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Hard Palate Monomorphic Adenoma

MedGen UID:
234335
•Concept ID:
C1333937
•
Neoplastic Process
Synonyms: Monomorphic Adenoma of Hard Palate; Monomorphic Adenoma of the Hard Palate

Definition

A benign epithelial neoplasm arising from the minor salivary glands in the hard palate. It is characterized by the presence of a monomorphic cellular infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHard Palate Monomorphic Adenoma

Professional guidelines

PubMed

Review of 109 cases of primary malignant orofacial lesions seen at a Nigerian Tertiary Hospital.
Adesina OM, Soyele OO, Oyetola EO, Fatusi OA
Niger Postgrad Med J 2018 Oct-Dec;25(4):246-251. doi: 10.4103/npmj.npmj_115_18. PMID: 30588946
Differential diagnosis between adenoid cystic carcinoma and pleomorphic adenoma of the minor salivary glands of palate.
Cerulli G, Renzi G, Perugini M, Becelli R
J Craniofac Surg 2004 Nov;15(6):1056-60. doi: 10.1097/00001665-200411000-00036. PMID: 15547405
Oral carcinoma of the upper jaw. Results of radiation treatment.
Shibuya H, Horiuchi J, Suzuki S, Amagasa M, Mashima K
Acta Radiol Oncol 1984;23(5):331-5. doi: 10.3109/02841868409136029. PMID: 6095603

Recent clinical studies

Etiology

Mucoepidermoid carcinoma of hard palate.
Gill S, Mohan A, Aggarwal S, Varshney A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):397-398. doi: 10.4103/IJPM.IJPM_617_17. PMID: 30004063
An Unusual Cause of Dyspnea.
Grzesik P, Passik C, Mahfoozi A
Ann Thorac Surg 2016 Oct;102(4):e333-4. doi: 10.1016/j.athoracsur.2016.02.051. PMID: 27645975
Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature.
Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, Chu PY, Chan KT, Tai SK, Wang YF, Kao SC, Kao SY, Lo WL, Wu CH, Shu WH, Ma S, Wang TH
Eur Arch Otorhinolaryngol 2011 Jul;268(7):1035-40. Epub 2010 Dec 1 doi: 10.1007/s00405-010-1437-2. PMID: 21120660
Minor salivary gland tumors: A clinicopathological study of 18 cases.
Pons Vicente O, Almendros Marqués N, Berini Aytés L, Gay Escoda C
Med Oral Patol Oral Cir Bucal 2008 Sep 1;13(9):E582-8. PMID: 18758404
Intraoral minor salivary gland tumors: a review of 75 cases in a Libyan population.
Jaber MA
Int J Oral Maxillofac Surg 2006 Feb;35(2):150-4. Epub 2005 Sep 21 doi: 10.1016/j.ijom.2005.07.006. PMID: 16181771

Diagnosis

Pleomorphic adenoma of hard palate: a case report.
Yousra Z, Saliha C
Pan Afr Med J 2021;38:146. Epub 2021 Feb 9 doi: 10.11604/pamj.2021.38.146.26508. PMID: 33912316Free PMC Article
Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Mucoepidermoid carcinoma of hard palate.
Gill S, Mohan A, Aggarwal S, Varshney A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):397-398. doi: 10.4103/IJPM.IJPM_617_17. PMID: 30004063
Canalicular adenoma: A systematic review.
Peraza AJ, Wright J, Gómez R
J Craniomaxillofac Surg 2017 Oct;45(10):1754-1758. Epub 2017 Aug 3 doi: 10.1016/j.jcms.2017.07.020. PMID: 28890252
Pleomorphic adenoma of the palate.
Erdem MA, Cankaya AB, Güven G, Olgaç V, Kasapoğlu C
J Craniofac Surg 2011 May;22(3):1131-4. doi: 10.1097/SCS.0b013e3182108f8b. PMID: 21586967

Therapy

Canalicular adenoma of a minor salivary gland on the palate: a case presentation.
Werder P, Altermatt HJ, Zbären P, Bornstein MM
Quintessence Int 2009 Sep;40(8):623-6. PMID: 19639085
Closure of palatal defects following excision of palatal pleomorphic adenomas.
Alkan A, Inal S
J Contemp Dent Pract 2008 Sep 1;9(6):99-107. PMID: 18784865

Prognosis

Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Molecular profile of a pleomorphic adenoma of the hard palate: A case report.
Iida Y, Serizawa M, Mukaigawa T, Kamijo T, Nakajima T, Asakura K, Kusuhara M, Yamaguchi K, Onitsuka T
Medicine (Baltimore) 2020 Jul 17;99(29):e21207. doi: 10.1097/MD.0000000000021207. PMID: 32702887Free PMC Article
An Unusual Cause of Dyspnea.
Grzesik P, Passik C, Mahfoozi A
Ann Thorac Surg 2016 Oct;102(4):e333-4. doi: 10.1016/j.athoracsur.2016.02.051. PMID: 27645975
Minor salivary gland tumors of the oral cavity: a case series with review of literature.
Vaidya AD, Pantvaidya GH, Metgudmath R, Kane SV, D'Cruz AK
J Cancer Res Ther 2012 Jan;8 Suppl 1:S111-5. doi: 10.4103/0973-1482.92224. PMID: 22322728
Palatal canalicular adenoma: report of 12 cases and review of the literature.
Suarez P, Hammond HL, Luna MA, Stimson PG
Ann Diagn Pathol 1998 Aug;2(4):224-8. doi: 10.1016/s1092-9134(98)80011-7. PMID: 9845742

Clinical prediction guides

Molecular profile of a pleomorphic adenoma of the hard palate: A case report.
Iida Y, Serizawa M, Mukaigawa T, Kamijo T, Nakajima T, Asakura K, Kusuhara M, Yamaguchi K, Onitsuka T
Medicine (Baltimore) 2020 Jul 17;99(29):e21207. doi: 10.1097/MD.0000000000021207. PMID: 32702887Free PMC Article
Approach to benign tumors of the palate: analysis of 28 cases.
Ural A, Livaoğlu M, Bektaş D, Bahadır O, Hesapçıoğlu A, Imamoğlu M, Işık AU
Ear Nose Throat J 2011 Aug;90(8):382-5. doi: 10.1177/014556131109000813. PMID: 21853443
Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature.
Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, Chu PY, Chan KT, Tai SK, Wang YF, Kao SC, Kao SY, Lo WL, Wu CH, Shu WH, Ma S, Wang TH
Eur Arch Otorhinolaryngol 2011 Jul;268(7):1035-40. Epub 2010 Dec 1 doi: 10.1007/s00405-010-1437-2. PMID: 21120660
Plasmacytoid myoepithelioma of the palate. Report of one case and review of the literature.
Cuadra Zelaya F, Quezada Rivera D, Tapia Vazquez JL, Paez Valencia C, Gaitán Cepeda LA
Med Oral Patol Oral Cir Bucal 2007 Dec 1;12(8):E552-5. PMID: 18059237
Differential diagnosis between adenoid cystic carcinoma and pleomorphic adenoma of the minor salivary glands of palate.
Cerulli G, Renzi G, Perugini M, Becelli R
J Craniofac Surg 2004 Nov;15(6):1056-60. doi: 10.1097/00001665-200411000-00036. PMID: 15547405

Recent systematic reviews

Systematic Review of Clinical and Radiographic Signs of Pediatric Pleomorphic Adenoma of Minor Salivary Glands.
Alsufyani NA, Altowaijri AA, Alshehri BM, Alsadhan MS
J Contemp Dent Pract 2021 Sep 1;22(9):1063-1068. PMID: 35000954
Why is the histomorphological diagnosis of tumours of minor salivary glands much more difficult?
Ihrler S, Agaimy A, Guntinas-Lichius O, Haas CJ, Mollenhauer M, Sandison A, Greber L
Histopathology 2021 Nov;79(5):779-790. Epub 2021 Aug 18 doi: 10.1111/his.14421. PMID: 34042205
Canalicular adenoma: A systematic review.
Peraza AJ, Wright J, Gómez R
J Craniomaxillofac Surg 2017 Oct;45(10):1754-1758. Epub 2017 Aug 3 doi: 10.1016/j.jcms.2017.07.020. PMID: 28890252

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