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Adenosarcoma

MedGen UID:
126
•Concept ID:
C0001442
•
Neoplastic Process
Synonym: Adenosarcomas
SNOMED CT: Adenosarcoma (31470003)
 
Monarch Initiative: MONDO:0005636

Definition

A low grade malignant neoplasm characterized by the presence of a benign epithelial component (tubular and cleft-like glands) and a low grade sarcomatous component that contains varying amounts of fibrous and smooth muscle tissues. In a minority of cases, the sarcomatous component contains heterologous elements including striated muscle, cartilage, and fat. It occurs in the uterine corpus, ovary, fallopian tube, cervix, and vagina. It may recur and in a minority of cases may metastasize to distant anatomic sites. [from NCI]

Professional guidelines

PubMed

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Management of sarcomas of the uterus.
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299
Diagnosis and treatment of sarcoma of the uterus. A review.
Tropé CG, Abeler VM, Kristensen GB
Acta Oncol 2012 Jul;51(6):694-705. doi: 10.3109/0284186X.2012.689111. PMID: 22793037

Recent clinical studies

Etiology

Current Concepts in the Imaging of Uterine Sarcomas.
Petrocelli R, Hindman N, Reinhold C
Radiol Clin North Am 2023 Jul;61(4):627-638. Epub 2023 Apr 3 doi: 10.1016/j.rcl.2023.02.008. PMID: 37169428
Novel Therapeutics in the Treatment of Uterine Sarcoma.
Bose S, Schwartz GK, Ingham M
Am Soc Clin Oncol Educ Book 2022 Apr;42:900-909. doi: 10.1200/EDBK_350541. PMID: 35714303
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Management of sarcomas of the uterus.
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299
Uterine sarcomas: a review.
D'Angelo E, Prat J
Gynecol Oncol 2010 Jan;116(1):131-9. Epub 2009 Oct 23 doi: 10.1016/j.ygyno.2009.09.023. PMID: 19853898

Diagnosis

Novel Therapeutics in the Treatment of Uterine Sarcoma.
Bose S, Schwartz GK, Ingham M
Am Soc Clin Oncol Educ Book 2022 Apr;42:900-909. doi: 10.1200/EDBK_350541. PMID: 35714303
Uterine Adenosarcoma.
Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467
Uterine Adenosarcoma.
Pinto A, Howitt B
Arch Pathol Lab Med 2016 Mar;140(3):286-90. doi: 10.5858/arpa.2014-0523-RS. PMID: 26927725
Management of sarcomas of the uterus.
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299
Pathology of mixed Müllerian tumours.
D'Angelo E, Prat J
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):705-18. Epub 2011 Jul 13 doi: 10.1016/j.bpobgyn.2011.05.010. PMID: 21742560

Therapy

State of the science: Uterine sarcomas: From pathology to practice.
Shushkevich A, Thaker PH, Littell RD, Shah NA, Chiang S, Thornton K, Hensley ML, Slomovitz BM, Holcomb KM, Leitao MM, Toboni MD, Powell MA, Levine DA, Dowdy SC, Klopp A, Brown J
Gynecol Oncol 2020 Oct;159(1):3-7. Epub 2020 Aug 21 doi: 10.1016/j.ygyno.2020.08.008. PMID: 32839026
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Management of sarcomas of the uterus.
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299
Uterine sarcomas: a review.
D'Angelo E, Prat J
Gynecol Oncol 2010 Jan;116(1):131-9. Epub 2009 Oct 23 doi: 10.1016/j.ygyno.2009.09.023. PMID: 19853898
Endometrial pathology.
Czernobilsky B, Lifschitz-Mercer B
Curr Opin Obstet Gynecol 1997 Feb;9(1):52-6. PMID: 9090483

Prognosis

Uterine sarcomas.
Mbatani N, Olawaiye AB, Prat J
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:51-58. doi: 10.1002/ijgo.12613. PMID: 30306577
Uterine Adenosarcoma.
Pinto A, Howitt B
Arch Pathol Lab Med 2016 Mar;140(3):286-90. doi: 10.5858/arpa.2014-0523-RS. PMID: 26927725
Management of sarcomas of the uterus.
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299
Prognostic factors in uterine sarcoma.
Gadducci A
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):783-95. Epub 2011 Jul 18 doi: 10.1016/j.bpobgyn.2011.06.002. PMID: 21764643
Endometrial pathology.
Czernobilsky B, Lifschitz-Mercer B
Curr Opin Obstet Gynecol 1997 Feb;9(1):52-6. PMID: 9090483

Clinical prediction guides

Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
The significance of recurrence in endometrial polyps: a clinicopathologic analysis.
Ciscato A, Zare SY, Fadare O
Hum Pathol 2020 Jun;100:38-44. Epub 2020 Apr 22 doi: 10.1016/j.humpath.2020.03.005. PMID: 32334830
Diagnostic challenges: low-grade adenosarcoma on deep endometriosis.
Vilches Jimenez JC, Villegas Muñoz E, González Poveda I, Santos Lorente D, Sanchez Pérez B, Jimenez Lopez JS
BMC Womens Health 2019 Oct 26;19(1):124. doi: 10.1186/s12905-019-0815-1. PMID: 31655582Free PMC Article
Uterine sarcomas: a review.
D'Angelo E, Prat J
Gynecol Oncol 2010 Jan;116(1):131-9. Epub 2009 Oct 23 doi: 10.1016/j.ygyno.2009.09.023. PMID: 19853898
Primary gastric adenosarcoma.
Kallakury BV, Bui HX, delRosario A, Wallace J, Solis OG, Ross JS
Arch Pathol Lab Med 1993 Mar;117(3):299-301. PMID: 8382916

Recent systematic reviews

Is Adnexectomy Mandatory at the Time of Hysterectomy for Uterine Sarcomas? A Systematic Review and Meta-Analysis.
Ronsini C, Foresta A, Giudice M, Reino A, La Verde M, Della Corte L, Bifulco G, Franciscis P, Cianci S, Capozzi VA
Medicina (Kaunas) 2022 Aug 23;58(9) doi: 10.3390/medicina58091140. PMID: 36143817Free PMC Article
Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis.
Travaglino A, Raffone A, Saccone G, Fuggi M, De Placido G, Mascolo M, Mollo A, Insabato L, Zullo F
Appl Immunohistochem Mol Morphol 2020 Sep;28(8):646-653. doi: 10.1097/PAI.0000000000000780. PMID: 31855579
Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article

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