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Carcinogenesis

MedGen UID:: 154544
•Concept ID:: C0596263
•: Neoplastic Process

Synonyms:

Carcinogeneses; Oncogeneses; Oncogenesis; Tumorigeneses; Tumorigenesis

Definition

A pathological process in which normal cells are transformed into malignant cancer cells within a primary tumor. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVCarcinogenesis

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Neoplastic Processes
        Carcinogenesis
        Cocarcinogenesis
        Hepatocarcinogenesis
        Skin Carcinogenesis
        Tumorigenesis
        B-Lymphoma Development
        Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
        Cancer Cell Growth
        Leukemogenesis
        Mammary Tumorigenesis
        Tumor Initiation
        Transformation
        Tumor Promotion

Professional guidelines

PubMed

Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement.

Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N, Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL, Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L, Touraine P, van Santen HM, Johannsson G
Eur J Endocrinol 2022 Apr 21;186(6):P35-P52. doi: 10.1530/EJE-21-1186. PMID: 35319491 Free PMC Article

The Diagnosis and Treatment of Penile Cancer.

Hakenberg OW, Dräger DL, Erbersdobler A, Naumann CM, Jünemann KP, Protzel C
Dtsch Arztebl Int 2018 Sep 28;115(39):646-652. doi: 10.3238/arztebl.2018.0646. PMID: 30375327 Free PMC Article

Melasma and Post Inflammatory Hyperpigmentation: Management Update and Expert Opinion.

Sofen B, Prado G, Emer J
Skin Therapy Lett 2016 Jan;21(1):1-7. PMID: 27224897

See all (1293)

Recent clinical studies

Etiology

Alcohol and Cancer: Epidemiology and Biological Mechanisms.

Rumgay H, Murphy N, Ferrari P, Soerjomataram I
Nutrients 2021 Sep 11;13(9) doi: 10.3390/nu13093173. PMID: 34579050 Free PMC Article

Role of Oncogenes and Tumor-suppressor Genes in Carcinogenesis: A Review.

Kontomanolis EN, Koutras A, Syllaios A, Schizas D, Mastoraki A, Garmpis N, Diakosavvas M, Angelou K, Tsatsaris G, Pagkalos A, Ntounis T, Fasoulakis Z
Anticancer Res 2020 Nov;40(11):6009-6015. doi: 10.21873/anticanres.14622. PMID: 33109539

Alcohol and hepatocarcinogenesis.

Taniai M
Clin Mol Hepatol 2020 Oct;26(4):736-741. Epub 2020 Oct 1 doi: 10.3350/cmh.2020.0203. PMID: 33053943 Free PMC Article

Metals and molecular carcinogenesis.

Zhu Y, Costa M
Carcinogenesis 2020 Sep 24;41(9):1161-1172. doi: 10.1093/carcin/bgaa076. PMID: 32674145 Free PMC Article

Heat Shock Proteins and Cancer.

Wu J, Liu T, Rios Z, Mei Q, Lin X, Cao S
Trends Pharmacol Sci 2017 Mar;38(3):226-256. Epub 2016 Dec 22 doi: 10.1016/j.tips.2016.11.009. PMID: 28012700

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Diagnosis

The oral microbiota and its role in carcinogenesis.

Stasiewicz M, Karpiński TM
Semin Cancer Biol 2022 Nov;86(Pt 3):633-642. Epub 2021 Nov 4 doi: 10.1016/j.semcancer.2021.11.002. PMID: 34743032

Cervical Carcinoma: Oncobiology and Biomarkers.

Volkova LV, Pashov AI, Omelchuk NN
Int J Mol Sci 2021 Nov 22;22(22) doi: 10.3390/ijms222212571. PMID: 34830452 Free PMC Article

The roles of metallothioneins in carcinogenesis.

Si M, Lang J
J Hematol Oncol 2018 Aug 23;11(1):107. doi: 10.1186/s13045-018-0645-x. PMID: 30139373 Free PMC Article

Human Gut Microbiota and Gastrointestinal Cancer.

Meng C, Bai C, Brown TD, Hood LE, Tian Q
Genomics Proteomics Bioinformatics 2018 Feb;16(1):33-49. Epub 2018 Feb 21 doi: 10.1016/j.gpb.2017.06.002. PMID: 29474889 Free PMC Article

Cancer and the microbiota.

Garrett WS
Science 2015 Apr 3;348(6230):80-6. doi: 10.1126/science.aaa4972. PMID: 25838377 Free PMC Article

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Therapy

An expanded universe of cancer targets.

Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS; Cancer Target Discovery and Development Network
Cell 2021 Mar 4;184(5):1142-1155. doi: 10.1016/j.cell.2021.02.020. PMID: 33667368 Free PMC Article

Review of precision cancer medicine: Evolution of the treatment paradigm.

Tsimberidou AM, Fountzilas E, Nikanjam M, Kurzrock R
Cancer Treat Rev 2020 Jun;86:102019. Epub 2020 Mar 31 doi: 10.1016/j.ctrv.2020.102019. PMID: 32251926 Free PMC Article

Update on oncogenesis and therapy for Kaposi sarcoma.

Dupin N
Curr Opin Oncol 2020 Mar;32(2):122-128. doi: 10.1097/CCO.0000000000000601. PMID: 31815777

Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer.

Cheng X, Xu X, Chen D, Zhao F, Wang W
Biomed Pharmacother 2019 Feb;110:473-481. Epub 2018 Dec 6 doi: 10.1016/j.biopha.2018.11.082. PMID: 30530050

Targeting the microenvironment in solid tumors.

Belli C, Trapani D, Viale G, D'Amico P, Duso BA, Della Vigna P, Orsi F, Curigliano G
Cancer Treat Rev 2018 Apr;65:22-32. Epub 2018 Feb 22 doi: 10.1016/j.ctrv.2018.02.004. PMID: 29502037

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Prognosis

Field cancerization: Definition, epidemiology, risk factors, and outcomes.

Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665

Gastric Cancer: Where Are We Heading?

Petryszyn P, Chapelle N, Matysiak-Budnik T
Dig Dis 2020;38(4):280-285. Epub 2020 Feb 17 doi: 10.1159/000506509. PMID: 32062657

Risk Factors for Recurrent Colorectal Polyps.

Hao Y, Wang Y, Qi M, He X, Zhu Y, Hong J
Gut Liver 2020 Jul 15;14(4):399-411. doi: 10.5009/gnl19097. PMID: 31547641 Free PMC Article

Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial.

Li WQ, Zhang JY, Ma JL, Li ZX, Zhang L, Zhang Y, Guo Y, Zhou T, Li JY, Shen L, Liu WD, Han ZX, Blot WJ, Gail MH, Pan KF, You WC
BMJ 2019 Sep 11;366:l5016. doi: 10.1136/bmj.l5016. PMID: 31511230 Free PMC Article

Analysis of status and countermeasures of cancer incidence and mortality in China.

Wu C, Li M, Meng H, Liu Y, Niu W, Zhou Y, Zhao R, Duan Y, Zeng Z, Li X, Li G, Xiong W, Zhou M
Sci China Life Sci 2019 May;62(5):640-647. Epub 2019 Mar 12 doi: 10.1007/s11427-018-9461-5. PMID: 30900169

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Clinical prediction guides

Distribution and density of tertiary lymphoid structures predict clinical outcome in intrahepatic cholangiocarcinoma.

Ding GY, Ma JQ, Yun JP, Chen X, Ling Y, Zhang S, Shi JY, Chang YQ, Ji Y, Wang XY, Tan WM, Yuan KF, Yan B, Zhang XM, Liang F, Zhou J, Fan J, Zeng Y, Cai MY, Gao Q
J Hepatol 2022 Mar;76(3):608-618. Epub 2021 Nov 15 doi: 10.1016/j.jhep.2021.10.030. PMID: 34793865

Identification of potential diagnostic and prognostic biomarkers for LUAD based on TCGA and GEO databases.

Zheng Q, Min S, Zhou Q
Biosci Rep 2021 Jun 25;41(6) doi: 10.1042/BSR20204370. PMID: 34017995 Free PMC Article

Role of liver and spleen stiffness in predicting the recurrence of hepatocellular carcinoma after resection.

Marasco G, Colecchia A, Colli A, Ravaioli F, Casazza G, Bacchi Reggiani ML, Cucchetti A, Cescon M, Festi D
J Hepatol 2019 Mar;70(3):440-448. Epub 2018 Oct 31 doi: 10.1016/j.jhep.2018.10.022. PMID: 30389551

Gastric cancer and family history.

Choi YJ, Kim N
Korean J Intern Med 2016 Nov;31(6):1042-1053. Epub 2016 Nov 1 doi: 10.3904/kjim.2016.147. PMID: 27809451 Free PMC Article

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.

Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377 Free PMC Article

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Recent systematic reviews

Blood-based DNA methylation signatures in cancer: A systematic review.

Li Y, Fan Z, Meng Y, Liu S, Zhan H
Biochim Biophys Acta Mol Basis Dis 2023 Jan 1;1869(1):166583. Epub 2022 Oct 18 doi: 10.1016/j.bbadis.2022.166583. PMID: 36270476

The association between human papillomavirus and bladder cancer: Evidence from meta-analysis and two-sample mendelian randomization.

Sun JX, Xu JZ, Liu CQ, An Y, Xu MY, Zhong XY, Zeng N, Ma SY, He HD, Hu J, Liu Z, Wang SG, Xia QD
J Med Virol 2023 Jan;95(1):e28208. Epub 2022 Oct 25 doi: 10.1002/jmv.28208. PMID: 36226344 Free PMC Article

Alternative splicing and cancer: a systematic review.

Zhang Y, Qian J, Gu C, Yang Y
Signal Transduct Target Ther 2021 Feb 24;6(1):78. doi: 10.1038/s41392-021-00486-7. PMID: 33623018 Free PMC Article

Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis.

Applegate CC, Rowles JL, Ranard KM, Jeon S, Erdman JW
Nutrients 2018 Jan 4;10(1) doi: 10.3390/nu10010040. PMID: 29300347 Free PMC Article

Cytology versus HPV testing for cervical cancer screening in the general population.

Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882 Free PMC Article

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