U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spindle cell liposarcoma

MedGen UID:
266156
Concept ID:
C1275275
Neoplastic Process
Synonyms: Atypical Spindle Cell Lipoma; Atypical Spindle Cell/Pleomorphic Lipomatous Tumor; spindle cell liposarcoma
SNOMED CT: Spindle cell liposarcoma (404073009)
 
Monarch Initiative: MONDO:0003596

Definition

A benign adipocytic neoplasm, characterized by ill-defined tumor margins and the presence of variable proportions of mild to moderately atypical spindle cells, adipocytes, lipoblasts, pleomorphic cells, multinucleated giant cells, and a myxoid or collagenous extracellular matrix. It has a low tendency for local recurrence if incompletely excised. Unlike conventional atypical lipomatous tumors, there is no risk for dedifferentiation. (WHO 2020) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpindle cell liposarcoma

Professional guidelines

PubMed

Thway K, Fisher C
Semin Diagn Pathol 2021 Nov;38(6):170-186. Epub 2021 Sep 29 doi: 10.1053/j.semdp.2021.09.005. PMID: 34602314
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Barisella M, Giannini L, Piazza C
Curr Opin Otolaryngol Head Neck Surg 2020 Apr;28(2):136-143. doi: 10.1097/MOO.0000000000000608. PMID: 32011399

Recent clinical studies

Etiology

Occidental M, Shen G, Feng X, Zhu K, Kelly K, Nie Q, Reddi HV, Lakiotaki E, Viniou NA, Korkolopoulou P, Linos K, Jour G
Genes Chromosomes Cancer 2020 Sep;59(9):544-548. Epub 2020 May 6 doi: 10.1002/gcc.22856. PMID: 32352179
Deyrup AT, Chibon F, Guillou L, Lagarde P, Coindre JM, Weiss SW
Am J Surg Pathol 2013 Sep;37(9):1373-8. doi: 10.1097/PAS.0b013e31829562ed. PMID: 23887155
Dei Tos AP
Ann Diagn Pathol 2000 Aug;4(4):252-66. doi: 10.1053/adpa.2000.8133. PMID: 10982304
Mentzel T, Fletcher CD
Virchows Arch 1995;427(4):353-63. doi: 10.1007/BF00199383. PMID: 8548119
Dei Tos AP, Mentzel T, Newman PL, Fletcher CD
Am J Surg Pathol 1994 Sep;18(9):913-21. doi: 10.1097/00000478-199409000-00006. PMID: 8067512

Diagnosis

Liao X, Fulmer S, Zhang D
In Vivo 2021 Sep-Oct;35(5):2779-2783. doi: 10.21873/invivo.12563. PMID: 34410968Free PMC Article
Laurino L, Furlanetto A, Orvieto E, Dei Tos AP
Semin Diagn Pathol 2001 Nov;18(4):258-62. PMID: 11757865
Dei Tos AP
Ann Diagn Pathol 2000 Aug;4(4):252-66. doi: 10.1053/adpa.2000.8133. PMID: 10982304
Gómez-Román JJ, Val-Bernal JF
Pathology 1997 Nov;29(4):428-30. doi: 10.1080/00313029700169475. PMID: 9423230
Mentzel T, Fletcher CD
Virchows Arch 1995;427(4):353-63. doi: 10.1007/BF00199383. PMID: 8548119

Therapy

Tehrani AH, Heegaard S, Prause JU, Fledelius HC, Daugaard S
Eur J Ophthalmol 2003 Jan-Feb;13(1):108-12. doi: 10.1177/112067210301300121. PMID: 12635688

Prognosis

Fletcher CD
Mod Pathol 2014 Jan;27 Suppl 1:S98-112. doi: 10.1038/modpathol.2013.172. PMID: 24384856
Shioi Y, Hasegawa T, Otsuka K, Fujisawa K, Itabashi T, Kimura T, Wakabayashi G, Mue Y, Uesugi N, Sugai T
Pathol Int 2010 Jun;60(6):472-6. doi: 10.1111/j.1440-1827.2010.02541.x. PMID: 20518903
Agostini T, Catelani C, Acocella A, Franchi A, Bertolai R, Sacco R, Lazzeri D, Shokrollahi K
Br J Dermatol 2010 Sep;163(3):638-40. Epub 2010 May 8 doi: 10.1111/j.1365-2133.2010.09847.x. PMID: 20456346
Dei Tos AP
Ann Diagn Pathol 2000 Aug;4(4):252-66. doi: 10.1053/adpa.2000.8133. PMID: 10982304
Gómez-Román JJ, Val-Bernal JF
Pathology 1997 Nov;29(4):428-30. doi: 10.1080/00313029700169475. PMID: 9423230

Clinical prediction guides

Mustapar N, Zawawi MSF, Tuan Sharif SE
Asian Pac J Cancer Prev 2020 Mar 1;21(3):699-705. doi: 10.31557/APJCP.2020.21.3.699. PMID: 32212796Free PMC Article
Fletcher CD
Mod Pathol 2014 Jan;27 Suppl 1:S98-112. doi: 10.1038/modpathol.2013.172. PMID: 24384856
Dei Tos AP
Ann Diagn Pathol 2000 Aug;4(4):252-66. doi: 10.1053/adpa.2000.8133. PMID: 10982304
Fanburg-Smith JC, Devaney KO, Miettinen M, Weiss SW
Am J Surg Pathol 1998 Jan;22(1):40-8. doi: 10.1097/00000478-199801000-00005. PMID: 9422314
Dei Tos AP, Mentzel T, Newman PL, Fletcher CD
Am J Surg Pathol 1994 Sep;18(9):913-21. doi: 10.1097/00000478-199409000-00006. PMID: 8067512

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...