.
Mendenhall WM, Mendenhall CM, Lewis SB, Villaret DB, Mendenhall NP
Head Neck 2005 Feb;27(2):159-65. doi: 10.1002/hed.20144. PMID: 15641104

Therapy

Vision loss following high-dose proton-based radiotherapy for skull-base chordoma and chondrosarcoma.
De Leo AN, Holtzman AL, Ho MW, Morris CG, Rutenberg MS, Rotondo RL, Bates JE, Indelicato DJ, Rao D, Asa Hasan M, Mendenhall WM
Radiother Oncol 2021 May;158:125-130. Epub 2021 Feb 19 doi: 10.1016/j.radonc.2021.02.012. PMID: 33610625
Dosimetric analysis of local failures in skull-base chordoma and chondrosarcoma following pencil beam scanning proton therapy.
Basler L, Poel R, Schröder C, Bolsi A, Lomax A, Tanadini-Lang S, Guckenberger M, Weber DC
Radiat Oncol 2020 Nov 16;15(1):266. doi: 10.1186/s13014-020-01711-3. PMID: 33198810Free PMC Article
Long-term outcomes of skull base chordoma treated with high-dose carbon-ion radiotherapy.
Koto M, Ikawa H, Kaneko T, Hagiwara Y, Hayashi K, Tsuji H
Head Neck 2020 Sep;42(9):2607-2613. Epub 2020 May 30 doi: 10.1002/hed.26307. PMID: 32472716Free PMC Article
Iatrogenic seeding of skull base chordoma following endoscopic endonasal surgery.
Fernandes Cabral DT, Zenonos GA, Fernandez-Miranda JC, Wang EW, Gardner PA
J Neurosurg 2018 Oct;129(4):947-953. Epub 2017 Dec 22 doi: 10.3171/2017.6.JNS17111. PMID: 29271711
On the cost-effectiveness of Carbon ion radiation therapy for skull base chordoma.
Jäkel O, Land B, Combs SE, Schulz-Ertner D, Debus J
Radiother Oncol 2007 May;83(2):133-8. Epub 2007 May 8 doi: 10.1016/j.radonc.2007.03.010. PMID: 17490770

Prognosis

Prognostic Factors in Skull Base Chordoma: A Systematic Literature Review and Meta-Analysis.
Zou MX, Lv GH, Zhang QS, Wang SF, Li J, Wang XB
World Neurosurg 2018 Jan;109:307-327. Epub 2017 Oct 16 doi: 10.1016/j.wneu.2017.10.010. PMID: 29045855
Genetic aberrations and molecular biology of skull base chordoma and chondrosarcoma.
Kitamura Y, Sasaki H, Yoshida K
Brain Tumor Pathol 2017 Apr;34(2):78-90. Epub 2017 Apr 21 doi: 10.1007/s10014-017-0283-y. PMID: 28432450
Genomic and transcriptomic characterization of skull base chordoma.
Sa JK, Lee IH, Hong SD, Kong DS, Nam DH
Oncotarget 2017 Jan 3;8(1):1321-1328. doi: 10.18632/oncotarget.13616. PMID: 27901492Free PMC Article
Endoscopic Endonasal Management of Skull Base Chordomas: Surgical Technique, Nuances, and Pitfalls.
Mangussi-Gomes J, Beer-Furlan A, Balsalobre L, Vellutini EA, Stamm AC
Otolaryngol Clin North Am 2016 Feb;49(1):167-82. doi: 10.1016/j.otc.2015.09.011. PMID: 26614836
Skull base chordoma.
Mendenhall WM, Mendenhall CM, Lewis SB, Villaret DB, Mendenhall NP
Head Neck 2005 Feb;27(2):159-65. doi: 10.1002/hed.20144. PMID: 15641104

Clinical prediction guides

Revisitation of imaging features of skull base chondrosarcoma in comparison to chordoma.
Hasegawa H, Shin M, Niwa R, Koizumi S, Yoshimoto S, Shono N, Shinya Y, Takami H, Tanaka S, Umekawa M, Amemiya S, Kin T, Saito N
J Neurooncol 2022 Sep;159(3):581-590. Epub 2022 Jul 26 doi: 10.1007/s11060-022-04097-2. PMID: 35882753
Skull Base Chordoma: Long-Term Observation and Evaluation of Prognostic Factors after Surgical Resection.
Roy A, Warade A, Jha AK, Misra BK
Neurol India 2021 Nov-Dec;69(6):1608-1612. doi: 10.4103/0028-3886.333474. PMID: 34979650
SNF5 as a prognostic factor in skull base chordoma.
Li M, Zhai Y, Bai J, Wang S, Gao H, Li C, Gui S, Du J, Zhang Y
J Neurooncol 2018 Mar;137(1):139-146. Epub 2017 Dec 8 doi: 10.1007/s11060-017-2706-3. PMID: 29222701
Prognostic Factors in Skull Base Chordoma: A Systematic Literature Review and Meta-Analysis.
Zou MX, Lv GH, Zhang QS, Wang SF, Li J, Wang XB
World Neurosurg 2018 Jan;109:307-327. Epub 2017 Oct 16 doi: 10.1016/j.wneu.2017.10.010. PMID: 29045855
Genomic and transcriptomic characterization of skull base chordoma.
Sa JK, Lee IH, Hong SD, Kong DS, Nam DH
Oncotarget 2017 Jan 3;8(1):1321-1328. doi: 10.18632/oncotarget.13616. PMID: 27901492Free PMC Article

Recent systematic reviews

Adjuvant stereotactic radiosurgery with or without postoperative fractionated radiation therapy in adults with skull base chordomas: a systematic review.
Bin-Alamer O, Mallela AN, Palmisciano P, Gersey ZC, Elarjani T, Labib MA, Zenonos GA, Dehdashti AR, Sheehan JP, Couldwell WT, Lunsford LD, Abou-Al-Shaar H
Neurosurg Focus 2022 Nov;53(5):E5. doi: 10.3171/2022.8.FOCUS22239. PMID: 36321281
Prognostic Factors in Skull Base Chordoma: A Systematic Literature Review and Meta-Analysis.
Zou MX, Lv GH, Zhang QS, Wang SF, Li J, Wang XB
World Neurosurg 2018 Jan;109:307-327. Epub 2017 Oct 16 doi: 10.1016/j.wneu.2017.10.010. PMID: 29045855

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