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Dyskinesia of esophagus

MedGen UID:
41868
Concept ID:
C0014858
Disease or Syndrome
Synonyms: Disorder, Esophageal Motility; Disorders, Esophageal Motility; Dysmotilities, Esophageal; Dysmotility, Esophageal; Esophageal Dysmotilities; Esophageal Dysmotility; Esophageal Motility Disorder; Esophageal Motility Disorders; Motility Disorder, Esophageal; Motility Disorders, Esophageal
SNOMED CT: Esophageal dysmotility (266434009); Dyskinesia of esophagus (79962008); Esophageal motility disorder (79962008); Esophageal motor disorder (79962008)
 
Monarch Initiative: MONDO:0004729

Definition

Disorders affecting the motor function of the upper esophageal sphincter; lower esophageal sphincter; the esophagus body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (gastroesophageal reflux). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus). [from MONDO]

Professional guidelines

PubMed

Yadlapati R, Gyawali CP, Pandolfino JE; CGIT GERD Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 May;20(5):984-994.e1. Epub 2022 Feb 2 doi: 10.1016/j.cgh.2022.01.025. PMID: 35123084Free PMC Article
Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R, Spechler SJ
Am J Gastroenterol 2022 Jan 1;117(1):27-56. doi: 10.14309/ajg.0000000000001538. PMID: 34807007Free PMC Article
Chen J, Brady P
Gastroenterol Nurs 2019 Jan/Feb;42(1):20-28. doi: 10.1097/SGA.0000000000000359. PMID: 30688703

Recent clinical studies

Etiology

Lin J, Liu G, Duan Z
Expert Rev Gastroenterol Hepatol 2021 Aug;15(8):919-927. Epub 2021 Jul 1 doi: 10.1080/17474124.2021.1945921. PMID: 34156876
Savarino E, Marabotto E, Savarino V
Curr Opin Gastroenterol 2018 Jul;34(4):243-248. doi: 10.1097/MOG.0000000000000439. PMID: 29846257
Kahrilas PJ, Bredenoord AJ, Fox M, Gyawali CP, Roman S, Smout AJ, Pandolfino JE; International High Resolution Manometry Working Group
Neurogastroenterol Motil 2015 Feb;27(2):160-74. Epub 2014 Dec 3 doi: 10.1111/nmo.12477. PMID: 25469569Free PMC Article
Roman S, Tutuian R
Neurogastroenterol Motil 2012 Mar;24 Suppl 1:32-9. doi: 10.1111/j.1365-2982.2011.01837.x. PMID: 22248106
Wilson JA, Pryde A, Allan PL, Maran AG
Otolaryngol Head Neck Surg 1992 Feb;106(2):163-8. PMID: 1738548

Diagnosis

Hoshikawa Y, Iwakiri K
Digestion 2024;105(1):11-17. Epub 2023 Aug 25 doi: 10.1159/000533347. PMID: 37634495
Patel DA, Yadlapati R, Vaezi MF
Gastroenterology 2022 May;162(6):1617-1634. Epub 2022 Feb 25 doi: 10.1053/j.gastro.2021.12.289. PMID: 35227779Free PMC Article
Yadlapati R, Kahrilas PJ, Fox MR, Bredenoord AJ, Prakash Gyawali C, Roman S, Babaei A, Mittal RK, Rommel N, Savarino E, Sifrim D, Smout A, Vaezi MF, Zerbib F, Akiyama J, Bhatia S, Bor S, Carlson DA, Chen JW, Cisternas D, Cock C, Coss-Adame E, de Bortoli N, Defilippi C, Fass R, Ghoshal UC, Gonlachanvit S, Hani A, Hebbard GS, Wook Jung K, Katz P, Katzka DA, Khan A, Kohn GP, Lazarescu A, Lengliner J, Mittal SK, Omari T, Park MI, Penagini R, Pohl D, Richter JE, Serra J, Sweis R, Tack J, Tatum RP, Tutuian R, Vela MF, Wong RK, Wu JC, Xiao Y, Pandolfino JE
Neurogastroenterol Motil 2021 Jan;33(1):e14058. doi: 10.1111/nmo.14058. PMID: 33373111Free PMC Article
Wilkinson JM, Halland M
Am Fam Physician 2020 Sep 1;102(5):291-296. PMID: 32866357
Triggs J, Pandolfino J
F1000Res 2019;8 Epub 2019 Aug 29 doi: 10.12688/f1000research.18900.1. PMID: 31508201Free PMC Article

Therapy

Hoshikawa Y, Iwakiri K
Digestion 2024;105(1):11-17. Epub 2023 Aug 25 doi: 10.1159/000533347. PMID: 37634495
Wilkinson JM, Halland M
Am Fam Physician 2020 Sep 1;102(5):291-296. PMID: 32866357
Snyder DL, Vela MF
Curr Opin Gastroenterol 2020 Jul;36(4):344-350. doi: 10.1097/MOG.0000000000000648. PMID: 32427604
Kim JP, Kahrilas PJ
Curr Gastroenterol Rep 2019 Aug 20;21(10):49. doi: 10.1007/s11894-019-0718-1. PMID: 31432250
Roman S, Kahrilas PJ
Curr Opin Gastroenterol 2015 Jul;31(4):328-33. doi: 10.1097/MOG.0000000000000187. PMID: 26039725

Prognosis

Triadafilopoulos G, Mashimo H, Tatum R, O'Clarke J, Hawn M
Dig Dis Sci 2023 Sep;68(9):3542-3554. Epub 2023 Jul 20 doi: 10.1007/s10620-023-08008-x. PMID: 37470896
Zheng Z, Shang Y, Wang N, Liu X, Xin C, Yan X, Zhai Y, Yin J, Zhang J, Zhang Z
Int J Biol Sci 2021;17(15):4154-4164. Epub 2021 Oct 3 doi: 10.7150/ijbs.65066. PMID: 34803489Free PMC Article
Kim JP, Kahrilas PJ
Curr Gastroenterol Rep 2019 Aug 20;21(10):49. doi: 10.1007/s11894-019-0718-1. PMID: 31432250
Rohof WOA, Bredenoord AJ
Curr Gastroenterol Rep 2017 Aug;19(8):37. doi: 10.1007/s11894-017-0576-7. PMID: 28730503Free PMC Article
Kruger D
JAAPA 2014 May;27(5):23-30. doi: 10.1097/01.JAA.0000446227.85554.fb. PMID: 24691181

Clinical prediction guides

Ladrón Abia P, Ortiz V, García-Campos M, Saéz-González E, Mínguez Sabater A, Izquierdo R, Garrigues V
Gastroenterol Hepatol 2023 Apr;46(4):249-254. Epub 2022 May 20 doi: 10.1016/j.gastrohep.2022.05.004. PMID: 35605820
Zhang B, Hu Y, Shi X, Li W, Zeng X, Liu F, Chen JDZ, Xie WF
Am J Gastroenterol 2021 Jul 1;116(7):1495-1505. doi: 10.14309/ajg.0000000000001203. PMID: 34183577
Achem SR, Vazquez-Elizondo G, Fass R
J Clin Gastroenterol 2021 May-Jun 01;55(5):369-379. doi: 10.1097/MCG.0000000000001472. PMID: 33337637
Hani A, Zuluaga C, Costa V, Leguizamo AM, Puentes G, Ardila AF, Achem SR
Rev Gastroenterol Mex (Engl Ed) 2020 Oct-Dec;85(4):421-427. Epub 2020 Jan 6 doi: 10.1016/j.rgmx.2019.11.002. PMID: 31917034
Min YW, Rhee PL
Ann N Y Acad Sci 2016 Sep;1380(1):27-32. Epub 2016 Aug 6 doi: 10.1111/nyas.13182. PMID: 27496289

Recent systematic reviews

Zdrhova L, Bitnar P, Balihar K, Kolar P, Madle K, Martinek M, Pandolfino JE, Martinek J
Dysphagia 2023 Apr;38(2):609-621. Epub 2022 Jul 16 doi: 10.1007/s00455-022-10494-6. PMID: 35842548Free PMC Article
Eusebi LH, Ratnakumaran R, Yuan Y, Solaymani-Dodaran M, Bazzoli F, Ford AC
Gut 2018 Mar;67(3):430-440. Epub 2017 Feb 23 doi: 10.1136/gutjnl-2016-313589. PMID: 28232473
Ness-Jensen E, Hveem K, El-Serag H, Lagergren J
Clin Gastroenterol Hepatol 2016 Feb;14(2):175-82.e1-3. Epub 2015 May 6 doi: 10.1016/j.cgh.2015.04.176. PMID: 25956834Free PMC Article
Pandolfino JE, Gawron AJ
JAMA 2015 May 12;313(18):1841-52. doi: 10.1001/jama.2015.2996. PMID: 25965233
Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group
Am J Gastroenterol 2006 Aug;101(8):1900-20; quiz 1943. doi: 10.1111/j.1572-0241.2006.00630.x. PMID: 16928254

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