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Esophageal Squamous Intraepithelial Neoplasia

MedGen UID:
234234
•Concept ID:
C1333468
•
Neoplastic Process
Synonym: Esophageal Squamous Dysplasia

Definition

A lesion in which the architectural and cytologic abnormalities involve either the lower or both the lower and the upper half of the esophageal squamous epithelium. [from NCI]

Professional guidelines

PubMed

Updated German guideline on diagnosis and treatment of squamous cell carcinoma and adenocarcinoma of the esophagus.
Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Vanhoefer U, Ebert MPA
United European Gastroenterol J 2024 Apr;12(3):399-411. Epub 2024 Jan 29 doi: 10.1002/ueg2.12523. PMID: 38284661Free PMC Article
Preventive Treatment with PD-1 Antibody Increases Tissue-resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis.
Xiao Z, Yan R, Liu H, Huang X, Liang Z, An G, Ge Y
Cancer Prev Res (Phila) 2023 Dec 1;16(12):669-679. doi: 10.1158/1940-6207.CAPR-23-0196. PMID: 37857481Free PMC Article
A review of the current understanding and clinical utility of miRNAs in esophageal cancer.
Sakai NS, Samia-Aly E, Barbera M, Fitzgerald RC
Semin Cancer Biol 2013 Dec;23(6 Pt B):512-21. Epub 2013 Sep 3 doi: 10.1016/j.semcancer.2013.08.005. PMID: 24013023

Recent clinical studies

Etiology

iTRAQ-Based Quantitative Proteomic Analyses of High Grade Esophageal Squamous Intraepithelial Neoplasia.
Zhang J, Zhi C, Zhen F, Yuan X, Jiao C, Zhu H, Zhu H, Feng Y
Proteomics Clin Appl 2017 Dec;11(11-12) Epub 2017 Sep 25 doi: 10.1002/prca.201600167. PMID: 28816019
γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.
Takemura K, Kawachi H, Eishi Y, Kitagaki K, Negi M, Kobayashi M, Uchida K, Inoue J, Inazawa J, Kawano T, Board PG
Hum Pathol 2014 Feb;45(2):331-41. Epub 2013 Oct 3 doi: 10.1016/j.humpath.2013.09.009. PMID: 24342434
Reduced expression of cytokeratin 4 and 13 is a valuable marker for histologic grading of esophageal squamous intraepithelial neoplasia.
Takashima M, Kawachi H, Yamaguchi T, Nakajima Y, Kitagaki K, Sekine M, Iida T, Takemura K, Kawano T, Eishi Y
J Med Dent Sci 2012 Mar 13;59(1):17-28. PMID: 23896961

Diagnosis

Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection.
Li M, Kong J, Wang L, Yan H, Liang W, Wang N, Zhao J
World J Surg Oncol 2022 May 12;20(1):155. doi: 10.1186/s12957-022-02612-3. PMID: 35549728Free PMC Article
iTRAQ-Based Quantitative Proteomic Analyses of High Grade Esophageal Squamous Intraepithelial Neoplasia.
Zhang J, Zhi C, Zhen F, Yuan X, Jiao C, Zhu H, Zhu H, Feng Y
Proteomics Clin Appl 2017 Dec;11(11-12) Epub 2017 Sep 25 doi: 10.1002/prca.201600167. PMID: 28816019
ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma.
Li M, Cui X, Shen Y, Dong H, Liang W, Chen Y, Hu J, Li S, Kong J, Li H, Zhao J, Li F
Hum Pathol 2015 May;46(5):707-15. Epub 2015 Feb 4 doi: 10.1016/j.humpath.2015.01.009. PMID: 25732110
γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.
Takemura K, Kawachi H, Eishi Y, Kitagaki K, Negi M, Kobayashi M, Uchida K, Inoue J, Inazawa J, Kawano T, Board PG
Hum Pathol 2014 Feb;45(2):331-41. Epub 2013 Oct 3 doi: 10.1016/j.humpath.2013.09.009. PMID: 24342434
Ki-67 and ProExC are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia.
Wang WC, Wu TT, Chandan VS, Lohse CM, Zhang L
Hum Pathol 2011 Oct;42(10):1430-7. Epub 2011 Mar 21 doi: 10.1016/j.humpath.2010.12.009. PMID: 21420715

Prognosis

Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection.
Li M, Kong J, Wang L, Yan H, Liang W, Wang N, Zhao J
World J Surg Oncol 2022 May 12;20(1):155. doi: 10.1186/s12957-022-02612-3. PMID: 35549728Free PMC Article
ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma.
Li M, Cui X, Shen Y, Dong H, Liang W, Chen Y, Hu J, Li S, Kong J, Li H, Zhao J, Li F
Hum Pathol 2015 May;46(5):707-15. Epub 2015 Feb 4 doi: 10.1016/j.humpath.2015.01.009. PMID: 25732110
Ki-67 and ProExC are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia.
Wang WC, Wu TT, Chandan VS, Lohse CM, Zhang L
Hum Pathol 2011 Oct;42(10):1430-7. Epub 2011 Mar 21 doi: 10.1016/j.humpath.2010.12.009. PMID: 21420715

Clinical prediction guides

Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection.
Li M, Kong J, Wang L, Yan H, Liang W, Wang N, Zhao J
World J Surg Oncol 2022 May 12;20(1):155. doi: 10.1186/s12957-022-02612-3. PMID: 35549728Free PMC Article
ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma.
Li M, Cui X, Shen Y, Dong H, Liang W, Chen Y, Hu J, Li S, Kong J, Li H, Zhao J, Li F
Hum Pathol 2015 May;46(5):707-15. Epub 2015 Feb 4 doi: 10.1016/j.humpath.2015.01.009. PMID: 25732110
γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.
Takemura K, Kawachi H, Eishi Y, Kitagaki K, Negi M, Kobayashi M, Uchida K, Inoue J, Inazawa J, Kawano T, Board PG
Hum Pathol 2014 Feb;45(2):331-41. Epub 2013 Oct 3 doi: 10.1016/j.humpath.2013.09.009. PMID: 24342434
Reduced expression of cytokeratin 4 and 13 is a valuable marker for histologic grading of esophageal squamous intraepithelial neoplasia.
Takashima M, Kawachi H, Yamaguchi T, Nakajima Y, Kitagaki K, Sekine M, Iida T, Takemura K, Kawano T, Eishi Y
J Med Dent Sci 2012 Mar 13;59(1):17-28. PMID: 23896961

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