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Neoplasm of the inner ear

MedGen UID:
268582
•Concept ID:
C1512779
•
Neoplastic Process
Synonyms: Inner Ear Neoplasm; inner ear neoplasm; inner Ear neoplasm; Inner ear tumor; Inner ear tumour; Internal Ear Neoplasm; internal Ear neoplasm; internal ear neoplasm; internal ear neoplasm (disease); internal ear tumor; internal ear tumour; neoplasm of internal ear; tumor of internal ear; tumour of internal ear
 
HPO: HP:0040096
Monarch Initiative: MONDO:0024320

Definition

A tumor (abnormal growth of tissue) of the inner ear. [from HPO]

Professional guidelines

PubMed

The Future of Vestibular Schwannoma Management.
Moore LS, Stankovic KM
Otolaryngol Clin North Am 2023 Jun;56(3):611-622. Epub 2023 Apr 3 doi: 10.1016/j.otc.2023.02.018. PMID: 37019772
Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss.
Young YH
Int J Audiol 2020 Apr;59(4):243-253. Epub 2019 Nov 12 doi: 10.1080/14992027.2019.1689432. PMID: 31714154
Current Treatment of Endolymphatic Sac Tumor of the Temporal Bone.
Mendenhall WM, Suárez C, Skálová A, Strojan P, Triantafyllou A, Devaney KO, Williams MD, Rinaldo A, Ferlito A
Adv Ther 2018 Jul;35(7):887-898. Epub 2018 Jun 19 doi: 10.1007/s12325-018-0730-0. PMID: 29923043Free PMC Article

Recent clinical studies

Etiology

SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss.
Young YH
Int J Audiol 2020 Apr;59(4):243-253. Epub 2019 Nov 12 doi: 10.1080/14992027.2019.1689432. PMID: 31714154
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.
Kros CJ, Steyger PS
Cold Spring Harb Perspect Med 2019 Nov 1;9(11) doi: 10.1101/cshperspect.a033548. PMID: 30559254Free PMC Article
Auditory brainstem implant program development.
Schwartz MS, Wilkinson EP
Laryngoscope 2017 Aug;127(8):1909-1915. Epub 2016 Sep 26 doi: 10.1002/lary.26312. PMID: 27716925
Radiotherapy-induced ear toxicity.
Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R
Cancer Treat Rev 2003 Oct;29(5):417-30. doi: 10.1016/s0305-7372(03)00066-5. PMID: 12972360

Diagnosis

The Vestibulocochlear Nerve: Anatomy and Pathology.
Corrêa DG, Hygino da Cruz LC Jr, Freddi TAL
Semin Ultrasound CT MR 2023 Apr;44(2):81-94. Epub 2023 Mar 22 doi: 10.1053/j.sult.2023.03.007. PMID: 37055143
Intralabyrinthine schwannomas.
Frisch CD, Eckel LJ, Lane JI, Neff BA
Otolaryngol Clin North Am 2015 Jun;48(3):423-41. Epub 2015 Apr 9 doi: 10.1016/j.otc.2015.02.004. PMID: 25863567
Endolymphatic sac tumors.
Wick CC, Manzoor NF, Semaan MT, Megerian CA
Otolaryngol Clin North Am 2015 Apr;48(2):317-30. Epub 2015 Jan 31 doi: 10.1016/j.otc.2014.12.006. PMID: 25650230
Radiotherapy-induced ear toxicity.
Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R
Cancer Treat Rev 2003 Oct;29(5):417-30. doi: 10.1016/s0305-7372(03)00066-5. PMID: 12972360
Diagnostic imaging.
Pappas DG Jr, Curé JK
Otolaryngol Clin North Am 2002 Dec;35(6):1317-63, ix. doi: 10.1016/s0030-6665(02)00097-x. PMID: 12687746

Therapy

Circulating IL-17 reduces the risk of cisplatin-induced hearing loss in children: a bidirectional two-sample Mendelian randomization study.
Xu Y, Huang C, Liu J, Xu Y, Yang H
Sci Rep 2023 Nov 2;13(1):18957. doi: 10.1038/s41598-023-46299-2. PMID: 37919361Free PMC Article
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.
Kros CJ, Steyger PS
Cold Spring Harb Perspect Med 2019 Nov 1;9(11) doi: 10.1101/cshperspect.a033548. PMID: 30559254Free PMC Article
Irradiated ears in nasopharyngeal carcinoma survivors: A review.
Young YH
Laryngoscope 2019 Mar;129(3):637-642. Epub 2018 Sep 8 doi: 10.1002/lary.27303. PMID: 30194730
Relapsing polychondritis.
Gergely P Jr, Poór G
Best Pract Res Clin Rheumatol 2004 Oct;18(5):723-38. doi: 10.1016/j.berh.2004.05.012. PMID: 15454129
Medical audiology.
Sataloff J, Vassallo L
Arch Otolaryngol 1970 Feb;91(2):208-11. doi: 10.1001/archotol.1970.00770040278023. PMID: 4905384

Prognosis

The Natural History of Primary Inner Ear Schwannomas: Outcomes of Long-Term Follow-Up.
Khera Z, Kay-Rivest E, Friedmann DR, McMenomey SO, Thomas Roland J Jr, Jethanamest D
Otol Neurotol 2022 Dec 1;43(10):e1168-e1173. Epub 2022 Sep 22 doi: 10.1097/MAO.0000000000003698. PMID: 36136609
Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss.
Young YH
Int J Audiol 2020 Apr;59(4):243-253. Epub 2019 Nov 12 doi: 10.1080/14992027.2019.1689432. PMID: 31714154
Growth rate of vestibular schwannoma.
Paldor I, Chen AS, Kaye AH
J Clin Neurosci 2016 Oct;32:1-8. Epub 2016 Jul 20 doi: 10.1016/j.jocn.2016.05.003. PMID: 27450283
Relapsing polychondritis.
Gergely P Jr, Poór G
Best Pract Res Clin Rheumatol 2004 Oct;18(5):723-38. doi: 10.1016/j.berh.2004.05.012. PMID: 15454129
Radiotherapy-induced ear toxicity.
Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R
Cancer Treat Rev 2003 Oct;29(5):417-30. doi: 10.1016/s0305-7372(03)00066-5. PMID: 12972360

Clinical prediction guides

Burden of serious harms from diagnostic error in the USA.
Newman-Toker DE, Nassery N, Schaffer AC, Yu-Moe CW, Clemens GD, Wang Z, Zhu Y, Saber Tehrani AS, Fanai M, Hassoon A, Siegal D
BMJ Qual Saf 2024 Jan 19;33(2):109-120. doi: 10.1136/bmjqs-2021-014130. PMID: 37460118Free PMC Article
SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Pendred syndrome.
Wémeau JL, Kopp P
Best Pract Res Clin Endocrinol Metab 2017 Mar;31(2):213-224. Epub 2017 May 10 doi: 10.1016/j.beem.2017.04.011. PMID: 28648509
Intralabyrinthine schwannomas.
Neff BA, Willcox TO Jr, Sataloff RT
Otol Neurotol 2003 Mar;24(2):299-307. doi: 10.1097/00129492-200303000-00028. PMID: 12621348
von Hippel-Lindau disease.
Singh AD, Shields CL, Shields JA
Surv Ophthalmol 2001 Sep-Oct;46(2):117-42. doi: 10.1016/s0039-6257(01)00245-4. PMID: 11578646

Recent systematic reviews

Surgical Management of Endolymphatic Sac Tumor: A Systematic Review and Meta-Analysis.
Gioacchini FM, Chiarella G, Kaleci S, Iannella G, Viola P, Pisani D, Scarpa A, Tulli M, Re M
J Int Adv Otol 2023 Jun;19(3):248-254. doi: 10.5152/iao.2023.22957. PMID: 37272644Free PMC Article
Pre-habilitation with intratympanic gentamicin in vestibular schwannomas: a systematic review.
Potdar T, Kontorinis G
J Laryngol Otol 2023 Sep;137(9):985-991. Epub 2023 Apr 26 doi: 10.1017/S0022215123000725. PMID: 37185086
Systematic Review of Endolymphatic Sac Tumor Treatment and Outcomes.
Tang JD, Grady AJ, Nickel CJ, Ryan LE, Malone A, Canvasser L, Boyev KP
Otolaryngol Head Neck Surg 2023 Mar;168(3):282-290. Epub 2023 Jan 27 doi: 10.1177/01945998221108313. PMID: 35763364
Indications and contraindications of auditory brainstem implants: systematic review and illustrative cases.
Merkus P, Di Lella F, Di Trapani G, Pasanisi E, Beltrame MA, Zanetti D, Negri M, Sanna M
Eur Arch Otorhinolaryngol 2014 Jan;271(1):3-13. Epub 2013 Feb 13 doi: 10.1007/s00405-013-2378-3. PMID: 23404468
Primary inner ear schwannomas: a case series and systematic review of the literature.
Van Abel KM, Carlson ML, Link MJ, Neff BA, Beatty CW, Lohse CM, Eckel LJ, Lane JI, Driscoll CL
Laryngoscope 2013 Aug;123(8):1957-66. Epub 2013 Jan 18 doi: 10.1002/lary.23928. PMID: 23335152

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