U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Intraductal breast papillomatosis

MedGen UID:
235224
•Concept ID:
C1334247
•
Neoplastic Process
Synonyms: Breast Intraductal Papillomatosis; breast intraductal papillomatosis; Breast Multiple Intraductal Papillomas; intraductal breast papillomatosis; intraductal papillomatosis of breast; intraductal papillomatosis of the breast
 
Monarch Initiative: MONDO:0004253

Definition

A benign breast neoplasm characterized by the presence of multiple intraductal papillomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntraductal breast papillomatosis

Professional guidelines

PubMed

Differential Diagnosis of Benign and Malignant Breast Papillary Neoplasms on MRI With Non-mass Enhancement.
Zhou J, Li M, Liu D, Sheng F, Cai J
Acad Radiol 2023 Sep;30 Suppl 2:S127-S132. Epub 2023 Mar 9 doi: 10.1016/j.acra.2023.02.010. PMID: 36906443
Evidence-Based Pragmatic Approach to the Management of Borderline or High-Risk Breast Lesions.
Lamb LR, Bahl M
AJR Am J Roentgenol 2022 Jan;218(1):186-187. Epub 2021 Jul 21 doi: 10.2214/AJR.21.26340. PMID: 34286593
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Recent clinical studies

Etiology

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Intraductal Papillomas.
Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Management of High-Risk Breast Lesions.
Bahl M
Radiol Clin North Am 2021 Jan;59(1):29-40. doi: 10.1016/j.rcl.2020.08.005. PMID: 33222998
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Diagnosis

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Intraductal Papillomas.
Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Therapy

Unusual recurrent metastasizing benign breast papilloma: a case report.
Jain AL, Mullins J, Smith JR, Valasareddy P, Miller E, Chaudhry A, Ryder J, Hare F, Ranganath H, Berry M, Robins D, Schwartzberg L, Vidal GA
J Med Case Rep 2020 Feb 19;14(1):33. doi: 10.1186/s13256-020-2354-7. PMID: 32070435Free PMC Article
Effectiveness of the diagnostic pathway of BLES: could it be safely used as a therapeutic method in selected benign lesions?
Kurtoğlu Özçağlayan Tİ, Özkan Gürdal S, Öznur M, Özçağlayan Ö, Doğru M, Topçu B
Diagn Interv Radiol 2019 Nov;25(6):428-434. doi: 10.5152/dir.2019.18427. PMID: 31650964Free PMC Article
Underestimation of breast cancer in intraductal papillomas treated with vacuum-assisted core needle biopsy.
Hodorowicz-Zaniewska D, Siarkiewicz B, Brzuszkiewicz K, Szpor J
Ginekol Pol 2019;90(3):122-127. doi: 10.5603/GP.2019.0022. PMID: 30950000
Liver abscess with Citrobacter koseri bacteremia.
Kanzawa Y, Ishimaru N, Seto H, Tsutsumi T, Kinami S
Infez Med 2018 Sep 1;26(3):266-269. PMID: 30246771
Minimal breast carcinoma.
Nevin JE, Pinzón G, Morán TJ, Baggerly JT
Am J Surg 1980 Mar;139(3):357-9. doi: 10.1016/0002-9610(80)90293-7. PMID: 6244748

Prognosis

Papillary neoplasms of the breast-reviewing the spectrum.
Tay TKY, Tan PH
Mod Pathol 2021 Jun;34(6):1044-1061. Epub 2021 Jan 18 doi: 10.1038/s41379-020-00732-3. PMID: 33462367
Are we overtreating intraductal papillomas?
Kiran S, Jeong YJ, Nelson ME, Ring A, Johnson MB, Sheth PA, Ma Y, Sener SF, Lang JE
J Surg Res 2018 Nov;231:387-394. Epub 2018 Jun 29 doi: 10.1016/j.jss.2018.06.008. PMID: 30278958Free PMC Article
Papillary Lesions of the Breast: An Update.
Wei S
Arch Pathol Lab Med 2016 Jul;140(7):628-43. doi: 10.5858/arpa.2015-0092-RA. PMID: 27362568
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Precancerous lesions of the breast.
Costa A, Zanini V
Nat Clin Pract Oncol 2008 Dec;5(12):700-4. Epub 2008 Sep 30 doi: 10.1038/ncponc1239. PMID: 18825141

Clinical prediction guides

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Sonographic prediction of intraductal papillary carcinoma with partially cystic breast lesions.
Gao L, Lai X, Zhang J, Jiang Y, Li J
BMC Med Imaging 2023 Jan 6;23(1):3. doi: 10.1186/s12880-022-00934-y. PMID: 36609236Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Whole-exome sequencing analysis of juvenile papillomatosis and coexisting breast carcinoma.
D'Alfonso TM, Pareja F, Da Cruz Paula A, Vahdatinia M, Gazzo A, Ferrando L, da Silva EM, Cheng E, Sclafani L, Chandarlapaty S, Zhang H, Hoda SA, Wen HY, Brogi E, Weigelt B, Reis-Filho JS
J Pathol Clin Res 2021 Mar;7(2):113-120. Epub 2020 Dec 2 doi: 10.1002/cjp2.190. PMID: 33263939Free PMC Article
Are we overtreating intraductal papillomas?
Kiran S, Jeong YJ, Nelson ME, Ring A, Johnson MB, Sheth PA, Ma Y, Sener SF, Lang JE
J Surg Res 2018 Nov;231:387-394. Epub 2018 Jun 29 doi: 10.1016/j.jss.2018.06.008. PMID: 30278958Free PMC Article

Recent systematic reviews

Malignant upgrade rate and associated clinicopathologic predictors for concordant intraductal papilloma without atypia: A systematic review and meta-analysis.
Keating N, Cevik J, Hopkins D, Lippey J
J Surg Oncol 2024 May;129(6):1025-1033. Epub 2024 Feb 2 doi: 10.1002/jso.27592. PMID: 38305061

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...