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Atypical breast papilloma

MedGen UID:
233997
•Concept ID:
C1332346
•
Neoplastic Process
Synonyms: Atypical Breast Papilloma; atypical breast papilloma; Breast Atypical Papilloma; Intraductal Breast Papilloma with Atypia
 
Monarch Initiative: MONDO:0004507

Definition

An intraductal papilloma of the breast characterized by the presence of focal epithelial atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAtypical breast papilloma

Professional guidelines

PubMed

Evidence-Based Pragmatic Approach to the Management of Borderline or High-Risk Breast Lesions.
Lamb LR, Bahl M
AJR Am J Roentgenol 2022 Jan;218(1):186-187. Epub 2021 Jul 21 doi: 10.2214/AJR.21.26340. PMID: 34286593
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Pathological criteria and practical issues in papillary lesions of the breast - a review.
Ni YB, Tse GM
Histopathology 2016 Jan;68(1):22-32. doi: 10.1111/his.12866. PMID: 26768027

Recent clinical studies

Etiology

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Management of High-Risk Breast Lesions.
Bahl M
Radiol Clin North Am 2021 Jan;59(1):29-40. doi: 10.1016/j.rcl.2020.08.005. PMID: 33222998
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Premalignant Disorders of the Breast in Pregnancy and Lactation.
Omranipour R, Alipour S, Ensani F, Nakhlis F
Adv Exp Med Biol 2020;1252:63-72. doi: 10.1007/978-3-030-41596-9_8. PMID: 32816263
How Do We Approach Benign Proliferative Lesions?
Nakhlis F
Curr Oncol Rep 2018 Mar 23;20(4):34. doi: 10.1007/s11912-018-0682-1. PMID: 29572753

Diagnosis

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast - review and practical issues.
Ni Y, Tse GM
Semin Diagn Pathol 2022 Sep;39(5):344-354. Epub 2022 Jun 11 doi: 10.1053/j.semdp.2022.06.001. PMID: 35718581
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Premalignant Disorders of the Breast in Pregnancy and Lactation.
Omranipour R, Alipour S, Ensani F, Nakhlis F
Adv Exp Med Biol 2020;1252:63-72. doi: 10.1007/978-3-030-41596-9_8. PMID: 32816263
How Do We Approach Benign Proliferative Lesions?
Nakhlis F
Curr Oncol Rep 2018 Mar 23;20(4):34. doi: 10.1007/s11912-018-0682-1. PMID: 29572753

Therapy

Testosterone therapy and breast histopathological features in transgender individuals.
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article
Unusual recurrent metastasizing benign breast papilloma: a case report.
Jain AL, Mullins J, Smith JR, Valasareddy P, Miller E, Chaudhry A, Ryder J, Hare F, Ranganath H, Berry M, Robins D, Schwartzberg L, Vidal GA
J Med Case Rep 2020 Feb 19;14(1):33. doi: 10.1186/s13256-020-2354-7. PMID: 32070435Free PMC Article
Effectiveness of the diagnostic pathway of BLES: could it be safely used as a therapeutic method in selected benign lesions?
Kurtoğlu Özçağlayan Tİ, Özkan Gürdal S, Öznur M, Özçağlayan Ö, Doğru M, Topçu B
Diagn Interv Radiol 2019 Nov;25(6):428-434. doi: 10.5152/dir.2019.18427. PMID: 31650964Free PMC Article
Underestimation of breast cancer in intraductal papillomas treated with vacuum-assisted core needle biopsy.
Hodorowicz-Zaniewska D, Siarkiewicz B, Brzuszkiewicz K, Szpor J
Ginekol Pol 2019;90(3):122-127. doi: 10.5603/GP.2019.0022. PMID: 30950000
A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer.
Kabat GC, Jones JG, Olson N, Negassa A, Duggan C, Ginsberg M, Kandel RA, Glass AG, Rohan TE
Cancer Causes Control 2010 Jun;21(6):821-8. Epub 2010 Jan 19 doi: 10.1007/s10552-010-9508-7. PMID: 20084540Free PMC Article

Prognosis

Upgrade Rate and Predictive Factors for Breast Benign Intraductal Papilloma Diagnosed at Biopsy: A Meta-Analysis.
Zhang X, Liu W, Hai T, Li F
Ann Surg Oncol 2021 Dec;28(13):8643-8650. Epub 2021 Jul 30 doi: 10.1245/s10434-021-10188-7. PMID: 34331160
Papillary lesions of the breast: A systematic evaluation of cytologic parameters.
Jamidi SK, Li JJX, Aphivatanasiri C, Chow MBCY, Chan RCK, Ng JKM, Tsang JY, Tse GM
Cancer Cytopathol 2021 Aug;129(8):649-661. Epub 2021 Feb 9 doi: 10.1002/cncy.22412. PMID: 33561323
Pathology of breast papillary neoplasms: Community hospital experience.
Vdovenko AA
Ann Diagn Pathol 2020 Dec;49:151605. Epub 2020 Sep 6 doi: 10.1016/j.anndiagpath.2020.151605. PMID: 32920473
Are we overtreating intraductal papillomas?
Kiran S, Jeong YJ, Nelson ME, Ring A, Johnson MB, Sheth PA, Ma Y, Sener SF, Lang JE
J Surg Res 2018 Nov;231:387-394. Epub 2018 Jun 29 doi: 10.1016/j.jss.2018.06.008. PMID: 30278958Free PMC Article
Papillomas of the breast: factors associated with underestimation.
Boufelli G, Giannotti MA, Ruiz CA, Barros N, Chala LF, Maesaka JY, Goncalves R, Bresciani BH, Vianna P, Soares JM Jr, Baracat EC, Filassi JR
Eur J Cancer Prev 2018 Jul;27(4):310-314. doi: 10.1097/CEJ.0000000000000343. PMID: 28296665Free PMC Article

Clinical prediction guides

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Pathology of breast papillary neoplasms: Community hospital experience.
Vdovenko AA
Ann Diagn Pathol 2020 Dec;49:151605. Epub 2020 Sep 6 doi: 10.1016/j.anndiagpath.2020.151605. PMID: 32920473
Benign breast papilloma: Is surgical excision necessary?
Moynihan A, Quinn EM, Smith CS, Stokes M, Kell M, Barry JM, Walsh SM
Breast J 2020 Apr;26(4):705-710. Epub 2019 Oct 14 doi: 10.1111/tbj.13642. PMID: 31612568
Are we overtreating intraductal papillomas?
Kiran S, Jeong YJ, Nelson ME, Ring A, Johnson MB, Sheth PA, Ma Y, Sener SF, Lang JE
J Surg Res 2018 Nov;231:387-394. Epub 2018 Jun 29 doi: 10.1016/j.jss.2018.06.008. PMID: 30278958Free PMC Article
Noninvasive papillary proliferations.
Oyama T, Koerner FC
Semin Diagn Pathol 2004 Feb;21(1):32-41. doi: 10.1053/j.semdp.2003.10.011. PMID: 15074557

Recent systematic reviews

High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis.
Forester ND, Lowes S, Mitchell E, Twiddy M
Eur J Surg Oncol 2019 Apr;45(4):519-527. Epub 2018 Dec 11 doi: 10.1016/j.ejso.2018.12.008. PMID: 30579653

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