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DNA Adduction

MedGen UID:
268315
•Concept ID:
C1511660
•
Cell or Molecular Dysfunction
Synonym: DNA Adduct Formation

Definition

DNA Adduction involves formation of a covalent bond between a molecule and the DNA macromolecule. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Adduction

Professional guidelines

PubMed

The dual role of DNA repair protein MGMT in cancer prevention and treatment.
Bai P, Fan T, Sun G, Wang X, Zhao L, Zhong R
DNA Repair (Amst) 2023 Mar;123:103449. Epub 2023 Jan 14 doi: 10.1016/j.dnarep.2023.103449. PMID: 36680944
Colorectal Cancer Chemotherapy: The Evolution of Treatment and New Approaches.
McQuade RM, Stojanovska V, Bornstein JC, Nurgali K
Curr Med Chem 2017;24(15):1537-1557. doi: 10.2174/0929867324666170111152436. PMID: 28079003
Risk biomarkers for assessment and chemoprevention of liver fluke-associated cholangiocarcinoma.
Yongvanit P, Pinlaor S, Loilome W
J Hepatobiliary Pancreat Sci 2014 May;21(5):309-15. Epub 2014 Jan 10 doi: 10.1002/jhbp.63. PMID: 24408859

Recent clinical studies

Etiology

Chemical mechanisms of DNA damage by carcinogenic chromium(VI).
Krawic C, Zhitkovich A
Adv Pharmacol 2023;96:25-46. Epub 2022 Aug 26 doi: 10.1016/bs.apha.2022.07.003. PMID: 36858775Free PMC Article
Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer.
Caliri AW, Tommasi S, Besaratinia A
Mutat Res Rev Mutat Res 2021 Jan-Jun;787:108365. Epub 2021 Jan 11 doi: 10.1016/j.mrrev.2021.108365. PMID: 34083039Free PMC Article
An update on direct genotoxicity as a molecular mechanism of ochratoxin a carcinogenicity.
Pfohl-Leszkowicz A, Manderville RA
Chem Res Toxicol 2012 Feb 20;25(2):252-62. Epub 2011 Nov 16 doi: 10.1021/tx200430f. PMID: 22054007
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans.
Pfohl-Leszkowicz A, Manderville RA
Mol Nutr Food Res 2007 Jan;51(1):61-99. doi: 10.1002/mnfr.200600137. PMID: 17195275
Carcinogenicity of the chlorination disinfection by-product MX.
McDonald TA, Komulainen H
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2005;23(2):163-214. doi: 10.1080/10590500500234988. PMID: 16291527

Diagnosis

Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing.
Madeen E, Siddens LK, Uesugi S, McQuistan T, Corley RA, Smith J, Waters KM, Tilton SC, Anderson KA, Ognibene T, Turteltaub K, Williams DE
Toxicol Appl Pharmacol 2019 Feb 1;364:97-105. Epub 2018 Dec 21 doi: 10.1016/j.taap.2018.12.010. PMID: 30582946Free PMC Article
Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel.
Wang S, Scharadin TM, Zimmermann M, Malfatti MA, Turteltaub KW, de Vere White R, Pan CX, Henderson PT
Chem Res Toxicol 2018 Dec 17;31(12):1293-1304. Epub 2018 Nov 19 doi: 10.1021/acs.chemrestox.8b00170. PMID: 30381944Free PMC Article
Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism.
Guttmann D, Poage G, Johnston T, Zhitkovich A
Chem Res Toxicol 2008 Nov;21(11):2188-94. doi: 10.1021/tx800265g. PMID: 18808157Free PMC Article
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans.
Pfohl-Leszkowicz A, Manderville RA
Mol Nutr Food Res 2007 Jan;51(1):61-99. doi: 10.1002/mnfr.200600137. PMID: 17195275
Assessment of the DNA adduction and pharmacokinetics of PhIP and MeIOx in rodents at doses approximating human exposure using the technique of accelerator mass spectrometry (AMS) and 32P-postlabeling.
Turteltaub KW, Vogel JS, Frantz C, Felton JS, McManus M
Princess Takamatsu Symp 1995;23:93-102. PMID: 8844800

Therapy

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer.
Caliri AW, Tommasi S, Besaratinia A
Mutat Res Rev Mutat Res 2021 Jan-Jun;787:108365. Epub 2021 Jan 11 doi: 10.1016/j.mrrev.2021.108365. PMID: 34083039Free PMC Article
Biotransformation and Toxicities of Aristolochic Acids.
Sidorenko VS
Adv Exp Med Biol 2020;1241:139-166. doi: 10.1007/978-3-030-41283-8_9. PMID: 32383120
Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel.
Wang S, Scharadin TM, Zimmermann M, Malfatti MA, Turteltaub KW, de Vere White R, Pan CX, Henderson PT
Chem Res Toxicol 2018 Dec 17;31(12):1293-1304. Epub 2018 Nov 19 doi: 10.1021/acs.chemrestox.8b00170. PMID: 30381944Free PMC Article
Chemopreventive properties and mechanisms of N-Acetylcysteine. The experimental background.
De Flora S, Cesarone CF, Balansky RM, Albini A, D'Agostini F, Bennicelli C, Bagnasco M, Camoirano A, Scatolini L, Rovida A
J Cell Biochem Suppl 1995;22:33-41. doi: 10.1002/jcb.240590806. PMID: 8538208
Intraepithelial and postinvasive neoplasia as a stochastic continuum of clonal evolution, and its relationship to mechanisms of chemopreventive drug action.
Boone CW, Kelloff GJ, Freedman LS
J Cell Biochem Suppl 1993;17G:14-25. doi: 10.1002/jcb.240531104. PMID: 8007692

Prognosis

A novel approach to predict the comprehensive EROD potency: Mechanism-based curve fitting of CYP1A1 activity by PAHs.
Chen C, Zhang D, Yuan A, Shen J, Wang L, Wang SL
Sci Total Environ 2022 Oct 15;843:157052. Epub 2022 Jul 1 doi: 10.1016/j.scitotenv.2022.157052. PMID: 35787903
Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel.
Wang S, Scharadin TM, Zimmermann M, Malfatti MA, Turteltaub KW, de Vere White R, Pan CX, Henderson PT
Chem Res Toxicol 2018 Dec 17;31(12):1293-1304. Epub 2018 Nov 19 doi: 10.1021/acs.chemrestox.8b00170. PMID: 30381944Free PMC Article
Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions.
Besaratinia A, Tommasi S
FASEB J 2013 Jun;27(6):2090-100. Epub 2013 Feb 28 doi: 10.1096/fj.12-227074. PMID: 23449930
Chemical and biological factors affecting mutagen potency.
Colvin ME, Hatch FT, Felton JS
Mutat Res 1998 May 25;400(1-2):479-92. doi: 10.1016/s0027-5107(98)00073-6. PMID: 9685706
Replication blocks and sequence interaction specificities in the codon 12 region of the c-Ha-ras proto-oncogene induced by four carcinogens in vitro.
Mariën K, Mathews K, van Holde K, Bailey G
J Biol Chem 1989 Aug 5;264(22):13226-32. PMID: 2502547

Clinical prediction guides

A novel approach to predict the comprehensive EROD potency: Mechanism-based curve fitting of CYP1A1 activity by PAHs.
Chen C, Zhang D, Yuan A, Shen J, Wang L, Wang SL
Sci Total Environ 2022 Oct 15;843:157052. Epub 2022 Jul 1 doi: 10.1016/j.scitotenv.2022.157052. PMID: 35787903
Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel.
Wang S, Scharadin TM, Zimmermann M, Malfatti MA, Turteltaub KW, de Vere White R, Pan CX, Henderson PT
Chem Res Toxicol 2018 Dec 17;31(12):1293-1304. Epub 2018 Nov 19 doi: 10.1021/acs.chemrestox.8b00170. PMID: 30381944Free PMC Article
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans.
Pfohl-Leszkowicz A, Manderville RA
Mol Nutr Food Res 2007 Jan;51(1):61-99. doi: 10.1002/mnfr.200600137. PMID: 17195275
Carcinogenicity of the chlorination disinfection by-product MX.
McDonald TA, Komulainen H
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2005;23(2):163-214. doi: 10.1080/10590500500234988. PMID: 16291527
Chemical and biological factors affecting mutagen potency.
Colvin ME, Hatch FT, Felton JS
Mutat Res 1998 May 25;400(1-2):479-92. doi: 10.1016/s0027-5107(98)00073-6. PMID: 9685706

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