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Differentiating neuroblastoma

MedGen UID:
268734
•Concept ID:
C1511934
•
Neoplastic Process
Synonyms: Differentiating Neuroblastoma; differentiating neuroblastoma
SNOMED CT: Differentiating neuroblastoma (1290245004)
 
Monarch Initiative: MONDO:0002899

Definition

Differentiating neuroblastoma grade includes greater than 5% differentiated ganglion cells and an active neuritic process from the neoplastic cells. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDifferentiating neuroblastoma

Professional guidelines

PubMed

Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee.
Suganuma R, Wang LL, Sano H, Naranjo A, London WB, Seeger RC, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Amann G, Beiske K, Cullinane CJ, d'Amore ES, Gambini C, Jarzembowski JA, Joshi VV, Navarro S, Peuchmaur M, Shimada H
Pediatr Blood Cancer 2013 Mar;60(3):363-70. Epub 2012 Jun 28 doi: 10.1002/pbc.24238. PMID: 22744966Free PMC Article
Conventional versus modified morphologic criteria for ganglioneuroblastoma. A review of cases from the Pediatric Oncology Group.
Joshi VV, Cantor AB, Altshuler G, Cohen LJ, Larkin EW, Shuster JJ, Rao PV, Holbrook CT, Hayes FA, Castleberry RP
Arch Pathol Lab Med 1996 Sep;120(9):859-65. PMID: 9140292
Diagnosis and follow-up of neuroblastoma by means of iodine-123 metaiodobenzylguanidine scintigraphy and bone scan, and the influence of histology.
Hadj-Djilani NL, Lebtahi NE, Delaloye AB, Laurini R, Beck D
Eur J Nucl Med 1995 Apr;22(4):322-9. doi: 10.1007/BF00941848. PMID: 7607262

Recent clinical studies

Therapy

Whole-tumor radiomics analysis of T2-weighted imaging in differentiating neuroblastoma from ganglioneuroblastoma/ganglioneuroma in children: an exploratory study.
Wang H, Chen X, Yu W, Xie M, Zhang L, Ding H, Li T, Qin J, He L
Abdom Radiol (NY) 2023 Apr;48(4):1372-1382. Epub 2023 Mar 9 doi: 10.1007/s00261-023-03862-9. PMID: 36892608
Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics.
Stefanowicz J, Izycka-Swieszewska E, Drozyńska E, Pienczk J, Połczyńska K, Czauderna P, Sierota D, Bień E, Stachowicz-Stencel T, Kosiak W, Balcerska A
Folia Neuropathol 2008;46(3):176-85. PMID: 18825593

Prognosis

Diagnostic Utility of GATA3 and ISL1 in Differentiating Neuroblastoma From Other Pediatric Malignant Small Round Blue Cell Tumors.
Mohanty SK, Diwaker P, Mishra SK, Jha S, Lobo A, Panda SP, Sharma S, Kumar M, Arora S, Mallik V, Jain D, Jain E, Chakrabarti I, Varshney J, Beg A, Dixit M, Baisakh MR, Naik S, Sahoo SK, Akgul M, Balzer BL, Amin MB, Parwani AV
Int J Surg Pathol 2024 Apr;32(2):294-303. Epub 2023 Jun 13 doi: 10.1177/10668969231177700. PMID: 37312579
Whole-tumor radiomics analysis of T2-weighted imaging in differentiating neuroblastoma from ganglioneuroblastoma/ganglioneuroma in children: an exploratory study.
Wang H, Chen X, Yu W, Xie M, Zhang L, Ding H, Li T, Qin J, He L
Abdom Radiol (NY) 2023 Apr;48(4):1372-1382. Epub 2023 Mar 9 doi: 10.1007/s00261-023-03862-9. PMID: 36892608
Pediatric neuroblastic tumors: A critical evaluation of cytomorphological features for risk stratification on aspiration cytology.
Behera G, Chhabra G, Mishra P, Sable M
Diagn Cytopathol 2020 May;48(5):464-474. Epub 2020 Feb 11 doi: 10.1002/dc.24389. PMID: 32043835
Oncologic Phenotype of Peripheral Neuroblastic Tumors Associated With PHOX2B Non-Polyalanine Repeat Expansion Mutations.
Heide S, Masliah-Planchon J, Isidor B, Guimier A, Bodet D, Coze C, Deville A, Thebault E, Pasquier CJ, Cassagnau E, Pierron G, Clément N, Schleiermacher G, Amiel J, Delattre O, Peuchmaur M, Bourdeaut F
Pediatr Blood Cancer 2016 Jan;63(1):71-7. Epub 2015 Sep 16 doi: 10.1002/pbc.25723. PMID: 26375764
Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics.
Stefanowicz J, Izycka-Swieszewska E, Drozyńska E, Pienczk J, Połczyńska K, Czauderna P, Sierota D, Bień E, Stachowicz-Stencel T, Kosiak W, Balcerska A
Folia Neuropathol 2008;46(3):176-85. PMID: 18825593

Clinical prediction guides

Diagnostic Utility of GATA3 and ISL1 in Differentiating Neuroblastoma From Other Pediatric Malignant Small Round Blue Cell Tumors.
Mohanty SK, Diwaker P, Mishra SK, Jha S, Lobo A, Panda SP, Sharma S, Kumar M, Arora S, Mallik V, Jain D, Jain E, Chakrabarti I, Varshney J, Beg A, Dixit M, Baisakh MR, Naik S, Sahoo SK, Akgul M, Balzer BL, Amin MB, Parwani AV
Int J Surg Pathol 2024 Apr;32(2):294-303. Epub 2023 Jun 13 doi: 10.1177/10668969231177700. PMID: 37312579
Whole-tumor radiomics analysis of T2-weighted imaging in differentiating neuroblastoma from ganglioneuroblastoma/ganglioneuroma in children: an exploratory study.
Wang H, Chen X, Yu W, Xie M, Zhang L, Ding H, Li T, Qin J, He L
Abdom Radiol (NY) 2023 Apr;48(4):1372-1382. Epub 2023 Mar 9 doi: 10.1007/s00261-023-03862-9. PMID: 36892608
Cells with ganglionic differentiation frequently stain for VE1 antibody: a potential pitfall.
Tan CL, Lian DWQ, Kuick CH, Chan YH, Chang KTE
Brain Tumor Pathol 2020 Jan;37(1):14-21. Epub 2019 Dec 9 doi: 10.1007/s10014-019-00356-9. PMID: 31820133
Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics.
Stefanowicz J, Izycka-Swieszewska E, Drozyńska E, Pienczk J, Połczyńska K, Czauderna P, Sierota D, Bień E, Stachowicz-Stencel T, Kosiak W, Balcerska A
Folia Neuropathol 2008;46(3):176-85. PMID: 18825593
Cholinesterases in neural development: new findings and toxicologic implications.
Brimijoin S, Koenigsberger C
Environ Health Perspect 1999 Feb;107 Suppl 1(Suppl 1):59-64. doi: 10.1289/ehp.99107s159. PMID: 10229707Free PMC Article

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