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Epithelioid trophoblastic tumor

MedGen UID:
266107
Concept ID:
C1266159
Neoplastic Process
Synonyms: Epithelioid Trophoblastic Tumor; epithelioid trophoblastic tumor; ETT; Trophoblastic tumor, epithelioid
SNOMED CT: Trophoblastic tumor, epithelioid (128767001); Epithelioid trophoblastic tumor (609515005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016787
Orphanet: ORPHA254698

Definition

A rare gestational trophoblastic neoplasmcharacterized histologically by invasion of the myometrium and/or cervix uteri by regular epithelioid cells of chorion laeve type intermediate trophoblasts which clusters in a hyaline stroma. The disease generally occurs several years after pregnancy and indicative signs are irregular metrorrhagia and moderate increases in chorionic gonadotropin levels. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpithelioid trophoblastic tumor
Follow this link to review classifications for Epithelioid trophoblastic tumor in Orphanet.

Professional guidelines

PubMed

Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Recent clinical studies

Etiology

Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Dash SS, Sakhadeo U, Karmarkar S, Mittal N, Menon S, Rekhi B, Deodhar KK
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):148-151. doi: 10.4103/ijpm.ijpm_212_22. PMID: 36656227
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Diagnosis

Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Dash SS, Sakhadeo U, Karmarkar S, Mittal N, Menon S, Rekhi B, Deodhar KK
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):148-151. doi: 10.4103/ijpm.ijpm_212_22. PMID: 36656227
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Therapy

Deleuze A, Massard C, Le Du F, You B, Lefeuvre-Plesse C, Bolze PA, de la Motte Rouge T
Expert Rev Anticancer Ther 2023 Jul;23(7):699-708. Epub 2023 May 22 doi: 10.1080/14737140.2023.2215438. PMID: 37198729
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Horowitz NS, Goldstein DP, Berkowitz RS
Gynecol Oncol 2017 Jan;144(1):208-214. Epub 2016 Oct 24 doi: 10.1016/j.ygyno.2016.10.024. PMID: 27789086
Lurain JR
Am J Obstet Gynecol 2011 Jan;204(1):11-8. Epub 2010 Aug 24 doi: 10.1016/j.ajog.2010.06.072. PMID: 20739008
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Prognosis

Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Buza N
Surg Pathol Clin 2022 Jun;15(2):197-218. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.002. PMID: 35715158
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586
Keser SH, Kokten SC, Cakir C, Sensu S, Buyukbayrak EE, Karadayi N
Taiwan J Obstet Gynecol 2015 Oct;54(5):621-4. doi: 10.1016/j.tjog.2015.08.020. PMID: 26522123
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Clinical prediction guides

Chawla T, Bouchard-Fortier G, Turashvili G, Osborne R, Hack K, Glanc P
Abdom Radiol (NY) 2023 May;48(5):1793-1815. Epub 2023 Feb 10 doi: 10.1007/s00261-023-03820-5. PMID: 36763119
Gorun F, Tomescu L, Motoc A, Citu C, Sas I, Serban DM, Forga M, Citu IM, Gorun OM
Medicine (Baltimore) 2022 Jul 29;101(30):e29934. doi: 10.1097/MD.0000000000029934. PMID: 35905248Free PMC Article
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):86-93. doi: 10.1002/ijgo.13877. PMID: 34669197Free PMC Article
Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753
Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK, Lurain JR, Massuger L
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85. doi: 10.1002/ijgo.12615. PMID: 30306586

Recent systematic reviews

Gorun F, Tomescu L, Motoc A, Citu C, Sas I, Serban DM, Forga M, Citu IM, Gorun OM
Medicine (Baltimore) 2022 Jul 29;101(30):e29934. doi: 10.1097/MD.0000000000029934. PMID: 35905248Free PMC Article
Joneborg U, Coopmans L, van Trommel N, Seckl M, Lok CAR
Int J Gynecol Cancer 2021 Mar;31(3):399-411. doi: 10.1136/ijgc-2020-001784. PMID: 33649007
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2019 Jun;153(3):684-693. Epub 2019 Apr 30 doi: 10.1016/j.ygyno.2019.03.011. PMID: 31047719

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