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Prostate Stromal Tumor of Uncertain Malignant Potential

MedGen UID:
271404
•Concept ID:
C1514517
•
Neoplastic Process
Synonyms: Prostate Stromal Proliferation of Uncertain Malignant Potential; Prostatic Stromal Tumor of Uncertain Malignant Potential

Definition

A neoplastic lesion that arises from the prostate gland stroma. Morphologic characteristics include hypercellular stroma with scattered atypical cells, prominent overgrowth of the prostatic stroma, or changes resembling benign phyllodes tumor. The majority of cases do not have an aggressive clinical course. A minority of cases however, may progress to stromal sarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate Stromal Tumor of Uncertain Malignant Potential

Professional guidelines

PubMed

Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions.
Li Y, Mongan J, Behr SC, Sud S, Coakley FV, Simko J, Westphalen AC
Radiographics 2016 Jul-Aug;36(4):1055-75. Epub 2016 Jun 17 doi: 10.1148/rg.2016150226. PMID: 27315446

Recent clinical studies

Etiology

Magnetic resonance imaging features of prostatic stromal tumour of uncertain malignant potential.
Liu Y, Wu J, Shen Q, Li D, He Z, Zhou L, Xiao J
J Med Imaging Radiat Oncol 2022 Dec;66(8):1065-1072. Epub 2022 Apr 26 doi: 10.1111/1754-9485.13414. PMID: 35470966
Clinical and Pathological Features of Prostatic Stromal Tumor of Uncertain Malignant Potential: A Retrospective Study of 23 Chinese Cases.
Shen Q, Zhou Z, Liu Z, Hu S, Lin Z, Li S, Li S, Song H, Chen Y, Meng Y, Wang Y, Fan Y, Li X, Xiao Y, He Q, Jin J, Zhang Q, Yu W
Urol Int 2021;105(3-4):206-214. Epub 2020 Nov 20 doi: 10.1159/000508763. PMID: 33221793
Clinicopathological features to distinguish malignant solitary fibrous tumors of the prostate from prostatic stromal tumors.
Xu Y, Li Z, Shi J, Fu Y, Zhu L, Fan X, Foo WC
Virchows Arch 2021 Apr;478(4):619-626. Epub 2020 Aug 20 doi: 10.1007/s00428-020-02909-2. PMID: 32820389
The Prevalence of Prostatic Stromal Tumor of Uncertain Malignant Potential in Specimens Diagnosed as Prostatic Hyperplasia.
Mokhtari M, Homayoun M, Yazdan Panah S
Arch Iran Med 2016 Jul;19(7):488-90. PMID: 27362242
Sarcomas and related proliferative lesions of specialized prostatic stroma: a clinicopathologic study of 22 cases.
Gaudin PB, Rosai J, Epstein JI
Am J Surg Pathol 1998 Feb;22(2):148-62. doi: 10.1097/00000478-199802000-00002. PMID: 9500215

Diagnosis

Prostatic stromal proliferations: a review.
Bostwick DG, Egevad L
Pathology 2021 Jan;53(1):12-25. Epub 2020 Nov 13 doi: 10.1016/j.pathol.2020.09.017. PMID: 33190920
Mesenchymal tumors of the prostate.
McKenney JK
Mod Pathol 2018 Jan;31(S1):S133-142. doi: 10.1038/modpathol.2017.155. PMID: 29297486
Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions.
Li Y, Mongan J, Behr SC, Sud S, Coakley FV, Simko J, Westphalen AC
Radiographics 2016 Jul-Aug;36(4):1055-75. Epub 2016 Jun 17 doi: 10.1148/rg.2016150226. PMID: 27315446
Stromal tumor of uncertain malignant potential of the prostate.
Murer LM, Talmon GA
Arch Pathol Lab Med 2014 Nov;138(11):1542-5. doi: 10.5858/arpa.2013-0212-RS. PMID: 25357117
Mesenchymal tumours of the bladder and prostate: an update.
Tavora F, Kryvenko ON, Epstein JI
Pathology 2013 Feb;45(2):104-15. doi: 10.1097/PAT.0b013e32835c768b. PMID: 23250042

Therapy

Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.
Heymach JV, Shackleford TJ, Tran HT, Yoo SY, Do KA, Wergin M, Saintigny P, Vollmer RT, Polascik TJ, Snyder DC, Ruffin MT 4th, Yan S, Dewhirst M, Kunnumakkara AB, Aggarwal BB, Demark-Wahnefried W
Cancer Prev Res (Phila) 2011 Oct;4(10):1590-8. Epub 2011 Jul 15 doi: 10.1158/1940-6207.CAPR-10-0136. PMID: 21764858Free PMC Article

Prognosis

Magnetic resonance imaging features of prostatic stromal tumour of uncertain malignant potential.
Liu Y, Wu J, Shen Q, Li D, He Z, Zhou L, Xiao J
J Med Imaging Radiat Oncol 2022 Dec;66(8):1065-1072. Epub 2022 Apr 26 doi: 10.1111/1754-9485.13414. PMID: 35470966
Mesenchymal Neoplasms of the Prostate and Seminal Vesicles: Spectrum of Disease with Radiologic-Pathologic Correlation.
Marcal LP, Surabhi VR, Ramani NS, Katabathina VS, Paspulati RM, Prasad SR
Radiographics 2022 Mar-Apr;42(2):417-432. Epub 2022 Jan 14 doi: 10.1148/rg.210084. PMID: 35030067
Stromal tumor of uncertain malignant potential of the prostate.
Murer LM, Talmon GA
Arch Pathol Lab Med 2014 Nov;138(11):1542-5. doi: 10.5858/arpa.2013-0212-RS. PMID: 25357117
Mesenchymal tumours of the bladder and prostate: an update.
Tavora F, Kryvenko ON, Epstein JI
Pathology 2013 Feb;45(2):104-15. doi: 10.1097/PAT.0b013e32835c768b. PMID: 23250042
Atypical prostatic stromal lesions.
Cohen MB
Adv Anat Pathol 1998 Nov;5(6):359-66. doi: 10.1097/00125480-199811000-00002. PMID: 10095877

Clinical prediction guides

Magnetic resonance imaging features of prostatic stromal tumour of uncertain malignant potential.
Liu Y, Wu J, Shen Q, Li D, He Z, Zhou L, Xiao J
J Med Imaging Radiat Oncol 2022 Dec;66(8):1065-1072. Epub 2022 Apr 26 doi: 10.1111/1754-9485.13414. PMID: 35470966
A rare case of malignant solitary fibrous tumor in prostate with review of the literature.
Ronchi A, La Mantia E, Gigantino V, Perdonà S, De Sio M, Facchini G, Franco R, De Chiara A
Diagn Pathol 2017 Jul 7;12(1):50. doi: 10.1186/s13000-017-0640-5. PMID: 28687087Free PMC Article
Round cell pattern of prostatic stromal tumor of uncertain malignant potential: a subtle newly recognized variant.
Sadimin ET, Epstein JI
Hum Pathol 2016 Jun;52:68-73. Epub 2016 Feb 1 doi: 10.1016/j.humpath.2016.01.002. PMID: 26980017
Mixed epithelial-stromal tumor (MEST) of seminal vesicle: a proposal for unified nomenclature.
Reikie BA, Yilmaz A, Medlicott S, Trpkov K
Adv Anat Pathol 2015 Mar;22(2):113-20. doi: 10.1097/PAP.0000000000000057. PMID: 25664946
Phyllodes tumor of the prostate: long-term followup study of 23 cases.
Bostwick DG, Hossain D, Qian J, Neumann RM, Yang P, Young RH, di Sant'agnese PA, Jones EC
J Urol 2004 Sep;172(3):894-9. doi: 10.1097/01.ju.0000134580.71261.57. PMID: 15310992

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