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DNA Replication Damage

MedGen UID:
267857
•Concept ID:
C1511690
•
Cell or Molecular Dysfunction
Synonym: DNA Replicating Damage

Definition

DNA sequence errors introduced via DNA replication. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Replication Damage

Professional guidelines

PubMed

Molecular pathways: rodent parvoviruses--mechanisms of oncolysis and prospects for clinical cancer treatment.
Nüesch JP, Lacroix J, Marchini A, Rommelaere J
Clin Cancer Res 2012 Jul 1;18(13):3516-23. Epub 2012 May 7 doi: 10.1158/1078-0432.CCR-11-2325. PMID: 22566376

Recent clinical studies

Etiology

GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.
Guerenne L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P, Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME, Pla M, Fenaux P, Padua RA, Chomienne C, Krief P
J Hematol Oncol 2016 Jan 27;9:5. doi: 10.1186/s13045-016-0235-8. PMID: 26817437Free PMC Article
Heterozygous mutations in PALB2 cause DNA replication and damage response defects.
Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech H, Winqvist R
Nat Commun 2013;4:2578. doi: 10.1038/ncomms3578. PMID: 24153426Free PMC Article
Breast cancer and post-menopausal hormone therapy.
Kenemans P, Bosman A
Best Pract Res Clin Endocrinol Metab 2003 Mar;17(1):123-37. doi: 10.1016/s1521-690x(02)00084-2. PMID: 12763516

Diagnosis

Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.
Yan Y, Han X, Qing Y, Condie AG, Gorityala S, Yang S, Xu Y, Zhang Y, Gerson SL
Oncotarget 2016 Sep 13;7(37):59299-59313. doi: 10.18632/oncotarget.11151. PMID: 27517750Free PMC Article
 p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.
Sanhaji M, Kreis NN, Zimmer B, Berg T, Louwen F, Yuan J
Cell Cycle 2012 Feb 1;11(3):543-53. doi: 10.4161/cc.11.3.19076. PMID: 22262171
Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses.
Noguchi K, Fukazawa H, Murakami Y, Uehara Y
J Biol Chem 2002 Oct 18;277(42):39655-65. Epub 2002 Aug 1 doi: 10.1074/jbc.M204599200. PMID: 12154088

Therapy

Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.
Yan Y, Han X, Qing Y, Condie AG, Gorityala S, Yang S, Xu Y, Zhang Y, Gerson SL
Oncotarget 2016 Sep 13;7(37):59299-59313. doi: 10.18632/oncotarget.11151. PMID: 27517750Free PMC Article
Breast cancer and post-menopausal hormone therapy.
Kenemans P, Bosman A
Best Pract Res Clin Endocrinol Metab 2003 Mar;17(1):123-37. doi: 10.1016/s1521-690x(02)00084-2. PMID: 12763516

Prognosis

Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA.
Sugitani N, Chazin WJ
Prog Biophys Mol Biol 2015 Mar;117(2-3):206-211. Epub 2014 Dec 25 doi: 10.1016/j.pbiomolbio.2014.12.001. PMID: 25542993Free PMC Article
 p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.
Sanhaji M, Kreis NN, Zimmer B, Berg T, Louwen F, Yuan J
Cell Cycle 2012 Feb 1;11(3):543-53. doi: 10.4161/cc.11.3.19076. PMID: 22262171
Breast cancer and post-menopausal hormone therapy.
Kenemans P, Bosman A
Best Pract Res Clin Endocrinol Metab 2003 Mar;17(1):123-37. doi: 10.1016/s1521-690x(02)00084-2. PMID: 12763516

Clinical prediction guides

Heterozygous mutations in PALB2 cause DNA replication and damage response defects.
Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech H, Winqvist R
Nat Commun 2013;4:2578. doi: 10.1038/ncomms3578. PMID: 24153426Free PMC Article
 p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors.
Sanhaji M, Kreis NN, Zimmer B, Berg T, Louwen F, Yuan J
Cell Cycle 2012 Feb 1;11(3):543-53. doi: 10.4161/cc.11.3.19076. PMID: 22262171
Breast cancer and post-menopausal hormone therapy.
Kenemans P, Bosman A
Best Pract Res Clin Endocrinol Metab 2003 Mar;17(1):123-37. doi: 10.1016/s1521-690x(02)00084-2. PMID: 12763516

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