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Testicular leukemia

MedGen UID:
234941
Concept ID:
C1336711
Neoplastic Process
Synonyms: Testicular Leukemia; testicular leukemia
 
Monarch Initiative: MONDO:0001482

Definition

A myeloid or more commonly lymphoid leukemia (acute or chronic) affecting the testis. Microscopically, there is interstitial infiltration of the testis by leukemic cells. Acute lymphoblastic leukemia with testicular involvement is not uncommon in boys. Sometimes (up to 10% of the cases), testicular involvement may be the initial manifestation of relapsed acute lymphoblastic leukemia. --03 [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular leukemia

Professional guidelines

PubMed

Wen J, Zhou M, Shen Y, Long Y, Guo Y, Song L, Xiao J
BMC Cancer 2022 Aug 6;22(1):859. doi: 10.1186/s12885-022-09804-w. PMID: 35933338Free PMC Article
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Heaney JA, Klauber GT, Conley GR
Urology 1983 Jun;21(6):573-7. doi: 10.1016/0090-4295(83)90194-2. PMID: 6575491

Recent clinical studies

Etiology

Zhang H, Wan Y, Wang H, Cai J, Yu J, Hu S, Fang Y, Gao J, Jiang H, Yang M, Liang C, Jin R, Tian X, Ju X, Hu Q, Jiang H, Li Z, Wang N, Sun L, Leung AWK, Wu X, Qian X, Qian M, Li CK, Yang J, Tang J, Zhu X, Shen S, Zhang L, Pui CH, Zhai X
Cancer 2023 Jun 1;129(11):1691-1703. Epub 2023 Mar 21 doi: 10.1002/cncr.34741. PMID: 36943767
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Tian J, Ma K, Pei CB, Zhang SH, Li X, Zhou Y, Yan B, Wang HY, Ma LH
Stem Cell Res Ther 2019 Dec 16;10(1):382. doi: 10.1186/s13287-019-1481-9. PMID: 31842987Free PMC Article
Winter SS, Dunsmore KP, Devidas M, Wood BL, Esiashvili N, Chen Z, Eisenberg N, Briegel N, Hayashi RJ, Gastier-Foster JM, Carroll AJ, Heerema NA, Asselin BL, Gaynon PS, Borowitz MJ, Loh ML, Rabin KR, Raetz EA, Zweidler-Mckay PA, Winick NJ, Carroll WL, Hunger SP
J Clin Oncol 2018 Oct 10;36(29):2926-2934. Epub 2018 Aug 23 doi: 10.1200/JCO.2018.77.7250. PMID: 30138085Free PMC Article
Mazzu D, Jeffrey RB Jr, Ralls PW
AJR Am J Roentgenol 1995 Mar;164(3):645-7. doi: 10.2214/ajr.164.3.7863887. PMID: 7863887

Diagnosis

Zhang H, Wan Y, Wang H, Cai J, Yu J, Hu S, Fang Y, Gao J, Jiang H, Yang M, Liang C, Jin R, Tian X, Ju X, Hu Q, Jiang H, Li Z, Wang N, Sun L, Leung AWK, Wu X, Qian X, Qian M, Li CK, Yang J, Tang J, Zhu X, Shen S, Zhang L, Pui CH, Zhai X
Cancer 2023 Jun 1;129(11):1691-1703. Epub 2023 Mar 21 doi: 10.1002/cncr.34741. PMID: 36943767
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Gutjahr P, Humpl T
World J Urol 1995;13(4):230-2. doi: 10.1007/BF00182968. PMID: 8528297
Heaney JA, Klauber GT, Conley GR
Urology 1983 Jun;21(6):573-7. doi: 10.1016/0090-4295(83)90194-2. PMID: 6575491
Wong KY, Ballard ET, Strayer FH, Kisker CT, Lampkin BC
J Pediatr 1980 Mar;96(3 Pt 2):569-74. doi: 10.1016/s0022-3476(80)80868-7. PMID: 6928464

Therapy

Zhang H, Wan Y, Wang H, Cai J, Yu J, Hu S, Fang Y, Gao J, Jiang H, Yang M, Liang C, Jin R, Tian X, Ju X, Hu Q, Jiang H, Li Z, Wang N, Sun L, Leung AWK, Wu X, Qian X, Qian M, Li CK, Yang J, Tang J, Zhu X, Shen S, Zhang L, Pui CH, Zhai X
Cancer 2023 Jun 1;129(11):1691-1703. Epub 2023 Mar 21 doi: 10.1002/cncr.34741. PMID: 36943767
Nguyen HTK, Terao MA, Green DM, Pui CH, Inaba H
Cancer 2021 Sep 1;127(17):3067-3081. Epub 2021 May 25 doi: 10.1002/cncr.33609. PMID: 34031876Free PMC Article
Chen X, Wang Y, Ruan M, Li J, Zhong M, Li Z, Liu F, Wang S, Chen Y, Liu L, Yang JJ, Zhu X, Wang J, Pui CH
Clin Lymphoma Myeloma Leuk 2020 Jun;20(6):366-370. Epub 2019 Oct 23 doi: 10.1016/j.clml.2019.10.016. PMID: 32205078Free PMC Article
Winter SS, Dunsmore KP, Devidas M, Wood BL, Esiashvili N, Chen Z, Eisenberg N, Briegel N, Hayashi RJ, Gastier-Foster JM, Carroll AJ, Heerema NA, Asselin BL, Gaynon PS, Borowitz MJ, Loh ML, Rabin KR, Raetz EA, Zweidler-Mckay PA, Winick NJ, Carroll WL, Hunger SP
J Clin Oncol 2018 Oct 10;36(29):2926-2934. Epub 2018 Aug 23 doi: 10.1200/JCO.2018.77.7250. PMID: 30138085Free PMC Article
Nurmio M, Keros V, Lähteenmäki P, Salmi T, Kallajoki M, Jahnukainen K
J Clin Endocrinol Metab 2009 Jun;94(6):2119-22. Epub 2009 Mar 24 doi: 10.1210/jc.2009-0060. PMID: 19318447

Prognosis

Zhang H, Wan Y, Wang H, Cai J, Yu J, Hu S, Fang Y, Gao J, Jiang H, Yang M, Liang C, Jin R, Tian X, Ju X, Hu Q, Jiang H, Li Z, Wang N, Sun L, Leung AWK, Wu X, Qian X, Qian M, Li CK, Yang J, Tang J, Zhu X, Shen S, Zhang L, Pui CH, Zhai X
Cancer 2023 Jun 1;129(11):1691-1703. Epub 2023 Mar 21 doi: 10.1002/cncr.34741. PMID: 36943767
Wen J, Zhou M, Shen Y, Long Y, Guo Y, Song L, Xiao J
BMC Cancer 2022 Aug 6;22(1):859. doi: 10.1186/s12885-022-09804-w. PMID: 35933338Free PMC Article
Gutjahr P, Humpl T
World J Urol 1995;13(4):230-2. doi: 10.1007/BF00182968. PMID: 8528297
Sullivan MP, Perez CA, Herson J, Silva-Sousa M, Land V, Dyment PG, Chan R, Ayala AG
Cancer 1980 Aug 1;46(3):508-15. doi: 10.1002/1097-0142(19800801)46:3<508::aid-cncr2820460315>3.0.co;2-i. PMID: 6994868
Wong KY, Ballard ET, Strayer FH, Kisker CT, Lampkin BC
J Pediatr 1980 Mar;96(3 Pt 2):569-74. doi: 10.1016/s0022-3476(80)80868-7. PMID: 6928464

Clinical prediction guides

Tian J, Ma K, Pei CB, Zhang SH, Li X, Zhou Y, Yan B, Wang HY, Ma LH
Stem Cell Res Ther 2019 Dec 16;10(1):382. doi: 10.1186/s13287-019-1481-9. PMID: 31842987Free PMC Article
Wofford MM, Smith SD, Shuster JJ, Johnson W, Buchanan GR, Wharam MD, Ritchey AK, Rosen D, Haggard ME, Golembe BL
J Clin Oncol 1992 Apr;10(4):624-30. doi: 10.1200/JCO.1992.10.4.624. PMID: 1548525
Tsukimoto I
Acta Paediatr Jpn 1991 Aug;33(4):540-7. doi: 10.1111/j.1442-200x.1991.tb02583.x. PMID: 1792914
Miller DR, Leikin SL, Albo VC, Sather H, Hammond GD
J Clin Oncol 1989 Mar;7(3):316-25. doi: 10.1200/JCO.1989.7.3.316. PMID: 2645385
Uderzo C, Locasciulli A, Marzorati R, Adamoli L, Di Natale B, Nizzoli G, Cazzaniga M, Masera G
Med Pediatr Oncol 1984;12(2):97-100. doi: 10.1002/mpo.2950120207. PMID: 6422220

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