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Moderately Differentiated Ovarian Sertoli-Leydig Cell Tumor

MedGen UID:
268604
•Concept ID:
C1512860
•
Neoplastic Process
Synonym: Intermediate Differentiated Ovarian Sertoli-Leydig Cell Tumor

Definition

A Sertoli-Leydig cell tumor of the ovary characterized by the presence of spindle-shaped gonadal stromal cells and Sertoli cells, some of which are atypical. Leydig cells are also present forming clusters at the periphery of the cellular aggregates. Metastases have been reported in a minority of patients. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerately Differentiated Ovarian Sertoli-Leydig Cell Tumor

Professional guidelines

PubMed

Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Clinicopathologic Study of 94 Cases Emphasizing Issues in Differential Diagnosis Staging, and Prognostic Factors.
Devins KM, Young RH, Ghioni M, Burandt E, Bennett JA, Oliva E
Am J Surg Pathol 2022 Nov 1;46(11):1477-1489. Epub 2022 Aug 9 doi: 10.1097/PAS.0000000000001933. PMID: 35941719
Value of A103 (melan-A) immunostaining in the differential diagnosis of ovarian sex cord stromal tumours.
Stewart CJ, Nandini CL, Richmond JA
J Clin Pathol 2000 Mar;53(3):206-11. doi: 10.1136/jcp.53.3.206. PMID: 10823140Free PMC Article

Recent clinical studies

Etiology

Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Characteristics and outcomes analysis of ovarian Sertoli-Leydig cell tumors (SLCTs): analysis of 15 patients.
Wang G, Zhang R, Li C, Chen A
J Ovarian Res 2021 Nov 4;14(1):150. doi: 10.1186/s13048-021-00909-7. PMID: 34736487Free PMC Article
Moderately differentiated Sertoli-Leydig cell tumor of ovary with associated mucinous carcinoma and carcinoid-A case report and review of literature.
Ravichandaran A, Lakshmanan A, Kurian A, Prasad S
Indian J Pathol Microbiol 2021 Jul-Sep;64(3):528-531. doi: 10.4103/IJPM.IJPM_672_20. PMID: 34341265
Ovarian Sertoli-Leydig Cell Tumors: Epidemiological, Clinical and Prognostic Factors.
Castro BGR, Souza CP, Andrade CEMDC, Vieira MA, Andrade DAP, Reis RD
Rev Bras Ginecol Obstet 2019 Jul;41(7):440-448. Epub 2019 Jul 25 doi: 10.1055/s-0039-1693056. PMID: 31344718Free PMC Article
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database.
Bhat RA, Lim YK, Chia YN, Yam KL
J Obstet Gynaecol Res 2013 Jan;39(1):305-10. Epub 2012 Jun 13 doi: 10.1111/j.1447-0756.2012.01928.x. PMID: 22691037

Diagnosis

Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
DICER1 -Altered Extraovarian Moderately Differentiated Sertoli-Leydig Cell Tumor: Report of a Rare Case.
Lau JCC, McCluggage WG, Yuen LYP, Shing MMK, Chan GCF, Yam FSD, Leung MWY, Ng WF, Liu APY
Int J Gynecol Pathol 2023 Jul 1;42(4):421-425. Epub 2022 Aug 3 doi: 10.1097/PGP.0000000000000902. PMID: 36044308
Moderately differentiated Sertoli-Leydig cell tumor of ovary with associated mucinous carcinoma and carcinoid-A case report and review of literature.
Ravichandaran A, Lakshmanan A, Kurian A, Prasad S
Indian J Pathol Microbiol 2021 Jul-Sep;64(3):528-531. doi: 10.4103/IJPM.IJPM_672_20. PMID: 34341265
DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.
de Kock L, Terzic T, McCluggage WG, Stewart CJR, Shaw P, Foulkes WD, Clarke BA
Am J Surg Pathol 2017 Sep;41(9):1178-1187. doi: 10.1097/PAS.0000000000000895. PMID: 28654427
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database.
Bhat RA, Lim YK, Chia YN, Yam KL
J Obstet Gynaecol Res 2013 Jan;39(1):305-10. Epub 2012 Jun 13 doi: 10.1111/j.1447-0756.2012.01928.x. PMID: 22691037

Therapy

Characteristics and outcomes analysis of ovarian Sertoli-Leydig cell tumors (SLCTs): analysis of 15 patients.
Wang G, Zhang R, Li C, Chen A
J Ovarian Res 2021 Nov 4;14(1):150. doi: 10.1186/s13048-021-00909-7. PMID: 34736487Free PMC Article
Ovarian Sertoli-Leydig Cell Tumor With Heterologous Hepatocytes and a Hepatocellular Carcinomatous Element.
Yamamoto S, Sakai Y
Int J Gynecol Pathol 2019 May;38(3):247-252. doi: 10.1097/PGP.0000000000000499. PMID: 29620585
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database.
Bhat RA, Lim YK, Chia YN, Yam KL
J Obstet Gynaecol Res 2013 Jan;39(1):305-10. Epub 2012 Jun 13 doi: 10.1111/j.1447-0756.2012.01928.x. PMID: 22691037
Recurrence of a gonadal stromal cell tumor (Sertoli Leydig cell with heterologous elements) in a teenager.
Nolan T, Gallup DG, Dufour DR
Gynecol Oncol 1983 Feb;15(1):111-9. doi: 10.1016/0090-8258(83)90123-3. PMID: 6822363

Prognosis

Sertoli-Leydig cell tumor: a clinicopathological analysis in a comprehensive, national cohort.
Bekker P, Miland-Samuelsen AR, Smerdel MP, Schnack TH, Lauszus FF, Karstensen SH
Int J Gynecol Cancer 2023 Dec 4;33(12):1921-1927. doi: 10.1136/ijgc-2023-004945. PMID: 37907261
Characteristics and outcomes analysis of ovarian Sertoli-Leydig cell tumors (SLCTs): analysis of 15 patients.
Wang G, Zhang R, Li C, Chen A
J Ovarian Res 2021 Nov 4;14(1):150. doi: 10.1186/s13048-021-00909-7. PMID: 34736487Free PMC Article
Clinical Characteristics and Mutation Analyses of Ovarian Sertoli-Leydig Cell Tumors.
Yuan Z, Huo X, Jiang D, Yu M, Cao D, Wu H, Shen K, Yang J, Zhang Y, Zhou H, Wang Y
Oncologist 2020 Sep;25(9):e1396-e1405. Epub 2020 Aug 11 doi: 10.1634/theoncologist.2020-0110. PMID: 32557933Free PMC Article
Ovarian Sertoli-Leydig Cell Tumors: Epidemiological, Clinical and Prognostic Factors.
Castro BGR, Souza CP, Andrade CEMDC, Vieira MA, Andrade DAP, Reis RD
Rev Bras Ginecol Obstet 2019 Jul;41(7):440-448. Epub 2019 Jul 25 doi: 10.1055/s-0039-1693056. PMID: 31344718Free PMC Article
Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database.
Bhat RA, Lim YK, Chia YN, Yam KL
J Obstet Gynaecol Res 2013 Jan;39(1):305-10. Epub 2012 Jun 13 doi: 10.1111/j.1447-0756.2012.01928.x. PMID: 22691037

Clinical prediction guides

Well-differentiated Sertoli-Leydig Cell Tumors (SLCTs) Are Not Associated With DICER1 Pathogenic Variants and Represent a Different Tumor Type to Moderately and Poorly Differentiated SLCTs.
McCluggage WG, Rivera B, Chong AS, Clarke BA, Schultz KAP, Dehner LP, Tchrakian N, Apellaniz-Ruiz M, Gilks CB, Kommoss F, Stewart CJR, Foulkes WD
Am J Surg Pathol 2023 Apr 1;47(4):490-496. Epub 2022 Dec 30 doi: 10.1097/PAS.0000000000002010. PMID: 36583307
Characteristics and outcomes analysis of ovarian Sertoli-Leydig cell tumors (SLCTs): analysis of 15 patients.
Wang G, Zhang R, Li C, Chen A
J Ovarian Res 2021 Nov 4;14(1):150. doi: 10.1186/s13048-021-00909-7. PMID: 34736487Free PMC Article
The role of FOXL2, SOX9, and β-catenin expression and DICER1 mutation in differentiating sex cord tumor with annular tubules from other sex cord tumors of the ovary.
Onder S, Hurdogan O, Bayram A, Yilmaz I, Sozen H, Yavuz E
Virchows Arch 2021 Aug;479(2):317-324. Epub 2021 Feb 10 doi: 10.1007/s00428-021-03052-2. PMID: 33566167
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review.
Burnik Papler T, Frković Grazio S, Kobal B
J Ovarian Res 2016 Jul 30;9(1):46. doi: 10.1186/s13048-016-0257-4. PMID: 27473538Free PMC Article
Retiform Sertoli-Leydig cell tumours: clinical, morphological and immunohistochemical findings.
Mooney EE, Nogales FF, Bergeron C, Tavassoli FA
Histopathology 2002 Aug;41(2):110-7. doi: 10.1046/j.1365-2559.2002.01426.x. PMID: 12147087

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