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Bladder papillary urothelial neoplasm

MedGen UID:
267741
•Concept ID:
C1511197
•
Neoplastic Process
Synonyms: Bladder Papillary Transitional Cell Neoplasm; bladder papillary transitional cell neoplasm; Bladder Papillary Urothelial Neoplasm; bladder papillary urothelial neoplasm; Urinary Bladder Papillary Transitional Cell Neoplasm; urinary bladder papillary transitional cell neoplasm; Urinary Bladder Papillary Urothelial Neoplasm; urinary bladder papillary urothelial neoplasm; urinary bladder urothelium papillary epithelial neoplasm
 
Monarch Initiative: MONDO:0003442

Definition

A neoplasm with papillary architectural pattern arising from the bladder urothelial cells. [from NCI]

Professional guidelines

PubMed

APOBEC3C is a novel target for the immune treatment of lower-grade gliomas.
Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
The urothelial gene regulatory network: understanding biology to improve bladder cancer management.
Ramal M, Corral S, Kalisz M, Lapi E, Real FX
Oncogene 2024 Jan;43(1):1-21. Epub 2023 Nov 23 doi: 10.1038/s41388-023-02876-3. PMID: 37996699
Update on Flat and Papillary Urothelial Lesions: Genitourinary Pathology Society Consensus Recommendations.
Compérat E, Oszwald A, Wasinger G, Shariat S, Amin M
Surg Pathol Clin 2022 Dec;15(4):629-640. Epub 2022 Oct 13 doi: 10.1016/j.path.2022.07.009. PMID: 36344180

Recent clinical studies

Etiology

Nadofaragene Firadenovec: First Approval.
Lee A
Drugs 2023 Mar;83(4):353-357. doi: 10.1007/s40265-023-01846-z. PMID: 36856952Free PMC Article
The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
The germline mutational landscape of genitourinary cancers and its indication for prognosis and risk.
Yang Y, Zhang G, Hu C, Luo W, Jiang H, Liu S, Yang H
BMC Urol 2022 Nov 30;22(1):196. doi: 10.1186/s12894-022-01141-1. PMID: 36451132Free PMC Article
European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ).
Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Dominguez Escrig JL, Gontero P, Liedberg F, Masson-Lecomte A, Mostafid AH, Palou J, van Rhijn BWG, Rouprêt M, Shariat SF, Seisen T, Soukup V, Sylvester RJ
Eur Urol 2022 Jan;81(1):75-94. Epub 2021 Sep 10 doi: 10.1016/j.eururo.2021.08.010. PMID: 34511303
Expression of Nectin-4 in Bladder Urothelial Carcinoma, in Morphologic Variants, and Nonurothelial Histotypes.
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article

Diagnosis

International Society of Urological Pathology (ISUP) Consensus Conference on Current Issues in Bladder Cancer. Working Group 2: Grading of Mixed Grade, Invasive Urothelial Carcinoma Including Histologic Subtypes and Divergent Differentiations, and Non-Urothelial Carcinomas.
Paner GP, Kamat A, Netto GJ, Samaratunga H, Varma M, Bubendorf L, van der Kwast TH, Cheng L; Members of the ISUP Bladder Tumor Consensus Panel
Am J Surg Pathol 2024 Jan 1;48(1):e11-e23. Epub 2023 Jun 29 doi: 10.1097/PAS.0000000000002077. PMID: 37382156
Paraneoplastic sacroiliitis.
Arad U, Werren C, White D
BMJ Case Rep 2023 Aug 31;16(8) doi: 10.1136/bcr-2022-252572. PMID: 37652573Free PMC Article
European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ).
Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Dominguez Escrig JL, Gontero P, Liedberg F, Masson-Lecomte A, Mostafid AH, Palou J, van Rhijn BWG, Rouprêt M, Shariat SF, Seisen T, Soukup V, Sylvester RJ
Eur Urol 2022 Jan;81(1):75-94. Epub 2021 Sep 10 doi: 10.1016/j.eururo.2021.08.010. PMID: 34511303
Bladder cancer genomics.
Siracusano S, Rizzetto R, Porcaro AB
Urologia 2020 May;87(2):49-56. Epub 2020 Jan 16 doi: 10.1177/0391560319899011. PMID: 31942831
European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ) - 2019 Update.
Babjuk M, Burger M, Compérat EM, Gontero P, Mostafid AH, Palou J, van Rhijn BWG, Rouprêt M, Shariat SF, Sylvester R, Zigeuner R, Capoun O, Cohen D, Escrig JLD, Hernández V, Peyronnet B, Seisen T, Soukup V
Eur Urol 2019 Nov;76(5):639-657. Epub 2019 Aug 20 doi: 10.1016/j.eururo.2019.08.016. PMID: 31443960

Therapy

Nadofaragene Firadenovec: First Approval.
Lee A
Drugs 2023 Mar;83(4):353-357. doi: 10.1007/s40265-023-01846-z. PMID: 36856952Free PMC Article
European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ).
Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Dominguez Escrig JL, Gontero P, Liedberg F, Masson-Lecomte A, Mostafid AH, Palou J, van Rhijn BWG, Rouprêt M, Shariat SF, Seisen T, Soukup V, Sylvester RJ
Eur Urol 2022 Jan;81(1):75-94. Epub 2021 Sep 10 doi: 10.1016/j.eururo.2021.08.010. PMID: 34511303
European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ) - 2019 Update.
Babjuk M, Burger M, Compérat EM, Gontero P, Mostafid AH, Palou J, van Rhijn BWG, Rouprêt M, Shariat SF, Sylvester R, Zigeuner R, Capoun O, Cohen D, Escrig JLD, Hernández V, Peyronnet B, Seisen T, Soukup V
Eur Urol 2019 Nov;76(5):639-657. Epub 2019 Aug 20 doi: 10.1016/j.eururo.2019.08.016. PMID: 31443960
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article
Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non-Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial.
Messing EM, Tangen CM, Lerner SP, Sahasrabudhe DM, Koppie TM, Wood DP Jr, Mack PC, Svatek RS, Evans CP, Hafez KS, Culkin DJ, Brand TC, Karsh LI, Holzbeierlein JM, Wilson SS, Wu G, Plets M, Vogelzang NJ, Thompson IM Jr
JAMA 2018 May 8;319(18):1880-1888. doi: 10.1001/jama.2018.4657. PMID: 29801011Free PMC Article

Prognosis

Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ.
Yao Z, Xu N, Shang G, Wang H, Tao H, Wang Y, Qin Z, Tan S, Feng J, Zhu J, Ma F, Tian S, Zhang Q, Qu Y, Hou J, Guo J, Zhao J, Hou Y, Ding C
Nat Commun 2023 Sep 13;14(1):5670. doi: 10.1038/s41467-023-41139-3. PMID: 37704624Free PMC Article
Pan-cancer analysis of G6PD carcinogenesis in human tumors.
Liu B, Fu X, Du Y, Feng Z, Chen R, Liu X, Yu F, Zhou G, Ba Y
Carcinogenesis 2023 Aug 18;44(6):525-534. doi: 10.1093/carcin/bgad043. PMID: 37335542
The germline mutational landscape of genitourinary cancers and its indication for prognosis and risk.
Yang Y, Zhang G, Hu C, Luo W, Jiang H, Liu S, Yang H
BMC Urol 2022 Nov 30;22(1):196. doi: 10.1186/s12894-022-01141-1. PMID: 36451132Free PMC Article
European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ).
Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Dominguez Escrig JL, Gontero P, Liedberg F, Masson-Lecomte A, Mostafid AH, Palou J, van Rhijn BWG, Rouprêt M, Shariat SF, Seisen T, Soukup V, Sylvester RJ
Eur Urol 2022 Jan;81(1):75-94. Epub 2021 Sep 10 doi: 10.1016/j.eururo.2021.08.010. PMID: 34511303
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Clinical prediction guides

Pan-cancer analysis predicts CANT1 as a potential prognostic, immunologic biomarker.
Yang W, Liu Z, Liu T
Cell Signal 2024 May;117:111107. Epub 2024 Feb 16 doi: 10.1016/j.cellsig.2024.111107. PMID: 38369265
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
Expression of Nectin-4 in Bladder Urothelial Carcinoma, in Morphologic Variants, and Nonurothelial Histotypes.
Hoffman-Censits JH, Lombardo KA, Parimi V, Kamanda S, Choi W, Hahn NM, McConkey DJ, McGuire BM, Bivalacqua TJ, Kates M, Matoso A
Appl Immunohistochem Mol Morphol 2021 Sep 1;29(8):619-625. doi: 10.1097/PAI.0000000000000938. PMID: 33901032Free PMC Article
European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ) - 2019 Update.
Babjuk M, Burger M, Compérat EM, Gontero P, Mostafid AH, Palou J, van Rhijn BWG, Rouprêt M, Shariat SF, Sylvester R, Zigeuner R, Capoun O, Cohen D, Escrig JLD, Hernández V, Peyronnet B, Seisen T, Soukup V
Eur Urol 2019 Nov;76(5):639-657. Epub 2019 Aug 20 doi: 10.1016/j.eururo.2019.08.016. PMID: 31443960
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Recent systematic reviews

Diagnostic and prognostic roles of CK20 in the pathology of urothelial lesions. A systematic review.
Sanguedolce F, Russo D, Calò B, Cindolo L, Carrieri G, Cormio L
Pathol Res Pract 2019 Jun;215(6):152413. Epub 2019 Apr 6 doi: 10.1016/j.prp.2019.04.005. PMID: 30987832
Micropapillary Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-analysis of Disease Characteristics and Treatment Outcomes.
Abufaraj M, Foerster B, Schernhammer E, Moschini M, Kimura S, Hassler MR, Preston MA, Karakiewicz PI, Remzi M, Shariat SF
Eur Urol 2019 Apr;75(4):649-658. Epub 2018 Dec 13 doi: 10.1016/j.eururo.2018.11.052. PMID: 30553613
Hexyl aminolevulinate-guided fluorescence cystoscopy in the diagnosis and follow-up of patients with non-muscle-invasive bladder cancer: a critical review of the current literature.
Rink M, Babjuk M, Catto JW, Jichlinski P, Shariat SF, Stenzl A, Stepp H, Zaak D, Witjes JA
Eur Urol 2013 Oct;64(4):624-38. Epub 2013 Jul 19 doi: 10.1016/j.eururo.2013.07.007. PMID: 23906669
Results and outcomes after endoscopic treatment of upper urinary tract carcinoma: the Austrian experience.
Fajkovic H, Klatte T, Nagele U, Dunzinger M, Zigeuner R, Hübner W, Remzi M
World J Urol 2013 Feb;31(1):37-44. Epub 2012 Sep 27 doi: 10.1007/s00345-012-0948-4. PMID: 23014836
Inverted papilloma of the bladder: a review and an analysis of the recent literature of 365 patients.
Picozzi S, Casellato S, Bozzini G, Ratti D, Macchi A, Rubino B, Pace G, Carmignani L
Urol Oncol 2013 Nov;31(8):1584-90. Epub 2012 Apr 19 doi: 10.1016/j.urolonc.2012.03.009. PMID: 22520573

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