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Testicular Mixed Embryonal Carcinoma and Seminoma

MedGen UID:
237003
Concept ID:
C1336715
Neoplastic Process
Synonyms: Mixed Embryonal Carcinoma and Seminoma of Testis; Mixed Embryonal Carcinoma and Seminoma of the Testis

Definition

A malignant mixed germ cell tumor arising from the testis. It is characterized by the presence of a mixture of embryonal carcinoma and a seminomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Embryonal Carcinoma and Seminoma

Professional guidelines

PubMed

Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
Lau SK, Weiss LM, Chu PG
Mod Pathol 2007 Mar;20(3):320-5. Epub 2007 Feb 2 doi: 10.1038/modpathol.3800749. PMID: 17277761
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Cano Garcia C, Panunzio A, Tappero S, Piccinelli ML, Barletta F, Incesu RB, Law KW, Scheipner L, Tian Z, Saad F, Shariat SF, Tilki D, Briganti A, De Cobelli O, Terrone C, Antonelli A, Banek S, Kluth LA, Chun FKH, Karakiewicz PI
Medicina (Kaunas) 2023 Feb 24;59(3) doi: 10.3390/medicina59030451. PMID: 36984452Free PMC Article
Orsatti A, Sirolli M, Ambrosi F, Franceschini T, Giunchi F, Franchini E, Grillini M, Massari F, Mollica V, Bianchi FM, Colecchia M, Fiorentino M, Ricci C
Pathol Res Pract 2022 Sep;237:154044. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154044. PMID: 35930824
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Micali S, Maggisano V, Cesinaro A, Celano M, Territo A, Reggiani Bonetti L, Sponziello M, Migaldi M, Navarra M, Bianchi G, Filetti S, Russo D
J Endocrinol 2013 Feb;216(2):125-33. Epub 2013 Jan 18 doi: 10.1530/JOE-12-0495. PMID: 23117572

Diagnosis

Kerkar A, Kundu R, Kaur A, Rohilla M, Gupta P, Gupta N, Srinivasan R, Kakkar N, Dey P
Diagn Cytopathol 2023 Oct;51(10):646-653. Epub 2023 Jul 14 doi: 10.1002/dc.25194. PMID: 37452481
Yao X, Zhou H, Duan C, Wu X, Li B, Liu H, Zhang Y
Front Immunol 2022;13:1096494. Epub 2023 Jan 13 doi: 10.3389/fimmu.2022.1096494. PMID: 36713456Free PMC Article
Xue N, Zhang S, Wang G
BMC Urol 2022 Dec 22;22(1):210. doi: 10.1186/s12894-022-01163-9. PMID: 36550425Free PMC Article
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Young RH
Arch Pathol Lab Med 2008 Apr;132(4):548-64. doi: 10.5858/2008-132-548-TTNAAF. PMID: 18384207

Therapy

Al-Obaidy KI, Trevino KE, Idrees MT
Int J Surg Pathol 2019 Sep;27(6):619-623. Epub 2019 Apr 15 doi: 10.1177/1066896919842939. PMID: 30983459
Jostes S, Nettersheim D, Fellermeyer M, Schneider S, Hafezi F, Honecker F, Schumacher V, Geyer M, Kristiansen G, Schorle H
J Cell Mol Med 2017 Jul;21(7):1300-1314. Epub 2016 Dec 27 doi: 10.1111/jcmm.13059. PMID: 28026145Free PMC Article
Som A, Zhu R, Guo CC, Efstathiou E, Xiao L, Pisters LL, Matin A, Tu SM
Urol Oncol 2012 Jul-Aug;30(4):494-501. Epub 2010 Sep 6 doi: 10.1016/j.urolonc.2010.05.011. PMID: 20822932Free PMC Article
Nazeer T, Ro JY, Kee KH, Ayala AG
Mod Pathol 1996 Jul;9(7):762-6. PMID: 8832559
Bergmann KA
Clin Pharm 1987 Sep;6(9):693-706. PMID: 2445518

Prognosis

Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Stang A, Trocchi P, Kajüter H, Trabert B, Oosterhuis JW, McGlynn KA
Andrology 2023 Jan;11(1):65-72. Epub 2022 Sep 12 doi: 10.1111/andr.13282. PMID: 36059277
Scandura G, Verrill C, Protheroe A, Joseph J, Ansell W, Sahdev A, Shamash J, Berney DM
BJU Int 2018 Apr;121(4):575-582. Epub 2017 Nov 12 doi: 10.1111/bju.14056. PMID: 29032579
Micali S, Maggisano V, Cesinaro A, Celano M, Territo A, Reggiani Bonetti L, Sponziello M, Migaldi M, Navarra M, Bianchi G, Filetti S, Russo D
J Endocrinol 2013 Feb;216(2):125-33. Epub 2013 Jan 18 doi: 10.1530/JOE-12-0495. PMID: 23117572
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189

Clinical prediction guides

Yao X, Zhou H, Duan C, Wu X, Li B, Liu H, Zhang Y
Front Immunol 2022;13:1096494. Epub 2023 Jan 13 doi: 10.3389/fimmu.2022.1096494. PMID: 36713456Free PMC Article
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Orsatti A, Sirolli M, Ambrosi F, Franceschini T, Giunchi F, Franchini E, Grillini M, Massari F, Mollica V, Bianchi FM, Colecchia M, Fiorentino M, Ricci C
Pathol Res Pract 2022 Sep;237:154044. Epub 2022 Jul 28 doi: 10.1016/j.prp.2022.154044. PMID: 35930824
Micali S, Maggisano V, Cesinaro A, Celano M, Territo A, Reggiani Bonetti L, Sponziello M, Migaldi M, Navarra M, Bianchi G, Filetti S, Russo D
J Endocrinol 2013 Feb;216(2):125-33. Epub 2013 Jan 18 doi: 10.1530/JOE-12-0495. PMID: 23117572
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189

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