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Childhood Nongerminomatous Germ Cell Tumor

MedGen UID:
903302
•Concept ID:
C4086166
•
Neoplastic Process
Synonym: Childhood Non-Germinomatous Germ Cell Tumor

Definition

A nongerminomatous germ cell tumor occurring in children. [from NCI]

Professional guidelines

PubMed

Longitudinal evaluation of neurocognitive function after treatment for central nervous system germ cell tumors in childhood.
Mabbott DJ, Monsalves E, Spiegler BJ, Bartels U, Janzen L, Guger S, Laperriere N, Andrews N, Bouffet E
Cancer 2011 Dec 1;117(23):5402-11. Epub 2011 May 11 doi: 10.1002/cncr.26127. PMID: 21563173
Treatment of tumours of the pineal region and posterior part of the third ventricle.
Herrmann HD, Winkler D, Westphal M
Acta Neurochir (Wien) 1992;116(2-4):137-46. doi: 10.1007/BF01540866. PMID: 1502947

Recent clinical studies

Etiology

Challenges in the Management of Childhood Intracranial Germ Cell Tumors in Middle-Income Countries: A 20-Year Retrospective Review From a Single Tertiary Center in Malaysia.
Rajagopal R, Leong SH, Jawin V, Foo JC, Ahmad Bahuri NF, Mun KS, Azman RR, Loh J, Yap TY, Ariffin H, Moreira DC, Gottardo NG, Bouffet E, Ganesan D
J Pediatr Hematol Oncol 2021 Oct 1;43(7):e913-e923. doi: 10.1097/MPH.0000000000002116. PMID: 33633029
Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Long-term outcomes and late effects for childhood and young adulthood intracranial germinomas.
Acharya S, DeWees T, Shinohara ET, Perkins SM
Neuro Oncol 2015 May;17(5):741-6. Epub 2014 Nov 23 doi: 10.1093/neuonc/nou311. PMID: 25422317Free PMC Article
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259
Nongerminomatous malignant germ cell tumors in children. A review of 89 cases from the Pediatric Oncology Group, 1971-1984.
Hawkins EP, Finegold MJ, Hawkins HK, Krischer JP, Starling KA, Weinberg A
Cancer 1986 Dec 15;58(12):2579-84. doi: 10.1002/1097-0142(19861215)58:12<2579::aid-cncr2820581204>3.0.co;2-v. PMID: 3022907

Diagnosis

Challenges in the Management of Childhood Intracranial Germ Cell Tumors in Middle-Income Countries: A 20-Year Retrospective Review From a Single Tertiary Center in Malaysia.
Rajagopal R, Leong SH, Jawin V, Foo JC, Ahmad Bahuri NF, Mun KS, Azman RR, Loh J, Yap TY, Ariffin H, Moreira DC, Gottardo NG, Bouffet E, Ganesan D
J Pediatr Hematol Oncol 2021 Oct 1;43(7):e913-e923. doi: 10.1097/MPH.0000000000002116. PMID: 33633029
Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Growing teratoma syndrome in a patient with intracranial germ cell tumor.
Zheludkova OG, Shishkina LV, Konovalov AN, Ryzhova MV, Kislyakov AN, Ozerov SS, Trunin YY, Mazerkina NA, Klimchuk OV, Tarasova EM
Zh Vopr Neirokhir Im N N Burdenko 2015;79(3):69-74. doi: 10.17116/neiro201579369-74. PMID: 26529536
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259
Pineal region tumours in childhood. A 30-year experience.
Drummond KJ, Rosenfeld JV
Childs Nerv Syst 1999 Mar;15(2-3):119-26; discussion 127. doi: 10.1007/s003810050347. PMID: 10230668

Therapy

Survival outcomes, hematologic complications and growth impairment after sequential chemoradiotherapy in intracranial NGGCTs: a retrospective study.
Wen L, Li J, Lai M, Zhou Z, Hu Q, Deng G, Shan C, Ai R, Li H, Lu M, Zhang L, Wu T, Zhu D, Chen Y, Chen L, Cai L, Zhou C
Strahlenther Onkol 2022 May;198(5):458-467. Epub 2021 Oct 21 doi: 10.1007/s00066-021-01857-3. PMID: 34673990
Challenges in the Management of Childhood Intracranial Germ Cell Tumors in Middle-Income Countries: A 20-Year Retrospective Review From a Single Tertiary Center in Malaysia.
Rajagopal R, Leong SH, Jawin V, Foo JC, Ahmad Bahuri NF, Mun KS, Azman RR, Loh J, Yap TY, Ariffin H, Moreira DC, Gottardo NG, Bouffet E, Ganesan D
J Pediatr Hematol Oncol 2021 Oct 1;43(7):e913-e923. doi: 10.1097/MPH.0000000000002116. PMID: 33633029
Intracranial germ cell tumors: a comprehensive update of the European data.
Calaminus G, Bamberg M, Baranzelli MC, Benoit Y, di Montezemolo LC, Fossati-Bellani F, Jürgens H, Kühl HJ, Lenard HG, Curto ML
Neuropediatrics 1994 Feb;25(1):26-32. doi: 10.1055/s-2008-1071577. PMID: 8208347
Treatment of tumours of the pineal region and posterior part of the third ventricle.
Herrmann HD, Winkler D, Westphal M
Acta Neurochir (Wien) 1992;116(2-4):137-46. doi: 10.1007/BF01540866. PMID: 1502947

Prognosis

Challenges in the Management of Childhood Intracranial Germ Cell Tumors in Middle-Income Countries: A 20-Year Retrospective Review From a Single Tertiary Center in Malaysia.
Rajagopal R, Leong SH, Jawin V, Foo JC, Ahmad Bahuri NF, Mun KS, Azman RR, Loh J, Yap TY, Ariffin H, Moreira DC, Gottardo NG, Bouffet E, Ganesan D
J Pediatr Hematol Oncol 2021 Oct 1;43(7):e913-e923. doi: 10.1097/MPH.0000000000002116. PMID: 33633029
Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Long-term outcomes and late effects for childhood and young adulthood intracranial germinomas.
Acharya S, DeWees T, Shinohara ET, Perkins SM
Neuro Oncol 2015 May;17(5):741-6. Epub 2014 Nov 23 doi: 10.1093/neuonc/nou311. PMID: 25422317Free PMC Article
Fourth-ventricular immature teratoma.
Furtado SV, Ghosal N, Rokade VB, Hegde AS
J Clin Neurosci 2011 Feb;18(2):296-8. Epub 2010 Oct 27 doi: 10.1016/j.jocn.2010.03.061. PMID: 21030259
Nongerminomatous malignant germ cell tumors in children. A review of 89 cases from the Pediatric Oncology Group, 1971-1984.
Hawkins EP, Finegold MJ, Hawkins HK, Krischer JP, Starling KA, Weinberg A
Cancer 1986 Dec 15;58(12):2579-84. doi: 10.1002/1097-0142(19861215)58:12<2579::aid-cncr2820581204>3.0.co;2-v. PMID: 3022907

Clinical prediction guides

Survival outcomes, hematologic complications and growth impairment after sequential chemoradiotherapy in intracranial NGGCTs: a retrospective study.
Wen L, Li J, Lai M, Zhou Z, Hu Q, Deng G, Shan C, Ai R, Li H, Lu M, Zhang L, Wu T, Zhu D, Chen Y, Chen L, Cai L, Zhou C
Strahlenther Onkol 2022 May;198(5):458-467. Epub 2021 Oct 21 doi: 10.1007/s00066-021-01857-3. PMID: 34673990
Relapsing intracranial germ cell tumours warrant retreatment.
Callec L, Lardy-Cleaud A, Guerrini-Rousseau L, Alapetite C, Vignon L, Chastagner P, Frappaz D, Faure-Conter C
Eur J Cancer 2020 Sep;136:186-194. Epub 2020 Jul 22 doi: 10.1016/j.ejca.2020.06.012. PMID: 32711377
Long-term outcomes and late effects for childhood and young adulthood intracranial germinomas.
Acharya S, DeWees T, Shinohara ET, Perkins SM
Neuro Oncol 2015 May;17(5):741-6. Epub 2014 Nov 23 doi: 10.1093/neuonc/nou311. PMID: 25422317Free PMC Article
Epidemiologic analysis of 1,442 children and adolescents registered in the German germ cell tumor protocols.
Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ, Harms D, Göbel U
Pediatr Blood Cancer 2004 Feb;42(2):169-75. doi: 10.1002/pbc.10321. PMID: 14752882

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