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Metastatic Bone Ewing Sarcoma

MedGen UID:
233698
•Concept ID:
C1334713
•
Neoplastic Process
Synonyms: Metastatic Bone Ewing's Sarcoma; Metastatic Ewing's Sarcoma of Bone; Metastatic Ewing's Sarcoma of the Bone; Metastatic Osseous Ewing's Sarcoma; Metastatic Skeletal Ewing's Sarcoma

Definition

An Ewing sarcoma of the bone which has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Bone Ewing Sarcoma

Professional guidelines

PubMed

Treatment outcomes of extraskeletal Ewing sarcoma.
Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS
J Surg Oncol 2023 Jul;128(1):105-110. Epub 2023 Mar 31 doi: 10.1002/jso.27250. PMID: 36999583
Diagnosis and treatment of Ewing sarcoma of the bone: a review article.
Ozaki T
J Orthop Sci 2015 Mar;20(2):250-63. Epub 2015 Feb 19 doi: 10.1007/s00776-014-0687-z. PMID: 25691401Free PMC Article
Management of metastatic epidural disease in children.
Allen JC
J Pediatr 1984 Feb;104(2):241-2. doi: 10.1016/s0022-3476(84)81001-x. PMID: 6694017

Recent clinical studies

Etiology

Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031.
Cash T, Krailo MD, Buxton AB, Pawel BR, Healey JH, Binitie O, Marcus KJ, Grier HE, Grohar PJ, Reed DR, Weiss AR, Gorlick R, Janeway KA, DuBois SG, Womer RB
J Clin Oncol 2023 Oct 20;41(30):4724-4728. Epub 2023 Aug 31 doi: 10.1200/JCO.23.00053. PMID: 37651654Free PMC Article
Small round cell sarcomas.
Cidre-Aranaz F, Watson S, Amatruda JF, Nakamura T, Delattre O, de Alava E, Dirksen U, Grünewald TGP
Nat Rev Dis Primers 2022 Oct 6;8(1):66. doi: 10.1038/s41572-022-00393-3. PMID: 36202860
Ewing sarcoma.
Eaton BR, Claude L, Indelicato DJ, Vatner R, Yeh B, Schwarz R, Laack N
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28355. doi: 10.1002/pbc.28355. PMID: 33818887
Ewing sarcoma.
Grünewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Álava E, Kovar H, Sorensen PH, Delattre O, Dirksen U
Nat Rev Dis Primers 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x. PMID: 29977059
Ewing's sarcoma.
Balamuth NJ, Womer RB
Lancet Oncol 2010 Feb;11(2):184-92. doi: 10.1016/S1470-2045(09)70286-4. PMID: 20152770

Diagnosis

Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents.
Setty BA, Gikandi A, DuBois SG
Paediatr Drugs 2023 Jul;25(4):389-397. Epub 2023 Apr 4 doi: 10.1007/s40272-023-00568-9. PMID: 37014523
Ewing sarcoma.
Grünewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Álava E, Kovar H, Sorensen PH, Delattre O, Dirksen U
Nat Rev Dis Primers 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x. PMID: 29977059
Ewing's sarcoma.
Balamuth NJ, Womer RB
Lancet Oncol 2010 Feb;11(2):184-92. doi: 10.1016/S1470-2045(09)70286-4. PMID: 20152770
Ewing sarcoma family of tumors.
Khoury JD
Adv Anat Pathol 2005 Jul;12(4):212-20. doi: 10.1097/01.pap.0000175114.55541.52. PMID: 16096383
Ewing's sarcoma.
Spjut HJ
Pediatr Pathol 1987;7(1):79-84. doi: 10.1080/15513818709177118. PMID: 3601820

Therapy

Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031.
Cash T, Krailo MD, Buxton AB, Pawel BR, Healey JH, Binitie O, Marcus KJ, Grier HE, Grohar PJ, Reed DR, Weiss AR, Gorlick R, Janeway KA, DuBois SG, Womer RB
J Clin Oncol 2023 Oct 20;41(30):4724-4728. Epub 2023 Aug 31 doi: 10.1200/JCO.23.00053. PMID: 37651654Free PMC Article
Management of sarcomas in children, adolescents and adults: Interactions in two different age groups under the umbrellas of GSF-GETO and SFCE, with the support of the NETSARC+ network.
Bompas E, Martin V, Meniai F, Toulmonde M, Marec-Berard P, Claude L, Ducimetiere F, Chargari C, Minard-Colin V, Corradini N, Laurence V, Piperno-Neumann S, Defachelles AS, Bernier V, Italiano A, Orbach D, Blay JY, Gaspar N, Berlanga P
Bull Cancer 2021 Feb;108(2):163-176. Epub 2021 Jan 14 doi: 10.1016/j.bulcan.2020.10.009. PMID: 33455736
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Ewing's sarcoma.
Balamuth NJ, Womer RB
Lancet Oncol 2010 Feb;11(2):184-92. doi: 10.1016/S1470-2045(09)70286-4. PMID: 20152770
Extra-osseous Ewing sarcoma.
van den Berg H, Heinen RC, van der Pal HJ, Merks JH
Pediatr Hematol Oncol 2009 Jun;26(4):175-85. doi: 10.1080/08880010902855581. PMID: 19437320

Prognosis

Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks.
Cillo AR, Mukherjee E, Bailey NG, Onkar S, Daley J, Salgado C, Li X, Liu D, Ranganathan S, Burgess M, Sembrat J, Weiss K, Watters R, Bruno TC, Vignali DAA, Bailey KM
Clin Cancer Res 2022 Nov 14;28(22):4968-4982. doi: 10.1158/1078-0432.CCR-22-1471. PMID: 36074145Free PMC Article
Ewing sarcoma.
Eaton BR, Claude L, Indelicato DJ, Vatner R, Yeh B, Schwarz R, Laack N
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28355. doi: 10.1002/pbc.28355. PMID: 33818887
Bone lesions: benign and malignant.
Gereige R, Kumar M
Pediatr Rev 2010 Sep;31(9):355-62; quiz 363. doi: 10.1542/pir.31-9-355. PMID: 20810699
Extra-osseous Ewing sarcoma.
van den Berg H, Heinen RC, van der Pal HJ, Merks JH
Pediatr Hematol Oncol 2009 Jun;26(4):175-85. doi: 10.1080/08880010902855581. PMID: 19437320
Ewing sarcoma family of tumors.
Khoury JD
Adv Anat Pathol 2005 Jul;12(4):212-20. doi: 10.1097/01.pap.0000175114.55541.52. PMID: 16096383

Clinical prediction guides

Artificial intelligence-based radiomics in bone tumors: Technical advances and clinical application.
Meng Y, Yang Y, Hu M, Zhang Z, Zhou X
Semin Cancer Biol 2023 Oct;95:75-87. Epub 2023 Jul 26 doi: 10.1016/j.semcancer.2023.07.003. PMID: 37499847
STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma.
Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, Lareau CA, Ross L, Lin S, Dela Cruz FS, Richardson M, Weintraub AS, Wang S, Iniguez AB, Dharia NV, Conway AS, Robichaud AL, Tanenbaum B, Krill-Burger JM, Vazquez F, Schenone M, Berman JN, Kung AL, Carr SA, Aryee MJ, Young RA, Crompton BD, Stegmaier K
Cancer Cell 2021 Jun 14;39(6):827-844.e10. doi: 10.1016/j.ccell.2021.05.007. PMID: 34129824Free PMC Article
BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR
Am J Surg Pathol 2018 May;42(5):604-615. doi: 10.1097/PAS.0000000000000965. PMID: 29300189Free PMC Article
Stanmore custom-made extendible distal femoral replacements. Clinical experience in children with primary malignant bone tumours.
Schindler OS, Cannon SR, Briggs TW, Blunn GW
J Bone Joint Surg Br 1997 Nov;79(6):927-37. doi: 10.1302/0301-620x.79b6.7164. PMID: 9393906
Chemotherapy as an alternative to laminectomy and radiation in the management of epidural tumor.
Hayes FA, Thompson EI, Hvizdala E, O'Connor D, Green AA
J Pediatr 1984 Feb;104(2):221-4. doi: 10.1016/s0022-3476(84)80996-8. PMID: 6694014

Recent systematic reviews

(18) F-FDG PET and PET/CT as a diagnostic method for Ewing sarcoma: A systematic review and meta-analysis.
Seth N, Seth I, Bulloch G, Siu AHY, Guo A, Chatterjee R, MacManus M, Donnan L
Pediatr Blood Cancer 2022 Mar;69(3):e29415. Epub 2021 Oct 28 doi: 10.1002/pbc.29415. PMID: 34709700
High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with primary metastatic Ewing sarcoma.
Haveman LM, van Ewijk R, van Dalen EC, Breunis WB, Kremer LC, van den Berg H, Dirksen U, Merks JH
Cochrane Database Syst Rev 2021 Sep 2;9(9):CD011405. doi: 10.1002/14651858.CD011405.pub2. PMID: 34472082Free PMC Article
Role of bone marrow biopsy for staging new patients with Ewing sarcoma: A systematic review.
Campbell KM, Shulman DS, Grier HE, DuBois SG
Pediatr Blood Cancer 2021 Feb;68(2):e28807. Epub 2020 Nov 21 doi: 10.1002/pbc.28807. PMID: 33219750
Whole Lung Irradiation in Patients with Osteosarcoma and Ewing Sarcoma.
Ronchi L, Buwenge M, Cortesi A, Ammendolia I, Frakulli R, Abate ME, Arcelli A, Donati CM, Macchia G, Morganti AG, Cammelli S
Anticancer Res 2018 Sep;38(9):4977-4985. doi: 10.21873/anticanres.12816. PMID: 30194141
A Review of Ewing Sarcoma Treatment: Is it Still a Subject of Debate?
Kridis WB, Toumi N, Chaari H, Khanfir A, Ayadi K, Keskes H, Boudawara T, Daoud J, Frikha M
Rev Recent Clin Trials 2017;12(1):19-23. doi: 10.2174/1574887112666170120100147. PMID: 28117008

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