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t(11;18)(q21;q21)

MedGen UID:
271862
•Concept ID:
C1515709
•
Cell or Molecular Dysfunction
Synonyms: API2-MLT Translocation; BIRC3-MALT1 Translocation

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(11;18)(q21;q21)

Professional guidelines

PubMed

Protease activity of the API2-MALT1 fusion oncoprotein in MALT lymphoma development and treatment.
Rosebeck S, Lucas PC, McAllister-Lucas LM
Future Oncol 2011 May;7(5):613-7. doi: 10.2217/fon.11.35. PMID: 21568677Free PMC Article
Molecular biology of gastric MALT lymphoma: application in clinical management.
Du MQ
Hematology 2002 Dec;7(6):339-44. doi: 10.1080/1024533021000047981. PMID: 12475738
Gastric MALT lymphoma: from aetiology to treatment.
Du MQ, Isaccson PG
Lancet Oncol 2002 Feb;3(2):97-104. doi: 10.1016/s1470-2045(02)00651-4. PMID: 11902529

Recent clinical studies

Etiology

Mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) translocation: long-term follow-up results.
Toyoda K, Maeshima AM, Nomoto J, Suzuki T, Yuda S, Yamauchi N, Taniguchi H, Makita S, Fukuhara S, Munakata W, Maruyama D, Tobinai K, Kobayashi Y
Ann Hematol 2019 Jul;98(7):1675-1687. Epub 2019 Mar 28 doi: 10.1007/s00277-019-03671-5. PMID: 30923996
Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review.
Asano N, Iijima K, Koike T, Imatani A, Shimosegawa T
World J Gastroenterol 2015 Jul 14;21(26):8014-20. doi: 10.3748/wjg.v21.i26.8014. PMID: 26185372Free PMC Article
Helicobacter pylori infection, chronic inflammation, and genomic transformations in gastric MALT lymphoma.
Witkowska M, Smolewski P
Mediators Inflamm 2013;2013:523170. Epub 2013 Mar 28 doi: 10.1155/2013/523170. PMID: 23606792Free PMC Article
The pathogenesis of MALT lymphomas: where do we stand?
Sagaert X, De Wolf-Peeters C, Noels H, Baens M
Leukemia 2007 Mar;21(3):389-96. Epub 2007 Jan 18 doi: 10.1038/sj.leu.2404517. PMID: 17230229
MALT Lymphomas.
Cavalli F, Isaacson PG, Gascoyne RD, Zucca E
Hematology Am Soc Hematol Educ Program 2001:241-58. doi: 10.1182/asheducation-2001.1.241. PMID: 11722987

Diagnosis

Mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) translocation: long-term follow-up results.
Toyoda K, Maeshima AM, Nomoto J, Suzuki T, Yuda S, Yamauchi N, Taniguchi H, Makita S, Fukuhara S, Munakata W, Maruyama D, Tobinai K, Kobayashi Y
Ann Hematol 2019 Jul;98(7):1675-1687. Epub 2019 Mar 28 doi: 10.1007/s00277-019-03671-5. PMID: 30923996
Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review.
Asano N, Iijima K, Koike T, Imatani A, Shimosegawa T
World J Gastroenterol 2015 Jul 14;21(26):8014-20. doi: 10.3748/wjg.v21.i26.8014. PMID: 26185372Free PMC Article
The t(14;18)(q32;q21)/IGH-MALT1 translocation in gastrointestinal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma).
Zhang S, Wei M, Liang Q, Johnson D, Dow N, Nelson A, Aguilera N, Auerbach A, Wang G
Histopathology 2014 May;64(6):791-8. Epub 2014 Jan 10 doi: 10.1111/his.12327. PMID: 24236896
Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma.
Farinha P, Gascoyne RD
J Clin Oncol 2005 Sep 10;23(26):6370-8. doi: 10.1200/JCO.2005.05.011. PMID: 16155022
Gastric MALT lymphoma: from aetiology to treatment.
Du MQ, Isaccson PG
Lancet Oncol 2002 Feb;3(2):97-104. doi: 10.1016/s1470-2045(02)00651-4. PMID: 11902529

Therapy

Efficacy of eradication therapy in Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma: A meta-analysis.
Jung K, Kim DH, Seo HI, Gong EJ, Bang CS
Helicobacter 2021 Apr;26(2):e12774. Epub 2021 Jan 5 doi: 10.1111/hel.12774. PMID: 33400830
Mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) translocation: long-term follow-up results.
Toyoda K, Maeshima AM, Nomoto J, Suzuki T, Yuda S, Yamauchi N, Taniguchi H, Makita S, Fukuhara S, Munakata W, Maruyama D, Tobinai K, Kobayashi Y
Ann Hematol 2019 Jul;98(7):1675-1687. Epub 2019 Mar 28 doi: 10.1007/s00277-019-03671-5. PMID: 30923996
First-line antibiotic therapy in Helicobacter pylori-negative low-grade gastric mucosa-associated lymphoid tissue lymphoma.
Kuo SH, Yeh KH, Wu MS, Lin CW, Wei MF, Liou JM, Wang HP, Chen LT, Cheng AL
Sci Rep 2017 Oct 30;7(1):14333. doi: 10.1038/s41598-017-14102-8. PMID: 29084984Free PMC Article
Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review.
Asano N, Iijima K, Koike T, Imatani A, Shimosegawa T
World J Gastroenterol 2015 Jul 14;21(26):8014-20. doi: 10.3748/wjg.v21.i26.8014. PMID: 26185372Free PMC Article
MALT Lymphomas.
Cavalli F, Isaacson PG, Gascoyne RD, Zucca E
Hematology Am Soc Hematol Educ Program 2001:241-58. doi: 10.1182/asheducation-2001.1.241. PMID: 11722987

Prognosis

Mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) translocation: long-term follow-up results.
Toyoda K, Maeshima AM, Nomoto J, Suzuki T, Yuda S, Yamauchi N, Taniguchi H, Makita S, Fukuhara S, Munakata W, Maruyama D, Tobinai K, Kobayashi Y
Ann Hematol 2019 Jul;98(7):1675-1687. Epub 2019 Mar 28 doi: 10.1007/s00277-019-03671-5. PMID: 30923996
Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review.
Asano N, Iijima K, Koike T, Imatani A, Shimosegawa T
World J Gastroenterol 2015 Jul 14;21(26):8014-20. doi: 10.3748/wjg.v21.i26.8014. PMID: 26185372Free PMC Article
Helicobacter pylori and t(11;18)(q21;q21) translocation in gastric malt lymphoma.
Lima KS, Albuquerque W, Arantes VN, Drummond-Lage AP, Coelho LG
Arq Gastroenterol 2014 Apr-Jun;51(2):84-9. doi: 10.1590/s0004-28032014000200003. PMID: 25003257
Molecular pathogenesis of mucosa-associated lymphoid tissue lymphoma.
Farinha P, Gascoyne RD
J Clin Oncol 2005 Sep 10;23(26):6370-8. doi: 10.1200/JCO.2005.05.011. PMID: 16155022
Gastric MALT lymphoma: from aetiology to treatment.
Du MQ, Isaccson PG
Lancet Oncol 2002 Feb;3(2):97-104. doi: 10.1016/s1470-2045(02)00651-4. PMID: 11902529

Clinical prediction guides

Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphomas: A review.
Asano N, Iijima K, Koike T, Imatani A, Shimosegawa T
World J Gastroenterol 2015 Jul 14;21(26):8014-20. doi: 10.3748/wjg.v21.i26.8014. PMID: 26185372Free PMC Article
Helicobacter pylori and t(11;18)(q21;q21) translocation in gastric malt lymphoma.
Lima KS, Albuquerque W, Arantes VN, Drummond-Lage AP, Coelho LG
Arq Gastroenterol 2014 Apr-Jun;51(2):84-9. doi: 10.1590/s0004-28032014000200003. PMID: 25003257
T(11;18)(q21;q21) in gastric MALT lymphoma and diffuse large B-cell lymphoma of Chinese patients.
Huang X, Zhang Z, Liu H, Ye H, Chuang SS, Wang J, Lin S, Gao Z, Du MQ
Hematol J 2003;4(5):342-5. doi: 10.1038/sj.thj.6200295. PMID: 14502259
High incidence of t(11;18)(q21;q21) in Helicobacter pylori-negative gastric MALT lymphoma.
Ye H, Liu H, Raderer M, Chott A, Ruskone-Fourmestraux A, Wotherspoon A, Dyer MJ, Chuang SS, Dogan A, Isaacson PG, Du MQ
Blood 2003 Apr 1;101(7):2547-50. Epub 2002 Nov 27 doi: 10.1182/blood-2002-10-3167. PMID: 12517817
MALT Lymphomas.
Cavalli F, Isaacson PG, Gascoyne RD, Zucca E
Hematology Am Soc Hematol Educ Program 2001:241-58. doi: 10.1182/asheducation-2001.1.241. PMID: 11722987

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