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Major Salivary Gland Acinic Cell Carcinoma

MedGen UID:
233138
Concept ID:
C1334546
Neoplastic Process
Synonyms: Acinic Cell Adenocarcinoma of Major Salivary Gland; Acinic Cell Adenocarcinoma of the Major Salivary Gland; Acinic Cell Carcinoma of Major Salivary Gland; Acinic Cell Carcinoma of the Major Salivary Gland; Major Salivary Gland Acinic Cell Adenocarcinoma

Definition

An adenocarcinoma with serous acinar cell differentiation that arises from the major salivary glands. The vast majority of cases occur in the parotid gland. Patients usually present with a slow growing mass in the parotid area. [from NCI]

Professional guidelines

PubMed

Zhang D, Wei Y, Chai Y, Qi F, Dong M
Otolaryngol Head Neck Surg 2023 May;168(5):1119-1129. Epub 2023 Jan 22 doi: 10.1002/ohn.195. PMID: 36939406
Pang Y, Sun L, Liu H, Ma J
Oral Oncol 2021 Aug;119:105370. Epub 2021 Jun 19 doi: 10.1016/j.oraloncology.2021.105370. PMID: 34157553
Ferrell JK, Mace JC, Clayburgh D
Eur Arch Otorhinolaryngol 2019 Apr;276(4):1135-1146. Epub 2019 Jan 16 doi: 10.1007/s00405-019-05282-2. PMID: 30649610

Recent clinical studies

Etiology

Zhang D, Wei Y, Chai Y, Qi F, Dong M
Otolaryngol Head Neck Surg 2023 May;168(5):1119-1129. Epub 2023 Jan 22 doi: 10.1002/ohn.195. PMID: 36939406
Dublin JC, Oliver JR, Tam MM, Persky MJ, Jacobson AS, Liu C, Hu KS, Vaezi AE, Morris LGT, Givi B
Otolaryngol Head Neck Surg 2022 Dec;167(6):941-951. Epub 2022 Mar 8 doi: 10.1177/01945998221083094. PMID: 35259039
Sideris A, Rao A, Maher N, Parker A, Crawford J, Smee R, Jacobson I, Gallagher R
ANZ J Surg 2021 Jun;91(6):1233-1239. Epub 2020 Nov 17 doi: 10.1111/ans.16421. PMID: 33205582
Ayre G, Hyrcza M, Wu J, Berthelet E, Skálová A, Thomson T
Head Neck 2019 May;41(5):1227-1236. Epub 2018 Dec 28 doi: 10.1002/hed.25536. PMID: 30592355
Son E, Panwar A, Mosher CH, Lydiatt D
J Oncol Pract 2018 Feb;14(2):99-108. doi: 10.1200/JOP.2017.026856. PMID: 29436307

Diagnosis

Fatima S, Ahmed A, Suleman S, Din NU
Ann Diagn Pathol 2023 Dec;67:152220. Epub 2023 Oct 28 doi: 10.1016/j.anndiagpath.2023.152220. PMID: 37924657
Pang Y, Sun L, Liu H, Ma J
Oral Oncol 2021 Aug;119:105370. Epub 2021 Jun 19 doi: 10.1016/j.oraloncology.2021.105370. PMID: 34157553
Son E, Panwar A, Mosher CH, Lydiatt D
J Oncol Pract 2018 Feb;14(2):99-108. doi: 10.1200/JOP.2017.026856. PMID: 29436307
Vander Poorten V, Triantafyllou A, Thompson LD, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP, Gnepp DR, Hellquist H, Wenig B, Bell D, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3511-3531. Epub 2015 Dec 19 doi: 10.1007/s00405-015-3855-7. PMID: 26685679
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Therapy

Warner BM, Baer AN, Lipson EJ, Allen C, Hinrichs C, Rajan A, Pelayo E, Beach M, Gulley JL, Madan RA, Feliciano J, Grisius M, Long L, Powers A, Kleiner DE, Cappelli L, Alevizos I
Oncologist 2019 Sep;24(9):1259-1269. Epub 2019 Apr 17 doi: 10.1634/theoncologist.2018-0823. PMID: 30996010Free PMC Article
Cheuk DK, Shek TW, Chan GC, Lau YL, Ha SY, Chiang AK
Pediatr Blood Cancer 2008 Mar;50(3):636-9. doi: 10.1002/pbc.21002. PMID: 16865683
Yamamoto T, Staples J, Wataha J, Lewis J, Lockwood P, Schoenlein P, Rao S, Osaki T, Dickinson D, Kamatani T, Schuster G, Hsu S
Anticancer Res 2004 Sep-Oct;24(5A):3065-73. PMID: 15517917

Prognosis

Fatima S, Ahmed A, Suleman S, Din NU
Ann Diagn Pathol 2023 Dec;67:152220. Epub 2023 Oct 28 doi: 10.1016/j.anndiagpath.2023.152220. PMID: 37924657
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041
Ayre G, Hyrcza M, Wu J, Berthelet E, Skálová A, Thomson T
Head Neck 2019 May;41(5):1227-1236. Epub 2018 Dec 28 doi: 10.1002/hed.25536. PMID: 30592355
Vander Poorten V, Triantafyllou A, Thompson LD, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP, Gnepp DR, Hellquist H, Wenig B, Bell D, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3511-3531. Epub 2015 Dec 19 doi: 10.1007/s00405-015-3855-7. PMID: 26685679
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Clinical prediction guides

Fatima S, Ahmed A, Suleman S, Din NU
Ann Diagn Pathol 2023 Dec;67:152220. Epub 2023 Oct 28 doi: 10.1016/j.anndiagpath.2023.152220. PMID: 37924657
Kirschnick LB, Silveira FM, Schuch LF, Vasconcelos ACU, Gomes AP, Santos JND, Santana DA, Fonseca FP, Mesquita RA, Mendonça EF, Sousa-Neto SS, Pontes HAR, Robinson L, Heerden WV, Carlos-Bregni R, Tager EMJR, Silva LCD, Zanella VG, Rivero LF, Bittencourt R, Martins MAT, Lopes MA, Wagner VP, Vargas PA, Martins MD
Braz Oral Res 2023;37:e050. Epub 2023 May 29 doi: 10.1590/1807-3107bor-2023.vol37.0050. PMID: 37255070
Zhang D, Wei Y, Chai Y, Qi F, Dong M
Otolaryngol Head Neck Surg 2023 May;168(5):1119-1129. Epub 2023 Jan 22 doi: 10.1002/ohn.195. PMID: 36939406
Shinmura K, Kusafuka K, Kawasaki H, Kato H, Hariyama T, Tsuchiya K, Kawanishi Y, Funai K, Misawa K, Mineta H, Sugimura H
J Pathol 2021 Aug;254(5):519-530. Epub 2021 May 29 doi: 10.1002/path.5688. PMID: 33931860
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Recent systematic reviews

Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041

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