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Polymorphonuclear Cell Infiltrate

MedGen UID:
235369
•Concept ID:
C1334962
•
Finding
Synonym: Neutrophilic infiltrate

Definition

A morphologic finding referring to an acute inflammatory infiltrate that is composed of polymorphonuclear cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolymorphonuclear Cell Infiltrate

Professional guidelines

PubMed

Treatment Strategies in Neutrophilic Dermatoses: A Comprehensive Review.
Starita-Fajardo G, Lucena-López D, Ballester-Martínez MA, Fernández-Guarino M, González-García A
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115622. PMID: 37958609Free PMC Article
Neutrophil-activating therapy for the treatment of cancer.
Linde IL, Prestwood TR, Qiu J, Pilarowski G, Linde MH, Zhang X, Shen L, Reticker-Flynn NE, Chiu DK, Sheu LY, Van Deursen S, Tolentino LL, Song WC, Engleman EG
Cancer Cell 2023 Feb 13;41(2):356-372.e10. Epub 2023 Jan 26 doi: 10.1016/j.ccell.2023.01.002. PMID: 36706760Free PMC Article
Diagnosis and management of leukocytoclastic vasculitis.
Fraticelli P, Benfaremo D, Gabrielli A
Intern Emerg Med 2021 Jun;16(4):831-841. Epub 2021 Mar 13 doi: 10.1007/s11739-021-02688-x. PMID: 33713282Free PMC Article

Recent clinical studies

Etiology

P-selectin expression, neutrophil infiltration, and histologic injury in neonates with necrotizing enterocolitis.
Stefanutti G, Lister P, Smith VV, Peters MJ, Klein NJ, Pierro A, Eaton S
J Pediatr Surg 2005 Jun;40(6):942-7; discussion 947-8. doi: 10.1016/j.jpedsurg.2005.03.027. PMID: 15991175
Histopathology of peripheral nerves in cutaneous herpesvirus infection.
Worrell JT, Cockerell CJ
Am J Dermatopathol 1997 Apr;19(2):133-7. doi: 10.1097/00000372-199704000-00006. PMID: 9129697
Helicobacter pylori infection and exaggerated gastrin release. Effects of inflammation and progastrin processing.
Graham DY, Go MF, Lew GM, Genta RM, Rehfeld JF
Scand J Gastroenterol 1993 Aug;28(8):690-4. doi: 10.3109/00365529309098274. PMID: 8210984

Diagnosis

Histopathology of peripheral nerves in cutaneous herpesvirus infection.
Worrell JT, Cockerell CJ
Am J Dermatopathol 1997 Apr;19(2):133-7. doi: 10.1097/00000372-199704000-00006. PMID: 9129697

Therapy

Helicobacter pylori infection and exaggerated gastrin release. Effects of inflammation and progastrin processing.
Graham DY, Go MF, Lew GM, Genta RM, Rehfeld JF
Scand J Gastroenterol 1993 Aug;28(8):690-4. doi: 10.3109/00365529309098274. PMID: 8210984
Exfoliative dermatitis in an infant. Association with enterotoxin F-producing staphylococci.
Chesney PJ, Jaucian RM, McDonald RA, Kapral FA, Bergdoll MS
Am J Dis Child 1983 Sep;137(9):899-901. doi: 10.1001/archpedi.1983.02140350073018. PMID: 6225331

Clinical prediction guides

Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System.
Langner M, Machado RS, Patrício FR, Kawakami E
Arq Gastroenterol 2009 Oct-Dec;46(4):328-32. doi: 10.1590/s0004-28032009000400015. PMID: 20232015
Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice.
Hill JA, Bell DA, Brintnell W, Yue D, Wehrli B, Jevnikar AM, Lee DM, Hueber W, Robinson WH, Cairns E
J Exp Med 2008 Apr 14;205(4):967-79. Epub 2008 Apr 7 doi: 10.1084/jem.20072051. PMID: 18391064Free PMC Article
Syndecans-1 and -4 are induced during wound repair of neonatal but not fetal skin.
Gallo R, Kim C, Kokenyesi R, Adzick NS, Bernfield M
J Invest Dermatol 1996 Nov;107(5):676-83. doi: 10.1111/1523-1747.ep12365571. PMID: 8875948

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