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Bladder Non-Invasive Papillary Urothelial Carcinoma, High Grade

MedGen UID:
268191
•Concept ID:
C1512434
•
Neoplastic Process
Synonym: Non-Invasive Bladder Papillary Urothelial Carcinoma, High Grade

Definition

Bladder non-invasive papillary urothelial carcinoma characterized by marked architectural and cytologic abnormalities and frequent mitotic figures (at all levels of the urothelium). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Non-Invasive Papillary Urothelial Carcinoma, High Grade

Recent clinical studies

Etiology

Prognostic significance of minor high grade component in non-invasive papillary urothelial carcinoma of urinary bladder: (A study of 273 consecutive cases over a period of 3 years).
Syed M, Mushtaq S, Loya A, Hassan U, Mir K, Hussain M, Hameed M, Sheikh UN
Ann Diagn Pathol 2023 Apr;63:152079. Epub 2022 Dec 13 doi: 10.1016/j.anndiagpath.2022.152079. PMID: 36549142
Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer.
Garczyk S, Degener S, Bischoff F, Schnitzler T, Salz A, Golz R, Buchner A, Schulz GB, Schneider U, Gaisa NT, Knüchel R
Virchows Arch 2022 Jul;481(1):83-92. Epub 2022 Apr 28 doi: 10.1007/s00428-022-03328-1. PMID: 35484425Free PMC Article
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
HMGB1 expression in urothelial carcinoma of the bladder.
Suren D, Yildirim HT, Atalay I, Sayiner A, Yildirim M, Alikanoglu AS, Sezer C
J BUON 2018 Nov-Dec;23(6):1882-1886. PMID: 30610817

Diagnosis

Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
MOLECULAR CHARACTERISTICS OF THE HETEROGENEITY OF NON-INVASIVE PAPILLARY UROTHELIAL CARCINOMAS AND THE MARKERS OF THEIR RECURRENCE.
Kajaia D, Kochiashvili D, Muzashvili T, Gachechiladze M, Burkadze G
Georgian Med News 2021 Jul-Aug;(316-317):178-184. PMID: 34511468
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
HMGB1 expression in urothelial carcinoma of the bladder.
Suren D, Yildirim HT, Atalay I, Sayiner A, Yildirim M, Alikanoglu AS, Sezer C
J BUON 2018 Nov-Dec;23(6):1882-1886. PMID: 30610817
Genetic and molecular markers of urothelial premalignancy and malignancy.
Cordon-Cardo C, Cote RJ, Sauter G
Scand J Urol Nephrol Suppl 2000;(205):82-93. doi: 10.1080/003655900750169338. PMID: 11144907

Therapy

Poncet's disease after the intravesical instillation of Bacillus Calmette-Guérin (BCG): a case report.
Sampaio PCM, Lira YG, Ribeiro HYU, de Paula Moreira F, Gadelha MSM, da Cruz SFS
BMC Res Notes 2017 Aug 18;10(1):416. doi: 10.1186/s13104-017-2606-9. PMID: 28821265Free PMC Article
Significance of a minor high-grade component in a low-grade noninvasive papillary urothelial carcinoma of bladder.
Reis LO, Taheri D, Chaux A, Guner G, Mendoza Rodriguez MA, Bivalacqua TJ, Schoenberg MP, Epstein JI, Netto GJ
Hum Pathol 2016 Jan;47(1):20-5. Epub 2015 Sep 25 doi: 10.1016/j.humpath.2015.09.007. PMID: 26520419

Prognosis

Prognostic significance of minor high grade component in non-invasive papillary urothelial carcinoma of urinary bladder: (A study of 273 consecutive cases over a period of 3 years).
Syed M, Mushtaq S, Loya A, Hassan U, Mir K, Hussain M, Hameed M, Sheikh UN
Ann Diagn Pathol 2023 Apr;63:152079. Epub 2022 Dec 13 doi: 10.1016/j.anndiagpath.2022.152079. PMID: 36549142
Multiparametric Classification of Non-Muscle Invasive Papillary Urothelial Neoplasms: Combining Morphological, Phenotypical, and Molecular Features for Improved Risk Stratification.
Montes-Mojarro IA, Hassas S, Staehle S, Sander P, Harland N, Serna-Higuita LM, Bonzheim I, Bösmüller H, Stenzl A, Fend F
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158133. PMID: 35897708Free PMC Article
Non-invasive papillary urothelial carcinoma with 'micropapillary' architecture: clinicopathological study of 18 patients emphasising clinical outcomes.
Sangoi AR, Cox RM, Higgins JP, Quick CM, McKenney JK
Histopathology 2020 Nov;77(5):728-733. Epub 2020 Sep 27 doi: 10.1111/his.14161. PMID: 32443178
HMGB1 expression in urothelial carcinoma of the bladder.
Suren D, Yildirim HT, Atalay I, Sayiner A, Yildirim M, Alikanoglu AS, Sezer C
J BUON 2018 Nov-Dec;23(6):1882-1886. PMID: 30610817
Non-invasive urothelial neoplasms: according to the most recent WHO classification.
Lopez-Beltran A, Montironi R
Eur Urol 2004 Aug;46(2):170-6. doi: 10.1016/j.eururo.2004.03.017. PMID: 15245809

Clinical prediction guides

Heterogenous NECTIN4 expression in urothelial high-risk non-muscle-invasive bladder cancer.
Garczyk S, Degener S, Bischoff F, Schnitzler T, Salz A, Golz R, Buchner A, Schulz GB, Schneider U, Gaisa NT, Knüchel R
Virchows Arch 2022 Jul;481(1):83-92. Epub 2022 Apr 28 doi: 10.1007/s00428-022-03328-1. PMID: 35484425Free PMC Article
Validation of grading of non-invasive urothelial carcinoma by digital pathology for routine diagnosis.
Colling R, Colling H, Browning L, Verrill C
BMC Cancer 2021 Sep 6;21(1):995. doi: 10.1186/s12885-021-08698-4. PMID: 34488682Free PMC Article
National incidence and survival of patients with non-invasive papillary urothelial carcinoma: a Danish population study.
Erikson MS, Petersen AC, Andersen KK, Andreasen AH, Friis S, Mogensen K, Hermann GG
Scand J Urol 2018 Oct-Dec;52(5-6):364-370. Epub 2018 Nov 1 doi: 10.1080/21681805.2018.1518926. PMID: 30382759
Molecular alterations associated with bladder cancer initiation and progression.
Cordon-Cardo C
Scand J Urol Nephrol Suppl 2008 Sep;(218):154-65. doi: 10.1080/03008880802291915. PMID: 18815930
Diagnostic algorithm for papillary urothelial tumors in the urinary bladder.
Shim JW, Cho KS, Choi YD, Park YW, Lee DW, Han WS, Shim SI, Kim HJ, Cho NH
Virchows Arch 2008 Apr;452(4):353-62. Epub 2008 Mar 1 doi: 10.1007/s00428-008-0585-x. PMID: 18311491Free PMC Article

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