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DNA Adduction

MedGen UID:
268315
•Concept ID:
C1511660
•
Cell or Molecular Dysfunction
Synonym: DNA Adduct Formation

Definition

DNA Adduction involves formation of a covalent bond between a molecule and the DNA macromolecule. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDNA Adduction

Professional guidelines

PubMed

The dual role of DNA repair protein MGMT in cancer prevention and treatment.
Bai P, Fan T, Sun G, Wang X, Zhao L, Zhong R
DNA Repair (Amst) 2023 Mar;123:103449. Epub 2023 Jan 14 doi: 10.1016/j.dnarep.2023.103449. PMID: 36680944
Colorectal Cancer Chemotherapy: The Evolution of Treatment and New Approaches.
McQuade RM, Stojanovska V, Bornstein JC, Nurgali K
Curr Med Chem 2017;24(15):1537-1557. doi: 10.2174/0929867324666170111152436. PMID: 28079003
Risk biomarkers for assessment and chemoprevention of liver fluke-associated cholangiocarcinoma.
Yongvanit P, Pinlaor S, Loilome W
J Hepatobiliary Pancreat Sci 2014 May;21(5):309-15. Epub 2014 Jan 10 doi: 10.1002/jhbp.63. PMID: 24408859

Recent clinical studies

Etiology

Chemical mechanisms of DNA damage by carcinogenic chromium(VI).
Krawic C, Zhitkovich A
Adv Pharmacol 2023;96:25-46. Epub 2022 Aug 26 doi: 10.1016/bs.apha.2022.07.003. PMID: 36858775Free PMC Article
Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer.
Caliri AW, Tommasi S, Besaratinia A
Mutat Res Rev Mutat Res 2021 Jan-Jun;787:108365. Epub 2021 Jan 11 doi: 10.1016/j.mrrev.2021.108365. PMID: 34083039Free PMC Article
An update on direct genotoxicity as a molecular mechanism of ochratoxin a carcinogenicity.
Pfohl-Leszkowicz A, Manderville RA
Chem Res Toxicol 2012 Feb 20;25(2):252-62. Epub 2011 Nov 16 doi: 10.1021/tx200430f. PMID: 22054007
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans.
Pfohl-Leszkowicz A, Manderville RA
Mol Nutr Food Res 2007 Jan;51(1):61-99. doi: 10.1002/mnfr.200600137. PMID: 17195275
Carcinogenicity of the chlorination disinfection by-product MX.
McDonald TA, Komulainen H
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2005;23(2):163-214. doi: 10.1080/10590500500234988. PMID: 16291527

Diagnosis

Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing.
Madeen E, Siddens LK, Uesugi S, McQuistan T, Corley RA, Smith J, Waters KM, Tilton SC, Anderson KA, Ognibene T, Turteltaub K, Williams DE
Toxicol Appl Pharmacol 2019 Feb 1;364:97-105. Epub 2018 Dec 21 doi: 10.1016/j.taap.2018.12.010. PMID: 30582946Free PMC Article
Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel.
Wang S, Scharadin TM, Zimmermann M, Malfatti MA, Turteltaub KW, de Vere White R, Pan CX, Henderson PT
Chem Res Toxicol 2018 Dec 17;31(12):1293-1304. Epub 2018 Nov 19 doi: 10.1021/acs.chemrestox.8b00170. PMID: 30381944Free PMC Article
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans.
Pfohl-Leszkowicz A, Manderville RA
Mol Nutr Food Res 2007 Jan;51(1):61-99. doi: 10.1002/mnfr.200600137. PMID: 17195275
Comparison of DNA adduct levels in nasal mucosa, lymphocytes and bronchial mucosa of cigarette smokers and interaction with metabolic gene polymorphisms.
Peluso M, Neri M, Margarino G, Mereu C, Munnia A, Ceppi M, Buratti M, Felletti R, Stea F, Quaglia R, Puntoni R, Taioli E, Garte S, Bonassi S
Carcinogenesis 2004 Dec;25(12):2459-65. Epub 2004 Aug 19 doi: 10.1093/carcin/bgh259. PMID: 15319297
Assessment of the DNA adduction and pharmacokinetics of PhIP and MeIOx in rodents at doses approximating human exposure using the technique of accelerator mass spectrometry (AMS) and 32P-postlabeling.
Turteltaub KW, Vogel JS, Frantz C, Felton JS, McManus M
Princess Takamatsu Symp 1995;23:93-102. PMID: 8844800

Therapy

Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer.
Caliri AW, Tommasi S, Besaratinia A
Mutat Res Rev Mutat Res 2021 Jan-Jun;787:108365. Epub 2021 Jan 11 doi: 10.1016/j.mrrev.2021.108365. PMID: 34083039Free PMC Article
Biotransformation and Toxicities of Aristolochic Acids.
Sidorenko VS
Adv Exp Med Biol 2020;1241:139-166. doi: 10.1007/978-3-030-41283-8_9. PMID: 32383120
Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel.
Wang S, Scharadin TM, Zimmermann M, Malfatti MA, Turteltaub KW, de Vere White R, Pan CX, Henderson PT
Chem Res Toxicol 2018 Dec 17;31(12):1293-1304. Epub 2018 Nov 19 doi: 10.1021/acs.chemrestox.8b00170. PMID: 30381944Free PMC Article
Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions.
Besaratinia A, Tommasi S
FASEB J 2013 Jun;27(6):2090-100. Epub 2013 Feb 28 doi: 10.1096/fj.12-227074. PMID: 23449930
Chemopreventive properties and mechanisms of N-Acetylcysteine. The experimental background.
De Flora S, Cesarone CF, Balansky RM, Albini A, D'Agostini F, Bennicelli C, Bagnasco M, Camoirano A, Scatolini L, Rovida A
J Cell Biochem Suppl 1995;22:33-41. doi: 10.1002/jcb.240590806. PMID: 8538208

Prognosis

A novel approach to predict the comprehensive EROD potency: Mechanism-based curve fitting of CYP1A1 activity by PAHs.
Chen C, Zhang D, Yuan A, Shen J, Wang L, Wang SL
Sci Total Environ 2022 Oct 15;843:157052. Epub 2022 Jul 1 doi: 10.1016/j.scitotenv.2022.157052. PMID: 35787903
Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel.
Wang S, Scharadin TM, Zimmermann M, Malfatti MA, Turteltaub KW, de Vere White R, Pan CX, Henderson PT
Chem Res Toxicol 2018 Dec 17;31(12):1293-1304. Epub 2018 Nov 19 doi: 10.1021/acs.chemrestox.8b00170. PMID: 30381944Free PMC Article
Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions.
Besaratinia A, Tommasi S
FASEB J 2013 Jun;27(6):2090-100. Epub 2013 Feb 28 doi: 10.1096/fj.12-227074. PMID: 23449930
Chemical and biological factors affecting mutagen potency.
Colvin ME, Hatch FT, Felton JS
Mutat Res 1998 May 25;400(1-2):479-92. doi: 10.1016/s0027-5107(98)00073-6. PMID: 9685706
Replication blocks and sequence interaction specificities in the codon 12 region of the c-Ha-ras proto-oncogene induced by four carcinogens in vitro.
Mariën K, Mathews K, van Holde K, Bailey G
J Biol Chem 1989 Aug 5;264(22):13226-32. PMID: 2502547

Clinical prediction guides

Correlation of Platinum Cytotoxicity to Drug-DNA Adduct Levels in a Breast Cancer Cell Line Panel.
Wang S, Scharadin TM, Zimmermann M, Malfatti MA, Turteltaub KW, de Vere White R, Pan CX, Henderson PT
Chem Res Toxicol 2018 Dec 17;31(12):1293-1304. Epub 2018 Nov 19 doi: 10.1021/acs.chemrestox.8b00170. PMID: 30381944Free PMC Article
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans.
Pfohl-Leszkowicz A, Manderville RA
Mol Nutr Food Res 2007 Jan;51(1):61-99. doi: 10.1002/mnfr.200600137. PMID: 17195275
Carcinogenicity of the chlorination disinfection by-product MX.
McDonald TA, Komulainen H
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2005;23(2):163-214. doi: 10.1080/10590500500234988. PMID: 16291527
DNA adduction by polychlorinated biphenyls: adducts derived from hepatic microsomal activation and from synthetic metabolites.
Pereg D, Robertson LW, Gupta RC
Chem Biol Interact 2002 Feb 20;139(2):129-44. doi: 10.1016/s0009-2797(01)00292-7. PMID: 11823002
Chemical and biological factors affecting mutagen potency.
Colvin ME, Hatch FT, Felton JS
Mutat Res 1998 May 25;400(1-2):479-92. doi: 10.1016/s0027-5107(98)00073-6. PMID: 9685706

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