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Major Salivary Gland Acinic Cell Carcinoma

MedGen UID:
233138
•Concept ID:
C1334546
•
Neoplastic Process
Synonyms: Acinic Cell Adenocarcinoma of Major Salivary Gland; Acinic Cell Adenocarcinoma of the Major Salivary Gland; Acinic Cell Carcinoma of Major Salivary Gland; Acinic Cell Carcinoma of the Major Salivary Gland; Major Salivary Gland Acinic Cell Adenocarcinoma

Definition

An adenocarcinoma with serous acinar cell differentiation that arises from the major salivary glands. The vast majority of cases occur in the parotid gland. Patients usually present with a slow growing mass in the parotid area. [from NCI]

Professional guidelines

PubMed

Prognostic Assessment and Risk Stratification in Patients With Postoperative Major Salivary Acinar Cell Carcinoma.
Zhang D, Wei Y, Chai Y, Qi F, Dong M
Otolaryngol Head Neck Surg 2023 May;168(5):1119-1129. Epub 2023 Jan 22 doi: 10.1002/ohn.195. PMID: 36939406
Differential diagnosis and treatment of salivary secretory carcinoma and acinic cell carcinoma.
Pang Y, Sun L, Liu H, Ma J
Oral Oncol 2021 Aug;119:105370. Epub 2021 Jun 19 doi: 10.1016/j.oraloncology.2021.105370. PMID: 34157553
Contemporary treatment patterns and outcomes of salivary gland carcinoma: a National Cancer Database review.
Ferrell JK, Mace JC, Clayburgh D
Eur Arch Otorhinolaryngol 2019 Apr;276(4):1135-1146. Epub 2019 Jan 16 doi: 10.1007/s00405-019-05282-2. PMID: 30649610

Recent clinical studies

Etiology

Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR-1 (NR4A3) immunohistochemistry.
Meiklejohn K, Hrones M, Wang M, Prasad ML, Cai G, Adeniran A, Gilani SM
Cytopathology 2023 May;34(3):219-224. Epub 2023 Mar 8 doi: 10.1111/cyt.13222. PMID: 36825365
Acinic cell carcinoma of the salivary gland in the adult and paediatric population: a survival analysis.
Sideris A, Rao A, Maher N, Parker A, Crawford J, Smee R, Jacobson I, Gallagher R
ANZ J Surg 2021 Jun;91(6):1233-1239. Epub 2020 Nov 17 doi: 10.1111/ans.16421. PMID: 33205582
Surgery Alone Is Effective in the Management of Pediatric Salivary Gland Acinic Cell Carcinoma.
Wang C, Mao M, Li B, Kim K, Han Z, Feng Z
J Oral Maxillofac Surg 2019 Aug;77(8):1713-1723. Epub 2019 Feb 5 doi: 10.1016/j.joms.2019.01.044. PMID: 30825434
Secretory carcinoma of the major salivary gland: Provincial population-based analysis of clinical behavior and outcomes.
Ayre G, Hyrcza M, Wu J, Berthelet E, Skálová A, Thomson T
Head Neck 2019 May;41(5):1227-1236. Epub 2018 Dec 28 doi: 10.1002/hed.25536. PMID: 30592355
Cancers of the Major Salivary Gland.
Son E, Panwar A, Mosher CH, Lydiatt D
J Oncol Pract 2018 Feb;14(2):99-108. doi: 10.1200/JOP.2017.026856. PMID: 29436307

Diagnosis

Differential diagnosis and treatment of salivary secretory carcinoma and acinic cell carcinoma.
Pang Y, Sun L, Liu H, Ma J
Oral Oncol 2021 Aug;119:105370. Epub 2021 Jun 19 doi: 10.1016/j.oraloncology.2021.105370. PMID: 34157553
Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041
Cancers of the Major Salivary Gland.
Son E, Panwar A, Mosher CH, Lydiatt D
J Oncol Pract 2018 Feb;14(2):99-108. doi: 10.1200/JOP.2017.026856. PMID: 29436307
Salivary acinic cell carcinoma: reappraisal and update.
Vander Poorten V, Triantafyllou A, Thompson LD, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP, Gnepp DR, Hellquist H, Wenig B, Bell D, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3511-3531. Epub 2015 Dec 19 doi: 10.1007/s00405-015-3855-7. PMID: 26685679
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Therapy

Sicca Syndrome Associated with Immune Checkpoint Inhibitor Therapy.
Warner BM, Baer AN, Lipson EJ, Allen C, Hinrichs C, Rajan A, Pelayo E, Beach M, Gulley JL, Madan RA, Feliciano J, Grisius M, Long L, Powers A, Kleiner DE, Cappelli L, Alevizos I
Oncologist 2019 Sep;24(9):1259-1269. Epub 2019 Apr 17 doi: 10.1634/theoncologist.2018-0823. PMID: 30996010Free PMC Article
Parotid acinar cell carcinoma in a long-term survivor of childhood acute lymphoblastic leukemia.
Cheuk DK, Shek TW, Chan GC, Lau YL, Ha SY, Chiang AK
Pediatr Blood Cancer 2008 Mar;50(3):636-9. doi: 10.1002/pbc.21002. PMID: 16865683
Protective effects of EGCG on salivary gland cells treated with gamma-radiation or cis-platinum(II)diammine dichloride.
Yamamoto T, Staples J, Wataha J, Lewis J, Lockwood P, Schoenlein P, Rao S, Osaki T, Dickinson D, Kamatani T, Schuster G, Hsu S
Anticancer Res 2004 Sep-Oct;24(5A):3065-73. PMID: 15517917

Prognosis

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041
Surgery Alone Is Effective in the Management of Pediatric Salivary Gland Acinic Cell Carcinoma.
Wang C, Mao M, Li B, Kim K, Han Z, Feng Z
J Oral Maxillofac Surg 2019 Aug;77(8):1713-1723. Epub 2019 Feb 5 doi: 10.1016/j.joms.2019.01.044. PMID: 30825434
Secretory carcinoma of the major salivary gland: Provincial population-based analysis of clinical behavior and outcomes.
Ayre G, Hyrcza M, Wu J, Berthelet E, Skálová A, Thomson T
Head Neck 2019 May;41(5):1227-1236. Epub 2018 Dec 28 doi: 10.1002/hed.25536. PMID: 30592355
Salivary acinic cell carcinoma: reappraisal and update.
Vander Poorten V, Triantafyllou A, Thompson LD, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP, Gnepp DR, Hellquist H, Wenig B, Bell D, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3511-3531. Epub 2015 Dec 19 doi: 10.1007/s00405-015-3855-7. PMID: 26685679
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Clinical prediction guides

Utility of MUC4 in the diagnosis of secretory carcinoma of salivary glands.
Fatima S, Ahmed A, Suleman S, Din NU
Ann Diagn Pathol 2023 Dec;67:152220. Epub 2023 Oct 28 doi: 10.1016/j.anndiagpath.2023.152220. PMID: 37924657
Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study.
Kirschnick LB, Silveira FM, Schuch LF, Vasconcelos ACU, Gomes AP, Santos JND, Santana DA, Fonseca FP, Mesquita RA, Mendonça EF, Sousa-Neto SS, Pontes HAR, Robinson L, Heerden WV, Carlos-Bregni R, Tager EMJR, Silva LCD, Zanella VG, Rivero LF, Bittencourt R, Martins MAT, Lopes MA, Wagner VP, Vargas PA, Martins MD
Braz Oral Res 2023;37:e050. Epub 2023 May 29 doi: 10.1590/1807-3107bor-2023.vol37.0050. PMID: 37255070
Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.
Shinmura K, Kusafuka K, Kawasaki H, Kato H, Hariyama T, Tsuchiya K, Kawanishi Y, Funai K, Misawa K, Mineta H, Sugimura H
J Pathol 2021 Aug;254(5):519-530. Epub 2021 May 29 doi: 10.1002/path.5688. PMID: 33931860
Surgery Alone Is Effective in the Management of Pediatric Salivary Gland Acinic Cell Carcinoma.
Wang C, Mao M, Li B, Kim K, Han Z, Feng Z
J Oral Maxillofac Surg 2019 Aug;77(8):1713-1723. Epub 2019 Feb 5 doi: 10.1016/j.joms.2019.01.044. PMID: 30825434
Salivary gland malignancies in children.
Yoshida EJ, García J, Eisele DW, Chen AM
Int J Pediatr Otorhinolaryngol 2014 Feb;78(2):174-8. Epub 2013 Nov 19 doi: 10.1016/j.ijporl.2013.11.001. PMID: 24332197

Recent systematic reviews

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041

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