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Hepatocarcinogenesis

MedGen UID:
268184
Concept ID:
C1512409
Neoplastic Process
Synonym: Liver Carcinogenesis

Definition

The processes which result in cancers in the liver. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatocarcinogenesis

Professional guidelines

PubMed

Damaskos C, Garmpis N, Dimitroulis D, Garmpi A, Psilopatis I, Sarantis P, Koustas E, Kanavidis P, Prevezanos D, Kouraklis G, Karamouzis MV, Marinos G, Kontzoglou K, Antoniou EA
Int J Mol Sci 2022 Nov 15;23(22) doi: 10.3390/ijms232214117. PMID: 36430594Free PMC Article
Yegin EG, Oymaci E, Karatay E, Coker A
Hepatobiliary Pancreat Dis Int 2016 Jun;15(3):234-56. doi: 10.1016/s1499-3872(16)60097-8. PMID: 27298100
Vilchez V, Turcios L, Marti F, Gedaly R
World J Gastroenterol 2016 Jan 14;22(2):823-32. doi: 10.3748/wjg.v22.i2.823. PMID: 26811628Free PMC Article

Recent clinical studies

Etiology

He F, Zhang P, Liu J, Wang R, Kaufman RJ, Yaden BC, Karin M
J Hepatol 2023 Aug;79(2):362-377. Epub 2023 Mar 28 doi: 10.1016/j.jhep.2023.03.016. PMID: 36996941Free PMC Article
Filliol A, Saito Y, Nair A, Dapito DH, Yu LX, Ravichandra A, Bhattacharjee S, Affo S, Fujiwara N, Su H, Sun Q, Savage TM, Wilson-Kanamori JR, Caviglia JM, Chin L, Chen D, Wang X, Caruso S, Kang JK, Amin AD, Wallace S, Dobie R, Yin D, Rodriguez-Fiallos OM, Yin C, Mehal A, Izar B, Friedman RA, Wells RG, Pajvani UB, Hoshida Y, Remotti HE, Arpaia N, Zucman-Rossi J, Karin M, Henderson NC, Tabas I, Schwabe RF
Nature 2022 Oct;610(7931):356-365. Epub 2022 Oct 5 doi: 10.1038/s41586-022-05289-6. PMID: 36198802Free PMC Article
Rizzo GEM, Cabibbo G, Craxì A
Viruses 2022 May 7;14(5) doi: 10.3390/v14050986. PMID: 35632728Free PMC Article
Ioannou GN
J Hepatol 2021 Dec;75(6):1476-1484. Epub 2021 Aug 25 doi: 10.1016/j.jhep.2021.08.012. PMID: 34453963
Marengo A, Rosso C, Bugianesi E
Annu Rev Med 2016;67:103-17. Epub 2015 Oct 14 doi: 10.1146/annurev-med-090514-013832. PMID: 26473416

Diagnosis

Wang Y, Zhao M, Zhao L, Geng Y, Li G, Chen L, Yu J, Yuan H, Zhang H, Yun H, Yuan Y, Wang G, Feng J, Xu L, Wang S, Hou C, Yang G, Zhang N, Lu W, Zhang X
Cancer Res 2023 Apr 4;83(7):1048-1061. doi: 10.1158/0008-5472.CAN-22-3169. PMID: 36745032
Zhan X, Wu R, Kong XH, You Y, He K, Sun XY, Huang Y, Chen WX, Duan L
Cancer Commun (Lond) 2023 Feb;43(2):225-245. Epub 2022 Nov 8 doi: 10.1002/cac2.12388. PMID: 36346061Free PMC Article
Xu C, Xu Z, Zhang Y, Evert M, Calvisi DF, Chen X
J Clin Invest 2022 Feb 15;132(4) doi: 10.1172/JCI154515. PMID: 35166233Free PMC Article
D'souza S, Lau KC, Coffin CS, Patel TR
World J Gastroenterol 2020 Oct 14;26(38):5759-5783. doi: 10.3748/wjg.v26.i38.5759. PMID: 33132633Free PMC Article
Marengo A, Rosso C, Bugianesi E
Annu Rev Med 2016;67:103-17. Epub 2015 Oct 14 doi: 10.1146/annurev-med-090514-013832. PMID: 26473416

Therapy

Li Z, Zhou Y, Jia K, Yang Y, Zhang L, Wang S, Dong Y, Wang M, Li Y, Lu S, Zhang W, Zhang L, Fan Y, Zhang D, Li N, Yu Y, Cao X, Hou J
J Hematol Oncol 2022 Nov 4;15(1):161. doi: 10.1186/s13045-022-01381-6. PMID: 36333807Free PMC Article
Yang Y, Sun M, Li W, Liu C, Jiang Z, Gu P, Li J, Wang W, You R, Ba Q, Li X, Wang H
Clin Transl Med 2021 Jul;11(7):e410. doi: 10.1002/ctm2.410. PMID: 34323416Free PMC Article
DeWaal D, Nogueira V, Terry AR, Patra KC, Jeon SM, Guzman G, Au J, Long CP, Antoniewicz MR, Hay N
Nat Commun 2018 Jan 31;9(1):446. doi: 10.1038/s41467-017-02733-4. PMID: 29386513Free PMC Article
Narsinh KH, Cui J, Papadatos D, Sirlin CB, Santillan CS
Abdom Radiol (NY) 2018 Jan;43(1):158-168. doi: 10.1007/s00261-017-1409-8. PMID: 29209739
Minemura M, Shimizu Y
World J Gastroenterol 2015 Feb 14;21(6):1691-702. doi: 10.3748/wjg.v21.i6.1691. PMID: 25684933Free PMC Article

Prognosis

Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu L
J Hepatol 2024 Feb;80(2):282-292. Epub 2023 Oct 27 doi: 10.1016/j.jhep.2023.10.018. PMID: 37890720Free PMC Article
Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M, Singer MT, Büttner V, Keysberg LS, Küsgens L, Kohlhepp M, Görg B, Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond AL, Albrecht W, Loosen SH, Lohr C, Jördens MS, Babler A, Hayat S, Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jörs S, Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G, Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C, Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M, Luedde T
Immunity 2023 Jul 11;56(7):1578-1595.e8. Epub 2023 Jun 16 doi: 10.1016/j.immuni.2023.05.017. PMID: 37329888
Zhan X, Wu R, Kong XH, You Y, He K, Sun XY, Huang Y, Chen WX, Duan L
Cancer Commun (Lond) 2023 Feb;43(2):225-245. Epub 2022 Nov 8 doi: 10.1002/cac2.12388. PMID: 36346061Free PMC Article
Hernandez-Meza G, von Felden J, Gonzalez-Kozlova EE, Garcia-Lezana T, Peix J, Portela A, Craig AJ, Sayols S, Schwartz M, Losic B, Mazzaferro V, Esteller M, Llovet JM, Villanueva A
Hepatology 2021 Jul;74(1):183-199. Epub 2021 Jun 15 doi: 10.1002/hep.31659. PMID: 33237575Free PMC Article
El-Serag HB, Rudolph KL
Gastroenterology 2007 Jun;132(7):2557-76. doi: 10.1053/j.gastro.2007.04.061. PMID: 17570226

Clinical prediction guides

Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu L
J Hepatol 2024 Feb;80(2):282-292. Epub 2023 Oct 27 doi: 10.1016/j.jhep.2023.10.018. PMID: 37890720Free PMC Article
Sun J, Ding J, Shen Q, Wang X, Wang M, Huang Y, Zhang X, Zhu H, Zhang F, Wu D, Peng M, Zhang Z, Yuan Y, Li W, She ZG, Zhang XJ, Li H, Zhang P, Huang Z
J Hepatol 2023 Mar;78(3):627-642. Epub 2022 Dec 1 doi: 10.1016/j.jhep.2022.11.017. PMID: 36462680
Zhan X, Wu R, Kong XH, You Y, He K, Sun XY, Huang Y, Chen WX, Duan L
Cancer Commun (Lond) 2023 Feb;43(2):225-245. Epub 2022 Nov 8 doi: 10.1002/cac2.12388. PMID: 36346061Free PMC Article
Liu B, Zhou Z, Jin Y, Lu J, Feng D, Peng R, Sun H, Mu X, Li C, Chen Y
J Immunother Cancer 2022 Jan;10(1) doi: 10.1136/jitc-2021-003069. PMID: 34996812Free PMC Article
Ponziani FR, Bhoori S, Castelli C, Putignani L, Rivoltini L, Del Chierico F, Sanguinetti M, Morelli D, Paroni Sterbini F, Petito V, Reddel S, Calvani R, Camisaschi C, Picca A, Tuccitto A, Gasbarrini A, Pompili M, Mazzaferro V
Hepatology 2019 Jan;69(1):107-120. Epub 2018 Jul 10 doi: 10.1002/hep.30036. PMID: 29665135

Recent systematic reviews

Damaskos C, Garmpis N, Dimitroulis D, Garmpi A, Psilopatis I, Sarantis P, Koustas E, Kanavidis P, Prevezanos D, Kouraklis G, Karamouzis MV, Marinos G, Kontzoglou K, Antoniou EA
Int J Mol Sci 2022 Nov 15;23(22) doi: 10.3390/ijms232214117. PMID: 36430594Free PMC Article
Wu IC, Liu WC, Chang TT
J Biomed Sci 2018 Jun 2;25(1):51. doi: 10.1186/s12929-018-0442-4. PMID: 29859540Free PMC Article
Zoller H, Tilg H
Metabolism 2016 Aug;65(8):1151-60. Epub 2016 Jan 23 doi: 10.1016/j.metabol.2016.01.010. PMID: 26907206
Pang Q, Qu K, Zhang JY, Song SD, Liu SS, Tai MH, Liu HC, Liu C
Medicine (Baltimore) 2015 Sep;94(37):e1431. doi: 10.1097/MD.0000000000001431. PMID: 26376382Free PMC Article
Zang JJ, Xie F, Xu JF, Qin YY, Shen RX, Yang JM, He J
World J Gastroenterol 2011 Jul 7;17(25):3043-8. doi: 10.3748/wjg.v17.i25.3043. PMID: 21799651Free PMC Article

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