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Testicular Mixed Choriocarcinoma and Seminoma

MedGen UID:
237002
•Concept ID:
C1336713
•
Neoplastic Process
Synonyms: Mixed Choriocarcinoma and Seminoma of Testis; Mixed Choriocarcinoma and Seminoma of the Testis

Definition

A malignant germ cell tumor arising from the testis. It is characterized by a mixture of choriocarcinoma and seminomatous morphologic elements. Patients may present with painless or painful testicular swelling. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Choriocarcinoma and Seminoma

Professional guidelines

PubMed

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30.
Lau SK, Weiss LM, Chu PG
Mod Pathol 2007 Mar;20(3):320-5. Epub 2007 Feb 2 doi: 10.1038/modpathol.3800749. PMID: 17277761
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253

Diagnosis

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Malignant germ cell tumours in the elderly: a histopathological review of 50 cases in men aged 60 years or over.
Berney DM, Warren AY, Verma M, Kudahetti S, Robson JM, Williams MW, Neal DE, Powles T, Shamash J, Oliver RT
Mod Pathol 2008 Jan;21(1):54-9. Epub 2007 Nov 2 doi: 10.1038/modpathol.3800978. PMID: 17975539
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
Differential diagnosis of testicular mass by cytological examination of seminal fluid collected by ejaculation or prostatic massage.
Yu DS, Wang J, Chang SY, Ma CP
Eur Urol 1990;18(3):193-6. doi: 10.1159/000463907. PMID: 2261930

Therapy

Role of High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Men With Previously Treated Germ Cell Tumors.
Pagliaro LC
J Clin Oncol 2017 Apr 1;35(10):1036-1040. Epub 2016 Dec 19 doi: 10.1200/JCO.2016.70.6523. PMID: 27992270
Long-term results of autologous marrow transplantation for relapsed or refractory male or female germ cell tumors.
Mandanas RA, Saez RA, Epstein RB, Confer DL, Selby GB
Bone Marrow Transplant 1998 Mar;21(6):569-76. doi: 10.1038/sj.bmt.1701132. PMID: 9543060
Potential therapeutic and diagnostic applications of the growth of testicular cancer in soft agar.
Foster BJ, Javadpour N, Ozols RF
Int J Cell Cloning 1983 Apr;1(1):2-14. doi: 10.1002/stem.5530010103. PMID: 6201566

Prognosis

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230
Immunohistological localization of AFP and HCG in uniformly classified testis tumors.
Wittekind C, Wichmann T, Von Kleist S
Anticancer Res 1983 Sep-Oct;3(5):327-30. PMID: 6197005

Clinical prediction guides

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Sodium/iodide symporter is expressed in the majority of seminomas and embryonal testicular carcinomas.
Micali S, Maggisano V, Cesinaro A, Celano M, Territo A, Reggiani Bonetti L, Sponziello M, Migaldi M, Navarra M, Bianchi G, Filetti S, Russo D
J Endocrinol 2013 Feb;216(2):125-33. Epub 2013 Jan 18 doi: 10.1530/JOE-12-0495. PMID: 23117572
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189
Primary testicular carcinoid.
Hodzic J, Golka K, Schulze H
Med Sci Monit 2004 Aug;10(8):CS46-8. Epub 2004 Jul 23 PMID: 15278003
Testicular tumors: clinically relevant histological findings.
Ayala AG, Ro JY
Semin Urol Oncol 1998 May;16(2):72-81. PMID: 9649230

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