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Epithelioid trophoblastic tumor

MedGen UID:
266107
•Concept ID:
C1266159
•
Neoplastic Process
Synonyms: Epithelioid Trophoblastic Tumor; epithelioid trophoblastic tumor; ETT; Trophoblastic tumor, epithelioid
SNOMED CT: Trophoblastic tumor, epithelioid (128767001); Epithelioid trophoblastic tumor (609515005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016787
Orphanet: ORPHA254698

Definition

A rare gestational trophoblastic neoplasmcharacterized histologically by invasion of the myometrium and/or cervix uteri by regular epithelioid cells of chorion laeve type intermediate trophoblasts which clusters in a hyaline stroma. The disease generally occurs several years after pregnancy and indicative signs are irregular metrorrhagia and moderate increases in chorionic gonadotropin levels. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpithelioid trophoblastic tumor
Follow this link to review classifications for Epithelioid trophoblastic tumor in Orphanet.

Professional guidelines

PubMed

Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Recent clinical studies

Etiology

Gestational trophoblastic disease: an update.
Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Epithelioid trophoblastic tumor: A case series.
Dash SS, Sakhadeo U, Karmarkar S, Mittal N, Menon S, Rekhi B, Deodhar KK
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):148-151. doi: 10.4103/ijpm.ijpm_212_22. PMID: 36656227
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Diagnosis

Gestational trophoblastic disease: an update.
Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Epithelioid trophoblastic tumor.
Keser SH, Kokten SC, Cakir C, Sensu S, Buyukbayrak EE, Karadayi N
Taiwan J Obstet Gynecol 2015 Oct;54(5):621-4. doi: 10.1016/j.tjog.2015.08.020. PMID: 26522123
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Therapy

Management of trophoblastic tumors : review of evidence, current practice, and future directions.
Deleuze A, Massard C, Le Du F, You B, Lefeuvre-Plesse C, Bolze PA, de la Motte Rouge T
Expert Rev Anticancer Ther 2023 Jul;23(7):699-708. Epub 2023 May 22 doi: 10.1080/14737140.2023.2215438. PMID: 37198729
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Placental site trophoblastic tumors and epithelioid trophoblastic tumors: Biology, natural history, and treatment modalities.
Horowitz NS, Goldstein DP, Berkowitz RS
Gynecol Oncol 2017 Jan;144(1):208-214. Epub 2016 Oct 24 doi: 10.1016/j.ygyno.2016.10.024. PMID: 27789086
Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia.
Lurain JR
Am J Obstet Gynecol 2011 Jan;204(1):11-8. Epub 2010 Aug 24 doi: 10.1016/j.ajog.2010.06.072. PMID: 20739008
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Prognosis

Gestational trophoblastic disease: an update.
Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Gestational Trophoblastic Disease: Contemporary Diagnostic Approach.
Buza N
Surg Pathol Clin 2022 Jun;15(2):197-218. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.002. PMID: 35715158
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Epithelioid trophoblastic tumor.
Keser SH, Kokten SC, Cakir C, Sensu S, Buyukbayrak EE, Karadayi N
Taiwan J Obstet Gynecol 2015 Oct;54(5):621-4. doi: 10.1016/j.tjog.2015.08.020. PMID: 26522123
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Clinical prediction guides

Gestational trophoblastic disease: an update.
Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Clinical features and management of trophoblastic epithelioid tumors: A systematic review.
Gorun F, Tomescu L, Motoc A, Citu C, Sas I, Serban DM, Forga M, Citu IM, Gorun OM
Medicine (Baltimore) 2022 Jul 29;101(30):e29934. doi: 10.1097/MD.0000000000029934. PMID: 35905248Free PMC Article
Diagnosis and management of gestational trophoblastic disease: 2021 update.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Gestational trophoblastic neoplasia: Novelties and challenges.
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Update on the diagnosis and management of gestational trophoblastic disease.
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586

Recent systematic reviews

Clinical features and management of trophoblastic epithelioid tumors: A systematic review.
Gorun F, Tomescu L, Motoc A, Citu C, Sas I, Serban DM, Forga M, Citu IM, Gorun OM
Medicine (Baltimore) 2022 Jul 29;101(30):e29934. doi: 10.1097/MD.0000000000029934. PMID: 35905248Free PMC Article
Fertility and pregnancy outcome in gestational trophoblastic disease.
Joneborg U, Coopmans L, van Trommel N, Seckl M, Lok CAR
Int J Gynecol Cancer 2021 Mar;31(3):399-411. doi: 10.1136/ijgc-2020-001784. PMID: 33649007
Placental site trophoblastic tumor and epithelioid trophoblastic tumor: Clinical and pathological features, prognostic variables and treatment strategy.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2019 Jun;153(3):684-693. Epub 2019 Apr 30 doi: 10.1016/j.ygyno.2019.03.011. PMID: 31047719

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