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Steroid lipomatosis

MedGen UID:
234364
•Concept ID:
C1336506
•
Neoplastic Process
Synonyms: Steroid Lipomatosis; steroid lipomatosis
 
Monarch Initiative: MONDO:0006612

Definition

A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the face, upper middle back, and sternal region. It is associated with adrenocortical steroid therapy or an increase in endogenous adrenocortical hormone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSteroid lipomatosis

Professional guidelines

PubMed

Current Trends in Management of Submental Liposis: A Pooled Analysis and Survey.
Patel S, Kridel R
JAMA Facial Plast Surg 2018 May 1;20(3):202-206. doi: 10.1001/jamafacial.2017.1567. PMID: 29049615Free PMC Article
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329
Spinal epidural lipomatosis: a review of its causes and recommendations for treatment.
Fassett DR, Schmidt MH
Neurosurg Focus 2004 Apr 15;16(4):E11. PMID: 15191340

Recent clinical studies

Etiology

Outcome of posterior decompression for spinal epidural lipomatosis.
Schmutzer-Sondergeld M, Zimmermann H, Trabold R, Liebig T, Schichor C, Siller S
Acta Neurochir (Wien) 2023 Nov;165(11):3479-3491. Epub 2023 Sep 25 doi: 10.1007/s00701-023-05814-0. PMID: 37743433Free PMC Article
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329
Idiopathic Spinal Epidural Lipomatosis in the Lumbar Spine.
Al-Omari AA, Phukan RD, Leonard DA, Herzog TL, Wood KB, Bono CM
Orthopedics 2016 May 1;39(3):163-8. Epub 2016 Mar 29 doi: 10.3928/01477447-20160315-04. PMID: 27018608
Multiple epidural steroid injections and body mass index linked with occurrence of epidural lipomatosis: a case series.
Jaimes R 3rd, Rocco AG
BMC Anesthesiol 2014;14:70. Epub 2014 Aug 15 doi: 10.1186/1471-2253-14-70. PMID: 25183952Free PMC Article
Lipoma excision.
Salam GA
Am Fam Physician 2002 Mar 1;65(5):901-4. PMID: 11898962

Diagnosis

Outcome of posterior decompression for spinal epidural lipomatosis.
Schmutzer-Sondergeld M, Zimmermann H, Trabold R, Liebig T, Schichor C, Siller S
Acta Neurochir (Wien) 2023 Nov;165(11):3479-3491. Epub 2023 Sep 25 doi: 10.1007/s00701-023-05814-0. PMID: 37743433Free PMC Article
Madelung's disease.
Yeh NC, Yang CY, Chou CW, Yen FC, Lee SY, Tien KJ
J Clin Endocrinol Metab 2012 Sep;97(9):3012-3. Epub 2012 Jun 14 doi: 10.1210/jc.2012-1649. PMID: 22701018
Lipoma excision.
Salam GA
Am Fam Physician 2002 Mar 1;65(5):901-4. PMID: 11898962
Epidural lipomatosis.
Quint DJ, Boulos RS, Sanders WP, Mehta BA, Patel SC, Tiel RL
Radiology 1988 Nov;169(2):485-90. doi: 10.1148/radiology.169.2.3174998. PMID: 3174998
Steroid-induced mesenteric lipomatosis.
Siskind BN, Weiner FR, Frank M, Weiner SN, Bernstein RG, Luftschein S
Comput Radiol 1984 May-Jun;8(3):175-7. doi: 10.1016/0730-4862(84)90057-x. PMID: 6734165

Therapy

Madelung Disease Treated With Deoxycholic Acid.
Rodriguez M, Beal BT, Khetarpal S, Vidimos A
Dermatol Surg 2021 Jun 1;47(6):879-880. doi: 10.1097/DSS.0000000000002722. PMID: 32897938
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329
Madelung's disease.
Yeh NC, Yang CY, Chou CW, Yen FC, Lee SY, Tien KJ
J Clin Endocrinol Metab 2012 Sep;97(9):3012-3. Epub 2012 Jun 14 doi: 10.1210/jc.2012-1649. PMID: 22701018
Steroid-induced mesenteric lipomatosis.
Siskind BN, Weiner FR, Frank M, Weiner SN, Bernstein RG, Luftschein S
Comput Radiol 1984 May-Jun;8(3):175-7. doi: 10.1016/0730-4862(84)90057-x. PMID: 6734165
Steroid-induced mediastinal lipomatosis.
Teates CD
Radiology 1970 Sep;96(3):501-2. doi: 10.1148/96.3.501. PMID: 5456303

Prognosis

Outcome of posterior decompression for spinal epidural lipomatosis.
Schmutzer-Sondergeld M, Zimmermann H, Trabold R, Liebig T, Schichor C, Siller S
Acta Neurochir (Wien) 2023 Nov;165(11):3479-3491. Epub 2023 Sep 25 doi: 10.1007/s00701-023-05814-0. PMID: 37743433Free PMC Article
Clinical and imaging characteristics in patients undergoing surgery for lumbar epidural lipomatosis.
Yasuda T, Suzuki K, Kawaguchi Y, Seki S, Makino H, Watanabe K, Hori T, Yamagami T, Kanamori M, Kimura T
BMC Musculoskelet Disord 2018 Mar 1;19(1):66. doi: 10.1186/s12891-018-1988-8. PMID: 29490659Free PMC Article
Current Trends in Management of Submental Liposis: A Pooled Analysis and Survey.
Patel S, Kridel R
JAMA Facial Plast Surg 2018 May 1;20(3):202-206. doi: 10.1001/jamafacial.2017.1567. PMID: 29049615Free PMC Article
Safety and efficacy of rituximab in severe juvenile dermatomyositis: results from 9 patients from the French Autoimmunity and Rituximab registry.
Bader-Meunier B, Decaluwe H, Barnerias C, Gherardi R, Quartier P, Faye A, Guigonis V, Pagnier A, Brochard K, Sibilia J, Gottenberg JE, Bodemer C; Club Rhumatismes et Inflammation
J Rheumatol 2011 Jul;38(7):1436-40. Epub 2011 Jun 15 doi: 10.3899/jrheum.101321. PMID: 21677003
Spinal epidural lipomatosis--a brief review.
Al-Khawaja D, Seex K, Eslick GD
J Clin Neurosci 2008 Dec;15(12):1323-6. Epub 2008 Oct 26 doi: 10.1016/j.jocn.2008.03.001. PMID: 18954986

Clinical prediction guides

Outcome of posterior decompression for spinal epidural lipomatosis.
Schmutzer-Sondergeld M, Zimmermann H, Trabold R, Liebig T, Schichor C, Siller S
Acta Neurochir (Wien) 2023 Nov;165(11):3479-3491. Epub 2023 Sep 25 doi: 10.1007/s00701-023-05814-0. PMID: 37743433Free PMC Article
Clinical and imaging characteristics in patients undergoing surgery for lumbar epidural lipomatosis.
Yasuda T, Suzuki K, Kawaguchi Y, Seki S, Makino H, Watanabe K, Hori T, Yamagami T, Kanamori M, Kimura T
BMC Musculoskelet Disord 2018 Mar 1;19(1):66. doi: 10.1186/s12891-018-1988-8. PMID: 29490659Free PMC Article
Transforaminal epidural steroid injection in the treatment of lumbosacral radicular pain caused by epidural lipomatosis: a case series and review.
McCormick Z, Plastaras C
J Back Musculoskelet Rehabil 2014;27(2):181-90. doi: 10.3233/BMR-130434. PMID: 24254495
Spinal epidural lipomatosis: a review of its causes and recommendations for treatment.
Fassett DR, Schmidt MH
Neurosurg Focus 2004 Apr 15;16(4):E11. PMID: 15191340
Differential clinical expression of multiple symmetric lipomatosis in men and women.
Busetto L, Sträter D, Enzi G, Coin A, Sergi G, Inelmen EM, Pigozzo S
Int J Obes Relat Metab Disord 2003 Nov;27(11):1419-22. doi: 10.1038/sj.ijo.0802427. PMID: 14574355

Recent systematic reviews

Etiologies and Outcomes of Spinal Epidural Lipomatosis: Systematic Review of the Literature and Meta-Analysis of Reported Cases.
Alomari S, Lubelski D, Khalifeh JM, Sacino AN, Theodore N, Witham T, Bydon A
Clin Spine Surg 2022 Nov 1;35(9):383-387. Epub 2022 May 9 doi: 10.1097/BSD.0000000000001344. PMID: 35552292
Metastatic Spinal Cord Compression and Steroid Treatment: A Systematic Review.
Kumar A, Weber MH, Gokaslan Z, Wolinsky JP, Schmidt M, Rhines L, Fehlings MG, Laufer I, Sciubba DM, Clarke MJ, Sundaresan N, Verlaan JJ, Sahgal A, Chou D, Fisher CG
Clin Spine Surg 2017 May;30(4):156-163. doi: 10.1097/BSD.0000000000000528. PMID: 28437329

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