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Recurrent Childhood Hepatocellular Carcinoma

MedGen UID:
235093
•Concept ID:
C1370832
•
Neoplastic Process
Synonyms: Recurrent Childhood Hepatoma; Recurrent Pediatric Hepatocellular Carcinoma; Recurrent Pediatric Hepatoma

Definition

A hepatocellular carcinoma that occurs during childhood and has recurred after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Hepatocellular Carcinoma

Professional guidelines

PubMed

Liver transplantation versus surgical resection for HCC meeting the Milan criteria: A propensity score analysis.
Shen JY, Li C, Wen TF, Yan LN, Li B, Wang WT, Yang JY, Xu MQ, Nazar Highness T
Medicine (Baltimore) 2016 Dec;95(52):e5756. doi: 10.1097/MD.0000000000005756. PMID: 28033289Free PMC Article
Patient-derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management.
Nicolle D, Fabre M, Simon-Coma M, Gorse A, Kappler R, Nonell L, Mallo M, Haidar H, Déas O, Mussini C, Guettier C, Redon MJ, Brugières L, Ghigna MR, Fadel E, Galmiche-Rolland L, Chardot C, Judde JG, Armengol C, Branchereau S, Cairo S
Hepatology 2016 Oct;64(4):1121-35. Epub 2016 Jun 16 doi: 10.1002/hep.28621. PMID: 27115099
Treatment of undifferentiated embryonal sarcoma of the liver in children--single center experience.
Ismail H, Dembowska-Bagińska B, Broniszczak D, Kaliciński P, Maruszewski P, Kluge P, Swięszkowska E, Kościesza A, Lembas A, Perek D
J Pediatr Surg 2013 Nov;48(11):2202-6. doi: 10.1016/j.jpedsurg.2013.05.020. PMID: 24210186

Recent clinical studies

Etiology

Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Pediatric hepatocellular carcinoma in a developing country: Is the etiology changing?
Palaniappan K, Borkar VV, Safwan M, Vij M, Govil S, Shanmugam N, Rela M
Pediatr Transplant 2016 Nov;20(7):898-903. Epub 2016 Jul 8 doi: 10.1111/petr.12754. PMID: 27392999
Autoimmune hepatitis.
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982
The genomic landscape of hepatoblastoma and their progenies with HCC-like features.
Eichenmüller M, Trippel F, Kreuder M, Beck A, Schwarzmayr T, Häberle B, Cairo S, Leuschner I, von Schweinitz D, Strom TM, Kappler R
J Hepatol 2014 Dec;61(6):1312-20. Epub 2014 Aug 15 doi: 10.1016/j.jhep.2014.08.009. PMID: 25135868
Hepatobiliary pathology.
Lefkowitch JH
Curr Opin Gastroenterol 2006 May;22(3):198-208. doi: 10.1097/01.mog.0000218955.55688.af. PMID: 16550033

Diagnosis

Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Hepatocellular carcinoma: old friends and new tricks.
Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834Free PMC Article
Autoimmune hepatitis.
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982
Hepatobiliary pathology.
Lefkowitch JH
Curr Opin Gastroenterol 2006 May;22(3):198-208. doi: 10.1097/01.mog.0000218955.55688.af. PMID: 16550033
Hepatic malignancies in childhood and adolescence (hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma).
Douglass EC
Cancer Treat Res 1997;92:201-12. doi: 10.1007/978-1-4615-5767-8_7. PMID: 9494762

Therapy

Salvage Liver Transplant in the Treatment of a Child With Local Recurrence of Hepatoblastoma.
Gumus E, Hizarcioglu Gulsen H, Ozen H, Orhan D, Varan A, Dincer HA, Dogrul AB
Exp Clin Transplant 2022 May;20(Suppl 3):62-65. doi: 10.6002/ect.PediatricSymp2022.O21. PMID: 35570603
Unusual presentation of a hepatocellular carcinoma as a potential late side effect of radiotherapy in a patient treated for Wilms tumor in childhood.
Repullo D, Diaz M, Holbrechts S, Gomez-Galdón M, Van Gestel D, Bohlok A, Liberale G, Donckier V
World J Surg Oncol 2018 Mar 7;16(1):48. doi: 10.1186/s12957-018-1346-1. PMID: 29514643Free PMC Article
Autoimmune hepatitis.
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982
Current therapeutic strategies for childhood hepatic malignant tumors.
Hiyama E
Int J Clin Oncol 2013 Dec;18(6):943-5. Epub 2013 Sep 21 doi: 10.1007/s10147-013-0607-9. PMID: 24057320
Hepatic malignancies in childhood and adolescence (hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma).
Douglass EC
Cancer Treat Res 1997;92:201-12. doi: 10.1007/978-1-4615-5767-8_7. PMID: 9494762

Prognosis

Hepatocellular carcinoma: old friends and new tricks.
Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834Free PMC Article
Incidence and long-term outcomes of surgically treated childhood hepatic malignancies in Finland.
Tiusanen T, Hukkinen M, Leskinen O, Soini T, Kanerva JA, Jahnukainen T, Mäkisalo H, Heikinheimo M, Pakarinen MP
Acta Paediatr 2020 Feb;109(2):404-414. Epub 2019 Aug 25 doi: 10.1111/apa.14952. PMID: 31350767
Autoimmune hepatitis.
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982
The genomic landscape of hepatoblastoma and their progenies with HCC-like features.
Eichenmüller M, Trippel F, Kreuder M, Beck A, Schwarzmayr T, Häberle B, Cairo S, Leuschner I, von Schweinitz D, Strom TM, Kappler R
J Hepatol 2014 Dec;61(6):1312-20. Epub 2014 Aug 15 doi: 10.1016/j.jhep.2014.08.009. PMID: 25135868
Hepatic malignancies in childhood and adolescence (hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma).
Douglass EC
Cancer Treat Res 1997;92:201-12. doi: 10.1007/978-1-4615-5767-8_7. PMID: 9494762

Clinical prediction guides

Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029Free PMC Article
Unusual presentation of a hepatocellular carcinoma as a potential late side effect of radiotherapy in a patient treated for Wilms tumor in childhood.
Repullo D, Diaz M, Holbrechts S, Gomez-Galdón M, Van Gestel D, Bohlok A, Liberale G, Donckier V
World J Surg Oncol 2018 Mar 7;16(1):48. doi: 10.1186/s12957-018-1346-1. PMID: 29514643Free PMC Article
Pediatric liver transplantation for hepatocellular cancer and rare liver malignancies: US multicenter and single-center experience (1981-2015).
Vinayak R, Cruz RJ Jr, Ranganathan S, Mohanka R, Mazariegos G, Soltys K, Bond G, Tadros S, Humar A, Marsh JW, Selby RR, Reyes J, Sun Q, Haberman K, Sindhi R
Liver Transpl 2017 Dec;23(12):1577-1588. doi: 10.1002/lt.24847. PMID: 28834194Free PMC Article
Patient-derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management.
Nicolle D, Fabre M, Simon-Coma M, Gorse A, Kappler R, Nonell L, Mallo M, Haidar H, Déas O, Mussini C, Guettier C, Redon MJ, Brugières L, Ghigna MR, Fadel E, Galmiche-Rolland L, Chardot C, Judde JG, Armengol C, Branchereau S, Cairo S
Hepatology 2016 Oct;64(4):1121-35. Epub 2016 Jun 16 doi: 10.1002/hep.28621. PMID: 27115099
Autoimmune hepatitis.
Sahebjam F, Vierling JM
Front Med 2015 Jun;9(2):187-219. Epub 2015 Mar 6 doi: 10.1007/s11684-015-0386-y. PMID: 25749982

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