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Adenosarcoma

MedGen UID:
126
•Concept ID:
C0001442
•
Neoplastic Process
Synonym: Adenosarcomas
SNOMED CT: Adenosarcoma (31470003)
 
Monarch Initiative: MONDO:0005636

Definition

A low grade malignant neoplasm characterized by the presence of a benign epithelial component (tubular and cleft-like glands) and a low grade sarcomatous component that contains varying amounts of fibrous and smooth muscle tissues. In a minority of cases, the sarcomatous component contains heterologous elements including striated muscle, cartilage, and fat. It occurs in the uterine corpus, ovary, fallopian tube, cervix, and vagina. It may recur and in a minority of cases may metastasize to distant anatomic sites. [from NCI]

Professional guidelines

PubMed

DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
Management of sarcomas of the uterus.
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299
Diagnosis and treatment of sarcoma of the uterus. A review.
Tropé CG, Abeler VM, Kristensen GB
Acta Oncol 2012 Jul;51(6):694-705. doi: 10.3109/0284186X.2012.689111. PMID: 22793037

Recent clinical studies

Etiology

Prognostic factors in patients with uterine sarcoma: the SARCUT study.
Zapardiel I, Gracia Segovia M, Macuks R, Mancari R, Achimas-Cadariu P, Corrado G, Bartusevicius A, Sukhin V, Muruzabal JC, Coronado Martín PJ, Gardella B, Piek JM, Concin N, Arab C, Papatheodorou D, Polterauer S, Iacoponi S, Nieto T, Lopez-Sanclemente MC, Trukhan H, Gil MM, Bakinovskaya I, Dalamanava A, Cucurull M, Rovski D, Baquedano L, Chiva L, Mardas M, Mavrichev SA, Klat J, Lopez de la Manzanara CA, Yildirim Y; SARCUT Study Group
Int J Gynecol Cancer 2023 Jun 5;33(6):897-904. doi: 10.1136/ijgc-2022-004204. PMID: 37192761
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Uterine Adenosarcoma: a Review.
Nathenson MJ, Ravi V, Fleming N, Wang WL, Conley A
Curr Oncol Rep 2016 Nov;18(11):68. doi: 10.1007/s11912-016-0552-7. PMID: 27718181
Management of sarcomas of the uterus.
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299

Diagnosis

Prognostic factors in patients with uterine sarcoma: the SARCUT study.
Zapardiel I, Gracia Segovia M, Macuks R, Mancari R, Achimas-Cadariu P, Corrado G, Bartusevicius A, Sukhin V, Muruzabal JC, Coronado Martín PJ, Gardella B, Piek JM, Concin N, Arab C, Papatheodorou D, Polterauer S, Iacoponi S, Nieto T, Lopez-Sanclemente MC, Trukhan H, Gil MM, Bakinovskaya I, Dalamanava A, Cucurull M, Rovski D, Baquedano L, Chiva L, Mardas M, Mavrichev SA, Klat J, Lopez de la Manzanara CA, Yildirim Y; SARCUT Study Group
Int J Gynecol Cancer 2023 Jun 5;33(6):897-904. doi: 10.1136/ijgc-2022-004204. PMID: 37192761
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Uterine Adenosarcoma.
Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
My approach to the interpretation of endometrial biopsies and curettings.
McCluggage WG
J Clin Pathol 2006 Aug;59(8):801-12. doi: 10.1136/jcp.2005.029702. PMID: 16873562Free PMC Article

Therapy

Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Hormonal therapies in uterine sarcomas, aggressive angiomyxoma, and desmoid-type fibromatosis.
Pannier D, Cordoba A, Ryckewaert T, Robin YM, Penel N
Crit Rev Oncol Hematol 2019 Nov;143:62-66. Epub 2019 Aug 31 doi: 10.1016/j.critrevonc.2019.08.007. PMID: 31494310
Recent advances in the treatment of sarcomas in gynecology.
Lange SS, Novetsky AP, Powell MA
Discov Med 2014 Sep;18(98):133-40. PMID: 25227754
Management of sarcomas of the uterus.
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299
Endometrial pathology.
Czernobilsky B, Lifschitz-Mercer B
Curr Opin Obstet Gynecol 1997 Feb;9(1):52-6. PMID: 9090483

Prognosis

Prognostic factors in patients with uterine sarcoma: the SARCUT study.
Zapardiel I, Gracia Segovia M, Macuks R, Mancari R, Achimas-Cadariu P, Corrado G, Bartusevicius A, Sukhin V, Muruzabal JC, Coronado Martín PJ, Gardella B, Piek JM, Concin N, Arab C, Papatheodorou D, Polterauer S, Iacoponi S, Nieto T, Lopez-Sanclemente MC, Trukhan H, Gil MM, Bakinovskaya I, Dalamanava A, Cucurull M, Rovski D, Baquedano L, Chiva L, Mardas M, Mavrichev SA, Klat J, Lopez de la Manzanara CA, Yildirim Y; SARCUT Study Group
Int J Gynecol Cancer 2023 Jun 5;33(6):897-904. doi: 10.1136/ijgc-2022-004204. PMID: 37192761
Uterine Adenosarcoma.
Ulrich UA, Denschlag D
Oncol Res Treat 2018;41(11):693-696. Epub 2018 Oct 17 doi: 10.1159/000494067. PMID: 30326467
Uterine sarcomas.
Mbatani N, Olawaiye AB, Prat J
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:51-58. doi: 10.1002/ijgo.12613. PMID: 30306577
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Uterine Adenosarcoma.
Pinto A, Howitt B
Arch Pathol Lab Med 2016 Mar;140(3):286-90. doi: 10.5858/arpa.2014-0523-RS. PMID: 26927725

Clinical prediction guides

Clinical characteristics and prognosis analysis of uterine sarcoma: a single-institution retrospective study.
Wang F, Dai X, Chen H, Hu X, Wang Y
BMC Cancer 2022 Oct 7;22(1):1050. doi: 10.1186/s12885-022-10129-x. PMID: 36207687Free PMC Article
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Prognostic factors for uterine adenosarcoma: a review.
Nathenson MJ, Conley AP
Expert Rev Anticancer Ther 2018 Nov;18(11):1093-1100. Epub 2018 Sep 11 doi: 10.1080/14737140.2018.1518136. PMID: 30169984
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Management of sarcomas of the uterus.
Novetsky AP, Powell MA
Curr Opin Oncol 2013 Sep;25(5):546-52. doi: 10.1097/CCO.0b013e328363e0ef. PMID: 23942299

Recent systematic reviews

Is Adnexectomy Mandatory at the Time of Hysterectomy for Uterine Sarcomas? A Systematic Review and Meta-Analysis.
Ronsini C, Foresta A, Giudice M, Reino A, La Verde M, Della Corte L, Bifulco G, Franciscis P, Cianci S, Capozzi VA
Medicina (Kaunas) 2022 Aug 23;58(9) doi: 10.3390/medicina58091140. PMID: 36143817Free PMC Article
Immunophenotype of Atypical Polypoid Adenomyoma of the Uterus: Diagnostic Value and Insight on Pathogenesis.
Travaglino A, Raffone A, Saccone G, Fuggi M, De Placido G, Mascolo M, Mollo A, Insabato L, Zullo F
Appl Immunohistochem Mol Morphol 2020 Sep;28(8):646-653. doi: 10.1097/PAI.0000000000000780. PMID: 31855579
Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article

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