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Childhood endodermal sinus tumor

MedGen UID:
234139
•Concept ID:
C1333016
•
Neoplastic Process
Synonyms: Childhood Endodermal Sinus Neoplasm; childhood endodermal sinus neoplasm; Childhood Endodermal Sinus Tumor; childhood endodermal sinus tumor; Childhood Yolk Sac Neoplasm; childhood yolk Sac neoplasm; Childhood Yolk Sac Tumor; childhood yolk Sac tumor; childhood yolk Sac tumour; paediatric endodermal sinus neoplasm; paediatric yolk Sac neoplasm; paediatric yolk Sac tumour; Pediatric Endodermal Sinus Neoplasm; pediatric endodermal sinus neoplasm; Pediatric Yolk Sac Neoplasm; pediatric yolk Sac neoplasm; Pediatric Yolk Sac Tumor; pediatric yolk Sac tumor
 
Monarch Initiative: MONDO:0003400

Definition

A yolk sac tumor that occurs during childhood. [from NCI]

Professional guidelines

PubMed

Testicular germ cell tumors in childhood: treatment results of 52 patients.
Güler E, Tezer Kutluk M, Büyükpamukçu N, Caglar M, Varan A, Akyüz C, Büyükpamukçu M
Pediatr Hematol Oncol 2004 Jan-Feb;21(1):49-56. PMID: 14660306
Management of primary intracranial germ cell tumors of childhood.
Allen JC
Pediatr Neurosci 1987;13(3):152-7. doi: 10.1159/000120321. PMID: 2841657
Conservative management of testicular endodermal sinus tumor in childhood.
Carroll WL, Kempson RL, Govan DE, Freiha FS, Shochat SJ, Link MP
J Urol 1985 Jun;133(6):1011-4. doi: 10.1016/s0022-5347(17)49354-2. PMID: 2582151

Recent clinical studies

Etiology

Vaginal tumours in childhood: a descriptive analysis from a large paediatric medical centre.
Meng Z, Lin D, Liu C, Wang G, Sun N
Pediatr Surg Int 2022 Jun;38(6):927-934. Epub 2022 Mar 24 doi: 10.1007/s00383-022-05085-3. PMID: 35325284
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Pelvic neoplasms in children.
Groff DB
J Surg Oncol 2001 May;77(1):65-71. doi: 10.1002/jso.1068. PMID: 11344486
Gynecologic tumors and symptoms in childhood and adolescence; 10-years' experience.
Imai A, Furui T, Tamaya T
Int J Gynaecol Obstet 1994 Jun;45(3):227-34. doi: 10.1016/0020-7292(94)90247-x. PMID: 7926241
Non-midline endodermal sinus tumor in the head and neck region: a case report.
Kebudi R, Ayan I, Darendeliler E, Ağaoğlu L, Kinay M, Olgaç V, Bilge N
Med Pediatr Oncol 1993;21(9):685-9. doi: 10.1002/mpo.2950210915. PMID: 8413005

Diagnosis

Vaginal tumours in childhood: a descriptive analysis from a large paediatric medical centre.
Meng Z, Lin D, Liu C, Wang G, Sun N
Pediatr Surg Int 2022 Jun;38(6):927-934. Epub 2022 Mar 24 doi: 10.1007/s00383-022-05085-3. PMID: 35325284
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Vaginal endodermal sinus tumor.
Kumar V, Kini P, Vepakomma D, Basant M
Indian J Pediatr 2005 Sep;72(9):797-8. doi: 10.1007/BF02734156. PMID: 16186686
Pelvic neoplasms in children.
Groff DB
J Surg Oncol 2001 May;77(1):65-71. doi: 10.1002/jso.1068. PMID: 11344486
Diagnostic value of alpha 1-fetoprotein and beta-human chorionic gonadotropin in infancy and childhood.
Schneider DT, Calaminus G, Göbel U
Pediatr Hematol Oncol 2001 Jan-Feb;18(1):11-26. doi: 10.1080/088800101750059828. PMID: 11205836

Therapy

Pitfalls in the diagnosis of yolk sac tumor: Lessons from a clinical trial.
Yang A, Patterson A, Pavlock T, Chen KS, Gagan J, Hatley ME, Frazier AL, Amatruda JF, Laetsch TW, Rakheja D
Pediatr Blood Cancer 2022 Feb;69(2):e29451. Epub 2021 Dec 5 doi: 10.1002/pbc.29451. PMID: 34866303Free PMC Article
Treatment of endodermal sinus tumor in children using a regimen that lacks bleomycin.
Frazier AL, Grier HE, Green DM
Med Pediatr Oncol 1996 Aug;27(2):69-73. doi: 10.1002/(SICI)1096-911X(199608)27:2<69::AID-MPO1>3.0.CO;2-R. PMID: 8649322
Endocrine status and growth after malignancy treated in childhood or adolescence.
Vilska S, Lähteenmäki P, Kaihola HL, Salmi TT
Int J Fertil 1988 Jul-Aug;33(4):283-90. PMID: 2902044
Management of primary intracranial germ cell tumors of childhood.
Allen JC
Pediatr Neurosci 1987;13(3):152-7. doi: 10.1159/000120321. PMID: 2841657
Successful treatment of metastatic extragonadal endodermal sinus (yolk sac) tumor in childhood.
Thomas WJ, Kelleher JF, Duval-Arnould B
Cancer 1981 Dec 1;48(11):2371-4. doi: 10.1002/1097-0142(19811201)48:11<2371::aid-cncr2820481106>3.0.co;2-#. PMID: 6170420

Prognosis

Vaginal tumours in childhood: a descriptive analysis from a large paediatric medical centre.
Meng Z, Lin D, Liu C, Wang G, Sun N
Pediatr Surg Int 2022 Jun;38(6):927-934. Epub 2022 Mar 24 doi: 10.1007/s00383-022-05085-3. PMID: 35325284
Pathology and molecular biology of teratomas in childhood and adolescence.
Harms D, Zahn S, Göbel U, Schneider DT
Klin Padiatr 2006 Nov-Dec;218(6):296-302. doi: 10.1055/s-2006-942271. PMID: 17080330
Vaginal endodermal sinus tumor.
Kumar V, Kini P, Vepakomma D, Basant M
Indian J Pediatr 2005 Sep;72(9):797-8. doi: 10.1007/BF02734156. PMID: 16186686
Germ cell tumors of the sacrococcygeal region: radiologic-pathologic correlation.
Keslar PJ, Buck JL, Suarez ES
Radiographics 1994 May;14(3):607-20; quiz 621-2. doi: 10.1148/radiographics.14.3.8066275. PMID: 8066275
Non-midline endodermal sinus tumor in the head and neck region: a case report.
Kebudi R, Ayan I, Darendeliler E, Ağaoğlu L, Kinay M, Olgaç V, Bilge N
Med Pediatr Oncol 1993;21(9):685-9. doi: 10.1002/mpo.2950210915. PMID: 8413005

Clinical prediction guides

Vaginal tumours in childhood: a descriptive analysis from a large paediatric medical centre.
Meng Z, Lin D, Liu C, Wang G, Sun N
Pediatr Surg Int 2022 Jun;38(6):927-934. Epub 2022 Mar 24 doi: 10.1007/s00383-022-05085-3. PMID: 35325284
Pediatric malignant germ cell tumors show characteristic transcriptome profiles.
Palmer RD, Barbosa-Morais NL, Gooding EL, Muralidhar B, Thornton CM, Pett MR, Roberts I, Schneider DT, Thorne N, Tavaré S, Nicholson JC, Coleman N; Children's Cancer and Leukaemia Group
Cancer Res 2008 Jun 1;68(11):4239-47. doi: 10.1158/0008-5472.CAN-07-5560. PMID: 18519683
Malignant liver tumors in South African children: a national audit.
Moore SW, Davidson A, Hadley GP, Kruger M, Poole J, Stones D, Wainwright L, Wessels G
World J Surg 2008 Jul;32(7):1389-95. doi: 10.1007/s00268-008-9526-8. PMID: 18305988
Activation of Wnt/beta-catenin signaling in distinct histologic subtypes of human germ cell tumors.
Fritsch MK, Schneider DT, Schuster AE, Murdoch FE, Perlman EJ
Pediatr Dev Pathol 2006 Mar-Apr;9(2):115-31. Epub 2006 Jun 16 doi: 10.2350/08-05-0097.1. PMID: 16822086
Clinical stage I nonseminomatous germ cell tumors of the testis in childhood and adolescence: an analysis of 31 cases.
Terenziani M, Piva L, Spreafico F, Salvioni R, Massimino M, Luksch R, Cefalo G, Casanova M, Ferrari A, Polastri D, Mazza E, Bellani FF, Nicolai N
J Pediatr Hematol Oncol 2002 Aug-Sep;24(6):454-8. doi: 10.1097/00043426-200208000-00009. PMID: 12218592

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