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Mediastinal Embryonal Carcinoma

MedGen UID:
233677
Concept ID:
C1334652
Neoplastic Process
Synonyms: Embryonal Carcinoma of Mediastinum; Embryonal Carcinoma of the Mediastinum

Definition

An extragonadal malignant germ cell tumor that arises from the mediastinum and is composed of primitive large cells with clear or granular cytoplasm forming solid, glandular, or papillary patterns. It usually affects young males. It manifests with respiratory distress, thoracic or shoulder pain, fever, cough, superior vena cava syndrome, or hoarseness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinal Embryonal Carcinoma

Professional guidelines

PubMed

Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Patrini D, Panagiotopoulos N, Lawrence D, Scarci M
Br J Hosp Med (Lond) 2017 Apr 2;78(4):192-198. doi: 10.12968/hmed.2017.78.4.192. PMID: 28398890
Sommer K, Brockmann WP, Hübener KH
Cancer 1990 Jul 15;66(2):259-63. doi: 10.1002/1097-0142(19900715)66:2<259::aid-cncr2820660211>3.0.co;2-o. PMID: 2114939

Recent clinical studies

Etiology

Kaikobad M, Cheng YC, Choi H, Teves D
WMJ 2007 Jul;106(4):225-8. PMID: 17844714
Murakawa Y, Satake N, Kato S, Yosioka T, Kanamaru R
Intern Med 2002 Oct;41(10):883-8. doi: 10.2169/internalmedicine.41.883. PMID: 12413016
Suster S, Moran CA, Dominguez-Malagon H, Quevedo-Blanco P
Hum Pathol 1998 Jul;29(7):737-42. doi: 10.1016/s0046-8177(98)90284-2. PMID: 9670832

Diagnosis

Kaikobad M, Cheng YC, Choi H, Teves D
WMJ 2007 Jul;106(4):225-8. PMID: 17844714
Hasegawa Y, Tomita K, Hashimoto K, Shigeoka Y, Watanabe M, Yamasaki A, Shimizu E
Anticancer Res 2005 Nov-Dec;25(6C):4569-71. PMID: 16334143
Chariot P, Monnet I, Gaulard P, Abd-Alsamad I, Ruffié P, De Cremoux H
Hum Pathol 1993 Jan;24(1):111-2. doi: 10.1016/0046-8177(93)90071-n. PMID: 8380274
Sangalli G, Livraghi T, Giordano F, Tavani E, Schiaffino E
Acta Cytol 1986 Sep-Oct;30(5):543-6. PMID: 2430391
Tarkkanen A, Laatikainen L, Mäkinen J, Merenmies L
Ophthalmologica 1979;179(2):77-82. doi: 10.1159/000308870. PMID: 548844

Therapy

Kawanami K, Wakao N, Kamiya M, Takeuchi M, Hirasawa A, Takahashi E, Sato K
Nagoya J Med Sci 2014 Feb;76(1-2):225-33. PMID: 25130010Free PMC Article
Murakawa Y, Satake N, Kato S, Yosioka T, Kanamaru R
Intern Med 2002 Oct;41(10):883-8. doi: 10.2169/internalmedicine.41.883. PMID: 12413016

Prognosis

Kawanami K, Wakao N, Kamiya M, Takeuchi M, Hirasawa A, Takahashi E, Sato K
Nagoya J Med Sci 2014 Feb;76(1-2):225-33. PMID: 25130010Free PMC Article
Murakawa Y, Satake N, Kato S, Yosioka T, Kanamaru R
Intern Med 2002 Oct;41(10):883-8. doi: 10.2169/internalmedicine.41.883. PMID: 12413016

Clinical prediction guides

Suster S, Moran CA, Dominguez-Malagon H, Quevedo-Blanco P
Hum Pathol 1998 Jul;29(7):737-42. doi: 10.1016/s0046-8177(98)90284-2. PMID: 9670832

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