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Laryngopharyngeal reflux

MedGen UID:
257909
•Concept ID:
C1168250
•
Disease or Syndrome
Synonyms: Laryngopharyngeal Reflux; Reflux, Laryngopharyngeal
SNOMED CT: Laryngopharyngeal reflux (414581006)

Definition

Back flow of gastric contents to the LARYNGOPHARYNX where it comes in contact with tissues of the upper aerodigestive tract. Laryngopharyngeal reflux is an extraesophageal manifestation of GASTROESOPHAGEAL REFLUX. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngopharyngeal reflux

Professional guidelines

PubMed

An update on current treatment strategies for laryngopharyngeal reflux symptoms.
Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412Free PMC Article
Advances in the diagnosis and management of gastroesophageal reflux disease.
Katzka DA, Kahrilas PJ
BMJ 2020 Nov 23;371:m3786. doi: 10.1136/bmj.m3786. PMID: 33229333
Asthma in adults: Principles of treatment.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):396-402. doi: 10.2500/aap.2019.40.4256. PMID: 31690379

Recent clinical studies

Etiology

Diet and Health in Otolaryngology.
Juszczak HM, Rosenfeld RM
Otolaryngol Clin North Am 2022 Oct;55(5):909-927. Epub 2022 Sep 7 doi: 10.1016/j.otc.2022.06.001. PMID: 36088162
Probiotics for Otolaryngologic Disorders.
Czibulka A
Otolaryngol Clin North Am 2022 Oct;55(5):939-946. Epub 2022 Sep 7 doi: 10.1016/j.otc.2022.06.003. PMID: 36088157
Dysphagia and Swallowing Disorders.
McCarty EB, Chao TN
Med Clin North Am 2021 Sep;105(5):939-954. doi: 10.1016/j.mcna.2021.05.013. PMID: 34391544
Reinke's Edema.
Tavaluc R, Tan-Geller M
Otolaryngol Clin North Am 2019 Aug;52(4):627-635. Epub 2019 May 14 doi: 10.1016/j.otc.2019.03.006. PMID: 31101355
Nasolaryngoscopy.
Moser SE
Prim Care 2014 Mar;41(1):109-13. doi: 10.1016/j.pop.2013.10.009. PMID: 24439885

Diagnosis

An update on current treatment strategies for laryngopharyngeal reflux symptoms.
Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412Free PMC Article
Dysphagia and Swallowing Disorders.
McCarty EB, Chao TN
Med Clin North Am 2021 Sep;105(5):939-954. doi: 10.1016/j.mcna.2021.05.013. PMID: 34391544
Review of management of laryngopharyngeal reflux disease.
Lechien JR, Mouawad F, Bobin F, Bartaire E, Crevier-Buchman L, Saussez S
Eur Ann Otorhinolaryngol Head Neck Dis 2021 Sep;138(4):257-267. Epub 2020 Nov 27 doi: 10.1016/j.anorl.2020.11.002. PMID: 33257265
Reinke's Edema.
Tavaluc R, Tan-Geller M
Otolaryngol Clin North Am 2019 Aug;52(4):627-635. Epub 2019 May 14 doi: 10.1016/j.otc.2019.03.006. PMID: 31101355
Airway reflux.
Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, DelGaudio J, Altman KW
Ann N Y Acad Sci 2016 Oct;1381(1):5-13. Epub 2016 Jun 16 doi: 10.1111/nyas.13080. PMID: 27310222

Therapy

AGA Clinical Practice Update on the Diagnosis and Management of Extraesophageal Gastroesophageal Reflux Disease: Expert Review.
Chen JW, Vela MF, Peterson KA, Carlson DA
Clin Gastroenterol Hepatol 2023 Jun;21(6):1414-1421.e3. Epub 2023 Apr 14 doi: 10.1016/j.cgh.2023.01.040. PMID: 37061897
An update on current treatment strategies for laryngopharyngeal reflux symptoms.
Krause AJ, Walsh EH, Weissbrod PA, Taft TH, Yadlapati R
Ann N Y Acad Sci 2022 Apr;1510(1):5-17. Epub 2021 Dec 17 doi: 10.1111/nyas.14728. PMID: 34921412Free PMC Article
Advances in the diagnosis and management of gastroesophageal reflux disease.
Katzka DA, Kahrilas PJ
BMJ 2020 Nov 23;371:m3786. doi: 10.1136/bmj.m3786. PMID: 33229333
Airway reflux.
Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, DelGaudio J, Altman KW
Ann N Y Acad Sci 2016 Oct;1381(1):5-13. Epub 2016 Jun 16 doi: 10.1111/nyas.13080. PMID: 27310222
Pathophysiology and treatment of muscle tension dysphonia: a review of the current knowledge.
Van Houtte E, Van Lierde K, Claeys S
J Voice 2011 Mar;25(2):202-7. Epub 2010 Apr 18 doi: 10.1016/j.jvoice.2009.10.009. PMID: 20400263

Prognosis

AGA Clinical Practice Update on the Diagnosis and Management of Extraesophageal Gastroesophageal Reflux Disease: Expert Review.
Chen JW, Vela MF, Peterson KA, Carlson DA
Clin Gastroenterol Hepatol 2023 Jun;21(6):1414-1421.e3. Epub 2023 Apr 14 doi: 10.1016/j.cgh.2023.01.040. PMID: 37061897
Role of Obesity in Otorhinolaryngologic Diseases.
Jung SY, Park DC, Kim SH, Yeo SG
Curr Allergy Asthma Rep 2019 Jun 3;19(7):34. doi: 10.1007/s11882-019-0865-3. PMID: 31161431
Laryngopharyngeal reflux and Helicobacter pylori.
Yılmaz T, Bajin MD, Günaydın RÖ, Ozer S, Sözen T
World J Gastroenterol 2014 Jul 21;20(27):8964-70. doi: 10.3748/wjg.v20.i27.8964. PMID: 25083069Free PMC Article
Paradoxic vocal fold movement disorder.
Matrka L
Otolaryngol Clin North Am 2014 Feb;47(1):135-46. Epub 2013 Oct 23 doi: 10.1016/j.otc.2013.08.014. PMID: 24286687
Pathophysiology and treatment of muscle tension dysphonia: a review of the current knowledge.
Van Houtte E, Van Lierde K, Claeys S
J Voice 2011 Mar;25(2):202-7. Epub 2010 Apr 18 doi: 10.1016/j.jvoice.2009.10.009. PMID: 20400263

Clinical prediction guides

Diet and Health in Otolaryngology.
Juszczak HM, Rosenfeld RM
Otolaryngol Clin North Am 2022 Oct;55(5):909-927. Epub 2022 Sep 7 doi: 10.1016/j.otc.2022.06.001. PMID: 36088162
Review of management of laryngopharyngeal reflux disease.
Lechien JR, Mouawad F, Bobin F, Bartaire E, Crevier-Buchman L, Saussez S
Eur Ann Otorhinolaryngol Head Neck Dis 2021 Sep;138(4):257-267. Epub 2020 Nov 27 doi: 10.1016/j.anorl.2020.11.002. PMID: 33257265
The role of pepsin in the laryngopharyngeal reflux.
Kowalik K, Krzeski A
Otolaryngol Pol 2017 Dec 30;71(6):7-13. doi: 10.5604/01.3001.0010.7194. PMID: 29327685
Laryngopharyngeal reflux and Helicobacter pylori.
Yılmaz T, Bajin MD, Günaydın RÖ, Ozer S, Sözen T
World J Gastroenterol 2014 Jul 21;20(27):8964-70. doi: 10.3748/wjg.v20.i27.8964. PMID: 25083069Free PMC Article
Pathophysiology and treatment of muscle tension dysphonia: a review of the current knowledge.
Van Houtte E, Van Lierde K, Claeys S
J Voice 2011 Mar;25(2):202-7. Epub 2010 Apr 18 doi: 10.1016/j.jvoice.2009.10.009. PMID: 20400263

Recent systematic reviews

Laryngopharyngeal Reflux and Benign Vocal Fold Lesions: A Systematic Review and Meta-analysis.
Ren QW, Lei G, Zhao YL, Zhou L, Luo XL, Peng SL
Otolaryngol Head Neck Surg 2024 Feb;170(2):309-319. Epub 2023 Sep 20 doi: 10.1002/ohn.529. PMID: 37727944
Association between laryngopharyngeal reflux, gastroesophageal reflux and recalcitrant chronic rhinosinusitis: A systematic review.
Lechien JR, Saussez S, Hopkins C
Clin Otolaryngol 2023 Jul;48(4):501-514. Epub 2023 Mar 9 doi: 10.1111/coa.14047. PMID: 36895147
Association Between Laryngopharyngeal Reflux and Media Otitis: A Systematic Review.
Lechien JR, Hans S, Simon F, Horoi M, Calvo-Henriquez C, Chiesa-Estomba CM, Mayo-Yáñez M, Bartel R, Piersiala K, Nguyen Y, Saussez S
Otol Neurotol 2021 Aug 1;42(7):e801-e814. doi: 10.1097/MAO.0000000000003123. PMID: 33710157
Dysphonia and reflux in children: A systematic review.
Saniasiaya J, Kulasegarah J
Int J Pediatr Otorhinolaryngol 2020 Dec;139:110473. Epub 2020 Oct 28 doi: 10.1016/j.ijporl.2020.110473. PMID: 33137676
Voice outcomes of laryngopharyngeal reflux treatment: a systematic review of 1483 patients.
Lechien JR, Finck C, Costa de Araujo P, Huet K, Delvaux V, Piccaluga M, Harmegnies B, Saussez S
Eur Arch Otorhinolaryngol 2017 Jan;274(1):1-23. Epub 2016 Mar 23 doi: 10.1007/s00405-016-3984-7. PMID: 27007132

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