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Lung mixed small cell and squamous cell carcinoma

MedGen UID:
235331
Concept ID:
C1334788
Neoplastic Process
Synonyms: Combined Lung Small Cell and Squamous Cell Carcinoma; Combined Small Cell and Squamous Cell Lung Carcinoma; combined small cell and squamous cell lung carcinoma; lung mixed small cell and squamous cell carcinoma; Mixed Small Cell and Squamous Cell Carcinoma of Lung; mixed small cell and squamous cell carcinoma of lung; Mixed Small Cell and Squamous Cell Carcinoma of the Lung; mixed small cell and squamous cell carcinoma of the lung; small cell and large cell carcinoma of the lung; Small Cell and Squamous Cell Carcinoma of Lung; small cell and squamous cell carcinoma of lung; Small Cell and Squamous Cell Carcinoma of the Lung; small cell and squamous cell carcinoma of the lung; Small Cell and Squamous Cell Lung Carcinoma; small cell and squamous cell lung carcinoma
 
Monarch Initiative: MONDO:0004100

Definition

A lung carcinoma characterized by a combination of small cell carcinoma and squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung mixed small cell and squamous cell carcinoma

Professional guidelines

PubMed

Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Kurzrock R, Stewart DJ
Clin Cancer Res 2017 Mar 1;23(5):1137-1148. Epub 2016 Dec 9 doi: 10.1158/1078-0432.CCR-16-1968. PMID: 27940520
Mordant P, Grand B, Cazes A, Foucault C, Dujon A, Le Pimpec Barthes F, Riquet M
Ann Thorac Surg 2013 Apr;95(4):1189-95. Epub 2013 Mar 6 doi: 10.1016/j.athoracsur.2012.12.037. PMID: 23473060

Recent clinical studies

Etiology

Biciuşcă V, Popescu IAS, Traşcă DM, Olteanu M, Stan IS, Durand P, Camen GC, Bălteanu MA, Cazacu IM, Demetrian AD, Streba CT, Călăraşu C, Cioboată R
Rom J Morphol Embryol 2022 Apr-Jun;63(2):369-381. doi: 10.47162/RJME.63.2.08. PMID: 36374142Free PMC Article
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Cheung AH, Tong JH, Chung LY, Chau SL, Ng CS, Wan IYP, To KF
Pathology 2020 Apr;52(3):323-328. Epub 2020 Feb 27 doi: 10.1016/j.pathol.2019.12.003. PMID: 32113673
de Bono JS, Concin N, Hong DS, Thistlethwaite FC, Machiels JP, Arkenau HT, Plummer R, Jones RH, Nielsen D, Windfeld K, Ghatta S, Slomovitz BM, Spicer JF, Yachnin J, Ang JE, Mau-Sørensen PM, Forster MD, Collins D, Dean E, Rangwala RA, Lassen U
Lancet Oncol 2019 Mar;20(3):383-393. Epub 2019 Feb 8 doi: 10.1016/S1470-2045(18)30859-3. PMID: 30745090
Müller KM, Fisseler-Eckhoff A
Pathol Res Pract 1988 Dec;184(1):108-15. doi: 10.1016/S0344-0338(88)80201-2. PMID: 2852798

Diagnosis

Biciuşcă V, Popescu IAS, Traşcă DM, Olteanu M, Stan IS, Durand P, Camen GC, Bălteanu MA, Cazacu IM, Demetrian AD, Streba CT, Călăraşu C, Cioboată R
Rom J Morphol Embryol 2022 Apr-Jun;63(2):369-381. doi: 10.47162/RJME.63.2.08. PMID: 36374142Free PMC Article
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Cheung AH, Tong JH, Chung LY, Chau SL, Ng CS, Wan IYP, To KF
Pathology 2020 Apr;52(3):323-328. Epub 2020 Feb 27 doi: 10.1016/j.pathol.2019.12.003. PMID: 32113673
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Wu Z, Ma JY, Yang JJ, Zhao YF, Zhang SF
World J Gastroenterol 2004 Dec 15;10(24):3680-2. doi: 10.3748/wjg.v10.i24.3680. PMID: 15534932Free PMC Article

Therapy

O'Byrne K, Popoff E, Badin F, Lee A, Yuan Y, Lozano-Ortega G, Eccles LJ, Varol N, Waser N, Penrod JR, Goring S
Lung Cancer 2023 Mar;177:11-20. Epub 2023 Jan 11 doi: 10.1016/j.lungcan.2023.01.006. PMID: 36669321
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Camidge DR, Morgensztern D, Heist RS, Barve M, Vokes E, Goldman JW, Hong DS, Bauer TM, Strickler JH, Angevin E, Motwani M, Parikh A, Sun Z, Bach BA, Wu J, Komarnitsky PB, Kelly K
Clin Cancer Res 2021 Nov 1;27(21):5781-5792. Epub 2021 Aug 23 doi: 10.1158/1078-0432.CCR-21-0765. PMID: 34426443Free PMC Article
de Bono JS, Concin N, Hong DS, Thistlethwaite FC, Machiels JP, Arkenau HT, Plummer R, Jones RH, Nielsen D, Windfeld K, Ghatta S, Slomovitz BM, Spicer JF, Yachnin J, Ang JE, Mau-Sørensen PM, Forster MD, Collins D, Dean E, Rangwala RA, Lassen U
Lancet Oncol 2019 Mar;20(3):383-393. Epub 2019 Feb 8 doi: 10.1016/S1470-2045(18)30859-3. PMID: 30745090
Kurzrock R, Stewart DJ
Clin Cancer Res 2017 Mar 1;23(5):1137-1148. Epub 2016 Dec 9 doi: 10.1158/1078-0432.CCR-16-1968. PMID: 27940520

Prognosis

Li Q, Wang R, Yang Z, Li W, Yang J, Wang Z, Bai H, Cui Y, Tian Y, Wu Z, Guo Y, Xu J, Wen L, He J, Tang F, Wang J
Genome Med 2022 Aug 13;14(1):87. doi: 10.1186/s13073-022-01089-9. PMID: 35962452Free PMC Article
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Allaj V, Manoj P, Shah NS, Chan JM, Ciampricotti M, Chow A, Offin M, Ray-Kirton J, Egger JD, Bhanot UK, Linkov I, Asher M, Roehrl MH, Ventura K, Qiu J, de Stanchina E, Chang JC, Rekhtman N, Houck-Loomis B, Koche RP, Yu HA, Sen T, Rudin CM
J Hematol Oncol 2021 Oct 16;14(1):170. doi: 10.1186/s13045-021-01186-z. PMID: 34656143Free PMC Article
Smolle E, Leko P, Stacher-Priehse E, Brcic L, El-Heliebi A, Hofmann L, Quehenberger F, Hrzenjak A, Popper HH, Olschewski H, Leithner K
Mol Oncol 2020 Nov;14(11):2853-2867. Epub 2020 Sep 1 doi: 10.1002/1878-0261.12780. PMID: 32777161Free PMC Article
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Clinical prediction guides

Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Allaj V, Manoj P, Shah NS, Chan JM, Ciampricotti M, Chow A, Offin M, Ray-Kirton J, Egger JD, Bhanot UK, Linkov I, Asher M, Roehrl MH, Ventura K, Qiu J, de Stanchina E, Chang JC, Rekhtman N, Houck-Loomis B, Koche RP, Yu HA, Sen T, Rudin CM
J Hematol Oncol 2021 Oct 16;14(1):170. doi: 10.1186/s13045-021-01186-z. PMID: 34656143Free PMC Article
Camidge DR, Morgensztern D, Heist RS, Barve M, Vokes E, Goldman JW, Hong DS, Bauer TM, Strickler JH, Angevin E, Motwani M, Parikh A, Sun Z, Bach BA, Wu J, Komarnitsky PB, Kelly K
Clin Cancer Res 2021 Nov 1;27(21):5781-5792. Epub 2021 Aug 23 doi: 10.1158/1078-0432.CCR-21-0765. PMID: 34426443Free PMC Article
Cheung AH, Tong JH, Chung LY, Chau SL, Ng CS, Wan IYP, To KF
Pathology 2020 Apr;52(3):323-328. Epub 2020 Feb 27 doi: 10.1016/j.pathol.2019.12.003. PMID: 32113673
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Recent systematic reviews

O'Byrne K, Popoff E, Badin F, Lee A, Yuan Y, Lozano-Ortega G, Eccles LJ, Varol N, Waser N, Penrod JR, Goring S
Lung Cancer 2023 Mar;177:11-20. Epub 2023 Jan 11 doi: 10.1016/j.lungcan.2023.01.006. PMID: 36669321
Hall H, Tocock A, Burdett S, Fisher D, Ricketts WM, Robson J, Round T, Gorolay S, MacArthur E, Chung D, Janes SM, Peake MD, Navani N
Thorax 2022 Aug;77(8):762-768. Epub 2021 Aug 17 doi: 10.1136/thoraxjnl-2021-216865. PMID: 34404753Free PMC Article
Greenhalgh J, Dwan K, Boland A, Bates V, Vecchio F, Dundar Y, Jain P, Green JA
Cochrane Database Syst Rev 2016 May 25;(5):CD010383. doi: 10.1002/14651858.CD010383.pub2. PMID: 27223332
Brown T, Pilkington G, Bagust A, Boland A, Oyee J, Tudur-Smith C, Blundell M, Lai M, Martin Saborido C, Greenhalgh J, Dundar Y, Dickson R
Health Technol Assess 2013 Jul;17(31):1-278. doi: 10.3310/hta17310. PMID: 23886301Free PMC Article
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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