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Recurrent Childhood Hepatocellular Carcinoma

MedGen UID:
235093
Concept ID:
C1370832
Neoplastic Process
Synonyms: Recurrent Childhood Hepatoma; Recurrent Pediatric Hepatocellular Carcinoma; Recurrent Pediatric Hepatoma

Definition

A hepatocellular carcinoma that occurs during childhood and has recurred after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Hepatocellular Carcinoma

Professional guidelines

PubMed

Shen JY, Li C, Wen TF, Yan LN, Li B, Wang WT, Yang JY, Xu MQ, Nazar Highness T
Medicine (Baltimore) 2016 Dec;95(52):e5756. doi: 10.1097/MD.0000000000005756. PMID: 28033289Free PMC Article
Nicolle D, Fabre M, Simon-Coma M, Gorse A, Kappler R, Nonell L, Mallo M, Haidar H, Déas O, Mussini C, Guettier C, Redon MJ, Brugières L, Ghigna MR, Fadel E, Galmiche-Rolland L, Chardot C, Judde JG, Armengol C, Branchereau S, Cairo S
Hepatology 2016 Oct;64(4):1121-35. Epub 2016 Jun 16 doi: 10.1002/hep.28621. PMID: 27115099
Ismail H, Dembowska-Bagińska B, Broniszczak D, Kaliciński P, Maruszewski P, Kluge P, Swięszkowska E, Kościesza A, Lembas A, Perek D
J Pediatr Surg 2013 Nov;48(11):2202-6. doi: 10.1016/j.jpedsurg.2013.05.020. PMID: 24210186

Recent clinical studies

Etiology

Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Palaniappan K, Borkar VV, Safwan M, Vij M, Govil S, Shanmugam N, Rela M
Pediatr Transplant 2016 Nov;20(7):898-903. Epub 2016 Jul 8 doi: 10.1111/petr.12754. PMID: 27392999
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982
Lefkowitch JH
Curr Opin Gastroenterol 2006 May;22(3):198-208. doi: 10.1097/01.mog.0000218955.55688.af. PMID: 16550033
Reyes JD, Carr B, Dvorchik I, Kocoshis S, Jaffe R, Gerber D, Mazariegos GV, Bueno J, Selby R
J Pediatr 2000 Jun;136(6):795-804. PMID: 10839879

Diagnosis

Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Whitlock RS, Patel KR, Yang T, Nguyen HN, Masand P, Vasudevan SA
J Pediatr Surg 2022 Apr;57(4):700-710. Epub 2021 Apr 25 doi: 10.1016/j.jpedsurg.2021.04.019. PMID: 34049689
Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834Free PMC Article
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982
Lefkowitch JH
Curr Opin Gastroenterol 2006 May;22(3):198-208. doi: 10.1097/01.mog.0000218955.55688.af. PMID: 16550033

Therapy

Repullo D, Diaz M, Holbrechts S, Gomez-Galdón M, Van Gestel D, Bohlok A, Liberale G, Donckier V
World J Surg Oncol 2018 Mar 7;16(1):48. doi: 10.1186/s12957-018-1346-1. PMID: 29514643Free PMC Article
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982
Hiyama E
Int J Clin Oncol 2013 Dec;18(6):943-5. Epub 2013 Sep 21 doi: 10.1007/s10147-013-0607-9. PMID: 24057320
Douglass EC
Cancer Treat Res 1997;92:201-12. doi: 10.1007/978-1-4615-5767-8_7. PMID: 9494762
Ni YH, Chang MH, Hsu HY, Hsu HC, Chen CC, Chen WJ, Lee CY
Cancer 1991 Oct 15;68(8):1737-41. doi: 10.1002/1097-0142(19911015)68:8<1737::aid-cncr2820680815>3.0.co;2-g. PMID: 1655224

Prognosis

Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834Free PMC Article
Tiusanen T, Hukkinen M, Leskinen O, Soini T, Kanerva JA, Jahnukainen T, Mäkisalo H, Heikinheimo M, Pakarinen MP
Acta Paediatr 2020 Feb;109(2):404-414. Epub 2019 Aug 25 doi: 10.1111/apa.14952. PMID: 31350767
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982
Reyes JD, Carr B, Dvorchik I, Kocoshis S, Jaffe R, Gerber D, Mazariegos GV, Bueno J, Selby R
J Pediatr 2000 Jun;136(6):795-804. PMID: 10839879
Douglass EC
Cancer Treat Res 1997;92:201-12. doi: 10.1007/978-1-4615-5767-8_7. PMID: 9494762

Clinical prediction guides

Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Vinayak R, Cruz RJ Jr, Ranganathan S, Mohanka R, Mazariegos G, Soltys K, Bond G, Tadros S, Humar A, Marsh JW, Selby RR, Reyes J, Sun Q, Haberman K, Sindhi R
Liver Transpl 2017 Dec;23(12):1577-1588. doi: 10.1002/lt.24847. PMID: 28834194Free PMC Article
Nicolle D, Fabre M, Simon-Coma M, Gorse A, Kappler R, Nonell L, Mallo M, Haidar H, Déas O, Mussini C, Guettier C, Redon MJ, Brugières L, Ghigna MR, Fadel E, Galmiche-Rolland L, Chardot C, Judde JG, Armengol C, Branchereau S, Cairo S
Hepatology 2016 Oct;64(4):1121-35. Epub 2016 Jun 16 doi: 10.1002/hep.28621. PMID: 27115099
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982
Ni YH, Chang MH, Hsu HY, Hsu HC, Chen CC, Chen WJ, Lee CY
Cancer 1991 Oct 15;68(8):1737-41. doi: 10.1002/1097-0142(19911015)68:8<1737::aid-cncr2820680815>3.0.co;2-g. PMID: 1655224

Supplemental Content

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