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Childhood endodermal sinus tumor

MedGen UID:
234139
•Concept ID:
C1333016
•
Neoplastic Process
Synonyms: Childhood Endodermal Sinus Neoplasm; childhood endodermal sinus neoplasm; Childhood Endodermal Sinus Tumor; childhood endodermal sinus tumor; Childhood Yolk Sac Neoplasm; childhood yolk Sac neoplasm; Childhood Yolk Sac Tumor; childhood yolk Sac tumor; childhood yolk Sac tumour; paediatric endodermal sinus neoplasm; paediatric yolk Sac neoplasm; paediatric yolk Sac tumour; Pediatric Endodermal Sinus Neoplasm; pediatric endodermal sinus neoplasm; Pediatric Yolk Sac Neoplasm; pediatric yolk Sac neoplasm; Pediatric Yolk Sac Tumor; pediatric yolk Sac tumor
 
Monarch Initiative: MONDO:0003400

Definition

A yolk sac tumor that occurs during childhood. [from NCI]

Professional guidelines

PubMed

Testicular germ cell tumors in childhood: treatment results of 52 patients.
Güler E, Tezer Kutluk M, Büyükpamukçu N, Caglar M, Varan A, Akyüz C, Büyükpamukçu M
Pediatr Hematol Oncol 2004 Jan-Feb;21(1):49-56. PMID: 14660306
Management of primary intracranial germ cell tumors of childhood.
Allen JC
Pediatr Neurosci 1987;13(3):152-7. doi: 10.1159/000120321. PMID: 2841657
Conservative management of testicular endodermal sinus tumor in childhood.
Carroll WL, Kempson RL, Govan DE, Freiha FS, Shochat SJ, Link MP
J Urol 1985 Jun;133(6):1011-4. doi: 10.1016/s0022-5347(17)49354-2. PMID: 2582151

Recent clinical studies

Etiology

Yolk Sac Tumor in an Infant with Androgen Insensitivity Syndrome: A Case Report and Review of the Literature.
Yang H, Wu Z, Tian Y, Yang Z, Yao X, Feng S
Int J Surg Pathol 2022 Oct;30(7):804-809. Epub 2022 Mar 7 doi: 10.1177/10668969221085292. PMID: 35253500
Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial.
Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D
Pediatr Blood Cancer 2022 Feb;69(2):e29451. Epub 2021 Dec 5 doi: 10.1002/pbc.29451. PMID: 34866303Free PMC Article
Prenatal Exposure to Air Toxics and Malignant Germ Cell Tumors in Young Children.
Hall C, Heck JE, Ritz B, Cockburn M, Escobedo LA, von Ehrenstein OS
J Occup Environ Med 2019 Jun;61(6):529-534. doi: 10.1097/JOM.0000000000001609. PMID: 31045852Free PMC Article
Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases.
Sebire NJ, Fowler D, Ramsay AD
Fetal Pediatr Pathol 2004 Sep-Dec;23(5-6):295-303. doi: 10.1080/15227950490952424. PMID: 16137166
Testicular germ cell tumours of childhood in Denmark, 1943-1989: incidence and evaluation of histology using immunohistochemical techniques.
Visfeldt J, Jørgensen N, Müller J, Møller H, Skakkebaek NE
J Pathol 1994 Sep;174(1):39-47. doi: 10.1002/path.1711740107. PMID: 7965402

Diagnosis

An unexpected intracardiac location of yolk sac tumor.
Sel K, Alehan D, Yalçin B, Önder SÇ, Aykan HH, Akyüz C, Doğan R
Cardiovasc Pathol 2023 Jan-Feb;62:107480. Epub 2022 Sep 30 doi: 10.1016/j.carpath.2022.107480. PMID: 36183854
Yolk Sac Tumor in an Infant with Androgen Insensitivity Syndrome: A Case Report and Review of the Literature.
Yang H, Wu Z, Tian Y, Yang Z, Yao X, Feng S
Int J Surg Pathol 2022 Oct;30(7):804-809. Epub 2022 Mar 7 doi: 10.1177/10668969221085292. PMID: 35253500
Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial.
Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D
Pediatr Blood Cancer 2022 Feb;69(2):e29451. Epub 2021 Dec 5 doi: 10.1002/pbc.29451. PMID: 34866303Free PMC Article
Unusual Presentation, Relapse, and Metastasis of a Pediatric Testicular Yolk Sac Tumor: Case Report.
Alshamsi H, Sarhan OM, Almatar A, Ali BA, Boqari D, Kawai FA
Urology 2021 Mar;149:e40-e43. Epub 2020 Oct 24 doi: 10.1016/j.urology.2020.10.014. PMID: 33141029
Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases.
Sebire NJ, Fowler D, Ramsay AD
Fetal Pediatr Pathol 2004 Sep-Dec;23(5-6):295-303. doi: 10.1080/15227950490952424. PMID: 16137166

Therapy

Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial.
Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D
Pediatr Blood Cancer 2022 Feb;69(2):e29451. Epub 2021 Dec 5 doi: 10.1002/pbc.29451. PMID: 34866303Free PMC Article
Successful orthotopic liver transplantation for treatment of a hepatic yolk sac tumor.
Abramson LP, Pillai S, Acton R, Melin-Aldana H, Superina R
J Pediatr Surg 2005 Jul;40(7):1185-7. doi: 10.1016/j.jpedsurg.2005.03.065. PMID: 16034768
Testicular germ cell tumors in childhood: treatment results of 52 patients.
Güler E, Tezer Kutluk M, Büyükpamukçu N, Caglar M, Varan A, Akyüz C, Büyükpamukçu M
Pediatr Hematol Oncol 2004 Jan-Feb;21(1):49-56. PMID: 14660306
Treatment of endodermal sinus tumor in children using a regimen that lacks bleomycin.
Frazier AL, Grier HE, Green DM
Med Pediatr Oncol 1996 Aug;27(2):69-73. doi: 10.1002/(SICI)1096-911X(199608)27:2<69::AID-MPO1>3.0.CO;2-R. PMID: 8649322
Successful treatment of metastatic extragonadal endodermal sinus (yolk sac) tumor in childhood.
Thomas WJ, Kelleher JF, Duval-Arnould B
Cancer 1981 Dec 1;48(11):2371-4. doi: 10.1002/1097-0142(19811201)48:11<2371::aid-cncr2820481106>3.0.co;2-#. PMID: 6170420

Prognosis

Vaginal tumours in childhood: a descriptive analysis from a large paediatric medical centre.
Meng Z, Lin D, Liu C, Wang G, Sun N
Pediatr Surg Int 2022 Jun;38(6):927-934. Epub 2022 Mar 24 doi: 10.1007/s00383-022-05085-3. PMID: 35325284
Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours.
Fustino N, Rakheja D, Ateek CS, Neumann JC, Amatruda JF
Int J Androl 2011 Aug;34(4 Pt 2):e218-33. Epub 2011 Jun 22 doi: 10.1111/j.1365-2605.2011.01186.x. PMID: 21696393Free PMC Article
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Vaginal endodermal sinus tumor.
Kumar V, Kini P, Vepakomma D, Basant M
Indian J Pediatr 2005 Sep;72(9):797-8. doi: 10.1007/BF02734156. PMID: 16186686
Treatment of endodermal sinus tumor in children using a regimen that lacks bleomycin.
Frazier AL, Grier HE, Green DM
Med Pediatr Oncol 1996 Aug;27(2):69-73. doi: 10.1002/(SICI)1096-911X(199608)27:2<69::AID-MPO1>3.0.CO;2-R. PMID: 8649322

Clinical prediction guides

An unexpected intracardiac location of yolk sac tumor.
Sel K, Alehan D, Yalçin B, Önder SÇ, Aykan HH, Akyüz C, Doğan R
Cardiovasc Pathol 2023 Jan-Feb;62:107480. Epub 2022 Sep 30 doi: 10.1016/j.carpath.2022.107480. PMID: 36183854
Pediatric germ cell tumors presenting beyond childhood?
Oosterhuis JW, Stoop JA, Rijlaarsdam MA, Biermann K, Smit VT, Hersmus R, Looijenga LH
Andrology 2015 Jan;3(1):70-7. Epub 2014 Nov 27 doi: 10.1111/andr.305. PMID: 25427839
Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours.
Fustino N, Rakheja D, Ateek CS, Neumann JC, Amatruda JF
Int J Androl 2011 Aug;34(4 Pt 2):e218-33. Epub 2011 Jun 22 doi: 10.1111/j.1365-2605.2011.01186.x. PMID: 21696393Free PMC Article
Neuropsychological outcome in long-term survivors of a childhood extracranial solid tumor who have undergone autologous bone marrow transplantation.
Notteghem P, Soler C, Dellatolas G, Kieffer-Renaux V, Valteau-Couanet D, Raimondo G, Hartmann O
Bone Marrow Transplant 2003 Apr;31(7):599-606. doi: 10.1038/sj.bmt.1703882. PMID: 12692628
Testicular germ cell tumours of childhood in Denmark, 1943-1989: incidence and evaluation of histology using immunohistochemical techniques.
Visfeldt J, Jørgensen N, Müller J, Møller H, Skakkebaek NE
J Pathol 1994 Sep;174(1):39-47. doi: 10.1002/path.1711740107. PMID: 7965402

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