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Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia

MedGen UID:
237013
•Concept ID:
C1336769
•
Neoplastic Process
Synonym: Topoisomerase II Inhibitor Related Acute Myeloid Leukemia

Definition

Acute myeloid leukemias arising as a result of the mutagenic effect of therapeutic agents targeting DNA-topoisomerase II. The vast majority of patients present without a preceding myelodysplastic phase. The acute myeloid leukemias are usually of the monoblastic or myelomonocytic type. Clonal cytogenetic abnormalities are frequently present and usually involve chromosome 11q23 (MLL gene). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTopoisomerase II Inhibitor-Related Acute Myeloid Leukemia

Recent clinical studies

Etiology

Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
Topoisomerase II inhibitor-related acute myeloid leukaemia.
Pui CH, Relling MV
Br J Haematol 2000 Apr;109(1):13-23. doi: 10.1046/j.1365-2141.2000.01843.x. PMID: 10848777

Diagnosis

A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma.
Jang GD, Kim SW, Suh CW, Kim EK, Bahng HS, Jeong YH, Park IG, Kim WK, Kim SH, Suh EJ, Park CJ, Ji HS, Lee JS
J Korean Med Sci 2002 Aug;17(4):555-9. doi: 10.3346/jkms.2002.17.4.555. PMID: 12172056Free PMC Article
ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.
Felix CA, Hosler MR, Winick NJ, Masterson M, Wilson AE, Lange BJ
Blood 1995 Jun 1;85(11):3250-6. PMID: 7756657

Therapy

Recurrent Translocations in Topoisomerase Inhibitor-Related Leukemia Are Determined by the Features of DNA Breaks Rather Than by the Proximity of the Translocating Genes.
Lomov NA, Viushkov VS, Ulianov SV, Gavrilov AA, Alexeyevsky DA, Artemov AV, Razin SV, Rubtsov MA
Int J Mol Sci 2022 Aug 29;23(17) doi: 10.3390/ijms23179824. PMID: 36077220Free PMC Article
Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article
A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma.
Jang GD, Kim SW, Suh CW, Kim EK, Bahng HS, Jeong YH, Park IG, Kim WK, Kim SH, Suh EJ, Park CJ, Ji HS, Lee JS
J Korean Med Sci 2002 Aug;17(4):555-9. doi: 10.3346/jkms.2002.17.4.555. PMID: 12172056Free PMC Article
Topoisomerase II inhibitor-related acute myeloid leukaemia.
Pui CH, Relling MV
Br J Haematol 2000 Apr;109(1):13-23. doi: 10.1046/j.1365-2141.2000.01843.x. PMID: 10848777
ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.
Felix CA, Hosler MR, Winick NJ, Masterson M, Wilson AE, Lange BJ
Blood 1995 Jun 1;85(11):3250-6. PMID: 7756657

Prognosis

Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article

Clinical prediction guides

Therapy-related myelodysplasia and acute myeloid leukemia.
Bhatia S
Semin Oncol 2013 Dec;40(6):666-75. doi: 10.1053/j.seminoncol.2013.09.013. PMID: 24331189Free PMC Article

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