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Sebaceous adenoma

MedGen UID:
237152
•Concept ID:
C1368816
•
Neoplastic Process
Synonym: Sebaceous adenomas
SNOMED CT: Sebaceous adenoma (78424008); Sebaceous adenoma of skin (307598005)
 
Monarch Initiative: MONDO:0002375

Definition

A benign, well circumscribed neoplasm arising from the sebaceous glands. It usually presents as a small yellowish tumor in the sun exposed skin of head and neck. It is characterized by the presence of sebaceous cells aggregates with a peripheral rim of basaloid cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSebaceous adenoma

Professional guidelines

PubMed

Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.
Vazmitsel M, Esebua M, Layfield LJ
Diagn Cytopathol 2020 May;48(5):424-429. Epub 2020 Jan 22 doi: 10.1002/dc.24357. PMID: 31967730
Muir-Torre syndrome (MTS): An update and approach to diagnosis and management.
John AM, Schwartz RA
J Am Acad Dermatol 2016 Mar;74(3):558-66. doi: 10.1016/j.jaad.2015.09.074. PMID: 26892655
Diethylstilbestrol in the treatment of senile sebaceous adenoma.
LOBITZ WC Jr, COLE DP
AMA Arch Derm Syphilol 1952 Sep;66(3):358-62. doi: 10.1001/archderm.1952.01530280062009. PMID: 14952023

Recent clinical studies

Etiology

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
Muir-Torre syndrome.
Bhaijee F, Brown AS
Arch Pathol Lab Med 2014 Dec;138(12):1685-9. doi: 10.5858/arpa.2013-0301-RS. PMID: 25427047
Muir-Torre syndrome.
Ponti G, Ponz de Leon M
Lancet Oncol 2005 Dec;6(12):980-7. doi: 10.1016/S1470-2045(05)70465-4. PMID: 16321766
The Muir-Torre syndrome: a 25-year retrospect.
Schwartz RA, Torre DP
J Am Acad Dermatol 1995 Jul;33(1):90-104. doi: 10.1016/0190-9622(95)90017-9. PMID: 7601953

Diagnosis

Molecular Genetics of Sebaceous Neoplasia.
North JP
Surg Pathol Clin 2021 Jun;14(2):273-284. doi: 10.1016/j.path.2021.03.005. PMID: 34023105
Sebaceous lesions of the skin.
Iacobelli J, Harvey NT, Wood BA
Pathology 2017 Dec;49(7):688-697. Epub 2017 Oct 25 doi: 10.1016/j.pathol.2017.08.012. PMID: 29078997
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
Muir-Torre syndrome.
Bhaijee F, Brown AS
Arch Pathol Lab Med 2014 Dec;138(12):1685-9. doi: 10.5858/arpa.2013-0301-RS. PMID: 25427047
Muir-Torre syndrome.
Ponti G, Ponz de Leon M
Lancet Oncol 2005 Dec;6(12):980-7. doi: 10.1016/S1470-2045(05)70465-4. PMID: 16321766

Therapy

Multi-organ carcinogenicity by inhalation exposure to 2-Bromopropane in rats.
Senoh H, Kasai T, Hirai S, Furukawa Y, Misumi K, Goto Y, Takanobu K, Matsumoto M, Fukushima S, Aiso S
J Occup Health 2023 Jan;65(1):e12388. doi: 10.1002/1348-9585.12388. PMID: 36756793Free PMC Article
Loss of ZNF750 in ocular and cutaneous sebaceous carcinoma.
North JP, Solomon DA, Golovato J, Bloomer M, Benz SC, Cho RJ
J Cutan Pathol 2019 Oct;46(10):736-741. Epub 2019 Jul 8 doi: 10.1111/cup.13516. PMID: 31148199Free PMC Article
New pharmaceutical concepts for sebaceous gland diseases: implementing today's pre-clinical data into tomorrow's daily clinical practice.
Zampeli VA, Makrantonaki E, Tzellos T, Zouboulis CC
Curr Pharm Biotechnol 2012 Aug;13(10):1898-913. doi: 10.2174/138920112802273173. PMID: 22250709
Demodex-associated dermatologic conditions--A coincidence or an etiological correlate. Review with a report of a rare case of sebaceous adenoma.
Dhingra KK, Saroha V, Gupta P, Khurana N
Pathol Res Pract 2009;205(6):423-6. Epub 2009 Jan 23 doi: 10.1016/j.prp.2008.11.013. PMID: 19167837
Diethylstilbestrol in the treatment of senile sebaceous adenoma.
LOBITZ WC Jr, COLE DP
AMA Arch Derm Syphilol 1952 Sep;66(3):358-62. doi: 10.1001/archderm.1952.01530280062009. PMID: 14952023

Prognosis

Update on the pathology, genetics and somatic landscape of sebaceous tumours.
Ferreira I, Wiedemeyer K, Demetter P, Adams DJ, Arends MJ, Brenn T
Histopathology 2020 Apr;76(5):640-649. Epub 2020 Mar 17 doi: 10.1111/his.14044. PMID: 31821583
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Frequent TLE1 Expression in Cutaneous Neoplasms.
Xiong Y, Dresser K, Cornejo KM
Am J Dermatopathol 2019 Jan;41(1):1-6. doi: 10.1097/DAD.0000000000001186. PMID: 30608261
Muir-Torre syndrome.
Ponti G, Ponz de Leon M
Lancet Oncol 2005 Dec;6(12):980-7. doi: 10.1016/S1470-2045(05)70465-4. PMID: 16321766
The Muir-Torre syndrome: a 25-year retrospect.
Schwartz RA, Torre DP
J Am Acad Dermatol 1995 Jul;33(1):90-104. doi: 10.1016/0190-9622(95)90017-9. PMID: 7601953

Clinical prediction guides

Dermoscopic features of benign sebaceous proliferations in dogs: Description, assessment and inter-observer agreement.
Scarampella F, Colombo S, Dehesa A, Godizzi F, Cavicchini S, Fabbri E, Roccabianca P
Vet Dermatol 2023 Dec;34(6):597-607. Epub 2023 Jul 28 doi: 10.1111/vde.13196. PMID: 37503675
Adipophilin expression in skin lesions with clear cell histology.
Li FZ, Ye Q, Ran LW, Fang S
J Clin Pathol 2022 Sep;75(9):627-631. Epub 2021 May 5 doi: 10.1136/jclinpath-2021-207443. PMID: 33952590
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.
Hellquist H, Paiva-Correia A, Vander Poorten V, Quer M, Hernandez-Prera JC, Andreasen S, Zbären P, Skalova A, Rinaldo A, Ferlito A
Adv Ther 2019 Aug;36(8):1950-1974. Epub 2019 Jun 17 doi: 10.1007/s12325-019-01007-3. PMID: 31209701Free PMC Article
Frequent TLE1 Expression in Cutaneous Neoplasms.
Xiong Y, Dresser K, Cornejo KM
Am J Dermatopathol 2019 Jan;41(1):1-6. doi: 10.1097/DAD.0000000000001186. PMID: 30608261
TdT expression in normal and neoplastic sebaceous cells.
Tzorakoleftheraki SE, Iliadis A, Kostopoulos I, Koletsa T
Histopathology 2017 Dec;71(6):985-988. Epub 2017 Sep 19 doi: 10.1111/his.13304. PMID: 28677299

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