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Recurrent Neck Squamous Cell Carcinoma of Unknown Primary

MedGen UID:
235540
Concept ID:
C1335714
Neoplastic Process
Synonyms: Recurrent Metastatic Epidermoid Carcinoma to the Neck with Occult Primary; Recurrent Metastatic Squamous Cell Carcinoma in the Neck with Occult Primary; Recurrent Neck Squamous Cell CUP; Relapsed Metastatic Epidermoid Carcinoma to the Neck with Occult Primary; Relapsed Metastatic Squamous Cell Carcinoma to the Neck with Occult Primary

Definition

The reemergence of metastatic squamous cell carcinoma of unknown primary in the neck region after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Neck Squamous Cell Carcinoma of Unknown Primary

Professional guidelines

PubMed

Gamez ME, Kraus R, Hinni ML, Moore EJ, Ma DJ, Ko SJ, Rwigema JCM, McGee LA, Halyard MY, Buras MR, Foote RL, Patel SH
Oral Oncol 2018 Dec;87:43-48. Epub 2018 Oct 22 doi: 10.1016/j.oraloncology.2018.10.014. PMID: 30527242
Goel R, Moore W, Sumer B, Khan S, Sher D, Subramaniam RM
AJR Am J Roentgenol 2017 Aug;209(2):289-303. doi: 10.2214/AJR.17.18301. PMID: 28731808
Galloway TJ, Ridge JA
J Clin Oncol 2015 Oct 10;33(29):3328-37. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.61.0063. PMID: 26351351

Recent clinical studies

Etiology

Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Hung YH, Liu SA, Wang CC, Wang CP, Jiang RS, Wu SH
PLoS One 2018;13(10):e0205365. Epub 2018 Oct 18 doi: 10.1371/journal.pone.0205365. PMID: 30335795Free PMC Article
Rokkjaer MS, Klug TE
Clin Otolaryngol 2018 Feb;43(1):1-6. Epub 2017 Sep 25 doi: 10.1111/coa.12981. PMID: 28891195
Lanzer M, Bachna-Rotter S, Graupp M, Bredell M, Rücker M, Huber G, Reinisch S, Schumann P
J Craniomaxillofac Surg 2015 May;43(4):574-9. Epub 2015 Mar 9 doi: 10.1016/j.jcms.2015.03.004. PMID: 25841309
Ojesina AI, Lichtenstein L, Freeman SS, Pedamallu CS, Imaz-Rosshandler I, Pugh TJ, Cherniack AD, Ambrogio L, Cibulskis K, Bertelsen B, Romero-Cordoba S, Treviño V, Vazquez-Santillan K, Guadarrama AS, Wright AA, Rosenberg MW, Duke F, Kaplan B, Wang R, Nickerson E, Walline HM, Lawrence MS, Stewart C, Carter SL, McKenna A, Rodriguez-Sanchez IP, Espinosa-Castilla M, Woie K, Bjorge L, Wik E, Halle MK, Hoivik EA, Krakstad C, Gabiño NB, Gómez-Macías GS, Valdez-Chapa LD, Garza-Rodríguez ML, Maytorena G, Vazquez J, Rodea C, Cravioto A, Cortes ML, Greulich H, Crum CP, Neuberg DS, Hidalgo-Miranda A, Escareno CR, Akslen LA, Carey TE, Vintermyr OK, Gabriel SB, Barrera-Saldaña HA, Melendez-Zajgla J, Getz G, Salvesen HB, Meyerson M
Nature 2014 Feb 20;506(7488):371-5. Epub 2013 Dec 25 doi: 10.1038/nature12881. PMID: 24390348Free PMC Article

Diagnosis

Strohl MP, Ha PK, Flavell RR, Yom SS
Semin Nucl Med 2021 Jan;51(1):50-58. Epub 2020 Aug 7 doi: 10.1053/j.semnuclmed.2020.07.009. PMID: 33246539
Szyszko TA, Cook GJR
Clin Radiol 2018 Jan;73(1):60-69. Epub 2017 Oct 10 doi: 10.1016/j.crad.2017.09.001. PMID: 29029767
Goel R, Moore W, Sumer B, Khan S, Sher D, Subramaniam RM
AJR Am J Roentgenol 2017 Aug;209(2):289-303. doi: 10.2214/AJR.17.18301. PMID: 28731808
Galloway TJ, Ridge JA
J Clin Oncol 2015 Oct 10;33(29):3328-37. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.61.0063. PMID: 26351351
Lanzer M, Bachna-Rotter S, Graupp M, Bredell M, Rücker M, Huber G, Reinisch S, Schumann P
J Craniomaxillofac Surg 2015 May;43(4):574-9. Epub 2015 Mar 9 doi: 10.1016/j.jcms.2015.03.004. PMID: 25841309

Therapy

Holm AIS, Elstrøm UV, Nielsen SB, Jensen K
Acta Oncol 2023 Nov;62(11):1412-1417. Epub 2023 Nov 7 doi: 10.1080/0284186X.2023.2263156. PMID: 37815913
Echevarria MI, Yang GQ, Chen DT, Kirtane K, Russell J, Kish J, Muzaffar J, Otto K, Padhya T, McMullen C, Patel K, Chung CH, Caudell JJ
Int J Radiat Oncol Biol Phys 2023 Oct 1;117(2):341-347. Epub 2023 Apr 25 doi: 10.1016/j.ijrobp.2023.04.007. PMID: 37105404
Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Kao HF, Liao BC, Huang YL, Huang HC, Chen CN, Chen TC, Hong YJ, Chan CY, Chia JS, Hong RL
Clin Cancer Res 2022 Apr 14;28(8):1560-1571. doi: 10.1158/1078-0432.CCR-21-3025. PMID: 35046059Free PMC Article
Hu Q, Wu T, Chen X, Li H, Du Z, Hao Y, Peng J, Tai S, Song M, Cheng B
Cancer Med 2018 Apr;7(4):1056-1069. Epub 2018 Feb 26 doi: 10.1002/cam4.1348. PMID: 29479858Free PMC Article

Prognosis

Kao HF, Liao BC, Huang YL, Huang HC, Chen CN, Chen TC, Hong YJ, Chan CY, Chia JS, Hong RL
Clin Cancer Res 2022 Apr 14;28(8):1560-1571. doi: 10.1158/1078-0432.CCR-21-3025. PMID: 35046059Free PMC Article
Strohl MP, Ha PK, Flavell RR, Yom SS
Semin Nucl Med 2021 Jan;51(1):50-58. Epub 2020 Aug 7 doi: 10.1053/j.semnuclmed.2020.07.009. PMID: 33246539
Hung YH, Liu SA, Wang CC, Wang CP, Jiang RS, Wu SH
PLoS One 2018;13(10):e0205365. Epub 2018 Oct 18 doi: 10.1371/journal.pone.0205365. PMID: 30335795Free PMC Article
Goel R, Moore W, Sumer B, Khan S, Sher D, Subramaniam RM
AJR Am J Roentgenol 2017 Aug;209(2):289-303. doi: 10.2214/AJR.17.18301. PMID: 28731808
Lanzer M, Bachna-Rotter S, Graupp M, Bredell M, Rücker M, Huber G, Reinisch S, Schumann P
J Craniomaxillofac Surg 2015 May;43(4):574-9. Epub 2015 Mar 9 doi: 10.1016/j.jcms.2015.03.004. PMID: 25841309

Clinical prediction guides

Echevarria MI, Yang GQ, Chen DT, Kirtane K, Russell J, Kish J, Muzaffar J, Otto K, Padhya T, McMullen C, Patel K, Chung CH, Caudell JJ
Int J Radiat Oncol Biol Phys 2023 Oct 1;117(2):341-347. Epub 2023 Apr 25 doi: 10.1016/j.ijrobp.2023.04.007. PMID: 37105404
Palma DA, Prisman E, Berthelet E, Tran E, Hamilton S, Wu J, Eskander A, Higgins K, Karam I, Poon I, Husain Z, Enepekides D, Hier M, Sultanem K, Richardson K, Mlynarek A, Johnson-Obaseki S, Odell M, Bayley A, Dowthwaite S, Jackson JE, Dzienis M, O'Neil J, Chandarana S, Banerjee R, Hart R, Chung J, Tenenholtz T, Krishnan S, Le H, Yoo J, Mendez A, Winquist E, Kuruvilla S, Stewart P, Warner A, Mitchell S, Chen J, Parker C, Wehrli B, Kwan K, Theurer J, Sathya J, Hammond JA, Read N, Venkatesan V, MacNeil SD, Fung K, Nichols AC
JAMA Oncol 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615. PMID: 35482348Free PMC Article
Kao HF, Liao BC, Huang YL, Huang HC, Chen CN, Chen TC, Hong YJ, Chan CY, Chia JS, Hong RL
Clin Cancer Res 2022 Apr 14;28(8):1560-1571. doi: 10.1158/1078-0432.CCR-21-3025. PMID: 35046059Free PMC Article
Strohl MP, Ha PK, Flavell RR, Yom SS
Semin Nucl Med 2021 Jan;51(1):50-58. Epub 2020 Aug 7 doi: 10.1053/j.semnuclmed.2020.07.009. PMID: 33246539
Ojesina AI, Lichtenstein L, Freeman SS, Pedamallu CS, Imaz-Rosshandler I, Pugh TJ, Cherniack AD, Ambrogio L, Cibulskis K, Bertelsen B, Romero-Cordoba S, Treviño V, Vazquez-Santillan K, Guadarrama AS, Wright AA, Rosenberg MW, Duke F, Kaplan B, Wang R, Nickerson E, Walline HM, Lawrence MS, Stewart C, Carter SL, McKenna A, Rodriguez-Sanchez IP, Espinosa-Castilla M, Woie K, Bjorge L, Wik E, Halle MK, Hoivik EA, Krakstad C, Gabiño NB, Gómez-Macías GS, Valdez-Chapa LD, Garza-Rodríguez ML, Maytorena G, Vazquez J, Rodea C, Cravioto A, Cortes ML, Greulich H, Crum CP, Neuberg DS, Hidalgo-Miranda A, Escareno CR, Akslen LA, Carey TE, Vintermyr OK, Gabriel SB, Barrera-Saldaña HA, Melendez-Zajgla J, Getz G, Salvesen HB, Meyerson M
Nature 2014 Feb 20;506(7488):371-5. Epub 2013 Dec 25 doi: 10.1038/nature12881. PMID: 24390348Free PMC Article

Recent systematic reviews

Hohenstein NA, Chan JW, Wu SY, Tahir P, Yom SS
PET Clin 2020 Jan;15(1):65-75. doi: 10.1016/j.cpet.2019.08.010. PMID: 31735303
Cosway B, Drinnan M, Paleri V
Head Neck 2016 Apr;38 Suppl 1:E2358-67. Epub 2016 Feb 18 doi: 10.1002/hed.24300. PMID: 26891200
Yoo J, Henderson S, Walker-Dilks C
Clin Oncol (R Coll Radiol) 2013 Apr;25(4):e33-66. Epub 2012 Sep 26 doi: 10.1016/j.clon.2012.08.007. PMID: 23021712

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