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Lacrimal gland carcinoma

MedGen UID:
233606
•Concept ID:
C1334358
•
Neoplastic Process
Synonyms: Carcinoma of Lacrimal Gland; carcinoma of lacrimal gland; Carcinoma of the Lacrimal Gland; carcinoma of the lacrimal gland; Lacrimal Gland Carcinoma; lacrimal gland carcinoma
 
Monarch Initiative: MONDO:0002463

Definition

A carcinoma that arises from the lacrimal glands. Representative examples include adenocarcinoma, carcinoma ex pleomorphic adenoma, squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. [from NCI]

Professional guidelines

PubMed

Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588
Eye-sparing multidisciplinary approach for the management of lacrimal gland carcinoma.
Esmaeli B, Yin VT, Hanna EY, Kies MS, William WN Jr, Bell D, Frank SJ
Head Neck 2016 Aug;38(8):1258-62. Epub 2016 Mar 29 doi: 10.1002/hed.24433. PMID: 27027275
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
Woo KI, Yeom A, Esmaeli B
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):1-10. doi: 10.1097/IOP.0000000000000531. PMID: 26291539

Recent clinical studies

Etiology

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
Risk and Lag-time for Development of Lacrimal Gland Carcinoma Expleomorphic Adenoma: Observations and Conjectural Study.
Rose GE, Vahdani K, Lewis J, Rose AM
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):563-566. Epub 2022 May 13 doi: 10.1097/IOP.0000000000002203. PMID: 35550483
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Primary Secretory Carcinoma of the Lacrimal Gland: Report of a New Entity.
Hyrcza MD, Andreasen S, Melchior LC, Tucker T, Heegaard S, White VA
Am J Ophthalmol 2018 Sep;193:178-183. Epub 2018 Jun 28 doi: 10.1016/j.ajo.2018.06.019. PMID: 29963997
Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588

Diagnosis

Risk and Lag-time for Development of Lacrimal Gland Carcinoma Expleomorphic Adenoma: Observations and Conjectural Study.
Rose GE, Vahdani K, Lewis J, Rose AM
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):563-566. Epub 2022 May 13 doi: 10.1097/IOP.0000000000002203. PMID: 35550483
Cranio-orbital Resection Does Not Appear to Improve Survival of Patients With Lacrimal Gland Carcinoma.
Rose GE, Gore SK, Plowman NP
Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):77-84. doi: 10.1097/IOP.0000000000001177. PMID: 30130333
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Primary Secretory Carcinoma of the Lacrimal Gland: Report of a New Entity.
Hyrcza MD, Andreasen S, Melchior LC, Tucker T, Heegaard S, White VA
Am J Ophthalmol 2018 Sep;193:178-183. Epub 2018 Jun 28 doi: 10.1016/j.ajo.2018.06.019. PMID: 29963997
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
Woo KI, Yeom A, Esmaeli B
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):1-10. doi: 10.1097/IOP.0000000000000531. PMID: 26291539

Therapy

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy.
Lin YH, Huang SM, Yap WK, Yang JW, Yeung L, Tsan DL, Chang JT, Chen LC
Radiat Oncol 2020 Jun 22;15(1):156. doi: 10.1186/s13014-020-01601-8. PMID: 32571366Free PMC Article
Corneal complications after orbital radiotherapy for primary epithelial malignancies of the lacrimal gland.
Gore SK, Plowman NP, Dharmasena A, Verity DH, Rose GE
Br J Ophthalmol 2018 Jul;102(7):882-884. Epub 2017 Oct 19 doi: 10.1136/bjophthalmol-2017-311134. PMID: 29051324
The "Wedge Sign": An Imaging Sign for Aggressive Lacrimal Gland Disease.
Lorenzano D, Rose GE
Ophthalmology 2017 Jul;124(7):1081-1083. Epub 2017 Mar 31 doi: 10.1016/j.ophtha.2017.03.004. PMID: 28372859
CORE needle biopsy of orbital tumors.
Yarovoy AA, Bulgakova ES, Shatskikh AV, Uzunyan DG, Kleyankina SS, Golubeva OV
Graefes Arch Clin Exp Ophthalmol 2013 Aug;251(8):2057-61. Epub 2013 Mar 21 doi: 10.1007/s00417-013-2315-6. PMID: 23515750

Prognosis

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
Prognostic factors for local recurrence and survival and impact of local treatments on survival in lacrimal gland carcinoma.
Ford JR, Rubin ML, Frank SJ, Ning J, Debnam JM, Bell D, El-Naggar A, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2021 Jun;105(6):768-774. Epub 2020 Jul 17 doi: 10.1136/bjophthalmol-2020-316142. PMID: 32680839
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Eye-sparing multidisciplinary approach for the management of lacrimal gland carcinoma.
Esmaeli B, Yin VT, Hanna EY, Kies MS, William WN Jr, Bell D, Frank SJ
Head Neck 2016 Aug;38(8):1258-62. Epub 2016 Mar 29 doi: 10.1002/hed.24433. PMID: 27027275
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
Woo KI, Yeom A, Esmaeli B
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):1-10. doi: 10.1097/IOP.0000000000000531. PMID: 26291539

Clinical prediction guides

Risk and Lag-time for Development of Lacrimal Gland Carcinoma Expleomorphic Adenoma: Observations and Conjectural Study.
Rose GE, Vahdani K, Lewis J, Rose AM
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):563-566. Epub 2022 May 13 doi: 10.1097/IOP.0000000000002203. PMID: 35550483
CORE needle biopsy of orbital tumors.
Yarovoy AA, Bulgakova ES, Shatskikh AV, Uzunyan DG, Kleyankina SS, Golubeva OV
Graefes Arch Clin Exp Ophthalmol 2013 Aug;251(8):2057-61. Epub 2013 Mar 21 doi: 10.1007/s00417-013-2315-6. PMID: 23515750
Metastatic orbital tumors in southern China during an 18-year period.
Yan J, Gao S
Graefes Arch Clin Exp Ophthalmol 2011 Sep;249(9):1387-93. Epub 2011 Apr 6 doi: 10.1007/s00417-011-1660-6. PMID: 21468734
Clinicopathological analysis of periocular sebaceous gland carcinoma.
Yoon JS, Kim SH, Lee CS, Lew H, Lee SY
Ophthalmologica 2007;221(5):331-9. doi: 10.1159/000104764. PMID: 17728556

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