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Uterine corpus adenosarcoma

MedGen UID:
237042
Concept ID:
C1336917
Neoplastic Process
Synonym: Adenosarcoma of the corpus uteri
 
Monarch Initiative: MONDO:0002878
Orphanet: ORPHA213600

Definition

A rare subtype of mixed epithelial-mesenchymal tumor, often presenting as a large, exophytic polypoid lesion, which may extend through the cervix, composed of benign or atypical epithelium and low-grade malignant stroma. It usually presents with dysfunctional bleeding or vaginal discharge and less often abdominal pain. Association with long-term unopposed estrogen therapy, tamoxifen therapy and a history of pelvic radiation has been reported. [from ORDO]

Professional guidelines

PubMed

Apellaniz-Ruiz M, McCluggage WG, Foulkes WD
Genes Chromosomes Cancer 2021 Mar;60(3):217-233. Epub 2020 Nov 19 doi: 10.1002/gcc.22913. PMID: 33135284
Lee SW, Lee TS, Hong DG, No JH, Park DC, Bae JM, Seong SJ, Shin SJ, Ju W, Lee KH, Lee YK, Cho H, Lee C, Paek J, Kim HJ, Lee JW, Kim JW, Bae DS
J Gynecol Oncol 2017 Jan;28(1):e12. Epub 2016 Oct 27 doi: 10.3802/jgo.2017.28.e12. PMID: 27894165Free PMC Article

Recent clinical studies

Diagnosis

Talia KL, Naaman Y, McCluggage WG
Int J Gynecol Pathol 2021 Jul 1;40(4):342-348. doi: 10.1097/PGP.0000000000000709. PMID: 32947330

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