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Thymus squamous cell carcinoma

MedGen UID:
234814
Concept ID:
C1336082
Neoplastic Process
Synonyms: Epidermoid Thymic Carcinoma; epidermoid thymic carcinoma; Squamous Cell Carcinoma of the Thymus; squamous cell carcinoma of the Thymus; Squamous Cell Carcinoma of Thymus; squamous cell carcinoma of Thymus; Thymic Squamous Cell Carcinoma; thymic squamous cell carcinoma; Thymus Squamous Cell Carcinoma; thymus squamous cell carcinoma
 
Monarch Initiative: MONDO:0003493

Definition

A rare primary thymic carcinoma, characterized by the presence of keratinizing or non-keratinizing malignant squamous cells. Approximately 10-20% of cases occur in combination with thymoma. The prognosis depends on the tumor stage and the degree of cellular differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymus squamous cell carcinoma

Professional guidelines

PubMed

Collins JA, Ping B, Bishop JA, Ali SZ
Acta Cytol 2016;60(5):421-428. Epub 2016 Sep 17 doi: 10.1159/000448836. PMID: 27643719
Mlika M, Boudaya S, Braham E, Chermiti F, Sayi A, Marghli A, El Mezni F
Asian Cardiovasc Thorac Ann 2016 May;24(4):350-4. Epub 2016 Mar 21 doi: 10.1177/0218492316640129. PMID: 27002097
Zhao Y, Zhao H, Hu D, Fan L, Shi J, Fang W
Ann Thorac Surg 2013 Sep;96(3):1019-24. Epub 2013 Jul 16 doi: 10.1016/j.athoracsur.2013.04.078. PMID: 23866799

Recent clinical studies

Etiology

Kashima J, Hashimoto T, Yoshida A, Goto Y, Ushiku T, Ohe Y, Watanabe SI, Yatabe Y
Virchows Arch 2022 Dec;481(6):893-901. Epub 2022 Oct 28 doi: 10.1007/s00428-022-03437-x. PMID: 36305944
Makita E, Sugawara D, Kuroda S, Itabashi K, Hirakubo Y, Nonaka K, Ichihashi K
Int Arch Allergy Immunol 2022;183(9):967-974. Epub 2022 May 10 doi: 10.1159/000524683. PMID: 35537383
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008

Diagnosis

Kashima J, Hashimoto T, Yoshida A, Goto Y, Ushiku T, Ohe Y, Watanabe SI, Yatabe Y
Virchows Arch 2022 Dec;481(6):893-901. Epub 2022 Oct 28 doi: 10.1007/s00428-022-03437-x. PMID: 36305944
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Hammond EH, Flinner RL
Ultrastruct Pathol 1991 Jul-Oct;15(4-5):419-38. doi: 10.3109/01913129109016250. PMID: 1755103

Therapy

Hao Y, Si J, Jin J, Wei J, Xiang J, Xu C, Song Z
Curr Oncol 2022 Dec 2;29(12):9452-9460. doi: 10.3390/curroncol29120743. PMID: 36547157Free PMC Article
Okawa T, Yamaguchi Y, Kou K, Ono J, Azuma Y, Komitsu N, Inoue Y, Kohno M, Matsukura S, Kambara T, Ohta S, Izuhara K, Aihara M
Allergol Int 2018 Jan;67(1):124-130. Epub 2017 Jul 19 doi: 10.1016/j.alit.2017.06.016. PMID: 28734739
Furugen M, Sekine I, Tsuta K, Horinouchi H, Nokihara H, Yamamoto N, Kubota K, Tamura T
Jpn J Clin Oncol 2011 Aug;41(8):1013-6. Epub 2011 Jul 7 doi: 10.1093/jjco/hyr089. PMID: 21742653
Marx A, Rieker R, Toker A, Länger F, Ströbel P
Thorac Surg Clin 2011 Feb;21(1):25-31. v-vi. doi: 10.1016/j.thorsurg.2010.08.010. PMID: 21070984
Kerrebijn JD, Simons PJ, Balm AJ, Tas M, Knegt PP, de Vries N, Tan IB, Drexhage HA
Head Neck 1996 Jul-Aug;18(4):335-42. doi: 10.1002/(SICI)1097-0347(199607/08)18:4<335::AID-HED4>3.0.CO;2-Z. PMID: 8780944

Prognosis

Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
Terzi N, Yilmaz I, Batur S, Yegen G, Yol C, Arikan E, Oz A
Pol J Pathol 2020;71(2):120-126. doi: 10.5114/pjp.2020.97019. PMID: 32729302
Hammond EH, Flinner RL
Ultrastruct Pathol 1991 Jul-Oct;15(4-5):419-38. doi: 10.3109/01913129109016250. PMID: 1755103
Walker AN, Mills SE, Fechner RE
Semin Diagn Pathol 1990 Nov;7(4):250-65. PMID: 2284513

Clinical prediction guides

Parrack PH, Hornick JL, Sholl LM
Hum Pathol 2023 Dec;142:7-14. Epub 2023 Sep 28 doi: 10.1016/j.humpath.2023.09.007. PMID: 37776957
Li J, Xiang R, Li Y, Liao Q, Liu Y
Virchows Arch 2023 May;482(5):813-822. Epub 2023 Apr 5 doi: 10.1007/s00428-023-03536-3. PMID: 37016248
Makita E, Sugawara D, Kuroda S, Itabashi K, Hirakubo Y, Nonaka K, Ichihashi K
Int Arch Allergy Immunol 2022;183(9):967-974. Epub 2022 May 10 doi: 10.1159/000524683. PMID: 35537383
Takeuchi S, Furusyo N, Ono J, Azuma Y, Takemura M, Esaki H, Yamamura K, Mitamura Y, Tsuji G, Kiyomatsu-Oda M, Hayashi J, Izuhara K, Furue M
J Dermatol Sci 2019 Aug;95(2):70-75. Epub 2019 Jul 24 doi: 10.1016/j.jdermsci.2019.07.005. PMID: 31378660
Suster D, Pihan G, Mackinnon AC, Suster S
Am J Surg Pathol 2018 Sep;42(9):1224-1236. doi: 10.1097/PAS.0000000000001101. PMID: 29975245

Recent systematic reviews

Roka S, Kornek G, Schüller J, Ortmann E, Feichtinger J, Armbruster C
Br J Surg 2004 Feb;91(2):142-5. doi: 10.1002/bjs.4510. PMID: 14760659

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