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Breast Ductal Carcinoma In Situ, Low Grade

MedGen UID:
233617
Concept ID:
C1334413
Neoplastic Process
Synonyms: DCIS Grade 1; Ductal Intraepithelial Neoplasia, Grade 1C; Low Grade Ductal Breast Carcinoma In Situ; Low-Grade DCIS; Low-Grade Ductal Carcinoma In Situ of Breast

Definition

Breast ductal carcinoma in situ characterized by the presence of small, monomorphic neoplastic cells that form cribriform, micropapillary, or solid patterns. The nuclei are uniform and mitotic figures are rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Ductal Carcinoma In Situ, Low Grade

Professional guidelines

PubMed

Shaitelman SF, Anderson BM, Arthur DW, Bazan JG, Bellon JR, Bradfield L, Coles CE, Gerber NK, Kathpal M, Kim L, Laronga C, Meattini I, Nichols EM, Pierce LJ, Poppe MM, Spears PA, Vinayak S, Whelan T, Lyons JA
Pract Radiat Oncol 2024 Mar-Apr;14(2):112-132. Epub 2023 Nov 15 doi: 10.1016/j.prro.2023.11.001. PMID: 37977261
Knowlton CA, Jimenez RB, Moran MS
Semin Radiat Oncol 2022 Jul;32(3):189-197. doi: 10.1016/j.semradonc.2022.01.005. PMID: 35688517
Shah C, Bremer T, Cox C, Whitworth P, Patel R, Patel A, Brown E, Gold L, Rock D, Riley L, Kesslering C, Brown S, Gabordi R, Pellicane J, Rabinovich R, Khan S, Templeton S, Majithia L, Willey SC, Wärnberg F, Gerber NK, Shivers S, Vicini FA
Ann Surg Oncol 2021 Oct;28(11):5974-5984. Epub 2021 Apr 5 doi: 10.1245/s10434-021-09903-1. PMID: 33821346Free PMC Article

Recent clinical studies

Etiology

Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Shah C, Bremer T, Cox C, Whitworth P, Patel R, Patel A, Brown E, Gold L, Rock D, Riley L, Kesslering C, Brown S, Gabordi R, Pellicane J, Rabinovich R, Khan S, Templeton S, Majithia L, Willey SC, Wärnberg F, Gerber NK, Shivers S, Vicini FA
Ann Surg Oncol 2021 Oct;28(11):5974-5984. Epub 2021 Apr 5 doi: 10.1245/s10434-021-09903-1. PMID: 33821346Free PMC Article
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Diagnosis

Wheelwright S, Matthews L, Jenkins V, May S, Rea D, Fairbrother P, Gaunt C, Young J, Pirrie S, Wallis MG, Fallowfield L; LORIS Trial Management Group
Trials 2023 Oct 14;24(1):670. doi: 10.1186/s13063-023-07703-4. PMID: 37838682Free PMC Article
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Peltecu G
Chirurgia (Bucur) 2021 Dec;116(5 Suppl):S5-S6. PMID: 34967322
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Therapy

Shaitelman SF, Anderson BM, Arthur DW, Bazan JG, Bellon JR, Bradfield L, Coles CE, Gerber NK, Kathpal M, Kim L, Laronga C, Meattini I, Nichols EM, Pierce LJ, Poppe MM, Spears PA, Vinayak S, Whelan T, Lyons JA
Pract Radiat Oncol 2024 Mar-Apr;14(2):112-132. Epub 2023 Nov 15 doi: 10.1016/j.prro.2023.11.001. PMID: 37977261
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Offersen BV, Alsner J, Nielsen HM, Jakobsen EH, Nielsen MH, Krause M, Stenbygaard L, Mjaaland I, Schreiber A, Kasti UM, Overgaard J; Danish Breast Cancer Group Radiation Therapy Committee
J Clin Oncol 2020 Nov 1;38(31):3615-3625. Epub 2020 Sep 10 doi: 10.1200/JCO.20.01363. PMID: 32910709
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Prognosis

Peltecu G
Chirurgia (Bucur) 2021 Dec;116(5 Suppl):S5-S6. PMID: 34967322
Shah C, Bremer T, Cox C, Whitworth P, Patel R, Patel A, Brown E, Gold L, Rock D, Riley L, Kesslering C, Brown S, Gabordi R, Pellicane J, Rabinovich R, Khan S, Templeton S, Majithia L, Willey SC, Wärnberg F, Gerber NK, Shivers S, Vicini FA
Ann Surg Oncol 2021 Oct;28(11):5974-5984. Epub 2021 Apr 5 doi: 10.1245/s10434-021-09903-1. PMID: 33821346Free PMC Article
Offersen BV, Alsner J, Nielsen HM, Jakobsen EH, Nielsen MH, Krause M, Stenbygaard L, Mjaaland I, Schreiber A, Kasti UM, Overgaard J; Danish Breast Cancer Group Radiation Therapy Committee
J Clin Oncol 2020 Nov 1;38(31):3615-3625. Epub 2020 Sep 10 doi: 10.1200/JCO.20.01363. PMID: 32910709
Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994
Giuliano AE, Connolly JL, Edge SB, Mittendorf EA, Rugo HS, Solin LJ, Weaver DL, Winchester DJ, Hortobagyi GN
CA Cancer J Clin 2017 Jul 8;67(4):290-303. Epub 2017 Mar 14 doi: 10.3322/caac.21393. PMID: 28294295

Clinical prediction guides

McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Shah C, Bremer T, Cox C, Whitworth P, Patel R, Patel A, Brown E, Gold L, Rock D, Riley L, Kesslering C, Brown S, Gabordi R, Pellicane J, Rabinovich R, Khan S, Templeton S, Majithia L, Willey SC, Wärnberg F, Gerber NK, Shivers S, Vicini FA
Ann Surg Oncol 2021 Oct;28(11):5974-5984. Epub 2021 Apr 5 doi: 10.1245/s10434-021-09903-1. PMID: 33821346Free PMC Article
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Giuliano AE, Connolly JL, Edge SB, Mittendorf EA, Rugo HS, Solin LJ, Weaver DL, Winchester DJ, Hortobagyi GN
CA Cancer J Clin 2017 Jul 8;67(4):290-303. Epub 2017 Mar 14 doi: 10.3322/caac.21393. PMID: 28294295
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Recent systematic reviews

Atakpa EC, Thorat MA, Cuzick J, Brentnall AR
Cochrane Database Syst Rev 2021 Oct 26;10(10):CD013091. doi: 10.1002/14651858.CD013091.pub2. PMID: 34697802Free PMC Article
van den Ende C, Oordt-Speets AM, Vroling H, van Agt HME
Int J Cancer 2017 Oct 1;141(7):1295-1306. Epub 2017 Jun 5 doi: 10.1002/ijc.30794. PMID: 28542784
El Hage Chehade H, Headon H, Wazir U, Abtar H, Kasem A, Mokbel K
Am J Surg 2017 Jan;213(1):171-180. Epub 2016 Sep 6 doi: 10.1016/j.amjsurg.2016.04.019. PMID: 27773373
Wang SY, Shamliyan T, Virnig BA, Kane R
Breast Cancer Res Treat 2011 May;127(1):1-14. Epub 2011 Feb 15 doi: 10.1007/s10549-011-1387-4. PMID: 21327465
Goodwin A, Parker S, Ghersi D, Wilcken N
Breast 2009 Jun;18(3):143-9. Epub 2009 May 17 doi: 10.1016/j.breast.2009.04.003. PMID: 19447038

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