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Sebaceoma

MedGen UID:
266153
•Concept ID:
C1275210
•
Neoplastic Process
Synonyms: Infundibular Adenoma; Poroma-Like Adnexal Neoplasm; Sebaceous Epithelioma; Sebocrine Adenoma; Sebomatricoma
SNOMED CT: Sebaceoma (403933005); Sebaceoma (1295243008)

Definition

A benign sebaceous neoplasm arising in the deep dermis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSebaceoma

Professional guidelines

PubMed

Dermoscopic features and differential diagnosis of sebaceous carcinoma.
Cheng CY, Su HJ, Kuo TT
J Dermatol 2020 Jul;47(7):755-762. Epub 2020 May 16 doi: 10.1111/1346-8138.15384. PMID: 32415798

Recent clinical studies

Etiology

Lynch syndrome: An unusal case of familial cancer unearthed.
Dhar S, Mannan AU, Singh JJ, Dhar S, Pradhan S
Indian J Pathol Microbiol 2022 Apr-Jun;65(2):465-467. doi: 10.4103/IJPM.IJPM_809_19. PMID: 35435397
CT and MRI features of scalp lesions.
Kawaguchi M, Kato H, Matsuo M
Radiol Med 2019 Oct;124(10):1049-1061. Epub 2019 Jul 3 doi: 10.1007/s11547-019-01060-6. PMID: 31270724
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome.
Roberts ME, Riegert-Johnson DL, Thomas BC, Rumilla KM, Thomas CS, Heckman MG, Purcell JU, Hanson NB, Leppig KA, Lim J, Cappel MA
Genet Med 2014 Sep;16(9):711-6. Epub 2014 Mar 6 doi: 10.1038/gim.2014.19. PMID: 24603434
Rippled-pattern sebaceoma: a report of a lesion on the back with a review of the literature.
Kiyohara T, Kumakiri M, Kuwahara H, Saitoh A, Ansai S
Am J Dermatopathol 2006 Oct;28(5):446-8. doi: 10.1097/01.dad.0000211504.14371.b2. PMID: 17012924

Diagnosis

Molecular Genetics of Sebaceous Neoplasia.
North JP
Surg Pathol Clin 2021 Jun;14(2):273-284. doi: 10.1016/j.path.2021.03.005. PMID: 34023105
CT and MRI features of scalp lesions.
Kawaguchi M, Kato H, Matsuo M
Radiol Med 2019 Oct;124(10):1049-1061. Epub 2019 Jul 3 doi: 10.1007/s11547-019-01060-6. PMID: 31270724
Sebaceous lesions of the skin.
Iacobelli J, Harvey NT, Wood BA
Pathology 2017 Dec;49(7):688-697. Epub 2017 Oct 25 doi: 10.1016/j.pathol.2017.08.012. PMID: 29078997
Sebaceous Neoplasms.
Flux K
Surg Pathol Clin 2017 Jun;10(2):367-382. doi: 10.1016/j.path.2017.01.009. PMID: 28477886
A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome.
Roberts ME, Riegert-Johnson DL, Thomas BC, Rumilla KM, Thomas CS, Heckman MG, Purcell JU, Hanson NB, Leppig KA, Lim J, Cappel MA
Genet Med 2014 Sep;16(9):711-6. Epub 2014 Mar 6 doi: 10.1038/gim.2014.19. PMID: 24603434

Therapy

Lipid synthesis and processing proteins ABHD5, PGRMC1 and squalene synthase can serve as novel immunohistochemical markers for sebaceous neoplasms and differentiate sebaceous carcinoma from sebaceoma and basal cell carcinoma with clear cell features.
Chen WS, Chen PL, Li J, Lind AC, Lu D
J Cutan Pathol 2013 Jul;40(7):631-8. Epub 2013 Apr 5 doi: 10.1111/cup.12147. PMID: 23557589

Prognosis

Update on the pathology, genetics and somatic landscape of sebaceous tumours.
Ferreira I, Wiedemeyer K, Demetter P, Adams DJ, Arends MJ, Brenn T
Histopathology 2020 Apr;76(5):640-649. Epub 2020 Mar 17 doi: 10.1111/his.14044. PMID: 31821583
Frequent TLE1 Expression in Cutaneous Neoplasms.
Xiong Y, Dresser K, Cornejo KM
Am J Dermatopathol 2019 Jan;41(1):1-6. doi: 10.1097/DAD.0000000000001186. PMID: 30608261
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome.
Roberts ME, Riegert-Johnson DL, Thomas BC, Rumilla KM, Thomas CS, Heckman MG, Purcell JU, Hanson NB, Leppig KA, Lim J, Cappel MA
Genet Med 2014 Sep;16(9):711-6. Epub 2014 Mar 6 doi: 10.1038/gim.2014.19. PMID: 24603434
Rippled-pattern sebaceoma: a report of a lesion on the back with a review of the literature.
Kiyohara T, Kumakiri M, Kuwahara H, Saitoh A, Ansai S
Am J Dermatopathol 2006 Oct;28(5):446-8. doi: 10.1097/01.dad.0000211504.14371.b2. PMID: 17012924

Clinical prediction guides

Frequent TLE1 Expression in Cutaneous Neoplasms.
Xiong Y, Dresser K, Cornejo KM
Am J Dermatopathol 2019 Jan;41(1):1-6. doi: 10.1097/DAD.0000000000001186. PMID: 30608261
Clinicopathological study of 47 cases of sebaceoma.
Bourlond F, Velter C, Cribier B
Ann Dermatol Venereol 2016 Dec;143(12):814-824. Epub 2016 Nov 9 doi: 10.1016/j.annder.2016.06.013. PMID: 27836252
Intraepidermal benign sebaceous neoplasm: apocrine poroma (hidroacanthoma simplex type) with extensive sebaceous differentiation with sebaceoma-like features.
Misago N, Inoue T, Toda S
J Cutan Pathol 2016 Feb;43(2):171-6. Epub 2015 Sep 21 doi: 10.1111/cup.12615. PMID: 26282586
A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome.
Roberts ME, Riegert-Johnson DL, Thomas BC, Rumilla KM, Thomas CS, Heckman MG, Purcell JU, Hanson NB, Leppig KA, Lim J, Cappel MA
Genet Med 2014 Sep;16(9):711-6. Epub 2014 Mar 6 doi: 10.1038/gim.2014.19. PMID: 24603434
Rippled-pattern sebaceoma.
Misago N, Narisawa Y
Am J Dermatopathol 2001 Oct;23(5):437-43. doi: 10.1097/00000372-200110000-00009. PMID: 11801777

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