U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Submandibular Gland Acinic Cell Carcinoma

MedGen UID:
234909
•Concept ID:
C1336520
•
Neoplastic Process
Synonyms: Acinic Cell Carcinoma of Submandibular Gland; Acinic Cell Carcinoma of Submaxillary Gland; Acinic Cell Carcinoma of the Submandibular Gland; Acinic Cell Carcinoma of the Submaxillary Gland; Submaxillary Gland Acinic Cell Carcinoma

Definition

An adenocarcinoma with serous acinar cell differentiation that arises from the submandibular gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubmandibular Gland Acinic Cell Carcinoma

Professional guidelines

PubMed

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Pediatric Salivary Cancer: Epidemiology, Treatment Trends, and Association of Treatment Modality with Survival.
Morse E, Fujiwara RJT, Husain Z, Judson B, Mehra S
Otolaryngol Head Neck Surg 2018 Sep;159(3):553-563. Epub 2018 Apr 24 doi: 10.1177/0194599818771926. PMID: 29688836
The congenital basal cell adenoma of salivary glands. Contribution to the differential diagnosis of congenital salivary gland tumours.
Seifert G, Donath K
Virchows Arch 1997 Apr;430(4):311-9. doi: 10.1007/BF01092754. PMID: 9134042

Recent clinical studies

Etiology

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Twenty-seven years of primary salivary gland carcinoma in Wales: an analysis of histological subtype and associated risk factors.
Leopard D, El-Hitti E, Puttasiddaiah P, Mcleod R, Owens D
J Laryngol Otol 2022 Feb;136(2):167-172. Epub 2022 Jan 10 doi: 10.1017/S002221512200007X. PMID: 35001862
Salivary gland tumours in Iceland 1986-2015: a nationwide epidemiological analysis over a 30-year time period.
Aegisdottir AL, Tryggvason G, Jonsdottir AM, Jonasson JG
APMIS 2021 Feb;129(2):55-60. Epub 2020 Nov 3 doi: 10.1111/apm.13090. PMID: 33064861
Acinic cell carcinoma of the head and neck: radiologic-pathologic correlation.
Suh SI, Seol HY, Kim TK, Lee NJ, Kim JH, Kim KA, Woo JS, Lee JH
J Comput Assist Tomogr 2005 Jan-Feb;29(1):121-6. doi: 10.1097/01.rct.0000150141.14113.ab. PMID: 15665697
Familial occurrence of acinic cell carcinoma of the parotid gland.
Depowski PL, Setzen G, Chui A, Koltai PJ, Dollar J, Ross JS
Arch Pathol Lab Med 1999 Nov;123(11):1118-20. doi: 10.5858/1999-123-1118-FOOACC. PMID: 10539921

Diagnosis

Primary salivary acinar cell carcinoma of the parotid gland with parietal skull metastasis: A case report.
Sun Y, Di G, Jiang X
Asian J Surg 2022 Mar;45(3):926-927. Epub 2022 Jan 6 doi: 10.1016/j.asjsur.2021.12.066. PMID: 35000858
Mucoacinar Carcinoma: A Rare Variant of Mucoepidermoid Carcinoma.
Bundele M, Weinreb I, Xu B, Chiosea S, Faquin W, Dias-Santagata D, Leon M, Hyrcza M, Seethala RR
Am J Surg Pathol 2021 Aug 1;45(8):1028-1037. doi: 10.1097/PAS.0000000000001752. PMID: 34091485
Perithyroidal Salivary Gland Acinic Cell Carcinoma: Morphological and Molecular Attributes of a Unique Lesion.
Juhlin CC, Asa SL, Jatta K, Naserhojati Rodsari H, Shabo I, Haglund F, Delahunt B, Samaratunga H, Egevad L, Höög A, Zedenius J
Head Neck Pathol 2021 Jun;15(2):628-637. Epub 2020 Jun 9 doi: 10.1007/s12105-020-01187-3. PMID: 32519264Free PMC Article
Stiffness of salivary gland and tumor measured by new ultrasonic techniques: Virtual touch quantification and IQ.
Matsuzuka T, Suzuki M, Saijo S, Ikeda M, Matsui T, Nomoto Y, Nomoto M, Imaizumi M, Tada Y, Omori K
Auris Nasus Larynx 2015 Apr;42(2):128-33. Epub 2014 Sep 26 doi: 10.1016/j.anl.2014.08.021. PMID: 25262550
Acinic cell carcinoma of the head and neck: radiologic-pathologic correlation.
Suh SI, Seol HY, Kim TK, Lee NJ, Kim JH, Kim KA, Woo JS, Lee JH
J Comput Assist Tomogr 2005 Jan-Feb;29(1):121-6. doi: 10.1097/01.rct.0000150141.14113.ab. PMID: 15665697

Therapy

PSMA PET/CT Identifies Intrapatient Variation in Salivary Gland Toxicity From Iodine-131 Therapy.
Mohan V, Vogel WV, Valk GD, de Boer JP, Lam MGEH, de Keizer B
Mol Imaging 2020 Jan-Dec;19:1536012120934992. doi: 10.1177/1536012120934992. PMID: 32619138Free PMC Article
Histopathological changes in parotid and submandibular glands of patients treated with preoperative chemoradiation therapy for oral cancer.
Teshima K, Murakami R, Yoshida R, Nakayama H, Hiraki A, Hirai T, Nakaguchi Y, Tsujita N, Tomitaka E, Furusawa M, Yamashita Y, Shinohara M
J Radiat Res 2012;53(3):492-6. Epub 2012 Apr 9 PMID: 22485019
Salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or without concurrent chemotherapy.
Schoenfeld JD, Sher DJ, Norris CM Jr, Haddad RI, Posner MR, Balboni TA, Tishler RB
Int J Radiat Oncol Biol Phys 2012 Jan 1;82(1):308-14. Epub 2010 Nov 13 doi: 10.1016/j.ijrobp.2010.09.042. PMID: 21075557
Adjuvant chemotherapy in breast cancer patients induces temporary salivary gland hypofunction.
Jensen SB, Mouridsen HT, Reibel J, Brünner N, Nauntofte B
Oral Oncol 2008 Feb;44(2):162-73. Epub 2007 Jun 27 doi: 10.1016/j.oraloncology.2007.01.015. PMID: 17588802
A qualitative and quantitative electronmicroscopic study of the structure of the adenoid cystic carcinoma of human minor salivary glands.
Chisholm DM, Waterhouse JP, Kraucunas E, Sciubba JJ
J Oral Pathol 1975 Oct;4(3):103-19. doi: 10.1111/j.1600-0714.1975.tb01859.x. PMID: 171355

Prognosis

Salivary gland tumours in Iceland 1986-2015: a nationwide epidemiological analysis over a 30-year time period.
Aegisdottir AL, Tryggvason G, Jonsdottir AM, Jonasson JG
APMIS 2021 Feb;129(2):55-60. Epub 2020 Nov 3 doi: 10.1111/apm.13090. PMID: 33064861
The number and ratio of positive lymph nodes are independent prognostic factors for patients with major salivary gland cancer: Results from the surveillance, epidemiology, and End Results dataset.
Qian K, Sun W, Guo K, Zheng X, Sun T, Chen L, Xiang J, Li D, Wu Y, Ji Q, Wang Z
Eur J Surg Oncol 2019 Jun;45(6):1025-1032. Epub 2018 Nov 15 doi: 10.1016/j.ejso.2018.11.008. PMID: 30472214
Pediatric Salivary Cancer: Epidemiology, Treatment Trends, and Association of Treatment Modality with Survival.
Morse E, Fujiwara RJT, Husain Z, Judson B, Mehra S
Otolaryngol Head Neck Surg 2018 Sep;159(3):553-563. Epub 2018 Apr 24 doi: 10.1177/0194599818771926. PMID: 29688836
Distant metastasis of parotid gland tumors.
Schwentner I, Obrist P, Thumfart W, Sprinzl G
Acta Otolaryngol 2006 Apr;126(4):340-5. doi: 10.1080/00016480500401035. PMID: 16608783
Carcinoma of the parotid and submandibular glands--a study of survival in 2465 patients.
Wahlberg P, Anderson H, Biörklund A, Möller T, Perfekt R
Oral Oncol 2002 Oct;38(7):706-13. doi: 10.1016/s1368-8375(02)00007-6. PMID: 12167424

Clinical prediction guides

Immunohistological profiling confirms salivary gland-like nature of the tubarial glands and suggests closest resemblance to the palatal salivary glands.
Pringle S, Bikker FJ, Vogel W, de Bakker BS, Hofland I, van der Vegt B, Bootsma H, Kroese F, Vissink A, Valstar M
Radiother Oncol 2023 Oct;187:109845. Epub 2023 Aug 4 doi: 10.1016/j.radonc.2023.109845. PMID: 37543053
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Pediatric Salivary Cancer: Epidemiology, Treatment Trends, and Association of Treatment Modality with Survival.
Morse E, Fujiwara RJT, Husain Z, Judson B, Mehra S
Otolaryngol Head Neck Surg 2018 Sep;159(3):553-563. Epub 2018 Apr 24 doi: 10.1177/0194599818771926. PMID: 29688836
Nodular oncocytic hyperplasia: Can cytomorphology allow for the preoperative diagnosis of a nonneoplastic salivary disease?
Rooper LM, Onenerk M, Siddiqui MT, Faquin WC, Bishop JA, Ali SZ
Cancer Cytopathol 2017 Aug;125(8):627-634. Epub 2017 Apr 14 doi: 10.1002/cncy.21865. PMID: 28411376
Stiffness of salivary gland and tumor measured by new ultrasonic techniques: Virtual touch quantification and IQ.
Matsuzuka T, Suzuki M, Saijo S, Ikeda M, Matsui T, Nomoto Y, Nomoto M, Imaizumi M, Tada Y, Omori K
Auris Nasus Larynx 2015 Apr;42(2):128-33. Epub 2014 Sep 26 doi: 10.1016/j.anl.2014.08.021. PMID: 25262550

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...