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Minimally Invasive Lung Non-Mucinous Adenocarcinoma

MedGen UID:
266089
•Concept ID:
C1266034
•
Neoplastic Process
Synonyms: Bronchiolo-alveolar carcinoma, Clara cell; Bronchiolo-alveolar carcinoma, non-mucinous; Bronchiolo-alveolar carcinoma, type II pneumocyte; Non-Mucinous Minimally Invasive Lung Adenocarcinoma
SNOMED CT: Bronchiolo-alveolar carcinoma, type II pneumocyte (128659000); Bronchiolo-alveolar carcinoma, Clara cell (128659000); Bronchiolo-alveolar carcinoma, non-mucinous (128659000)

Definition

A morphologic variant of minimally invasive lung adenocarcinoma characterized by the presence of Clara cells and/or type II cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMinimally Invasive Lung Non-Mucinous Adenocarcinoma

Recent clinical studies

Etiology

Validation Study of New IASLC Histology Grading System in Stage I Non-Mucinous Adenocarcinoma Comparing With Minimally Invasive Adenocarcinoma.
Woo W, Cha YJ, Kim BJ, Moon DH, Lee S
Clin Lung Cancer 2022 Nov;23(7):e435-e442. Epub 2022 Jun 22 doi: 10.1016/j.cllc.2022.06.004. PMID: 35945128
Distinctive clinicopathological features of adenocarcinoma in situ and minimally invasive adenocarcinoma of the lung: A retrospective study.
Ishida H, Shimizu Y, Sakaguchi H, Nitanda H, Kaneko K, Yamazaki N, Yanagihara A, Taguchi R, Sakai F, Yasuda M, Kobayashi K
Lung Cancer 2019 Mar;129:16-21. Epub 2018 Dec 19 doi: 10.1016/j.lungcan.2018.12.020. PMID: 30797486
Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases.
Yoshizawa A, Motoi N, Riely GJ, Sima CS, Gerald WL, Kris MG, Park BJ, Rusch VW, Travis WD
Mod Pathol 2011 May;24(5):653-64. Epub 2011 Jan 21 doi: 10.1038/modpathol.2010.232. PMID: 21252858

Diagnosis

Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases.
Yoshizawa A, Motoi N, Riely GJ, Sima CS, Gerald WL, Kris MG, Park BJ, Rusch VW, Travis WD
Mod Pathol 2011 May;24(5):653-64. Epub 2011 Jan 21 doi: 10.1038/modpathol.2010.232. PMID: 21252858

Prognosis

Validation Study of New IASLC Histology Grading System in Stage I Non-Mucinous Adenocarcinoma Comparing With Minimally Invasive Adenocarcinoma.
Woo W, Cha YJ, Kim BJ, Moon DH, Lee S
Clin Lung Cancer 2022 Nov;23(7):e435-e442. Epub 2022 Jun 22 doi: 10.1016/j.cllc.2022.06.004. PMID: 35945128
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases.
Yoshizawa A, Motoi N, Riely GJ, Sima CS, Gerald WL, Kris MG, Park BJ, Rusch VW, Travis WD
Mod Pathol 2011 May;24(5):653-64. Epub 2011 Jan 21 doi: 10.1038/modpathol.2010.232. PMID: 21252858

Clinical prediction guides

Validation Study of New IASLC Histology Grading System in Stage I Non-Mucinous Adenocarcinoma Comparing With Minimally Invasive Adenocarcinoma.
Woo W, Cha YJ, Kim BJ, Moon DH, Lee S
Clin Lung Cancer 2022 Nov;23(7):e435-e442. Epub 2022 Jun 22 doi: 10.1016/j.cllc.2022.06.004. PMID: 35945128
Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas.
Sakamoto H, Shimizu J, Horio Y, Ueda R, Takahashi T, Mitsudomi T, Yatabe Y
J Pathol 2007 Jul;212(3):287-94. doi: 10.1002/path.2165. PMID: 17534846

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