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EBV-Related Hodgkin Lymphoma

MedGen UID:
234225
•Concept ID:
C1333430
•
Neoplastic Process
Synonyms: EBV Related Hodgkin's Lymphoma; EBV-Related Hodgkin's Lymphoma; Epstein-Barr Virus Related Hodgkin's Lymphoma; Epstein-Barr Virus-Related Hodgkin Lymphoma; Epstein-Barr Virus-Related Hodgkin's Lymphoma

Definition

Hodgkin lymphoma that is caused by Epstein-Barr virus infection. [from NCI]

Professional guidelines

PubMed

Current Treatment Options for Older Patients with Hodgkin Lymphoma.
Carter J, David KA, Kritharis A, Evens AM
Curr Treat Options Oncol 2020 Apr 23;21(5):42. doi: 10.1007/s11864-020-00745-9. PMID: 32328822
In situ hybridisation for Epstein-Barr virus as a differential diagnostic tool for T- and natural killer/T-cell lymphomas in non-immunocompromised patients.
Chuang SS
Pathology 2014 Dec;46(7):581-91. doi: 10.1097/PAT.0000000000000161. PMID: 25393247
EBV-related lymphomas: new approaches to treatment.
Kanakry JA, Ambinder RF
Curr Treat Options Oncol 2013 Jun;14(2):224-36. doi: 10.1007/s11864-013-0231-y. PMID: 23549980Free PMC Article

Recent clinical studies

Etiology

Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas.
Kaulen LD, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann DC, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring JM, Brors B, Sahm F, Wick W
Acta Neuropathol 2023 Sep;146(3):499-514. Epub 2023 Jul 26 doi: 10.1007/s00401-023-02613-w. PMID: 37495858Free PMC Article
Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies.
Argirion I, Pfeiffer RM, Proietti C, Coghill AE, Yu KJ, Middeldorp JM, Sarathkumara YD, Hsu WL, Chien YC, Lou PJ, Wang CP, Rothman N, Lan Q, Chen CJ, Mbulaiteye SM, Jarrett RF, Glimelius I, Smedby KE, Hjalgrim H, Hildesheim A, Doolan DL, Liu Z
Cancer Epidemiol Biomarkers Prev 2023 May 1;32(5):687-696. doi: 10.1158/1055-9965.EPI-22-0452. PMID: 36788424Free PMC Article
Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?
Tatfi M, Hermine O, Suarez F
Front Immunol 2018;9:3060. Epub 2019 Jan 4 doi: 10.3389/fimmu.2018.03060. PMID: 30662441Free PMC Article
Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point.
Linke-Serinsöz E, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2017 Jul;34(4):352-363. Epub 2017 Apr 7 doi: 10.1053/j.semdp.2017.04.003. PMID: 28506687
Epstein-Barr virus (EBV)-associated lymphoid lesions of the head and neck.
Auerbach A, Aguilera NS
Semin Diagn Pathol 2015 Jan;32(1):12-22. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2014.12.001. PMID: 25804341

Diagnosis

NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Current Treatment Options for Older Patients with Hodgkin Lymphoma.
Carter J, David KA, Kritharis A, Evens AM
Curr Treat Options Oncol 2020 Apr 23;21(5):42. doi: 10.1007/s11864-020-00745-9. PMID: 32328822
Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma.
Zhu S, Chen J, Xiong Y, Kamara S, Gu M, Tang W, Chen S, Dong H, Xue X, Zheng ZM, Zhang L
PLoS Pathog 2020 Jan;16(1):e1008223. Epub 2020 Jan 6 doi: 10.1371/journal.ppat.1008223. PMID: 31905218Free PMC Article
Primary CNS lymphoma in HIV infection.
Brandsma D, Bromberg JEC
Handb Clin Neurol 2018;152:177-186. doi: 10.1016/B978-0-444-63849-6.00014-1. PMID: 29604975
Epstein-Barr virus (EBV)-associated lymphoid lesions of the head and neck.
Auerbach A, Aguilera NS
Semin Diagn Pathol 2015 Jan;32(1):12-22. Epub 2015 Feb 7 doi: 10.1053/j.semdp.2014.12.001. PMID: 25804341

Therapy

Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Novel EBV LMP-2-affibody and affitoxin in molecular imaging and targeted therapy of nasopharyngeal carcinoma.
Zhu S, Chen J, Xiong Y, Kamara S, Gu M, Tang W, Chen S, Dong H, Xue X, Zheng ZM, Zhang L
PLoS Pathog 2020 Jan;16(1):e1008223. Epub 2020 Jan 6 doi: 10.1371/journal.ppat.1008223. PMID: 31905218Free PMC Article
Primary CNS lymphoma in HIV infection.
Brandsma D, Bromberg JEC
Handb Clin Neurol 2018;152:177-186. doi: 10.1016/B978-0-444-63849-6.00014-1. PMID: 29604975
The epidemiology of cancers in human immunodeficiency virus infection and after organ transplantation.
Grulich AE, Vajdic CM
Semin Oncol 2015 Apr;42(2):247-57. Epub 2014 Dec 31 doi: 10.1053/j.seminoncol.2014.12.029. PMID: 25843729

Prognosis

Evidence for distinct mechanisms of immune suppression in EBV-positive and EBV-negative Hodgkin lymphoma.
Adam M, Bekuretsion Y, Gebremedhin A, Kwiecinska A, Howe R, Petros B, Jerkeman M
J Clin Exp Hematop 2023;63(4):230-239. doi: 10.3960/jslrt.23037. PMID: 38148013Free PMC Article
Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas.
Kaulen LD, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann DC, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring JM, Brors B, Sahm F, Wick W
Acta Neuropathol 2023 Sep;146(3):499-514. Epub 2023 Jul 26 doi: 10.1007/s00401-023-02613-w. PMID: 37495858Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?
Tatfi M, Hermine O, Suarez F
Front Immunol 2018;9:3060. Epub 2019 Jan 4 doi: 10.3389/fimmu.2018.03060. PMID: 30662441Free PMC Article
Primary CNS lymphoma in HIV infection.
Brandsma D, Bromberg JEC
Handb Clin Neurol 2018;152:177-186. doi: 10.1016/B978-0-444-63849-6.00014-1. PMID: 29604975

Clinical prediction guides

Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas.
Kaulen LD, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann DC, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring JM, Brors B, Sahm F, Wick W
Acta Neuropathol 2023 Sep;146(3):499-514. Epub 2023 Jul 26 doi: 10.1007/s00401-023-02613-w. PMID: 37495858Free PMC Article
Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies.
Argirion I, Pfeiffer RM, Proietti C, Coghill AE, Yu KJ, Middeldorp JM, Sarathkumara YD, Hsu WL, Chien YC, Lou PJ, Wang CP, Rothman N, Lan Q, Chen CJ, Mbulaiteye SM, Jarrett RF, Glimelius I, Smedby KE, Hjalgrim H, Hildesheim A, Doolan DL, Liu Z
Cancer Epidemiol Biomarkers Prev 2023 May 1;32(5):687-696. doi: 10.1158/1055-9965.EPI-22-0452. PMID: 36788424Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
NK-/T-cell lymphomas.
Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356Free PMC Article
Human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) related lymphomas, pathology view point.
Linke-Serinsöz E, Fend F, Quintanilla-Martinez L
Semin Diagn Pathol 2017 Jul;34(4):352-363. Epub 2017 Apr 7 doi: 10.1053/j.semdp.2017.04.003. PMID: 28506687

Recent systematic reviews

EBV Positivity and Programmed Death-ligand 1 Expression in Diffuse Large B-cell Lymphoma: A Systematic Review.
Barzyk GA, Sheriff V
Anticancer Res 2020 Nov;40(11):5951-5968. doi: 10.21873/anticanres.14616. PMID: 33109533

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